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Obinutuzumab Provides Two-Year Benefits for Lupus Nephritis
https://www.hcplive.com/view/obinutuzumab-two-year-benefits-lupus-nephritis

Nov 3rd, 2020 - After promising 18-month outcomes in patients with proliferative lupus nephritis, obinutuzumab showed sustained benefits through 2 years of treatment for patients burdened with the rheumatic disease.

Machine Learning Could Benefit Rheumatoid Arthritis Treatment with Sarilumab
https://www.hcplive.com/view/machine-learning-benefit-rheumatoid-arthritis-treatment-sarilumab

Nov 2nd, 2020 - As interleukin receptor (IL) inhibitors, the monoclonal antibody drug class has come to revolutionize fields of inflammatory disease care, though the utility and resourcing of such promising agents is yet to be fully refined. Namely, clinicians can stand to benefit from more biomarkers, more indications by which monoclonal antibodies are most impactful.

ACR 2020 Frequently Asked Questions
https://www.rheumatology.org/Annual-Meeting/Resources

Sep 6th, 2020 - Please refer to the Frequently Asked Questions (FAQs) below for more information on the all-virtual ACR Convergence 2020. We will share more details as they become available in the coming weeks and months.

ACR 2020 Permissions and Reprints
https://www.rheumatology.org/Annual-Meeting/Abstracts/Permissions-and-Reprints

Sep 6th, 2020 - ACR Convergence, the ACR's annual meeting, is a private event. Programs presented at the meeting are for the education of attendees and purchasers of recorded presentations as authorized by the American College of Rheumatology. The information and materials displayed and presented during this meeting are the property of the ACR and the presenter and cannot be photographed, copied, photocopied, ...

ACR 2020 General Meeting Information
https://www.rheumatology.org/Annual-Meeting/Resources/General-Meeting-Information

ACR Convergence, the American College of Rheumatology’s 2020 annual meeting will be in Washington, D.C. November 6 - 11.

ACR/ARHP 2020 American College of Rheumatology Annual Meeting 2020
https://acr-arhp2020.org/

American College of Rheumatology Annual Meeting 2020 06-11 November 2020 Washington DC.

ACR 2020 Abstract Embargo Policies
https://www.rheumatology.org/Annual-Meeting/Abstracts/Embargo-Policies

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new ...

ACR 2020 Online Program
https://plan.core-apps.com/tristar_acr20/customScreen/aboutACR20Program

The Online Program is your source for educational content and program information for the 2020 ACR/ARP Annual Meeting. Look for topics of interest, bookmark sessions, and/or create a customized itinerary. Use the navigation menu to browse sessions, faculty, abstracts, and other meeting content. You can also use the advanced search tool to find sessions.

ACR 2020 Contacts
https://www.rheumatology.org/Annual-Meeting/Resources/Annual-Meeting-Contacts

Registration and Hotels, Education, Abstracts, Exhibits, Press

ACR 2020 Abstracts
https://www.rheumatology.org/Annual-Meeting/Abstracts

Submission, presentation, permission/reprints, embargo, ACR Convergence Awards

ACR 2020 Program
https://www.rheumatology.org/Annual-Meeting/Program

The program has hundreds of sessions to educate professionals in every segment of rheumatology.

ACR 2020 Image Competition Guidelines & Procedures PDF
https://www.rheumatology.org/Portals/0/Files/Image-Competition-Guidelines.pdf

The American College of Rheumatology (ACR) and the Association of Rheumatology Professionals(ARP) invite you to submit a case-based image and take advantage of the opportunity to have your work peer-reviewed by experts in the field. If accepted, your image will be digitally displayed in the distinguished international venue of ACR Convergence 2020 and be added to the ACR Rheumatology Image Libr...

ACR 2020 Image Competition
https://www.rheumatology.org/Annual-Meeting/Program/Image-Competition

Call for Images, Submission Eligibility, Timeline, Permissions

https://www.the-rheumatologist.org/article/diversity-from-concepts-to-outcomes/
Diversity: From Concepts to Outcomes
The Rheumatologist; Bernstein S.

Nov 11th, 2020 - In 2020, terms like unconscious bias, diversity and inclusivity are buzzwords in rheumatology as well as throughout American society. The COVID-19 pandemic revealed stark disparities in healthcare outcomes for rheumatic disease patients of racial and ethnic minorities, including new research that shows Black and Latinx patients have a higher risk of hospitalization and threefold increased odds ...

PROs: Which Are Important to Patients and How Successfully Are They Integrated Into Clinical Care?
https://www.ajmc.com/view/pros-which-are-important-to-patients-and-how-successfully-are-they-integrated-into-clinical-care
The American Journal of Managed Care; Joszt L.

Nov 11th, 2020 - Although patient-reported outcomes (PROs) are increasingly being used to understand treatment effectiveness, there is still a lot unknown about what measures patients find most important. Two abstracts presented at the American College of Rheumatology’s annual meeting evaluated PROs in rheumatology and how PRO measures can be used in clinical care.

ACR Convergence 2020: Progress Toward COVID-19 Vaccines
https://www.the-rheumatologist.org/article/acr-convergence-2020-progress-toward-covid-19-vaccines/
The Rheumatologist; Hickman RJ.

Nov 10th, 2020 - A scientific session on Sunday, Nov. 8, focused on vaccine prospects in COVID-19. Dan Barouch, MD, PhD, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center and the William Bosworth Castle Professor of Medicine at Harvard Medical School in Boston, shared his insights about vaccine development across the field, reported on data concerning his lab’s con...

Inaugural ACR Distinguished Global Public Health Award Presented to Dr. Fauci
https://www.the-rheumatologist.org/article/inaugural-acr-distinguished-global-public-health-award-presented-to-dr-fauci/
The Rheumatologist; Bernstein S.

Nov 10th, 2020 - At the ACR’s fully virtual annual meeting on Saturday, Nov. 7, ACR President Ellen M. Gravallese, MD, chief of the Division of Rheumatology, Inflammation and Immunity at Brigham and Women’s Hospital, Boston, presented the inaugural ACR Distinguished Global Public Health Award to Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID), an ACR Master an...

COVID-19 antimalarial shortages affected rheumatology patients’ physical, mental health
https://www.healio.com/news/rheumatology/20201107/covid19-antimalarial-shortages-affected-rheumatology-patients-physical-mental-health

Nov 8th, 2020 - Antimalarial drug shortages due to COVID-19 affected more rheumatology patients in African and East Asian regions than those in the Americas and Europe, noted data from the COVID-19 Global Rheumatology Alliance Patient Experience Survey.

Comparative Performances of Sodium-Glucose Cotransporter-2 Inhibitors in Reducing Gout in Type 2 Diabetes
https://www.rheumatologyadvisor.com/home/conference-highlights/acr-convergence-2020/comparative-performance-of-sglt2-inhibitors-in-reducing-gout-in-t2d/

Nov 8th, 2020 - Among patients with type 2 diabetes (T2D), sodium-glucose cotransporter-2 (SGLT2) inhibitors dapagliflozin and empagliflozin vs canagliflozin show greater benefit in reducing gout, according to research results presented at the American College of Rheumatology (ACR) Convergence 2020, held virtually from November 5 to 9, 2020.

Under Pressure: An Update on Pulmonary Hypertension
https://www.the-rheumatologist.org/article/under-pressure-an-update-on-pulmonary-hypertension/
The Rheumatologist; Liebowitz J.

Nov 8th, 2020 - In patients with connective tissue diseases, such as systemic sclerosis (SSc), pulmonary hypertension (PH) remains one of the leading causes of morbidity and mortality. In her lecture on Friday, Nov. 6, Pulmonary Hypertension: An Update, Mardi Gomberg-Maitland, MD, MSc, professor of medicine and medical director of the Pulmonary Hypertension Program at The George Washington School of Medicine &...

ACR Convergence 2020: Study Data for Lupus & Rheumatoid Arthritis
https://www.the-rheumatologist.org/article/acr-convergence-2020-study-data-for-lupus-rheumatoid-arthritis/
The Rheumatologist; Hickman RJ.

