Comparison of Work Productivity Outcomes Between Chronic Back Pain Patients with and Without a Diagnosis of Axial Spondyloarthritis After 2-Year Protocolised Follow-Up: Data from the Spondyloarthri...
Anne Boel, Miranda van Lunteren, Karen Fagerli et. al.

Nov 9th, 2020 - Background/Purpose: The aim of this study was to compare work-productivity and activity impairment outcomes after two-year follow-up between chronic back pain (CBP) patients with and without an axSpA diagnosis Methods: Patients over 16 years of age referred to the rheumatology outpatient clinic with chronic back pain (≥ 3 months < 2 years) starting before the age of 45, suspected of axSpA were ...

Comparative Effectiveness of Secukinumab, Adalimumab and Other Tumor Necrosis Factor Inhibitors in the Treatment of Axial Spondyloarthritis
Loïc Choquette Sauvageau, Denis Choquette, Louis Bessette et. al.

Nov 9th, 2020 - Background/Purpose: Studies comparing the effectiveness of biologics in the treatment of axial spondyloarthritis (axSpA) are sparse [1]. One study comparing secukinumab and adalimumab biosimilar is ongoing. Secukinumab is an agent targetting Il-17. The aim of our analysis is to compare the effectiveness of the most frequently used biologic in axSpA since the marketing of secukinumab in all, fir...

Clinical Characteristics of Importance to Outcome in Patients with Axial Spondyloarthritis: A Prospective Cohort Study
Rikke Asmussen Andreasen, Xenofon Baraliakos, Lars Erik Kristensen et. al.

Nov 9th, 2020 - Background/Purpose: Despite better control of inflammation, many patients with axial spondyloarthritis (axSpA) still report pain, although they could be in remission. This suggests that in these patients chronic pain may prompt central sensitization. Our objective was to explore the prognostic value of the painDETECT questionnaire (PDQ) in relation to treatment outcomes in axSpA Methods: AxSpA ...

Association of Gut Dysbiosis with Radiographic and Enthesis Involvement, Disease Activity and Duration in Axial Spondyloarthritis. Data from CASTRO Registry
Ignacio Gómez-García, Isabel Moreno-Indias, María-Carmen Abalos-Aguilera et. al.

Nov 9th, 2020 - Background/Purpose: The etiopathogenesis of axial spondyloarthritis (AxSpA) is multifactorial. The possible role of alteration in gut microbiome (dysbiosis) has been recently suggested. However, the association of dysbiosis with structural damage is still unknown and further studies are needed to assess its association with disease activity. Objectives: To determine the alterations in the gut m...

Consensus Definitions for MRI Lesions in the Spine of Patients with Axial Spondyloarthritis: First Analysis from the Assessments in SpondyloArthritis International Society Classification Cohort
Walter Maksymowych, Iris Eshed, Pedro M Machado et. al.

Nov 9th, 2020 - Background/Purpose: A broad spectrum of MRI lesions has been described in the spine of patients with axial spondyloarthritis (axSpA) and a recent consensus from the ASAS MRI group has culminated in updated spine lesion definitions (ASAS_MRI_defn)1. There has been no central reader evaluation of MRI spine scans from the ASAS Classification Cohort (ASAS-CC)2. We aimed to determine the spectrum an...

Clinical History as Tool for Diagnosis and Classification of Patients with Ankylosing Spondylitis (Axial Spondyloarthritis): Evidence from a 35-Year Follow-up Family Study of a Swiss Cohort
Sjef van der Linden, Zhixiu Li, Matthew Brown et. al.

Nov 9th, 2020 - Background/Purpose: Lack of sensitivity or specificity of symptoms may induce uncertainty in diagnosis and classification of AS/axSpA. We investigated if balanced sensitivity and specificity of tools from the patient’s clinical history may help better define the ‘Gestalt’ of AS/axSpA Methods: In 1985 members of the Swiss AS Patient Society who had been diagnosed as having AS by their own physic...

Development and Validation of an Artificial Intelligence Approach for the Detection of Radiographic Sacroiliitis
Keno-Kyrill Bressem, Janis Vahldiek, Lisa Adams et. al.

