Osteoporosis 'largely ignored' in older men

Nov 6th, 2020 - Less than 3% of older men who had experienced an osteoporosis-related fracture had been properly diagnosed and treated, according to findings presented at ACR Convergence 2020.

Clinically Important Improvements in Patients with Osteoarthritis Treated with Subcutaneous Tanezumab: Results from a 56-Week Randomized NSAID-Controlled Study
David Hunter, Tuhina Neogi, Melvin Churchill et. al.

Nov 9th, 2020 - Background/Purpose: Subcutaneous (SC) tanezumab, a monoclonal antibody that inhibits nerve growth factor, was investigated for the relief of signs and symptoms of moderate-severe OA in patients (pts) for whom use of other analgesics was ineffective or not appropriate in a randomized NSAID-controlled global long-term safety study (NCT02528188). The current analysis examines the effect of tanezum...

An Oleuropein-based Dietary Supplement Improves Joint Function in Older People with High Knee Joint Pain
Marie-Noelle Horcajada, Maurice Beaumont, Nicolas Sauvageot et. al.

Nov 9th, 2020 - Background/Purpose: The aim of this study was to investigate the effects of a 6-month intervention with an Olive Leaf Extract (OLE) standardized for oleuropein content on knee functionality and biomarkers of bone/cartilage metabolism and inflammation. Methods: The study was a randomized, double-blind, placebo-controlled, multi-centric trial of 124 subjects with mild knee pain or mobility issues...

Cathepsin S Gene Expression Measured in the Peripheral Blood of Osteoarthritic Patients Prior to Surgery as a Biomarker of Post-operative Pain Development
Elena Tchetina, Kseniya Glemba, Galina Markova et. al.

Nov 9th, 2020 - Background/Purpose: Osteoarthritis (OA) is a chronic rheumatic disease, which involves pain, limited inflammation, and local destruction of the knee joint. OA pain is a major clinical symptom, which limits working capacity and denotes an important indication for joint replacement in the end-stage OA. In spite of significant number of positive outcomes, chronic postoperative pain represents a ma...

Comparison of Methotrexate and Glucosamine in Primary Knee Osteoarthritis with Inflammation
Biswadip Ghosh, Subhankar Haldar2 and Meghna Saha, IPGME&R et. al.

Nov 9th, 2020 - Background/Purpose: Many patients suffering from knee OA show swelling, warmth along with pain which are features of inflammation. There are no accepted pharmacological therapy for osteoarthritis that target inflammation though inflammation plays a crucial role in pain generation and progressive joint damage. There are some evidence that Methotrexate may be useful in knee osteoarthritis. The la...

Cost-effectiveness of Surgical and Non-Surgical Weight Loss Programs for Morbidly Obese Patients with Knee Osteoarthritis
Valia Leifer, Jeffrey Katz, Faith Selzer et. al.

Nov 9th, 2020 - Background/Purpose: Growing numbers of knee osteoarthritis (KOA) patients are morbidly obese (BMI ≥ 35 kg/m2). Evolving evidence suggests weight reduction may delay the structural progression of KOA, reduce knee pain, and improve total knee replacement (TKR) outcomes. The cost-effectiveness of surgical and non-surgical weight loss strategies among morbidly obese patients with KOA has not been a...

Clinically Important Improvement in Osteoarthritis Pain at Week 16 After Subcutaneous Administration of Tanezumab: Pooled Analysis from International Studies
Thomas Schnitzer, Francis Berenbaum, Philip G Conaghan et. al.

Nov 9th, 2020 - Background/Purpose: Tanezumab is under investigation for the treatment of moderate to severe OA pain. As part of the phase 3 OA program, two randomized, placebo-controlled studies were completed and the data reported separately. Both studies showed early and sustained pain relief, following subcutaneous administration of tanezumab, at the time of the respective primary endpoints. The objective ...

Effect of Knee Aspiration and Intra-articular Corticosteroid Injection on Gait Biomechanics and Strength Impairment in Patients with Signs of Inflammation Due to Knee Osteoarthritis
Ryan Pinto, Trevor Birmingham, Holly Philpott et. al.

Nov 9th, 2020 - Background/Purpose: Synovial inflammation in knees with OA can be measured with musculoskeletal ultrasound (MSK US), is associated with increased pain and disease progression, and may adversely affect joint biomechanics. Knee effusion has been associated with quadriceps avoidance gait (decreased external knee flexion moment (KFM) during walking, altered quadriceps and hamstring activation) in p...

Knee OA Outcomes in Patients with Severe Obesity Following Bariatric Surgery or Total Knee Arthroplasty
Jonathan Samuels, Stephen Zak, Ran Schwarzkopf et. al.

Nov 9th, 2020 - Background/Purpose: High body mass index (BMI, kg/m2) is a modifiable risk factor that has been associated with the development and progression of osteoarthritis (OA) and knee pain. While total knee arthroplasty (TKA) is the gold standard for the treatment of end stage OA, morbidly obese patients (BMI≥40kg/m2) are often required to lose weight prior to TKA due to increased surgical risk and a h...

Gut Microbiome Transplantation from MRL/MpJ Mice Prevents Post-Traumatic Osteoarthritis in C57BL6/J Mice
Matlock Jeffries, Jake Martin, Vladislav Izda et. al.

Nov 9th, 2020 - Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have previously shown that this ear wound healing trait is partially determined by the gut microbiome, and that gut microbial transplantation into non-healer mice can confer the ear wound healing phenotype. In this...

Do Comorbidities Limit Improvement in Pain and Physical Function After Total Knee Arthroplasty in Patients with Knee Osteoarthritis?
Lauren King, Esther Waugh, Allyson Jones et. al.