Nov 8th, 2020 - At the annual meeting’s second Plenary Session, Saturday, Nov. 7, speakers highlighted phase 2 results of a potential new biologic for systemic lupus erythematosus (SLE), as well as data on remission maintenance in rheumatoid arthritis (RA) after withdrawal of etanercept or methotrexate.

COVID-19 Infection Rates Low in People with Rheumatic Diseases, Most Report Mild Illness
https://www.newswise.com/coronavirus/covid-19-infection-rates-low-in-people-with-rheumatic-diseases-most-report-mild-illness/?article_id=740879

Nov 7th, 2020 - ATLANTA — A new study shows that the COVID-19 infection incidence has been low in people with rheumatic diseases, and most of those infected experience a mild course of illness. Additionally, fatalities have been low among rheumatic disease patients infected with COVID-19. Details of this research was presented at ACR Convergence, the American College of Rheumatology’s annual meeting (ABSTRACT ...

ACR RA guidelines ‘push the needle away’ from glucocorticoids as primary option
https://www.healio.com/news/rheumatology/20201109/acr-ra-guidelines-push-the-needle-away-from-glucocorticoids-as-primary-option

Nov 7th, 2020 - Glucocorticoids should no longer be the “default” option for many patients with rheumatoid arthritis, according to authors of a new recommendation document presented at ACR Convergence 2020.

Warfarin linked to greater hip, knee replacement risk
https://www.healio.com/news/rheumatology/20201108/warfarin-linked-to-greater-hip-knee-replacement-risk

Nov 7th, 2020 - Treatment with warfarin is associated with a significantly greater risk for hip or knee replacement compared with direct oral anticoagulants, according to a speaker at ACR Convergence.

Osteoporosis 'largely ignored' in older men
https://www.healio.com/news/rheumatology/20201110/osteoporosis-largely-ignored-in-older-men

Nov 6th, 2020 - Less than 3% of older men who had experienced an osteoporosis-related fracture had been properly diagnosed and treated, according to findings presented at ACR Convergence 2020.

Slow Taper off Antimalarial Is Best to Avoid Lupus Flare During Remission
https://www.medscape.com/viewarticle/941743

Nov 29th, 2020 - Slowly tapering off – or remaining on – antimalarial medications can help prevent disease flare in patients with systemic lupus erythematosus (SLE) who've achieved clinical remission for at least a year, according to a new study that was presented at the virtual annual meeting of the American College of Rheumatology. "Except in the setting of toxicity, cessation of antimalarial medication in pa...

RA Remission? Stop Methotrexate, Keep Etanercept
https://www.medscape.com/viewarticle/941555

Nov 23rd, 2020 - In patients with RA whose disease is well controlled by methotrexate combined with etanercept, withdrawal of methotrexate led to long-term outcomes that were nearly as good as continuation of combination therapy. The finding comes from the randomized, controlled SEAM-RA trial that sought to address weaknesses of previous studies. It included a long lead-in time with stringent criteria to ensure...

Gout Clinical Practice Guidelines (ACR, 2020)
https://reference.medscape.com/viewarticle/941449

Nov 23rd, 2020 - Guidelines for managing gout were published in June 2020 by the American College of Rheumatology (ACR).[1] Indications for Pharmacologic Urate-Lowering Therapy (ULT)   Initiating ULT is strongly recommended for gout patients with ≥1 subcutaneous tophi, evidence of radiographic damage (any modality) attributable to gout, or frequent gout flares (≥2 annually). Initiating ULT is conditionally reco...

Debate: After Methotrexate Failure, Is JAK Inhibitor or Biologic Next?
https://www.medscape.com/viewarticle/941432

Nov 22nd, 2020 - What is the next step in treatment after a person with rheumatoid arthritis fails to adequately respond to methotrexate — a Janus kinase (JAK) inhibitor or a biologic? That was the focus of a lively debate at the virtual annual meeting of the American College of Rheumatology. Vibeke Strand, MD, argued that JAK inhibitors offer the distinct advantage of a faster clinical response than biologics,...

Children With Kawasaki Disease Need Long-Term Surveillance for Heart Disease
https://www.medscape.com/viewarticle/940775

Nov 12th, 2020 - NEW YORK (Reuters Health) - Children with Kawasaki disease remain at an increased risk for heart problems more than 10 years after they leave the hospital, according to a new study. "The results justify additional follow up and surveillance for cardiovascular disease and cardiovascular disease risk factors, such as obesity, high blood pressure and high cholesterol, in Kawasaki disease survivors...

JIA Guideline Calls for Earlier Use of Targeted Therapies
https://www.staging.medscape.com/viewarticle/940926

Nov 12th, 2020 - A draft guideline for the management of patients with juvenile idiopathic arthritis reflects changes in therapy away from reliance on NSAIDs and glucocorticoids and toward earlier introduction of biologic disease-modifying antirheumatic drugs (DMARDs). The guideline, described in an oral session during the virtual annual meeting of the American College of Rheumatology, contains weighted recomme...

Methotrexate and Hydroxychloroquine Split on Cardiovascular Outcomes in RA
https://www.medscape.com/viewarticle/940971

Nov 12th, 2020 - No significant differences in major adverse cardiovascular events (MACE) emerged between methotrexate and hydroxychloroquine (HCQ) treatment in a comparison of adults 65 years or older with rheumatoid arthritis (RA). However, researchers reported some elevation in risk for stroke in the methotrexate group and for myocardial infarction (MI) and heart failure in the HCQ group. The primary outcome...

Sjögren's Symptom Clusters May Identify Treatment Options
https://www.medscape.com/viewarticle/940960

Nov 12th, 2020 - Patients with Sjögren's syndrome can be categorized into four distinct symptom clusters — independent of age, sex, and some disease manifestations — that may both improve symptom relief and aid in the development of targeted therapies, investigators reported. Analysis of data from a survey conducted by the Sjögren's Foundation identified four symptom clusters based on the grouping of five commo...

JIA Guideline Calls for Earlier Use of Targeted Therapies
https://www.medscape.com/viewarticle/940926

Nov 12th, 2020 - A draft guideline for the management of patients with juvenile idiopathic arthritis reflects changes in therapy away from reliance on NSAIDs and glucocorticoids and toward earlier introduction of biologic disease-modifying antirheumatic drugs (DMARDs). The guideline, described in an oral session during the virtual annual meeting of the American College of Rheumatology, contains weighted recomme...

'Reassuring' Data on Cardiac Toxicity With Hydroxychloroquine in RA, Lupus
https://www.staging.medscape.com/viewarticle/940635

Nov 9th, 2020 - NEW YORK (Reuters Health) - Hydroxychloroquine has no significant impact on heart rhythm in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), according to two studies featured at a press briefing at ACR Convergence, the 2020 annual virtual meeting of the American College of Rheumatology. "Our findings really do reinforce the fact that hydroxychloroquine is a safe an...

Treatment Sequence With Romosozumab Influences Osteoporosis Outcomes
https://www.staging.medscape.com/viewarticle/940675

Nov 9th, 2020 - Timing is everything when it comes to the use of the anabolic agent romosozumab (Evenity) for the treatment of advanced osteoporosis, a review of clinical trials suggests. In four studies with treatment sequences in which romosozumab was administered either before or following the use of an antiresorptive agent, initial treatment with 1 year of romosozumab produced substantial bone mineral dens...

'Reassuring' Data on Cardiac Toxicity With Hydroxychloroquine in RA, Lupus
https://www.medscape.com/viewarticle/940635

Nov 9th, 2020 - NEW YORK (Reuters Health) - Hydroxychloroquine has no significant impact on heart rhythm in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), according to two studies featured at a press briefing at ACR Convergence, the 2020 annual virtual meeting of the American College of Rheumatology. "Our findings really do reinforce the fact that hydroxychloroquine is a safe an...

Characterizing Morphea Subsets Using a Multi-center, Prospective, Cross-sectional Analysis
https://acrabstracts.org/abstract/characterizing-morphea-subsets-using-a-multi-center-prospective-cross-sectional-analysis/
Jane Zhu, Smriti Prasad, Kaila Schollaert-Fitch et. al.

