Combined Thermal and Ultrasound Imaging in Rheumatoid Arthritis Is Superior to Either Imaging Alone in Terms of Correlation with the 28-joint Disease Activity Score
York Kiat Tan, Cassandra Hong, HuiHua Li et. al.

Nov 9th, 2020 - Background/Purpose: Combined thermal and ultrasound (US) imaging modalities in detecting joint inflammation in rheumatoid arthritis (RA) has not been evaluated relative to thermal or US imaging alone. Therefore, we aim to compare outcomes of the combined imaging modalities versus single imaging modality using the routinely performed 28-joint disease activity score (DAS28). Methods: Thermography...

CB2 Receptor Distribution and Effects of LenabasumTM in Dermatomyositis In Vitro
Spandana Maddukuri, Jay Patel, Christina Bax et. al.

Nov 9th, 2020 - Background/Purpose: Dermatomyositis (DM) patients report poor quality of life due to disease activity and persistent itch. Lenabasum is an oral non-immunosuppressive, non-psychoactive cannabinoid type 2 receptor (CB2R) reverse agonist being investigated for use in DM. Our previous studies showed increased IFNγ in DM compared to healthy controls (HC) and a decrease in IFNγ as a result of Lenabas...

Comparison of MBDA Score, Patient Global Assessment and Evaluator Global Assessment for Predicting Risk of Radiographic Progression
Leonard Calabrese, Michael Weinblatt, Nancy Shadick et. al.

Nov 9th, 2020 - Background/Purpose: To compare the abilities of MBDA score, patient global assessment (PGA) and evaluator global assessment (EGA) to assess risk for radiographic progression (RP), and to assess the ability of MBDA score to predict RP among patients with concordant or discordant PGA and EGA. Methods: Patients were pooled from two RCTs of patients with recent onset RA treated with conventional an...

Clinical History as Tool for Diagnosis and Classification of Patients with Ankylosing Spondylitis (Axial Spondyloarthritis): Evidence from a 35-Year Follow-up Family Study of a Swiss Cohort
Sjef van der Linden, Zhixiu Li, Matthew Brown et. al.

Nov 9th, 2020 - Background/Purpose: Lack of sensitivity or specificity of symptoms may induce uncertainty in diagnosis and classification of AS/axSpA. We investigated if balanced sensitivity and specificity of tools from the patient’s clinical history may help better define the ‘Gestalt’ of AS/axSpA Methods: In 1985 members of the Swiss AS Patient Society who had been diagnosed as having AS by their own physic...

Cardiovascular Risk in Rheumatoid Arthritis Patients Treated with Methotrexate versus Hydroxychloroquine
Mengdong He, Ajinkya Pawar, Rishi Desai et. al.

Nov 9th, 2020 - Background/Purpose: Rheumatoid arthritis (RA) is a known risk factor for cardiovascular (CV) events. While most RA patients use conventional disease-modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX) and hydroxychloroquine (HCQ) as the 1st line DMARD, little is known about the comparative cardiovascular safety of these DMARDs. The objective of this study was to compare the incide...

Continued Treatment with Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Interim Analysis of SENSCIS-ON
Yannick Allanore, Madelon Vonk, Arata Azuma et. al.

Nov 9th, 2020 - Background/Purpose: In the SENSCIS trial in patients with SSc-ILD, nintedanib reduced the rate of decline in forced vital capacity (FVC) (mL/year) over 52 weeks by 44% compared with placebo, with adverse events that were manageable for most patients. The SENSCIS trial (NCT02597933) was followed by an open-label extension trial, SENSCIS-ON (NCT03313180), to provide safety data, including data on...

Coproduction of Care for Veterans with RA: Improving Elicitation and Documentation of Patient Goals
Swathi Reddy, Kyawt Shwin, Rashmi Arora et. al.

