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Under Pressure: An Update on Pulmonary Hypertension
https://www.the-rheumatologist.org/article/under-pressure-an-update-on-pulmonary-hypertension/
The Rheumatologist; Liebowitz J.

Nov 8th, 2020 - In patients with connective tissue diseases, such as systemic sclerosis (SSc), pulmonary hypertension (PH) remains one of the leading causes of morbidity and mortality. In her lecture on Friday, Nov. 6, Pulmonary Hypertension: An Update, Mardi Gomberg-Maitland, MD, MSc, professor of medicine and medical director of the Pulmonary Hypertension Program at The George Washington School of Medicine &...

ACR Convergence 2020: Study Data for Lupus & Rheumatoid Arthritis
https://www.the-rheumatologist.org/article/acr-convergence-2020-study-data-for-lupus-rheumatoid-arthritis/
The Rheumatologist; Hickman RJ.

Nov 8th, 2020 - At the annual meeting’s second Plenary Session, Saturday, Nov. 7, speakers highlighted phase 2 results of a potential new biologic for systemic lupus erythematosus (SLE), as well as data on remission maintenance in rheumatoid arthritis (RA) after withdrawal of etanercept or methotrexate.

COVID-19 Infection Rates Low in People with Rheumatic Diseases, Most Report Mild Illness
https://www.newswise.com/coronavirus/covid-19-infection-rates-low-in-people-with-rheumatic-diseases-most-report-mild-illness/?article_id=740879

Nov 7th, 2020 - ATLANTA — A new study shows that the COVID-19 infection incidence has been low in people with rheumatic diseases, and most of those infected experience a mild course of illness. Additionally, fatalities have been low among rheumatic disease patients infected with COVID-19. Details of this research was presented at ACR Convergence, the American College of Rheumatology’s annual meeting (ABSTRACT ...

ACR RA guidelines ‘push the needle away’ from glucocorticoids as primary option
https://www.healio.com/news/rheumatology/20201109/acr-ra-guidelines-push-the-needle-away-from-glucocorticoids-as-primary-option

Nov 7th, 2020 - Glucocorticoids should no longer be the “default” option for many patients with rheumatoid arthritis, according to authors of a new recommendation document presented at ACR Convergence 2020.

Warfarin linked to greater hip, knee replacement risk
https://www.healio.com/news/rheumatology/20201108/warfarin-linked-to-greater-hip-knee-replacement-risk

Nov 7th, 2020 - Treatment with warfarin is associated with a significantly greater risk for hip or knee replacement compared with direct oral anticoagulants, according to a speaker at ACR Convergence.

Osteoporosis 'largely ignored' in older men
https://www.healio.com/news/rheumatology/20201110/osteoporosis-largely-ignored-in-older-men

Nov 6th, 2020 - Less than 3% of older men who had experienced an osteoporosis-related fracture had been properly diagnosed and treated, according to findings presented at ACR Convergence 2020.

Slow Taper off Antimalarial Is Best to Avoid Lupus Flare During Remission
https://www.medscape.com/viewarticle/941743

Nov 29th, 2020 - Slowly tapering off – or remaining on – antimalarial medications can help prevent disease flare in patients with systemic lupus erythematosus (SLE) who've achieved clinical remission for at least a year, according to a new study that was presented at the virtual annual meeting of the American College of Rheumatology. "Except in the setting of toxicity, cessation of antimalarial medication in pa...

RA Remission? Stop Methotrexate, Keep Etanercept
https://www.medscape.com/viewarticle/941555

Nov 23rd, 2020 - In patients with RA whose disease is well controlled by methotrexate combined with etanercept, withdrawal of methotrexate led to long-term outcomes that were nearly as good as continuation of combination therapy. The finding comes from the randomized, controlled SEAM-RA trial that sought to address weaknesses of previous studies. It included a long lead-in time with stringent criteria to ensure...

Gout Clinical Practice Guidelines (ACR, 2020)
https://reference.medscape.com/viewarticle/941449

Nov 23rd, 2020 - Guidelines for managing gout were published in June 2020 by the American College of Rheumatology (ACR).[1] Indications for Pharmacologic Urate-Lowering Therapy (ULT)   Initiating ULT is strongly recommended for gout patients with ≥1 subcutaneous tophi, evidence of radiographic damage (any modality) attributable to gout, or frequent gout flares (≥2 annually). Initiating ULT is conditionally reco...

Debate: After Methotrexate Failure, Is JAK Inhibitor or Biologic Next?
https://www.medscape.com/viewarticle/941432

Nov 22nd, 2020 - What is the next step in treatment after a person with rheumatoid arthritis fails to adequately respond to methotrexate — a Janus kinase (JAK) inhibitor or a biologic? That was the focus of a lively debate at the virtual annual meeting of the American College of Rheumatology. Vibeke Strand, MD, argued that JAK inhibitors offer the distinct advantage of a faster clinical response than biologics,...

Children With Kawasaki Disease Need Long-Term Surveillance for Heart Disease
https://www.medscape.com/viewarticle/940775

Nov 12th, 2020 - NEW YORK (Reuters Health) - Children with Kawasaki disease remain at an increased risk for heart problems more than 10 years after they leave the hospital, according to a new study. "The results justify additional follow up and surveillance for cardiovascular disease and cardiovascular disease risk factors, such as obesity, high blood pressure and high cholesterol, in Kawasaki disease survivors...