Nov 9th, 2020 - Background/Purpose: Morphea, or localized scleroderma, is an inflammatory condition of the skin and soft tissue that results in excessive collagen deposition, often producing permanent functional and cosmetic impairment. Morphea affects both adults and children, with approximately 50% of patients having childhood onset disease1,2. Numerous classification schemes for morphea exist, but none have...

Curdlan-induced Villous Permeability, Luminal Pathobiont Translocation to the Ileal Crypts, Ileitis and Arthritis Are Mitigated by Clostridia in Colonised Germ-free SKG Mice
https://acrabstracts.org/abstract/curdlan-induced-villous-permeability-luminal-pathobiont-translocation-to-the-ileal-crypts-ileitis-and-arthritis-are-mitigated-by-clostridia-in-colonised-germ-free-skg-mice/
Anne-Sophie Bergot, Rabina Giri, Amy Cameron et. al.

Nov 9th, 2020 - Background/Purpose: IL-23 dependent spondylitis, arthritis and inflammatory bowel disease (IBD) recapitulate human spondyloarthropathy (SpA) in 1,3 beta glucan (curdlan)-treated SKG mice. Human SpA and SKG mice have fecal dysbiosis, with increased Bacteroidaceae and Porphyromonadaceae. In SKG mice, anti-IL-23 supports homeostatic bacteria, including Clostridiaceae, which produce the short chain...

Clinically Important Improvements in Patients with Osteoarthritis Treated with Subcutaneous Tanezumab: Results from a 56-Week Randomized NSAID-Controlled Study
https://acrabstracts.org/abstract/clinically-important-improvements-in-patients-with-osteoarthritis-treated-with-subcutaneous-tanezumab-results-from-a-56-week-randomized-nsaid-controlled-study/
David Hunter, Tuhina Neogi, Melvin Churchill et. al.

Nov 9th, 2020 - Background/Purpose: Subcutaneous (SC) tanezumab, a monoclonal antibody that inhibits nerve growth factor, was investigated for the relief of signs and symptoms of moderate-severe OA in patients (pts) for whom use of other analgesics was ineffective or not appropriate in a randomized NSAID-controlled global long-term safety study (NCT02528188). The current analysis examines the effect of tanezum...

Comparison of Two Rituximab Regimens for Induction of Remission in Antineutrophil Cytoplasm Antibody-associated Vasculitis: Systematic Review and Meta-analysis
https://acrabstracts.org/abstract/comparison-of-two-rituximab-regimens-for-induction-of-remission-in-antineutrophil-cytoplasm-antibody-associated-vasculitis-systematic-review-and-meta-analysis/
Valerie Benard, Cynthia Farhat, Melissa Zarandi-Nowroozi et. al.

Nov 9th, 2020 - Background/Purpose: Organ or life-threatening granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), two of the antineutrophil cytoplasm antibody-associated vasculitis (AAV), are treated with cyclophosphamide or rituximab (RTX) in combination with glucocorticoids. Different RTX regimens for induction of remission are available: the 4-dose AAV regimen at doses of 375 mg/m2 I....

Circulating Biomolecules as Potential Biomarkers of Early and Establishedresponse to TNFi Therapy in Rheumatoid Arthritis Patients
https://acrabstracts.org/abstract/circulating-biomolecules-as-potential-biomarkers-of-early-and-establishedresponse-to-tnfi-therapy-in-rheumatoid-arthritis-patients/
Chary Lopez-Pedrera, Maria Luque-Tevar, Carlos Pérez-Sánchez et. al.

Nov 9th, 2020 - Background/Purpose: To evaluate changes produced in circulating inflammatory mediators and their regulatory miRNAs in RA patients after 3 and 6 months of treatment with TNF-α inhibitors (TNFi), in order to identify biomarkers of clinical efficacy and potential predictors of therapeutic response to TNFi therapies. Methods: In a prospective RA cohort multicenter study, serum from125 RA patients w...

Cutaneous Side Effects of Hydroxychloroquine in Rheumatic Diseases –Combination of “Traditional” Multivariate Analysis for Risk Factors AndClassification Model Development Using Supervised Machine ...
https://acrabstracts.org/abstract/cutaneous-side-effects-of-hydroxychloroquine-in-rheumatic-diseases-combination-of-traditional-multivariate-analysis-for-risk-factors-andclassification-model-development-usin/
Sandeep Surendran, Mithun CB, Arun Tiwari et. al.

Nov 9th, 2020 - Background/Purpose: Hydroxychloroquine (HCQ) is associated with varied cutaneous side effects but only few studies in literature characterizing the risk factors for this. Recently machine learning tools have emerged as a promising option for predicting various outcomes. The aim of our study was to use “traditional” multivariate analysis along with novel machine learning (ML) methodology to anal...

Comparison of Work Productivity Outcomes Between Chronic Back Pain Patients with and Without a Diagnosis of Axial Spondyloarthritis After 2-Year Protocolised Follow-Up: Data from the Spondyloarthri...
https://acrabstracts.org/abstract/comparison-of-work-productivity-outcomes-between-chronic-back-pain-patients-with-and-without-a-diagnosis-of-axial-spondyloarthritis-after-2-year-protocolised-follow-up-data-from-the-spondyloarthritis/
Anne Boel, Miranda van Lunteren, Karen Fagerli et. al.

Nov 9th, 2020 - Background/Purpose: The aim of this study was to compare work-productivity and activity impairment outcomes after two-year follow-up between chronic back pain (CBP) patients with and without an axSpA diagnosis Methods: Patients over 16 years of age referred to the rheumatology outpatient clinic with chronic back pain (≥ 3 months < 2 years) starting before the age of 45, suspected of axSpA were ...

Comparative Effectiveness of Secukinumab, Adalimumab and Other Tumor Necrosis Factor Inhibitors in the Treatment of Axial Spondyloarthritis
https://acrabstracts.org/abstract/comparative-effectiveness-of-secukinumab-adalimumab-and-other-tumor-necrosis-factor-inhibitors-in-the-treatment-of-axial-spondyloarthritis/
Loïc Choquette Sauvageau, Denis Choquette, Louis Bessette et. al.

Nov 9th, 2020 - Background/Purpose: Studies comparing the effectiveness of biologics in the treatment of axial spondyloarthritis (axSpA) are sparse [1]. One study comparing secukinumab and adalimumab biosimilar is ongoing. Secukinumab is an agent targetting Il-17. The aim of our analysis is to compare the effectiveness of the most frequently used biologic in axSpA since the marketing of secukinumab in all, fir...

Characterization of Cytokine/chemokine Profile in Patient-derived M1/ M2 Macrophages to Identify Biomarkers for Genetically-defined Systemic Autoinflammatory Diseases
https://acrabstracts.org/abstract/characterization-of-cytokine-chemokine-profile-in-patient-derived-m1-m2-macrophages-to-identify-biomarkers-for-genetically-defined-systemic-autoinflammatory-diseases/
Farzana Bhuyan, Adriana Almeida de Jesus, Kim Johnson et. al.

Nov 9th, 2020 - Background/Purpose: Genetic mutations in key regulatory molecules of the innate immune system cause autoinflammatory diseases through propagation of hyperinflammatory responses. Monocytes/ macrophages regulate inflammatory processes during infection and homeostasis by secreting a wide range of cytokines and chemokines that control recruitment and migration of immune cells to inflamed tissue, an...

Clinical Characteristics of Importance to Outcome in Patients with Axial Spondyloarthritis: A Prospective Cohort Study
https://acrabstracts.org/abstract/clinical-characteristics-of-importance-to-outcome-in-patients-with-axial-spondyloarthritis-a-prospective-cohort-study/
Rikke Asmussen Andreasen, Xenofon Baraliakos, Lars Erik Kristensen et. al.

Nov 9th, 2020 - Background/Purpose: Despite better control of inflammation, many patients with axial spondyloarthritis (axSpA) still report pain, although they could be in remission. This suggests that in these patients chronic pain may prompt central sensitization. Our objective was to explore the prognostic value of the painDETECT questionnaire (PDQ) in relation to treatment outcomes in axSpA Methods: AxSpA ...