Nov 9th, 2020 - Background/Purpose: Coproduction of healthcare services offers a pathway to increase patient engagement in care. Patients and clinicians coproduce care by working together to: (1) co-assess health status; (2) co-decide next steps in the care plan based on the patient’s goals; (3) co-design the care plan to fit the patient’s goals, context, and capabilities; and, (4) co-deliver self-care and pro...

Characterization of Visual Manifestations and Identification of Risk Factors for Permanent Vision Loss in Patients with Giant Cell Arteritis
Hussein Baalbaki, Darya Jalaledin, Catherine Lachance2 and Jean-Paul Makhzoum et. al.

Nov 9th, 2020 - Background/Purpose: Permanent vision loss (PVL) is a feared complication and a leading cause of morbidity in Giant Cell Arteritis (GCA). Multiple risk factors for ocular involvement have been identified with variable consistency, including older age, male sex, presence of cardio-vascular risk factors, transient ischemic symptoms, jaw claudication and thrombocytosis. The objective of this study ...

Development and Validation of an Artificial Intelligence Approach for the Detection of Radiographic Sacroiliitis
Keno-Kyrill Bressem, Janis Vahldiek, Lisa Adams et. al.

Nov 9th, 2020 - Background/Purpose: Conventional radiography of the sacroiliac joints is still recommended as the first imaging method if axial spondyloarthritis (axSpA) is suspected. Furthermore, radiographic sacroiliitis is included – together with sacroiliitis on magnetic resonance imaging – in the Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axSpA. Depending on t...

Disease Features of Systemic Sclerosis Are Associated with Alterations in Gastrointestinal Microbial Composition in Two Independent Cohorts
Kristofer Andréasson, Sungeun Lee, Venu Lagishetty et. al.

Nov 9th, 2020 - Background/Purpose: Previous studies have demonstrated alterations in GI microbiota of patients with systemic sclerosis (SSc) compared with healthy controls [1]. However, these prior studies did not adequately examine the impact of disease features and patient characteristics on microbial composition. The purpose of the present study was to examine associations between specific SSc disease feat...

Comprehensive Efficacy of Anifrolumab Across Organ Domains in Patients with Active SLE: Pooled Data from 2 Phase 3 Trials
Eric Morand, Richard Furie, Ian Bruce et. al.

Nov 9th, 2020 - Background/Purpose: SLE is a heterogeneous autoimmune disease with clinical manifestations across multiple organ systems. In the phase 3 TULIP-1 and TULIP-2 trials, anifrolumab treatment resulted in greater percentages of patients with SLE achieving a BILAG-based Composite Lupus Assessment (BICLA) response vs placebo at Week 52.1,2 We further evaluated the effects of anifrolumab on organ domain...

Clinical Characteristics of Methotrexate Associated Lymphoproliferative Disorders and RA Treatment After Lymphoproliferative Onset in 92 Cases
Tomohiro Kameda, Shusaku Nakashima, Masayuki Inoo et. al.

Nov 9th, 2020 - Background/Purpose: Lymphoproliferative disorders (LPD) that develop in rheumatoid arthritis (RA) patients treated with MTX (MTX-LPD) is one of the important complications for RA patients. MTX-LPD has varied pathologies including various clinical manifestation and histological finding. Therefore, we need more information about MTX-LPD. In addition, it has not been established for RA treatment a...

Distinctive Molecular Signatures Among Monocytes from Childhood- and Adult-onset Systemic Lupus Erythematosus: Clinical Involvement and Relevance of Sustained Anti-dsDNA Positivity
Alejandra Maria Patiño-Trives, Concepción Aranda-Valera, R Roldan et. al.

Nov 9th, 2020 - Background/Purpose: By using integrative transcriptomic and protein analyses, this study aimed at identifying and characterize distinctive molecular signatures between childhood-onset (cSLE) and adult-onset Lupus (aSLE) patients, along with their involvement in immunological and clinical features, and to analyze the relevance of the sustained positivity for anti-dsDNA antibodies. Methods: Ninet...

Causal Pathways to Health-Related Quality of Life in Children with Juvenile Idiopathic Arthritis: Results from the ReACCh-Out Cohort
Kiem Oen, Jiahao Tian, Thomas Loughin et. al.

