Obinutuzumab Provides Two-Year Benefits for Lupus Nephritis

Nov 3rd, 2020 - After promising 18-month outcomes in patients with proliferative lupus nephritis, obinutuzumab showed sustained benefits through 2 years of treatment for patients burdened with the rheumatic disease.

ACR Convergence 2020: Study Data for Lupus & Rheumatoid Arthritis
The Rheumatologist; Hickman RJ.

Nov 8th, 2020 - At the annual meeting’s second Plenary Session, Saturday, Nov. 7, speakers highlighted phase 2 results of a potential new biologic for systemic lupus erythematosus (SLE), as well as data on remission maintenance in rheumatoid arthritis (RA) after withdrawal of etanercept or methotrexate.

Aerobic Exercise Improves Fatigue and Quality of Life in Women with Systemic Lupus Erythematosus (Preliminary Analysis)
Marquis Chapman, Sarthak Gupta, Jun Chu et. al.

Nov 9th, 2020 - Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease of female predominance. One of the most debilitating symptoms experienced by SLE-patients is persistent fatigue. Prior research from our group suggests that fatigue, as measured by the Fatigue Severity Scale (FSS), is independent of SLE disease activity, as measured by Safety of Estrogen in Lupus Ery...

Assessment of the Impact of Interferon Levels on Cognitive Dysfunction in Patients with SLE
Andrew Kwan, Joan Wither, Juan Pablo Diaz-Martinez et. al.

Nov 9th, 2020 - Background/Purpose: Cognitive impairment (CI) is among the earliest and the most prevalent manifestations of SLE. Previous studies have demonstrated that the increased levels of interferon (IFN)-induced gene expression in SLE are positively correlated with SLE disease activity and severity. The aim of this study is to examine the relationship between IFN levels and cognition as measured by the ...

An Engineered Extracellular Matrix‐rich Decellularized Substrate Based Podocytes Culture System to Study Intracellular Complement Production and Activation
Abhigyan Satyam, Maria Tsokos2 and George Tsokos, Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School et. al.

Nov 9th, 2020 - Background/Purpose: Current technologies do not support long-term cell viability, differentiation and maintenance of podocytes. We developed a biophysical approach, termed macromolecular crowding (MMC), to create extracellular matrix (ECM)-rich tissue equivalents and decellularization. This approach generates decellularized grafts that scaffold podocytes to grow in an environment similar to nat...

Association of Air Pollution with Systemic Lupus Erythematosus Disease Activity in the Central Valley of California
Mosaab Mohameden, Ali H.Ali, Zi Ying Li et. al.

Nov 9th, 2020 - Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease that affects at least 300,000 people in the United States creating a substantial socioeconomic burden. The exact etiology of SLE remains largely unknown. Both genetic factors and environmental exposures have been implicated in the etiology and progression of SLE. Air pollution is one of the major ...

Complement Activation in Systemic Lupus Erythematosus Patients with Low Disease Activity Is Not Inhibited by Hydroxychloroquine
Anne Margrethe Troldborg, Annette Hansen, Kristian Stengaard-Pedersen2 and Steffen Thiel et. al.

Nov 9th, 2020 - Background/Purpose: Mortality in patients with systemic lupus erythematosus (SLE) is significantly higher than in the general population. Treatment of SLE patients has improved, however, a majority of patients still experience symptoms like fatigue, pain and cognitive deficits even when they are clinically evaluated to have low disease activity (LDA) or being in remission. Immunosuppressants ar...

Cervical Cancer Screening Among Women with Systemic Lupus Erythematosus or Prescribed Tumor Necrosis Alpha-inhibitors Who Receive Outpatient Rheumatology Care
Mehret Birru Talabi, Kwonho Jeong, Kaleab Abebe et. al.

Nov 9th, 2020 - Background/Purpose: Cervical cancer screening is important for women with systemic lupus erythematosus (SLE) and women prescribed TNF-alpha inhibitors (TNFi), as they have an increased risk of cervical dysplasia and cancer due to immune dysfunction and/or suppression. We describe receipt of guidelines-concordant cervical cancer screening among women receiving rheumatology care in a large Pennsy...

Clinical Outcomes in Lupus Nephritis by Renal Response Status: A Retrospective Analysis of the Hopkins Lupus Cohort
Michelle Petri, Qinggong Fu, Yulia Green et. al.

Nov 9th, 2020 - Background/Purpose: A retrospective analysis of the Hopkins Lupus Cohort (a prospective, longitudinal study of patients [pts] with systemic lupus erythematosus) reported that renal response (complete/partial/none) at 24 months post-diagnosis of lupus nephritis (LN) predicts long-term renal survival.1 Here, we compare long-term renal survival and chronic renal insufficiency-free survival in pts ...

High-throughput Identification of Functional Regulatory SNPs Associated with Systemic Lupus Erythematosus
Qiang Wang, Marta Martínez, Matthew Weirauch3 and Peter Nigrovic et. al.

Nov 9th, 2020 - Background/Purpose: Systemic lupus erythematosus (SLE) is a disease involves the complex interplay of many genes, reflected in more than one hundred loci linked with disease risk by genome-wide association studies (GWAS). Decoding GWAS is, therefore, a promising strategy to identify novel drug targets in SLE. However, most of the identified disease-associated hits are noncoding single-nucleotid...

Changes in Macular Capillary Network Measured with Optical Coherence Tomography-angiography in Patients with Systemic Lupus Erythematosus
Laura Pelegrin, Marc Figueras-Roca, Alvaro Olate-Perez et. al.