Comparison of Nation-wide Epidemical Study on 2009 and That on 2019 Revealed That Improvement of Disease Severity and Mortality Rate May Come from Progress of Proficient Management in Patients with...
https://acrabstracts.org/abstract/comparison-of-nation-wide-epidemical-study-on-2009-and-that-on-2019-revealed-that-improvement-of-disease-severity-and-mortality-rate-may-come-from-progress-of-proficient-management-in-patients-with-re/
Jun Shimizu, Yoshihisa Yamano, Kimito Kawahata2 and Noboru Suzuki et. al.

Nov 9th, 2020 - Background/Purpose: We conducted a retrospective survey study in 2009 and collected clinical data of 239 patients with relapsing polychondritis (RP). Using the survey data, we found a strong inverse relationship between ear and airway involvement, suggesting that the two major clinical symptoms of RP occurred in a mutually exclusive manner (Arthritis Rheumatol. 2018). When we divided the patien...

Associations Between Patient Reported Outcomes and Impairments of Work and Activity in Patients with Rheumatoid Arthritis Who Achieved Clinical Remission; Retrospective Analysis Using the IORRA Dat...
https://acrabstracts.org/abstract/associations-between-patient-reported-outcomes-and-impairments-of-work-and-activity-in-patients-with-rheumatoid-arthritis-who-achieved-clinical-remission-retrospective-analysis-using-the-iorra-databa/
Ryoko Sakai, Eiichi Tanaka, Eisuke Inoue et. al.

Nov 9th, 2020 - Background/Purpose: Disease burden and subjective symptoms of rheumatoid arthritis (RA) remain even after achieving clinical remission or low disease activity. Impairments to work and societal/daily activity are relevant burdens for patients with RA. However, detailed analyses are rarely performed. For exploring a better strategy aiming at less burden beyond Treat-to-Target strategy, it is esse...

Aerobic Exercise Improves Fatigue and Quality of Life in Women with Systemic Lupus Erythematosus (Preliminary Analysis)
https://acrabstracts.org/abstract/aerobic-exercise-improves-fatigue-and-quality-of-life-in-women-with-systemic-lupus-erythematosus-preliminary-analysis/
Marquis Chapman, Sarthak Gupta, Jun Chu et. al.

Nov 9th, 2020 - Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease of female predominance. One of the most debilitating symptoms experienced by SLE-patients is persistent fatigue. Prior research from our group suggests that fatigue, as measured by the Fatigue Severity Scale (FSS), is independent of SLE disease activity, as measured by Safety of Estrogen in Lupus Ery...

Assessment of the Components of RAPID3 Patient Reported Outcomes in an Community Rheumatology Practice
https://acrabstracts.org/abstract/assessment-of-the-components-of-rapid3-patient-reported-outcomes-in-an-community-rheumatology-practice/
Elston He, Pratyusha Yalamanchi, William Arnold3 and Erin Arnold et. al.

Nov 9th, 2020 - Background/Purpose: Patient reported outcomes are integral to measuring patient response to treatment for rheumatoid arthritis (RA). RAPID3 is a patient reported outcome metric that consists of three categories: pain, global assessment of health, and physical functional assessment. Here we investigate the relationship between the components of RAPID3 and serum biomarkers as measures of disease ...

Association of Gut Dysbiosis with Radiographic and Enthesis Involvement, Disease Activity and Duration in Axial Spondyloarthritis. Data from CASTRO Registry
https://acrabstracts.org/abstract/association-of-gut-dysbiosis-with-radiographic-and-enthesis-involvement-disease-activity-and-duration-in-axial-spondyloarthritis-data-from-castro-registry/
Ignacio Gómez-García, Isabel Moreno-Indias, María-Carmen Abalos-Aguilera et. al.

Nov 9th, 2020 - Background/Purpose: The etiopathogenesis of axial spondyloarthritis (AxSpA) is multifactorial. The possible role of alteration in gut microbiome (dysbiosis) has been recently suggested. However, the association of dysbiosis with structural damage is still unknown and further studies are needed to assess its association with disease activity. Objectives: To determine the alterations in the gut m...

Assessing Patient Self-Reported Transition Readiness in a Large Pediatric Rheumatology Center
https://acrabstracts.org/abstract/assessing-patient-self-reported-transition-readiness-in-a-large-pediatric-rheumatology-center-2/
Alexander Alexander, Mary Robichaux, Priyanka Moolchandani et. al.

Nov 9th, 2020 - Background/Purpose: Pediatric rheumatology patients need effective transition from pediatric to adult providers. Texas Children’s Hospital (TCH) rheumatology clinic providers have developed a transition pathway, the BRIDGE (Baylor Rheumatology Initiative: Developing and Guiding Engagement), based on defined elements of transition and utilizing an electronic medical record-based transition plann...

Activated Memory T Cells Produce Ligands That Cause NF-κB-dependent Inflammatory Activation of the Endothelium: Identification of Novel Therapeutic Targets
https://acrabstracts.org/abstract/activated-memory-t-cells-produce-ligands-that-cause-nf-%ce%bab-dependent-inflammatory-activation-of-the-endothelium-identification-of-novel-therapeutic-targets/
Kim Jeucken, Jan Piet van Hamburg, Lotte Kocken1 and Sander Tas et. al.

Nov 9th, 2020 - Background/Purpose: Endothelial cells (EC) are important contributors to inflammation via expression of inflammatory mediators, including cytokines, chemokines and adhesion molecules. Production of these inflammatory mediators can be induced via canonical and NF-κB-inducing kinase (NIK)-dependent noncanonical NF-κB signalling. The ligands activating these pathways are well studied, but less is ...

A Single Cell Stromal Atlas Identifies Conserved Fibroblast Phenotypes Expanded in the Inflamed Synovium, Lung, Intestine, and Salivary Gland
https://acrabstracts.org/abstract/a-single-cell-stromal-atlas-identifies-conserved-fibroblast-phenotypes-expanded-in-the-inflamed-synovium-lung-intestine-and-salivary-gland/
Ilya Korsunsky, Kevin Wei, Mathilde Pohin et. al.

Nov 9th, 2020 - Background/Purpose: Pro-inflammatory fibroblasts have been independently implicated in the pathogenesis of rheumatoid arthritis (RA), inflammatory bowel disease (IBD), interstitial lung disease (ILD), and Sjogren’s syndrome (pSS). While these fibroblasts are likely affected by disease modifying antirheumatic drugs that target broad cytokine pathways such as TNF, IL6, and GM-CFS, recent work sug...

Anti-Melanoma Differentiation Associated Protein 5 (MDA5) Positive Juvenile Dermatomyositis: Focus on the Lung
https://acrabstracts.org/abstract/anti-melanoma-differentiation-associated-protein-5-mda5-positive-juvenile-dermatomyositis-focus-on-the-lung/
David Moreno McNeill, Miriah Gillispie-Taylor, Kevin Baszis et. al.

Nov 9th, 2020 - Background/Purpose: A subset of juvenile dermatomyositis (JDM), clinically amyopathic dermatomyositis (CADM), is uncommon and mainly described in adults. CADM is classically characterized by skin ulcerations, minimal muscle involvement, and interstitial lung disease (ILD). Anti-MDA5 antibodies are associated with CADM and ILD. A subset of anti-MDA5 patients have rapidly progressive ILD (RP-ILD)...

Assessing Preparation for Care Transition Among Adolescents with Rheumatologic Disease: A Quality Assessment with Patient Survey
https://acrabstracts.org/abstract/assessing-preparation-for-care-transition-among-adolescents-with-rheumatologic-disease-a-quality-assessment-with-patient-survey/
Jordan Roberts, Olha Halyabar, Carter Petty3 and Mary Beth Son et. al.

