Machine Learning Could Benefit Rheumatoid Arthritis Treatment with Sarilumab

Nov 2nd, 2020 - As interleukin receptor (IL) inhibitors, the monoclonal antibody drug class has come to revolutionize fields of inflammatory disease care, though the utility and resourcing of such promising agents is yet to be fully refined. Namely, clinicians can stand to benefit from more biomarkers, more indications by which monoclonal antibodies are most impactful.

ACR Convergence 2020: Study Data for Lupus & Rheumatoid Arthritis
The Rheumatologist; Hickman RJ.

Nov 8th, 2020 - At the annual meeting’s second Plenary Session, Saturday, Nov. 7, speakers highlighted phase 2 results of a potential new biologic for systemic lupus erythematosus (SLE), as well as data on remission maintenance in rheumatoid arthritis (RA) after withdrawal of etanercept or methotrexate.

Circulating Biomolecules as Potential Biomarkers of Early and Establishedresponse to TNFi Therapy in Rheumatoid Arthritis Patients
Chary Lopez-Pedrera, Maria Luque-Tevar, Carlos Pérez-Sánchez et. al.

Nov 9th, 2020 - Background/Purpose: To evaluate changes produced in circulating inflammatory mediators and their regulatory miRNAs in RA patients after 3 and 6 months of treatment with TNF-α inhibitors (TNFi), in order to identify biomarkers of clinical efficacy and potential predictors of therapeutic response to TNFi therapies. Methods: In a prospective RA cohort multicenter study, serum from125 RA patients w...

Associations Between Patient Reported Outcomes and Impairments of Work and Activity in Patients with Rheumatoid Arthritis Who Achieved Clinical Remission; Retrospective Analysis Using the IORRA Dat...
Ryoko Sakai, Eiichi Tanaka, Eisuke Inoue et. al.

Nov 9th, 2020 - Background/Purpose: Disease burden and subjective symptoms of rheumatoid arthritis (RA) remain even after achieving clinical remission or low disease activity. Impairments to work and societal/daily activity are relevant burdens for patients with RA. However, detailed analyses are rarely performed. For exploring a better strategy aiming at less burden beyond Treat-to-Target strategy, it is esse...

Assessment of the Components of RAPID3 Patient Reported Outcomes in an Community Rheumatology Practice
Elston He, Pratyusha Yalamanchi, William Arnold3 and Erin Arnold et. al.

Nov 9th, 2020 - Background/Purpose: Patient reported outcomes are integral to measuring patient response to treatment for rheumatoid arthritis (RA). RAPID3 is a patient reported outcome metric that consists of three categories: pain, global assessment of health, and physical functional assessment. Here we investigate the relationship between the components of RAPID3 and serum biomarkers as measures of disease ...

A Single Cell Stromal Atlas Identifies Conserved Fibroblast Phenotypes Expanded in the Inflamed Synovium, Lung, Intestine, and Salivary Gland
Ilya Korsunsky, Kevin Wei, Mathilde Pohin et. al.

Nov 9th, 2020 - Background/Purpose: Pro-inflammatory fibroblasts have been independently implicated in the pathogenesis of rheumatoid arthritis (RA), inflammatory bowel disease (IBD), interstitial lung disease (ILD), and Sjogren’s syndrome (pSS). While these fibroblasts are likely affected by disease modifying antirheumatic drugs that target broad cytokine pathways such as TNF, IL6, and GM-CFS, recent work sug...

Association of Obesity with Treatment Response to Methotrexate or Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis
Dilli Poudel, Ted Mikuls, Michael George et. al.

Nov 9th, 2020 - Background/Purpose: Obesity affects 30-40% of RA patients and is associated with higher clinical disease activity measures and progressive disability. Studies suggest that obesity may be associated with poor response to TNF inhibitors (TNFi), but the degree to which these prior results were impacted by unmeasured confounding factors is unclear. We aimed to evaluate differences in response to MT...