JIA Guideline Calls for Earlier Use of Targeted Therapies
https://www.staging.medscape.com/viewarticle/940926

Nov 12th, 2020 - A draft guideline for the management of patients with juvenile idiopathic arthritis reflects changes in therapy away from reliance on NSAIDs and glucocorticoids and toward earlier introduction of biologic disease-modifying antirheumatic drugs (DMARDs). The guideline, described in an oral session during the virtual annual meeting of the American College of Rheumatology, contains weighted recomme...

Methotrexate and Hydroxychloroquine Split on Cardiovascular Outcomes in RA
https://www.medscape.com/viewarticle/940971

Nov 12th, 2020 - No significant differences in major adverse cardiovascular events (MACE) emerged between methotrexate and hydroxychloroquine (HCQ) treatment in a comparison of adults 65 years or older with rheumatoid arthritis (RA). However, researchers reported some elevation in risk for stroke in the methotrexate group and for myocardial infarction (MI) and heart failure in the HCQ group. The primary outcome...

Sjögren's Symptom Clusters May Identify Treatment Options
https://www.medscape.com/viewarticle/940960

Nov 12th, 2020 - Patients with Sjögren's syndrome can be categorized into four distinct symptom clusters — independent of age, sex, and some disease manifestations — that may both improve symptom relief and aid in the development of targeted therapies, investigators reported. Analysis of data from a survey conducted by the Sjögren's Foundation identified four symptom clusters based on the grouping of five commo...

JIA Guideline Calls for Earlier Use of Targeted Therapies
https://www.medscape.com/viewarticle/940926

Nov 12th, 2020 - A draft guideline for the management of patients with juvenile idiopathic arthritis reflects changes in therapy away from reliance on NSAIDs and glucocorticoids and toward earlier introduction of biologic disease-modifying antirheumatic drugs (DMARDs). The guideline, described in an oral session during the virtual annual meeting of the American College of Rheumatology, contains weighted recomme...

'Reassuring' Data on Cardiac Toxicity With Hydroxychloroquine in RA, Lupus
https://www.staging.medscape.com/viewarticle/940635

Nov 9th, 2020 - NEW YORK (Reuters Health) - Hydroxychloroquine has no significant impact on heart rhythm in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), according to two studies featured at a press briefing at ACR Convergence, the 2020 annual virtual meeting of the American College of Rheumatology. "Our findings really do reinforce the fact that hydroxychloroquine is a safe an...

Treatment Sequence With Romosozumab Influences Osteoporosis Outcomes
https://www.staging.medscape.com/viewarticle/940675

Nov 9th, 2020 - Timing is everything when it comes to the use of the anabolic agent romosozumab (Evenity) for the treatment of advanced osteoporosis, a review of clinical trials suggests. In four studies with treatment sequences in which romosozumab was administered either before or following the use of an antiresorptive agent, initial treatment with 1 year of romosozumab produced substantial bone mineral dens...

'Reassuring' Data on Cardiac Toxicity With Hydroxychloroquine in RA, Lupus
https://www.medscape.com/viewarticle/940635

Nov 9th, 2020 - NEW YORK (Reuters Health) - Hydroxychloroquine has no significant impact on heart rhythm in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), according to two studies featured at a press briefing at ACR Convergence, the 2020 annual virtual meeting of the American College of Rheumatology. "Our findings really do reinforce the fact that hydroxychloroquine is a safe an...

Characterizing Morphea Subsets Using a Multi-center, Prospective, Cross-sectional Analysis
https://acrabstracts.org/abstract/characterizing-morphea-subsets-using-a-multi-center-prospective-cross-sectional-analysis/
Jane Zhu, Smriti Prasad, Kaila Schollaert-Fitch et. al.

Nov 9th, 2020 - Background/Purpose: Morphea, or localized scleroderma, is an inflammatory condition of the skin and soft tissue that results in excessive collagen deposition, often producing permanent functional and cosmetic impairment. Morphea affects both adults and children, with approximately 50% of patients having childhood onset disease1,2. Numerous classification schemes for morphea exist, but none have...

Curdlan-induced Villous Permeability, Luminal Pathobiont Translocation to the Ileal Crypts, Ileitis and Arthritis Are Mitigated by Clostridia in Colonised Germ-free SKG Mice
https://acrabstracts.org/abstract/curdlan-induced-villous-permeability-luminal-pathobiont-translocation-to-the-ileal-crypts-ileitis-and-arthritis-are-mitigated-by-clostridia-in-colonised-germ-free-skg-mice/
Anne-Sophie Bergot, Rabina Giri, Amy Cameron et. al.

Nov 9th, 2020 - Background/Purpose: IL-23 dependent spondylitis, arthritis and inflammatory bowel disease (IBD) recapitulate human spondyloarthropathy (SpA) in 1,3 beta glucan (curdlan)-treated SKG mice. Human SpA and SKG mice have fecal dysbiosis, with increased Bacteroidaceae and Porphyromonadaceae. In SKG mice, anti-IL-23 supports homeostatic bacteria, including Clostridiaceae, which produce the short chain...