Nov 9th, 2020 - Background/Purpose: Despite the risk for poor outcomes and gaps in care in the transition from pediatric to adult care, most pediatric rheumatology centers lack formal pathways for transition. We evaluated preparation for transition with a validated quality measure in a single pediatric rheumatology center. Methods: Patients 16 and older were sent the ADolescent Assessment of Preparation for Tr...

Assessment of the Impact of Interferon Levels on Cognitive Dysfunction in Patients with SLE
https://acrabstracts.org/abstract/assessment-of-the-impact-of-interferon-levels-on-cognitive-dysfunction-in-patients-with-sle/
Andrew Kwan, Joan Wither, Juan Pablo Diaz-Martinez et. al.

Nov 9th, 2020 - Background/Purpose: Cognitive impairment (CI) is among the earliest and the most prevalent manifestations of SLE. Previous studies have demonstrated that the increased levels of interferon (IFN)-induced gene expression in SLE are positively correlated with SLE disease activity and severity. The aim of this study is to examine the relationship between IFN levels and cognition as measured by the ...

An Artificial Intelligence (AI) Assistant Identifying Spinal Diffuse Idiopathic Skeletal Hyperostosis on Plain X-rays: A Pilot Deep Learning Study
https://acrabstracts.org/abstract/an-artificial-intelligence-ai-assistant-identifying-spinal-diffuse-idiopathic-skeletal-hyperostosis-on-plain-x-rays-a-pilot-deep-learning-study/
Sarah Ringsted, Nishad Sathe, Atul Deodhar2 and Dongseok Choi et. al.

Nov 9th, 2020 - Background/Purpose: Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory condition most classically seen in the spine, and is characterized by ossification of the spinal ligaments and entheses. DISH may be asymptomatic, but in some cases is associated with back pain and stiffness. Risk factors include male sex, increasing age, obesity and metabolic syndrome. Important radiograp...

Autoantibodies Targeting Complement Receptors C3aR and C5aR1 Are Decreased in ANCA-associated Vasculitis and Correlate with a Higher Relapse Rate
https://acrabstracts.org/abstract/autoantibodies-targeting-complement-receptors-c3ar-and-c5ar1-are-decreased-in-anca-associated-vasculitis-and-correlate-with-a-higher-relapse-rate/
Sebastian Klapa, Antje Müller, Andreas Koch et. al.

Nov 9th, 2020 - Background/Purpose: Activation of the alternative and common terminal complement pathways has been shown in ANCA-associated vasculitis (AAV). Circulating titers of the anaphylatoxin C5a are increased and correlate with disease activity in AAV. Binding to the corresponding G protein-coupled receptor (C5aR1/CD88) enhances the influx of neutrophils and their activation, leading to ROS generation a...

An Engineered Extracellular Matrix‐rich Decellularized Substrate Based Podocytes Culture System to Study Intracellular Complement Production and Activation
https://acrabstracts.org/abstract/an-engineered-extracellular-matrix%e2%80%90rich-decellularized-substrate-based-podocytes-culture-system-to-study-intracellular-complement-production-and-activation/
Abhigyan Satyam, Maria Tsokos2 and George Tsokos, Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School et. al.

Nov 9th, 2020 - Background/Purpose: Current technologies do not support long-term cell viability, differentiation and maintenance of podocytes. We developed a biophysical approach, termed macromolecular crowding (MMC), to create extracellular matrix (ECM)-rich tissue equivalents and decellularization. This approach generates decellularized grafts that scaffold podocytes to grow in an environment similar to nat...

Association of Obesity with Treatment Response to Methotrexate or Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis
https://acrabstracts.org/abstract/association-of-obesity-with-treatment-response-to-methotrexate-or-tumor-necrosis-factor-inhibitors-in-patients-with-rheumatoid-arthritis/
Dilli Poudel, Ted Mikuls, Michael George et. al.

Nov 9th, 2020 - Background/Purpose: Obesity affects 30-40% of RA patients and is associated with higher clinical disease activity measures and progressive disability. Studies suggest that obesity may be associated with poor response to TNF inhibitors (TNFi), but the degree to which these prior results were impacted by unmeasured confounding factors is unclear. We aimed to evaluate differences in response to MT...

Advanced Integrated Science Courses: A Novel Approach to Medical Student Science Education
https://acrabstracts.org/abstract/advanced-integrated-science-courses-a-novel-approach-to-medical-student-science-education/
Eli Miloslavsky, Henrike Besche2 and John Flanagan, Massachusetts General Hospital et. al.

Nov 9th, 2020 - Background/Purpose: Scientific research is at the core of evidence-based medicine, and is transforming medical care at an increasingly rapid pace. The ability of students to engage with science as life-long learners is an important goal of undergraduate medical education and critical for practicing rheumatologists. However, there has been a trend towards shortening  pre-clinical science curricu...

Association of Air Pollution with Systemic Lupus Erythematosus Disease Activity in the Central Valley of California
https://acrabstracts.org/abstract/association-of-air-pollution-with-systemic-lupus-erythematosus-disease-activity-in-the-central-valley-of-california/
Mosaab Mohameden, Ali H.Ali, Zi Ying Li et. al.

Nov 9th, 2020 - Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease that affects at least 300,000 people in the United States creating a substantial socioeconomic burden. The exact etiology of SLE remains largely unknown. Both genetic factors and environmental exposures have been implicated in the etiology and progression of SLE. Air pollution is one of the major ...

Average Follow-up Time After Telemedicine Visit Is Longer Than Conventional Face-to-Face Visit in Outpatient Rheumatology Practice During COVID-19 Pandemic
https://acrabstracts.org/abstract/average-follow-up-time-after-telemedicine-visit-is-longer-than-conventional-face-to-face-visit-in-outpatient-rheumatology-practice-during-covid-19-pandemic/
Deepan Dalal, Tzu-Chun Chu, Brad Crough et. al.

Nov 9th, 2020 - Background/Purpose: In the era of recent COVID-19 crisis, outpatient rheumatology practices resorted to telemedicine to deliver longitudinal care, a fundamental component of chronic disease management.  However, little is known regarding time to follow up after telemedicine visits as compared to conventional face-to-face encounters as a marker of longitudinal care. Methods: We used electronic m...

An Oleuropein-based Dietary Supplement Improves Joint Function in Older People with High Knee Joint Pain
https://acrabstracts.org/abstract/an-oleuropein-based-dietary-supplement-improves-joint-function-in-older-people-with-high-knee-joint-pain/
Marie-Noelle Horcajada, Maurice Beaumont, Nicolas Sauvageot et. al.

Nov 9th, 2020 - Background/Purpose: The aim of this study was to investigate the effects of a 6-month intervention with an Olive Leaf Extract (OLE) standardized for oleuropein content on knee functionality and biomarkers of bone/cartilage metabolism and inflammation. Methods: The study was a randomized, double-blind, placebo-controlled, multi-centric trial of 124 subjects with mild knee pain or mobility issues...

Complement Activation in Systemic Lupus Erythematosus Patients with Low Disease Activity Is Not Inhibited by Hydroxychloroquine
https://acrabstracts.org/abstract/complement-activation-in-systemic-lupus-erythematosus-patients-with-low-disease-activity-is-not-inhibited-by-hydroxychloroquine/
Anne Margrethe Troldborg, Annette Hansen, Kristian Stengaard-Pedersen2 and Steffen Thiel et. al.

Nov 9th, 2020 - Background/Purpose: Mortality in patients with systemic lupus erythematosus (SLE) is significantly higher than in the general population. Treatment of SLE patients has improved, however, a majority of patients still experience symptoms like fatigue, pain and cognitive deficits even when they are clinically evaluated to have low disease activity (LDA) or being in remission. Immunosuppressants ar...

Cervical Cancer Screening Among Women with Systemic Lupus Erythematosus or Prescribed Tumor Necrosis Alpha-inhibitors Who Receive Outpatient Rheumatology Care
https://acrabstracts.org/abstract/cervical-cancer-screening-among-women-with-systemic-lupus-erythematosus-or-prescribed-tumor-necrosis-alpha-inhibitors-who-receive-outpatient-rheumatology-care/
Mehret Birru Talabi, Kwonho Jeong, Kaleab Abebe et. al.