Nov 9th, 2020 - Background/Purpose: Conventional radiography of the sacroiliac joints is still recommended as the first imaging method if axial spondyloarthritis (axSpA) is suspected. Furthermore, radiographic sacroiliitis is included – together with sacroiliitis on magnetic resonance imaging – in the Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axSpA. Depending on t...

Clinical Features of Patients with Active Ankylosing Spondylitis Who Did Not Respond to Adalimumab but Responded to Ixekizumab: A Post-hoc Analysis
Xenofon Baraliakos, Rebecca Bolce, David Sandoval et. al.

Nov 9th, 2020 - Background/Purpose: Biologic therapy is recommended in patients with active ankylosing spondylitis (AS) despite adequate trial of NSAIDs. Biologic treatment in AS are currently limited to TNF and IL-17A inhibitors (IL-17Ai). It is unknown whether there are predictors of AS patients who only respond to 1 of these mechanisms of action or respond to switching from TNF-blocker to IL-17Ai. This post...

Development of a Deep Learning Algorithm to Predict Positive MRI of the Sacroiliac Joints According to the ASAS Definition in Patients with Recent Axial Spondyloarthritis
Théodore Aouad, Clementina Lopez-Medina, Anna Molto et. al.

Nov 9th, 2020 - Background/Purpose: The magnetic resonance imaging (MRI) of the sacroiliac joints (MRI-SIJ) represents an essential tool in the evaluation of patients with spondyloarthritis (SpA). However, despite a clear definition of positive and negative MRI-SIJ formulated by the ASAS/OMERACT working group, the inter-reader agreement between readers is never perfect. Moreover, in daily practice, the radiolo...

Development of Candidate Criteria for Axial Disease in Juvenile Spondyloarthritis: An International Collaboration
Pamela F. Weiss, Timothy G. Brandon, Amita Aggarwal et. al.

Nov 9th, 2020 - Background/Purpose: The lack of pediatric classification criteria for axial disease is a major impediment to the conduct of clinical trials for juvenile spondyloarthritis (SpA). Classification criteria for axial disease in children with SpA are being developed. The objective of this study was to identify and grade a set of items that maximizes the likelihood of accurate classification of childr...

Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum Using Digital Chromo-endoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without In...
Consuelo Romero-Sanchez, Cristian Florez-Sarmiento, Valerie Khoury-Rosas et. al.

Nov 9th, 2020 - Background/Purpose: Fecal calprotectin (FC) is a well bio-marker related to mucosal inflammation. Digital chromo-endoscopy (DCE) with magnification is a technique to identify microscopic inflammation. The objective of the study is to establish the association between FC levels and DCE/histology for the detection of early bowel lesions related to structural inflammatory changes in patients with ...

Intestinal Permeability in the Adjuvant Induced Arthritis Model: Preliminary Study and Impact of NSAIDs
Sophie Hecquet, Romain Bordy, Clement Prati et. al.

Nov 9th, 2020 - Background/Purpose: The gut is no longer considered as a simple element associated with spondyloarthritis but as a real actor of the disease. In patients with spondyloarthritis, the presence of intestinal inflammation and an increase in digestive permeability responsible for bacterial translocation has been described. No data are available on the effect of non-steroidal anti-inflammatory drugs ...

Improving Documentation of Smoking Cessation Counseling Among Spondyloarthropathy Smokers
Yusuf Chao, Jake Hutto, Elena Joerns et. al.

Nov 9th, 2020 - Background/Purpose: Smoking is prevalent among patients with spondyloarthropathies (SpA) and is associated with higher disease activity, poorer quality of life, and dampened response to biologic therapy. Despite the strong recommendation for smoking cessation in the 2018 American College of Rheumatology guidelines for management of psoriatic arthritis, providers do not routinely counsel smokers...

Findings Compatible with Axial Spondyloarthritis in Radiologist Reports
Rouhin Sen, Emmeline Kim, Evan Manning et. al.