Nov 9th, 2020 - Background/Purpose: The relative roles of disease activity and disability as determinants of health-related quality of life (HRQoL) in children with JIA have been controversial; sometimes their statistical significance disappears when pain is added to multivariate models.  We explored whether structural equation modelling (SEM) may help clarify the causal pathways leading to decreased HRQoL in ...

Clinical Features of Patients with Active Ankylosing Spondylitis Who Did Not Respond to Adalimumab but Responded to Ixekizumab: A Post-hoc Analysis
Xenofon Baraliakos, Rebecca Bolce, David Sandoval et. al.

Nov 9th, 2020 - Background/Purpose: Biologic therapy is recommended in patients with active ankylosing spondylitis (AS) despite adequate trial of NSAIDs. Biologic treatment in AS are currently limited to TNF and IL-17A inhibitors (IL-17Ai). It is unknown whether there are predictors of AS patients who only respond to 1 of these mechanisms of action or respond to switching from TNF-blocker to IL-17Ai. This post...

Change in Tophus Size Measured with Dual-energy CT and Ultrasound: A 1-year Multicenter Follow-up Study
Tristan Pascart, Pascal Richette, Sebastien Ottaviani et. al.

Nov 9th, 2020 - Background/Purpose: Dual-Energy computed tomography (DECT) and ultrasound are the two techniques able to identify and measure monosodium urate (MSU) crystal deposition, and both are considered for monitoring crystal depletion during urate lowering therapy (ULT). Particularly, both techniques are able to measure tophi, but it is unknown if their assessment of tophus size are correlated throughou...

Comparison of Methotrexate and Glucosamine in Primary Knee Osteoarthritis with Inflammation
Biswadip Ghosh, Subhankar Haldar2 and Meghna Saha, IPGME&R et. al.

Nov 9th, 2020 - Background/Purpose: Many patients suffering from knee OA show swelling, warmth along with pain which are features of inflammation. There are no accepted pharmacological therapy for osteoarthritis that target inflammation though inflammation plays a crucial role in pain generation and progressive joint damage. There are some evidence that Methotrexate may be useful in knee osteoarthritis. The la...

Curricular Implementation of the Rheumatic Disease Patient Expert Program: The Students’ Perspective
Eleni Sophocleous, Andri Phoka2 and Konstantinos Parperis, University of Cyprus Medical school et. al.

Nov 9th, 2020 - Background/Purpose: Medical education can be enriched by embracing patient involvement so that students can learn about rheumatic diseases (RMD) from patient experts. Patient experts have developed an expertise in their chronic disease by living with it, acquiring knowledge from courses and being empowered with the skills, needed to play an active role in teaching other patients and healthcare ...

Cost-effectiveness of Surgical and Non-Surgical Weight Loss Programs for Morbidly Obese Patients with Knee Osteoarthritis
Valia Leifer, Jeffrey Katz, Faith Selzer et. al.

Nov 9th, 2020 - Background/Purpose: Growing numbers of knee osteoarthritis (KOA) patients are morbidly obese (BMI ≥ 35 kg/m2). Evolving evidence suggests weight reduction may delay the structural progression of KOA, reduce knee pain, and improve total knee replacement (TKR) outcomes. The cost-effectiveness of surgical and non-surgical weight loss strategies among morbidly obese patients with KOA has not been a...

Clinically Important Improvement in Osteoarthritis Pain at Week 16 After Subcutaneous Administration of Tanezumab: Pooled Analysis from International Studies
Thomas Schnitzer, Francis Berenbaum, Philip G Conaghan et. al.

Nov 9th, 2020 - Background/Purpose: Tanezumab is under investigation for the treatment of moderate to severe OA pain. As part of the phase 3 OA program, two randomized, placebo-controlled studies were completed and the data reported separately. Both studies showed early and sustained pain relief, following subcutaneous administration of tanezumab, at the time of the respective primary endpoints. The objective ...