Nov 9th, 2020 - Background/Purpose: Cervical cancer screening is important for women with systemic lupus erythematosus (SLE) and women prescribed TNF-alpha inhibitors (TNFi), as they have an increased risk of cervical dysplasia and cancer due to immune dysfunction and/or suppression. We describe receipt of guidelines-concordant cervical cancer screening among women receiving rheumatology care in a large Pennsy...

Adverse Effects of Low Dose Methotrexate: Adjudicated Hematologic Outcomes in a Large Randomized Double-blind Placebo-controlled Trial
https://acrabstracts.org/abstract/adverse-effects-of-low-dose-methotrexate-adjudicated-hematologic-outcomes-in-a-large-randomized-double-blind-placebo-controlled-trial/
Kathleen Vanni, Nancy Berliner, Nina Paynter et. al.

Nov 9th, 2020 - Background/Purpose: Low dose methotrexate (LD-MTX), a cornerstone in the treatment of rheumatoid arthritis, is associated with a moderately increased risk of anemia and leukopenia, but the risk of myelosuppression during LD-MTX use of up to 20mg/week remains incompletely described. We examined the hematologic outcomes among patients taking LD-MTX versus placebo in a large randomized controlled ...

Clinical Outcomes in Lupus Nephritis by Renal Response Status: A Retrospective Analysis of the Hopkins Lupus Cohort
https://acrabstracts.org/abstract/clinical-outcomes-in-lupus-nephritis-by-renal-response-status-a-retrospective-analysis-of-the-hopkins-lupus-cohort/
Michelle Petri, Qinggong Fu, Yulia Green et. al.

Nov 9th, 2020 - Background/Purpose: A retrospective analysis of the Hopkins Lupus Cohort (a prospective, longitudinal study of patients [pts] with systemic lupus erythematosus) reported that renal response (complete/partial/none) at 24 months post-diagnosis of lupus nephritis (LN) predicts long-term renal survival.1 Here, we compare long-term renal survival and chronic renal insufficiency-free survival in pts ...

Health Assessment Questionnaire Predicts All-Cause Mortality at One Year in Patients with Early Rheumatoid Arthritis
https://acrabstracts.org/abstract/health-assessment-questionnaire-predicts-all-cause-mortality-at-one-year-in-patients-with-early-rheumatoid-arthritis/
Safoora Fatima, Orit Schieir, Marie-France Valois et. al.

Nov 9th, 2020 - Background/Purpose: Patients with RA are at greater risk of mortality than the general population. Higher HAQ disability has been associated with hospitalizations and mortality in established RA; whether HAQ disability predicts mortality in early RA (ERA) is unknown. Methods: Data were from adult early RA patients (symptoms < 1 year) enrolled in the Canadian Early Arthritis Cohort (CATCH) betwe...

High-throughput Identification of Functional Regulatory SNPs Associated with Systemic Lupus Erythematosus
https://acrabstracts.org/abstract/high-throughput-identification-of-functional-regulatory-snps-associated-with-systemic-lupus-erythematosus/
Qiang Wang, Marta Martínez, Matthew Weirauch3 and Peter Nigrovic et. al.

Nov 9th, 2020 - Background/Purpose: Systemic lupus erythematosus (SLE) is a disease involves the complex interplay of many genes, reflected in more than one hundred loci linked with disease risk by genome-wide association studies (GWAS). Decoding GWAS is, therefore, a promising strategy to identify novel drug targets in SLE. However, most of the identified disease-associated hits are noncoding single-nucleotid...

Geographic Distribution and Environmental Triggers of Systemic Sclerosis in Massachusetts
https://acrabstracts.org/abstract/geographic-distribution-and-environmental-triggers-of-systemic-sclerosis-in-massachusetts/
Anastasiya Muntyanu, Bina Kassamali, Ruth Ann Vleugels3 and Avery LaChance et. al.

Nov 9th, 2020 - Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune sclerosing disease with a 10-year survival rate of less than 65%. This rate has remained unchanged for over 40 years. Although the exact pathogenesis remains unclear, it has been hypothesized that an environmental trigger leads to disease development in a genetically predisposed host. Assessment of high incidence geographic di...

Gout as an Immune-Related Adverse Event from Immune Checkpoint Inhibitors
https://acrabstracts.org/abstract/gout-as-an-immune-related-adverse-event-from-immune-checkpoint-inhibitors/
Kevin Lee, Carrie Ye2 and Shokrollah Elahi, Internal Medicine et. al.

Nov 9th, 2020 - Background/Purpose: Immune checkpoint inhibitors (ICI) are novel treatments approved for various tumours including melanoma, lung and kidney. By interacting with immunoregulatory molecules (programmed death-1 (PD-1), PD-1 ligand (PD-L1), or cytotoxic T-lymphocyte associated protein (CTLA-4)), ICI prevent inhibition of T-cells and thereby increase immune activity. However, this T-cell activation...

Gap in Contraceptive Education to Females with Rheumatic Disease on Teratogenic Medications
https://acrabstracts.org/abstract/gap-in-contraceptive-education-to-females-with-rheumatic-disease-on-teratogenic-medications/
Andras Perl, Sundus Mian1 and Jihad Ben Gabr, SUNY Upstate Medical University et. al.

Nov 9th, 2020 - Background/Purpose: Teratogenic disease-modifying anti-rheumatic disease modifying drugs (DMARDs) are often prescribed to women of childbearing age. Contraception represents an important area of reproductive health for female patients with rheumatic diseases. Counseling prior to starting DMARDs can help prevent the potential pregnancy risks associated with such medications.  Methotrexate (MTX),...

Consensus Definitions for MRI Lesions in the Spine of Patients with Axial Spondyloarthritis: First Analysis from the Assessments in SpondyloArthritis International Society Classification Cohort
https://acrabstracts.org/abstract/consensus-definitions-for-mri-lesions-in-the-spine-of-patients-with-axial-spondyloarthritis-first-analysis-from-the-assessments-in-spondyloarthritis-international-society-classification-cohort/
Walter Maksymowych, Iris Eshed, Pedro M Machado et. al.

Nov 9th, 2020 - Background/Purpose: A broad spectrum of MRI lesions has been described in the spine of patients with axial spondyloarthritis (axSpA) and a recent consensus from the ASAS MRI group has culminated in updated spine lesion definitions (ASAS_MRI_defn)1. There has been no central reader evaluation of MRI spine scans from the ASAS Classification Cohort (ASAS-CC)2. We aimed to determine the spectrum an...

Complex, Dynamic Attributes of Antigen-specific T Cells in Rheumatoid Arthritis
https://acrabstracts.org/abstract/complex-dynamic-attributes-of-antigen-specific-t-cells-in-rheumatoid-arthritis/
Eddie James, Virginia Muir, Cliff Rims et. al.

Nov 9th, 2020 - Background/Purpose: CD4+ T cells are implicated in the pathogenesis of rheumatoid arthritis (RA) due to strong genetic association with HLA class II alleles, the presence of CD4+ T cells in the rheumatoid joint and the efficacy of T cell directed therapies. In addition, CD4+ T cells specific to citrullinated epitopes are increased in RA and their frequency is influenced by disease duration and ...

Changes in Macular Capillary Network Measured with Optical Coherence Tomography-angiography in Patients with Systemic Lupus Erythematosus
https://acrabstracts.org/abstract/changes-in-macular-capillary-network-measured-with-optical-coherence-tomography-angiography-in-patients-with-systemic-lupus-erythematosus/
Laura Pelegrin, Marc Figueras-Roca, Alvaro Olate-Perez et. al.

Nov 9th, 2020 - Background/Purpose: Eye involvement in systemic lupus erythematosus (SLE) occurs in approximately one-third of patients, usually related to disease activity. An early diagnosis and treatment could prevent structural eye damage and visual acuity worsening in these cases. The purpose of the present study was t o describe macular vascular findings by optical coherence tomography angiography (OCT-A...