Nov 9th, 2020 - Background/Purpose: The sacroiliac joint (SIJ) has a distinct anatomical shape that can pose challenges to standard planar imaging techniques making the detection of subtle changes difficult1. SIJ radiographs are a very important tool for the evaluation of disease in patients with suspected axial spondyloarthritis (axSpA). With lack of a reliable biomarker and limitations in physical examinatio...

KIR3DL2 Is Not Overexpressed on CD4+ T Cells and NK Cells in Patients with Axial Spondyloarthritis csDMARD and bDMARD Naive
Guillaume Larid, Sophie Trijau, Clothilde Barral et. al.

Nov 9th, 2020 - Background/Purpose: Overexpression of KIR3DL2 on CD4+ T-cells and NK-cells has been reported in patients with ankylosing spondylitis (AS) HLAB27+. We aimed to 1) analyse KIR3DL2 expression in patients with active axial spondyloarthritis, radiographic (AS) and non radiographic (nr-axSpA), HLA B27+ and HLA B27 – and 2) to assess the impact of pharmacological stimulation on CD4+ T-cells of those p...

Baseline Serum Biomarker Levels Predict Spinal Radiographic Progression in Ankylosing Spondylitis Patients on TNF Inhibitor Therapy
Judith Rademacher, Mark Siderius, Laura Gellert et. al.

Nov 9th, 2020 - Background/Purpose: Radiographic spinal progression determinates functional status and mobility in ankylosing spondylitis (AS) (Poddubnyy et al, 2018). Our objective was to analyze whether biomarker levels at baseline or their change after 3 months or 2 years can predict spinal radiographic progression in AS patients treated with TNF-α inhibitors (TNFi). Methods: Consecutive AS patients from th...

Assessment of Global DNA Methylation in Peripheral Blood Cell Subpopulations of Patients with Axial Spondyloarthritis : Preliminary Results
Eric Toussirot, Sebastien Pasquereau, Charline Vauchy et. al.

Nov 9th, 2020 - Background/Purpose: Axial spondyloarthritis (ax-SpA) corresponds to a group of chronic inflammatory disease mainly affecting the axial skeleton. TNF and IL-17A have been identified as key inflammatory mediators driving the inflammatory process of ax-SpA. Epigenetics refers to different mechanisms that alter gene expression without involving changes in DNA sequence. The mechanisms of epigenetic...

Are There Any Clues to Predict Bamboo Spine in Axial Spondyloarthritis?
Pamir Atagündüz, Sedat Kiraz, Servet Akar et. al.

Nov 9th, 2020 - Background/Purpose: Complete ankylosis of the entire spinal column is a severe condition seen in spondyloarthritis. This study aims to investigate the possible risk factors associated with the bamboo spine in axial Spondyloarthritis (axSpA) patients treated with biological DMARDs. Methods: TReasure; is a multicentre database, started in December 2017, in which clinical and demographic data of i...

Different Disease Activity Trajectories in Early Axial Spondyloarthritis Lead to Significantly Different Long-term Outcomes : A Cluster-based Analysis of the DESIR Cohort
Benattar Leslie, Anna Molto, Laure Gossec3 and Resche Rigon Matthieu et. al.

Nov 9th, 2020 - Background/Purpose:  AxSpA is a heterogeneous disease, leading to different treatment and follow-up modalities depending on the presentation, along with other elements (socio-economic, gender, etc..). In a previous work, we identified some disease activity trajectories in early axSpa, but we did not evaluate the long-term impact for patients in terms of outcomes such as function, work impairmen...

Diagnosis of Axial Spondyloarthritis: A Primary Unmet Educational Need for Rheumatologists Is Interpretation of MRI
Walter Maksymowych, Liron Caplan, Atul Deodhar et. al.

Nov 9th, 2020 - Background/Purpose: Diagnosis of axial spondyloarthritis (axSpA) is challenging because of absent physical findings in early disease and the limited diagnostic performance of laboratory markers. Considerable reliance is placed on imaging of the sacroiliac joints (SIJ). We aimed to identify what might be the primary unmet educational needs of rheumatologists completing fellowship training within...