Health Assessment Questionnaire Predicts All-Cause Mortality at One Year in Patients with Early Rheumatoid Arthritis
Safoora Fatima, Orit Schieir, Marie-France Valois et. al.

Nov 9th, 2020 - Background/Purpose: Patients with RA are at greater risk of mortality than the general population. Higher HAQ disability has been associated with hospitalizations and mortality in established RA; whether HAQ disability predicts mortality in early RA (ERA) is unknown. Methods: Data were from adult early RA patients (symptoms < 1 year) enrolled in the Canadian Early Arthritis Cohort (CATCH) betwe...

Complex, Dynamic Attributes of Antigen-specific T Cells in Rheumatoid Arthritis
Eddie James, Virginia Muir, Cliff Rims et. al.

Nov 9th, 2020 - Background/Purpose: CD4+ T cells are implicated in the pathogenesis of rheumatoid arthritis (RA) due to strong genetic association with HLA class II alleles, the presence of CD4+ T cells in the rheumatoid joint and the efficacy of T cell directed therapies. In addition, CD4+ T cells specific to citrullinated epitopes are increased in RA and their frequency is influenced by disease duration and ...

Combined Thermal and Ultrasound Imaging in Rheumatoid Arthritis Is Superior to Either Imaging Alone in Terms of Correlation with the 28-joint Disease Activity Score
York Kiat Tan, Cassandra Hong, HuiHua Li et. al.

Nov 9th, 2020 - Background/Purpose: Combined thermal and ultrasound (US) imaging modalities in detecting joint inflammation in rheumatoid arthritis (RA) has not been evaluated relative to thermal or US imaging alone. Therefore, we aim to compare outcomes of the combined imaging modalities versus single imaging modality using the routinely performed 28-joint disease activity score (DAS28). Methods: Thermography...

Comparison of MBDA Score, Patient Global Assessment and Evaluator Global Assessment for Predicting Risk of Radiographic Progression
Leonard Calabrese, Michael Weinblatt, Nancy Shadick et. al.

Nov 9th, 2020 - Background/Purpose: To compare the abilities of MBDA score, patient global assessment (PGA) and evaluator global assessment (EGA) to assess risk for radiographic progression (RP), and to assess the ability of MBDA score to predict RP among patients with concordant or discordant PGA and EGA. Methods: Patients were pooled from two RCTs of patients with recent onset RA treated with conventional an...

Cardiovascular Risk in Rheumatoid Arthritis Patients Treated with Methotrexate versus Hydroxychloroquine
Mengdong He, Ajinkya Pawar, Rishi Desai et. al.

Nov 9th, 2020 - Background/Purpose: Rheumatoid arthritis (RA) is a known risk factor for cardiovascular (CV) events. While most RA patients use conventional disease-modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX) and hydroxychloroquine (HCQ) as the 1st line DMARD, little is known about the comparative cardiovascular safety of these DMARDs. The objective of this study was to compare the incide...

Coproduction of Care for Veterans with RA: Improving Elicitation and Documentation of Patient Goals
Swathi Reddy, Kyawt Shwin, Rashmi Arora et. al.

Nov 9th, 2020 - Background/Purpose: Coproduction of healthcare services offers a pathway to increase patient engagement in care. Patients and clinicians coproduce care by working together to: (1) co-assess health status; (2) co-decide next steps in the care plan based on the patient’s goals; (3) co-design the care plan to fit the patient’s goals, context, and capabilities; and, (4) co-deliver self-care and pro...

Clinical Characteristics of Methotrexate Associated Lymphoproliferative Disorders and RA Treatment After Lymphoproliferative Onset in 92 Cases
Tomohiro Kameda, Shusaku Nakashima, Masayuki Inoo et. al.

Nov 9th, 2020 - Background/Purpose: Lymphoproliferative disorders (LPD) that develop in rheumatoid arthritis (RA) patients treated with MTX (MTX-LPD) is one of the important complications for RA patients. MTX-LPD has varied pathologies including various clinical manifestation and histological finding. Therefore, we need more information about MTX-LPD. In addition, it has not been established for RA treatment a...