Nov 9th, 2020 - Background/Purpose: Eye involvement in systemic lupus erythematosus (SLE) occurs in approximately one-third of patients, usually related to disease activity. An early diagnosis and treatment could prevent structural eye damage and visual acuity worsening in these cases. The purpose of the present study was t o describe macular vascular findings by optical coherence tomography angiography (OCT-A...

Comprehensive Efficacy of Anifrolumab Across Organ Domains in Patients with Active SLE: Pooled Data from 2 Phase 3 Trials
Eric Morand, Richard Furie, Ian Bruce et. al.

Nov 9th, 2020 - Background/Purpose: SLE is a heterogeneous autoimmune disease with clinical manifestations across multiple organ systems. In the phase 3 TULIP-1 and TULIP-2 trials, anifrolumab treatment resulted in greater percentages of patients with SLE achieving a BILAG-based Composite Lupus Assessment (BICLA) response vs placebo at Week 52.1,2 We further evaluated the effects of anifrolumab on organ domain...

Documentation of Pregnancy Counseling in SSA-Positive Patients of Childbearing Potential: A Cross-Sectional Study
Heinrich-Karl Greenblatt1 and Elena Weinstein, University of Colorado School of Medicine, Aurora et. al.

Nov 9th, 2020 - Background/Purpose: Systemic lupus erythematosus (SLE) and primary Sjogren’s Syndrome (SS) are highly associated with anti-SSA (anti-Ro) seropositivity. Anti-SSA autoantibodies may cross the placenta, causing a range of cutaneous and cardiac manifestations in the neonate. Approximately 2% of SSA-positive pregnancies result in complete congenital heart block, which is often fatal. Echocardiograp...

Etiologies and Management of Hemophagocytic Lymphohistiocytosis: Is It Time for an Updated Protocol and Targeted Treatments?
Therese Posas-Mendoza, Cara McLeod, William Davis2 and Robert Quinet et. al.

Nov 9th, 2020 - Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease characterized by immune-overstimulation and a hyperinflammatory response resulting in cytokine storm and multi-organ failure.1 Secondary HLH usually occurs in adults in the setting of malignancy, infection, or a rheumatic condition. It is often triggered by an infection such as Epstein-Barr virus (EB...

Intracellular Homocysteine and Homocysteine Metabolites in Systemic Lupus Erythematosus (SLE)
George Stojan, Jessica Li, Amrita Raj et. al.

Nov 9th, 2020 - Background/Purpose: In SLE, homocysteine has been shown to be a potentially modifiable, independent risk factor for stroke and thrombotic events. All previous epidemiological studies used total plasma homocysteine as a disease marker, but it remains unclear whether plasma or intracellular homocysteine is causing detrimental effects. Folic acid (0.5 mg/day) supplementation does lower homocystein...

IgG and IgA Autoantibodies Against L1 ORF1p Expressed in Granulocytes Correlate with Granulocyte Consumption and Disease Activity in Pediatric Systemic Lupus Erythematosus
Kennedy Ukadike, Kathryn Ni, Victoria Carter et. al.

Nov 9th, 2020 - Background/Purpose: To quantitate autoantibodies against the RNA-binding p40 (ORF1p) protein encoded by the L1 retroelement, expression of p40 itself, and markers of neutrophil death in patients with pediatric systemic lupus erythematosus (pSLE), and to determine if correlations exist between these and disease activity. Methods: Autoantibodies in the plasma of pSLE patients (n=30), healthy chil...

Impact of the Kynurenine/Tryptophan Pathway on Cognitive Dysfunction and Depression in Systemic Lupus Erythematosus
Erik Anderson, Joanna Fishbein, Joseph Hong et. al.

Nov 9th, 2020 - Background/Purpose: Tryptophan (TRP) is metabolized to kynurenine (KYN), quinolonic acid [QA, a N-methyl D-aspartate receptor (NMDAR) agonist] and kynurenic acid (KA, an NMDAR antagonist). KYN/TRP pathway stimulation by IFNa may create a potential neurotoxic QA/KA imbalance in SLE. We investigated QA/KA ratios in SLE subjects vs. healthy controls (HC) and their associations with cognition and d...

Altered Brain Functional Connectivity in Systemic Lupus Erythematosus
Michelle Barraclough, Shane McKie, Benjamin Parker et. al.

Nov 9th, 2020 - Background/Purpose: Cognitive dysfunction (CD) is very prevalent in SLE and significantly affects quality of life. Altered functional brain mechanisms are associated with CD in SLE. We previously used functional magnetic resonance imaging (fMRI) to show altered mechanisms in the Default Mode Network (DMN), a network involved in self-reflection and is acquiescent during cognitive tasks. In this ...

Hydroxychloroquine and QTc Prolongation in a Cohort of SLE Patients
Mayce Haj-Ali1 and H. Michael Belmont, NYU Langone Health, new york et. al.

Nov 9th, 2020 - Background/Purpose: Hydroxychloroquine (HCQ) is an antimalarial drug used in the treatment of systemic lupus erythematous (SLE). Cardiac toxicity is very rare in SLE, but has been reported in patients with ESRD. The normal corrected QT (QTc) interval is defined as 450 ms in males and 470 ms in females. Severe prolongation of QTc is defined as > 500 ms and is associated with higher risk of devel...

Goal-Setting Improves Transition Readiness in Adolescents with Juvenile Idiopathic Arthritis and Systemic Lupus Erythematosus
Teresa Semalulu, Karen Beattie, Jeanine McColl et. al.

Nov 9th, 2020 - Background/Purpose: The transition from pediatric to adult rheumatology care is associated with increased morbidity, mortality and loss to follow-up. This is largely due to a dramatic change in expectations as patients move from a family-centred, multidisciplinary pediatric care model to adult care models, which require independence and active engagement by the patient. Thus, adolescents must a...