Cathepsin S Gene Expression Measured in the Peripheral Blood of Osteoarthritic Patients Prior to Surgery as a Biomarker of Post-operative Pain Development
https://acrabstracts.org/abstract/cathepsin-s-gene-expression-measured-in-the-peripheral-blood-of-osteoarthritic-patients-prior-to-surgery-as-a-biomarker-of-post-operative-pain-development/
Elena Tchetina, Kseniya Glemba, Galina Markova et. al.

Nov 9th, 2020 - Background/Purpose: Osteoarthritis (OA) is a chronic rheumatic disease, which involves pain, limited inflammation, and local destruction of the knee joint. OA pain is a major clinical symptom, which limits working capacity and denotes an important indication for joint replacement in the end-stage OA. In spite of significant number of positive outcomes, chronic postoperative pain represents a ma...

Combined Thermal and Ultrasound Imaging in Rheumatoid Arthritis Is Superior to Either Imaging Alone in Terms of Correlation with the 28-joint Disease Activity Score
https://acrabstracts.org/abstract/combined-thermal-and-ultrasound-imaging-in-rheumatoid-arthritis-is-superior-to-either-imaging-alone-in-terms-of-correlation-with-the-28-joint-disease-activity-score/
York Kiat Tan, Cassandra Hong, HuiHua Li et. al.

Nov 9th, 2020 - Background/Purpose: Combined thermal and ultrasound (US) imaging modalities in detecting joint inflammation in rheumatoid arthritis (RA) has not been evaluated relative to thermal or US imaging alone. Therefore, we aim to compare outcomes of the combined imaging modalities versus single imaging modality using the routinely performed 28-joint disease activity score (DAS28). Methods: Thermography...

CB2 Receptor Distribution and Effects of LenabasumTM in Dermatomyositis In Vitro
https://acrabstracts.org/abstract/cb2-receptor-distribution-and-effects-of-lenabasumtm-in-dermatomyositis-in-vitro/
Spandana Maddukuri, Jay Patel, Christina Bax et. al.

Nov 9th, 2020 - Background/Purpose: Dermatomyositis (DM) patients report poor quality of life due to disease activity and persistent itch. Lenabasum is an oral non-immunosuppressive, non-psychoactive cannabinoid type 2 receptor (CB2R) reverse agonist being investigated for use in DM. Our previous studies showed increased IFNγ in DM compared to healthy controls (HC) and a decrease in IFNγ as a result of Lenabas...

Comparison of MBDA Score, Patient Global Assessment and Evaluator Global Assessment for Predicting Risk of Radiographic Progression
https://acrabstracts.org/abstract/comparison-of-mbda-score-patient-global-assessment-and-evaluator-global-assessment-for-predicting-risk-of-radiographic-progression/
Leonard Calabrese, Michael Weinblatt, Nancy Shadick et. al.

Nov 9th, 2020 - Background/Purpose: To compare the abilities of MBDA score, patient global assessment (PGA) and evaluator global assessment (EGA) to assess risk for radiographic progression (RP), and to assess the ability of MBDA score to predict RP among patients with concordant or discordant PGA and EGA. Methods: Patients were pooled from two RCTs of patients with recent onset RA treated with conventional an...

Clinical History as Tool for Diagnosis and Classification of Patients with Ankylosing Spondylitis (Axial Spondyloarthritis): Evidence from a 35-Year Follow-up Family Study of a Swiss Cohort
https://acrabstracts.org/abstract/clinical-history-as-tool-for-diagnosis-and-classification-of-patients-with-ankylosing-spondylitis-axial-spondyloarthritis-evidence-from-a-35-year-follow-up-family-study-of-a-swiss-cohort/
Sjef van der Linden, Zhixiu Li, Matthew Brown et. al.

Nov 9th, 2020 - Background/Purpose: Lack of sensitivity or specificity of symptoms may induce uncertainty in diagnosis and classification of AS/axSpA. We investigated if balanced sensitivity and specificity of tools from the patient’s clinical history may help better define the ‘Gestalt’ of AS/axSpA Methods: In 1985 members of the Swiss AS Patient Society who had been diagnosed as having AS by their own physic...

Cardiovascular Risk in Rheumatoid Arthritis Patients Treated with Methotrexate versus Hydroxychloroquine
https://acrabstracts.org/abstract/cardiovascular-risk-in-rheumatoid-arthritis-patients-treated-with-methotrexate-versus-hydroxychloroquine/
Mengdong He, Ajinkya Pawar, Rishi Desai et. al.

Nov 9th, 2020 - Background/Purpose: Rheumatoid arthritis (RA) is a known risk factor for cardiovascular (CV) events. While most RA patients use conventional disease-modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX) and hydroxychloroquine (HCQ) as the 1st line DMARD, little is known about the comparative cardiovascular safety of these DMARDs. The objective of this study was to compare the incide...

Continued Treatment with Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Interim Analysis of SENSCIS-ON
https://acrabstracts.org/abstract/continued-treatment-with-nintedanib-in-patients-with-systemic-sclerosis-associated-interstitial-lung-disease-ssc-ild-interim-analysis-of-senscis-on/
Yannick Allanore, Madelon Vonk, Arata Azuma et. al.

Nov 9th, 2020 - Background/Purpose: In the SENSCIS trial in patients with SSc-ILD, nintedanib reduced the rate of decline in forced vital capacity (FVC) (mL/year) over 52 weeks by 44% compared with placebo, with adverse events that were manageable for most patients. The SENSCIS trial (NCT02597933) was followed by an open-label extension trial, SENSCIS-ON (NCT03313180), to provide safety data, including data on...

Coproduction of Care for Veterans with RA: Improving Elicitation and Documentation of Patient Goals
https://acrabstracts.org/abstract/coproduction-of-care-for-veterans-with-ra-improving-elicitation-and-documentation-of-patient-goals/
Swathi Reddy, Kyawt Shwin, Rashmi Arora et. al.

Nov 9th, 2020 - Background/Purpose: Coproduction of healthcare services offers a pathway to increase patient engagement in care. Patients and clinicians coproduce care by working together to: (1) co-assess health status; (2) co-decide next steps in the care plan based on the patient’s goals; (3) co-design the care plan to fit the patient’s goals, context, and capabilities; and, (4) co-deliver self-care and pro...

Characterization of Visual Manifestations and Identification of Risk Factors for Permanent Vision Loss in Patients with Giant Cell Arteritis
https://acrabstracts.org/abstract/characterization-of-visual-manifestations-and-identification-of-risk-factors-for-permanent-vision-loss-in-patients-with-giant-cell-arteritis/
Hussein Baalbaki, Darya Jalaledin, Catherine Lachance2 and Jean-Paul Makhzoum et. al.

Nov 9th, 2020 - Background/Purpose: Permanent vision loss (PVL) is a feared complication and a leading cause of morbidity in Giant Cell Arteritis (GCA). Multiple risk factors for ocular involvement have been identified with variable consistency, including older age, male sex, presence of cardio-vascular risk factors, transient ischemic symptoms, jaw claudication and thrombocytosis. The objective of this study ...

Development and Validation of an Artificial Intelligence Approach for the Detection of Radiographic Sacroiliitis
https://acrabstracts.org/abstract/development-and-validation-of-an-artificial-intelligence-approach-for-the-detection-of-radiographic-sacroiliitis/
Keno-Kyrill Bressem, Janis Vahldiek, Lisa Adams et. al.

Nov 9th, 2020 - Background/Purpose: Conventional radiography of the sacroiliac joints is still recommended as the first imaging method if axial spondyloarthritis (axSpA) is suspected. Furthermore, radiographic sacroiliitis is included – together with sacroiliitis on magnetic resonance imaging – in the Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axSpA. Depending on t...

Disease Features of Systemic Sclerosis Are Associated with Alterations in Gastrointestinal Microbial Composition in Two Independent Cohorts
https://acrabstracts.org/abstract/disease-features-of-systemic-sclerosis-are-associated-with-alterations-in-gastrointestinal-microbial-composition-in-two-independent-cohorts/
Kristofer Andréasson, Sungeun Lee, Venu Lagishetty et. al.