Nov 9th, 2020 - Background/Purpose: Individuals with knee osteoarthritis (OA) are increasingly living with multiple comorbid conditions. The presence of comorbidities has been associated with having worse OA symptoms but few studies have assessed their impact on response to OA treatment. We assessed the impact if any of comorbidities on improvement in pain and physical function (patient-reported and performanc...

Bilateral vs Unilateral Total Knee Arthroplasty: Racial Variation in Utilization and In-Hospital Major Complication Rates
Bella Mehta, Kaylee Ho, Jennifer Bido et. al.

Nov 9th, 2020 - Background/Purpose: Compared to White Patients, African Americans (AAs) are reported to have lower utilization and higher complication rates outcomes in Unilateral Total knee arthroplasty (UTKA). It is unclear whether racial variations exist for Bilateral TKA (BTKA) Methods: In this retrospective analysis, we sought to examine BTKA vs UTKA utilization and in-hospital complications comparing AAs...

Do Weight-bearing versus Non-weight-bearing Pain Reflect Different Pain Mechanisms in Knee Osteoarthritis?: The Multicenter Osteoarthritis Study
Jean Liew, John Farrar, Na Wang et. al.

Nov 9th, 2020 - Background/Purpose: Pain with weightbearing in knee OA is thought to be related to the activation of nociceptors; however, this is not considered the sole mechanism by which pain is experienced in OA as it would not explain the pain with non-weight-bearing that often occurs. Pain sensitization, reflecting altered pain processing, may contribute to pain at rest or while sleeping. The aim of this...

Joint Damage and Malalignment Determine Articular Tenderness More Than Inflammation in Rheumatoid Arthritis, Psoriatic Arthritis or Osteoarthritis in Established Disease
Mihaela Popescu, Victoria Schimpl, Gabriela Supp et. al.

Nov 9th, 2020 - Background/Purpose: To determine whether clinical tenderness can be considered a sign of inflammatory joint activity in patients with rheumatoid arthritis (RA), osteoarthritis (OA) or psoriatic arthritis (PsA). Methods: Patients diagnosed with RA, PsA and OA underwent clinical and ultrasound examination of wrists and finger joints. Gray scale signs of synovitis (GS) and Power Doppler signal (PD...

Progression of Knee OA with Use of Intra-articular Corticosteroids (CS) vs Hyaluronic Acid (HA)
Justin Bucci, Xiaoyang Chen, James Torner et. al.

Nov 9th, 2020 - Background/Purpose: Recent studies have questioned whether CS injections (CSI), a popular treatment recommended by guidelines, hasten progression of knee OA.  A recent cohort study suggested a three-fold higher risk for knee OA progression with CSI. A limitation of such studies is CSI recipients have more advanced knee OA, which is itself a risk factor for OA progression, making it impossible, ...

Ultrasound in Knee Osteoarthritis: Reader Performance, Sonographic Features, and Correlation with Radiographic Findings
Ogonna Nwawka, Susan Lee, Bin Lin et. al.

Nov 9th, 2020 - Background/Purpose: Radiography is the most widespread imaging technique used in the evaluation of knee osteoarthritis (KOA), and MRI is known to be specific in characterization of cartilage disease. However, both modalities have their limitations, and there remains need for a reproducible and widely available imaging technique for characterization of KOA disease severity. The utility of ultras...

Evaluating Analgesic Response to Subcutaneous Tanezumab in Patients with Inadequate Treatment Response to Other Analgesics Based on Daily E-pain Diaries: A Pooled Analysis of 2 Randomized, Placebo-...
Thomas Schnitzer, Francis Berenbaum, Isabelle Davignon et. al.

Nov 9th, 2020 - Background/Purpose: Tanezumab is a monoclonal antibody against nerve growth factor being investigated for treatment of the signs and symptoms of osteoarthritis (OA). Subcutaneous tanezumab was efficacious, based on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain, WOMAC Function, and Patient’s Global Assessment of Osteoarthritis scores, in 2 recent Phase 3 studies, on...

A Double-Blind Randomized Trial to Evaluate the Efficacy of Corticosteroid Injections for Osteoarthritis of the Knee Using Mobile Devices
Joshua Baker, Mitesh Patel, Tuhina Neogi et. al.

Nov 9th, 2020 - Background/Purpose: The value of intra-articular (IA) corticosteroid injections for osteoarthritis of the knee (KOA) has recently been called into question.  Variability in clinical trial design has resulted in inconsistent results from clinical studies evaluating efficacy of this commonly performed procedure. We designed a pilot and feasibility double-blind trial to evaluate the benefit of IA ...

Observed Efficacy with Subcutaneous Tanezumab Is Early and Maintained in Patients with Osteoarthritis: Results from a 56-Week Randomized NSAID-Controlled Study
Tuhina Neogi, David Hunter, Melvin Churchill et. al.

Nov 9th, 2020 - Background/Purpose: Subcutaneous (SC) tanezumab, a monoclonal antibody that inhibits nerve growth factor, was investigated for the relief of signs and symptoms of moderate-severe OA in patients (pts) for whom use of other analgesics was ineffective or not appropriate in a randomized NSAID-controlled long-term global safety study (NCT02528188). The primary safety (joint safety over 80 weeks [Wk]...

NGF-Responsive Neurons Are Sensitized in Experimental Osteoarthritis
Rachel Miller, Shingo Ishihara, Alia Obeidat1 and Anne-Marie Malfait et. al.

Nov 9th, 2020 - Background/Purpose: Nerve growth factor (NGF) is under investigation as a promising target for osteoarthritis (OA) pain. NGF exerts its potent pro-algesic effects through sensitization of nociceptors. Sensitization is a key process in chronic pain states, including OA, characterized by exaggerated responses to innocuous stimuli. However, the precise biological mechanisms underlying the pain-pro...