Distinctive Molecular Signatures Among Monocytes from Childhood- and Adult-onset Systemic Lupus Erythematosus: Clinical Involvement and Relevance of Sustained Anti-dsDNA Positivity
Alejandra Maria Patiño-Trives, Concepción Aranda-Valera, R Roldan et. al.

Nov 9th, 2020 - Background/Purpose: By using integrative transcriptomic and protein analyses, this study aimed at identifying and characterize distinctive molecular signatures between childhood-onset (cSLE) and adult-onset Lupus (aSLE) patients, along with their involvement in immunological and clinical features, and to analyze the relevance of the sustained positivity for anti-dsDNA antibodies. Methods: Ninet...

Development and Delivery of Continuing Education Interventions Promoting Shared Decision Making in Rheumatoid Arthritis
Richard Martin, Marianna Shershneva2 and Lily Zurkovsky, Michigan State University College of Human Medicine et. al.

Nov 9th, 2020 - Background/Purpose: A core CMS policy goal is to improve patient experience by encouraging patient-centered care and shared decision making (SDM).  However, SDM techniques are underutilized in rheumatology practice1.  We created two continuing medical education (CME) activities that present ACR guidelines, treat-to-target (T2T) concepts, and SDM as vehicles to increase the equity of the provisi...

Effects of Abatacept and Tumor Necrosis Factor Inhibitor on the Normal Glycosylated Hemoglobin Level in Patients with Rheumatoid Arthritis
Yusuke Miwa1 and Yuko Mitamura, Division of Rheumatology, Department of Medicine et. al.

Nov 9th, 2020 - Background/Purpose: Rheumatoid arthritis (RA) and diabetes mellitus (DM) are associated with inflammation. Abatacept has been reported to be effective for type 1 diabetes. We aimed to investigate the influence of tumor necrosis factor inhibitors (TNFi) and abatacept (ABT) on the glucose metabolism of patients with RA. Methods: Patients with RA treated with TNFi or ABT from 2008 to 2018 were stu...

Exploring Novel Tenosynovitis and Combined Inflammation Imaging Outcomes: Results from a Randomized Controlled Trial in Early Rheumatoid Arthritis
Philip G Conaghan, Mikkel Østergaard, Orrin Troum et. al.

Nov 9th, 2020 - Background/Purpose: MRI trial outcomes have largely focused on synovitis, bone marrow edema (BME), and erosions. Tenosynovitis is a common manifestation of RA, but is relatively understudied; a combined inflammation score (CIS) that sums the 3 inflammatory markers (synovitis, BME, and tenosynovitis) may be a highly responsive outcome measure. We have previously demonstrated the responsiveness o...

Identification and Validation of Citrulline Specific TCRs in CD4+T Cells in Rheumatoid Arthritis
Ravi Kumar, Niyaz Yoosuf, Sanjay Boddul et. al.

Nov 9th, 2020 - Background/Purpose: Citrulline (cit) autoimmunity is central in rheumatoid arthritis (RA), including both anti-citrulline protein antibodies (ACPA) and autoreactive CD4+ T cells. While the ACPA are abundant, studies of cit-reactive T cells have been hampered by their scarcity. Still, cit-reactive T cells have been reported in the RA joint and in peripheral blood by peptide-HLA tetramer technolo...

Immunogenicity of Adjuvanted Herpes Zoster Subunit Vaccine in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors and Controls: Preliminary Results
Hanna Källmark, Birgitta Gullstrand, Johanna Nagel et. al.

Nov 9th, 2020 - Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of contracting herpes zoster (HZ) and treatment with JAnus Kinase inhibitors (JAKi) further adds on to that risk. A novel subunit vaccine against HZ (HZ/su; Shingrix) composed of VZV glycoprotein E (gE) and adjuvant system AS01B has recently been licensed. The HZ/su vaccine has been shown safe and effective in hea...