Nov 9th, 2020 - Background/Purpose: Previous studies have demonstrated alterations in GI microbiota of patients with systemic sclerosis (SSc) compared with healthy controls [1]. However, these prior studies did not adequately examine the impact of disease features and patient characteristics on microbial composition. The purpose of the present study was to examine associations between specific SSc disease feat...

Comprehensive Efficacy of Anifrolumab Across Organ Domains in Patients with Active SLE: Pooled Data from 2 Phase 3 Trials
https://acrabstracts.org/abstract/comprehensive-efficacy-of-anifrolumab-across-organ-domains-in-patients-with-active-sle-pooled-data-from-2-phase-3-trials/
Eric Morand, Richard Furie, Ian Bruce et. al.

Nov 9th, 2020 - Background/Purpose: SLE is a heterogeneous autoimmune disease with clinical manifestations across multiple organ systems. In the phase 3 TULIP-1 and TULIP-2 trials, anifrolumab treatment resulted in greater percentages of patients with SLE achieving a BILAG-based Composite Lupus Assessment (BICLA) response vs placebo at Week 52.1,2 We further evaluated the effects of anifrolumab on organ domain...

Clinical Characteristics of Methotrexate Associated Lymphoproliferative Disorders and RA Treatment After Lymphoproliferative Onset in 92 Cases
https://acrabstracts.org/abstract/clinical-characteristics-of-methotrexate-associated-lymphoproliferative-disorders-and-ra-treatment-after-lymphoproliferative-onset-in-92-cases/
Tomohiro Kameda, Shusaku Nakashima, Masayuki Inoo et. al.

Nov 9th, 2020 - Background/Purpose: Lymphoproliferative disorders (LPD) that develop in rheumatoid arthritis (RA) patients treated with MTX (MTX-LPD) is one of the important complications for RA patients. MTX-LPD has varied pathologies including various clinical manifestation and histological finding. Therefore, we need more information about MTX-LPD. In addition, it has not been established for RA treatment a...

Distinctive Molecular Signatures Among Monocytes from Childhood- and Adult-onset Systemic Lupus Erythematosus: Clinical Involvement and Relevance of Sustained Anti-dsDNA Positivity
https://acrabstracts.org/abstract/distinctive-molecular-signatures-among-monocytes-from-childhood-and-adult-onset-systemic-lupus-erythematosus-clinical-involvement-and-relevance-of-sustained-anti-dsdna-positivity/
Alejandra Maria Patiño-Trives, Concepción Aranda-Valera, R Roldan et. al.

Nov 9th, 2020 - Background/Purpose: By using integrative transcriptomic and protein analyses, this study aimed at identifying and characterize distinctive molecular signatures between childhood-onset (cSLE) and adult-onset Lupus (aSLE) patients, along with their involvement in immunological and clinical features, and to analyze the relevance of the sustained positivity for anti-dsDNA antibodies. Methods: Ninet...

Causal Pathways to Health-Related Quality of Life in Children with Juvenile Idiopathic Arthritis: Results from the ReACCh-Out Cohort
https://acrabstracts.org/abstract/causal-pathways-to-health-related-quality-of-life-in-children-with-juvenile-idiopathic-arthritis-results-from-the-reacch-out-cohort/
Kiem Oen, Jiahao Tian, Thomas Loughin et. al.

Nov 9th, 2020 - Background/Purpose: The relative roles of disease activity and disability as determinants of health-related quality of life (HRQoL) in children with JIA have been controversial; sometimes their statistical significance disappears when pain is added to multivariate models.  We explored whether structural equation modelling (SEM) may help clarify the causal pathways leading to decreased HRQoL in ...

Clinical Features of Patients with Active Ankylosing Spondylitis Who Did Not Respond to Adalimumab but Responded to Ixekizumab: A Post-hoc Analysis
https://acrabstracts.org/abstract/clinical-features-of-patients-with-active-ankylosing-spondylitis-who-did-not-respond-to-adalimumab-but-responded-to-ixekizumab-a-post-hoc-analysis/
Xenofon Baraliakos, Rebecca Bolce, David Sandoval et. al.

Nov 9th, 2020 - Background/Purpose: Biologic therapy is recommended in patients with active ankylosing spondylitis (AS) despite adequate trial of NSAIDs. Biologic treatment in AS are currently limited to TNF and IL-17A inhibitors (IL-17Ai). It is unknown whether there are predictors of AS patients who only respond to 1 of these mechanisms of action or respond to switching from TNF-blocker to IL-17Ai. This post...

Change in Tophus Size Measured with Dual-energy CT and Ultrasound: A 1-year Multicenter Follow-up Study
https://acrabstracts.org/abstract/change-in-tophus-size-measured-with-dual-energy-ct-and-ultrasound-a-1-year-multicenter-follow-up-study/
Tristan Pascart, Pascal Richette, Sebastien Ottaviani et. al.

Nov 9th, 2020 - Background/Purpose: Dual-Energy computed tomography (DECT) and ultrasound are the two techniques able to identify and measure monosodium urate (MSU) crystal deposition, and both are considered for monitoring crystal depletion during urate lowering therapy (ULT). Particularly, both techniques are able to measure tophi, but it is unknown if their assessment of tophus size are correlated throughou...

Comparison of Methotrexate and Glucosamine in Primary Knee Osteoarthritis with Inflammation
https://acrabstracts.org/abstract/comparison-of-methotrexate-and-glucosamine-in-primary-knee-osteoarthritis-with-inflammation/
Biswadip Ghosh, Subhankar Haldar2 and Meghna Saha, IPGME&R et. al.

Nov 9th, 2020 - Background/Purpose: Many patients suffering from knee OA show swelling, warmth along with pain which are features of inflammation. There are no accepted pharmacological therapy for osteoarthritis that target inflammation though inflammation plays a crucial role in pain generation and progressive joint damage. There are some evidence that Methotrexate may be useful in knee osteoarthritis. The la...

Curricular Implementation of the Rheumatic Disease Patient Expert Program: The Students’ Perspective
https://acrabstracts.org/abstract/curricular-implementation-of-the-rheumatic-disease-patient-expert-program-the-students-perspective/
Eleni Sophocleous, Andri Phoka2 and Konstantinos Parperis, University of Cyprus Medical school et. al.

Nov 9th, 2020 - Background/Purpose: Medical education can be enriched by embracing patient involvement so that students can learn about rheumatic diseases (RMD) from patient experts. Patient experts have developed an expertise in their chronic disease by living with it, acquiring knowledge from courses and being empowered with the skills, needed to play an active role in teaching other patients and healthcare ...

Cost-effectiveness of Surgical and Non-Surgical Weight Loss Programs for Morbidly Obese Patients with Knee Osteoarthritis
https://acrabstracts.org/abstract/cost-effectiveness-of-surgical-and-non-surgical-weight-loss-programs-for-morbidly-obese-patients-with-knee-osteoarthritis/
Valia Leifer, Jeffrey Katz, Faith Selzer et. al.

Nov 9th, 2020 - Background/Purpose: Growing numbers of knee osteoarthritis (KOA) patients are morbidly obese (BMI ≥ 35 kg/m2). Evolving evidence suggests weight reduction may delay the structural progression of KOA, reduce knee pain, and improve total knee replacement (TKR) outcomes. The cost-effectiveness of surgical and non-surgical weight loss strategies among morbidly obese patients with KOA has not been a...

Clinically Important Improvement in Osteoarthritis Pain at Week 16 After Subcutaneous Administration of Tanezumab: Pooled Analysis from International Studies
https://acrabstracts.org/abstract/clinically-important-improvement-in-osteoarthritis-pain-at-week-16-after-subcutaneous-administration-of-tanezumab-pooled-analysis-from-international-studies/
Thomas Schnitzer, Francis Berenbaum, Philip G Conaghan et. al.

Nov 9th, 2020 - Background/Purpose: Tanezumab is under investigation for the treatment of moderate to severe OA pain. As part of the phase 3 OA program, two randomized, placebo-controlled studies were completed and the data reported separately. Both studies showed early and sustained pain relief, following subcutaneous administration of tanezumab, at the time of the respective primary endpoints. The objective ...