Antibodies to Malondialdehyde-acetaldehyde (MAA) Protein Adduct as a Biomarker for Cardiovascular Manifestations in Systemic Lupus Erythematosus
Yangsheng Yu, Michelene Hearth-Holmes, Tammy Wang et. al.

Nov 12th, 2019 - Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by devastating end-organ manifestations. Cardiovascular disease (CVD) is a leading cause for premature death in SLE patients across different ethnicities. While the traditional Framingham risk factors likely contribute to CVD in SLE, they cannot fully account for the highly increased risk of CVD...

Adherence to Hydroxychloroquine Influences the Incidence of Organ Damage During Follow-up in Patients with Systemic Lupus Erythematosus
Ji-Hyoun Kang, Seong-Eun Choi, Haimuzi Xu et. al.

Nov 12th, 2019 - Background/Purpose: Hydroxychloroquine (HCQ) is a cornerstone drug in patients with systemic lupus erythematosus (SLE), decreasing the risk of flares and comorbidities and improving survival. This study investigated the effects of HCQ adherence on clinical manifestations, disease activity, and organ damage in Korean patients with SLE. Methods: Data on 299 SLE patients were obtained from the Kor...

Assessment of Bone Quality by Trabecular Bone Score (TBS) in Systemic Lupus Erythematosus Patients
Andrea Casabella, Sabrina Paolino, Alberto Sulli et. al.

Nov 12th, 2019 - Background/Purpose: Systemic lupus erythematosus (SLE) patients show an increased risk of low bone mass as a result of multifactorial events: physical inactivity, persistent inflammation, low vitamin D levels (protection to avoid photosensitivity) and glucocorticoid treatment. Trabecular Bone Score (TBS) is an index extracted from the dual-energy X-ray absorptiometry (DXA) that provides an indi...

An Updated Meta-Analysis of the Efficacy and Safety of Mycophenolate Mofetil in the Induction Treatment of Chinese Patients with Lupus Nephritis
Minlin Zhou, Yang yang, Xiaoyan Han et. al.

Nov 12th, 2019 - Background/Purpose: Achieving clinical remission while reducing toxicity are primary objectives in the treatment of lupus nephritis (LN). Mycophenolate mofetil (MMF) has demonstrated efficacy benefits with good tolerance as the induction therapy in LN patients of Hispanic or mixed race. However, a comprehensive view is lacking in its usage among Chinese patients with LN. We conducted this meta-...

Analysis of Discoid Lupus Erythematosus (DLE) Gene Expression Reveals Dysregulation of Pathogenic Pathways Associated with Infiltrating Immune/Inflammatory Cells
Frances Harris, Sarah Heuer, Robert Robl et. al.

Nov 12th, 2019 - Background/Purpose: DLE is a chronic, scarring inflammatory autoimmune disease of the skin. The precise molecular pathways underlying DLE pathogenesis have not been fully delineated. To obtain a more complete view of the pathologic processes involved in DLE, we undertook a comprehensive analysis of gene expression profiles from DLE affected skin. Methods: Microarray gene expression data was obt...

Aberrant H3K9me3 Modification in Promoter Region Up-regulates cAMP Response Element Modulator Alpha in Systemic Lupus Erythematosus
Huilin Zhang 1 and Qing Zhang, Clinical Nursing Teaching and Research Section, Second Xiangya Hospital et. al.

Nov 12th, 2019 - Background/Purpose: In recent years, accumulating evidences have demonstrated that increased cAMP response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in CD4+ T cells plays an essential role in the pathogenesis of systemic lupus erythematosus (SLE). However, the molecular mechanisms that result in CREMα over expression remain poorly understood. The aim of this study is ...

The Titer of Anti-Double Stranded DNA Antibody Could Affect the Apgar Score of Newborns, Which Is Considered as the Predictive Clinical Index for Neurological or Physical Development
Hiromi Shimada, Risa Wakiya, Mai Mahmoud Fahmy Mansour et. al.

Nov 12th, 2019 - Background/Purpose: Recently, the progression of treatment strategy enabled many systemic lupus erythematosus (SLE) women to become mothers. On the other hand, some reports have revealed another important problem about the associations between maternal SLE and neurological abnormalities including learning disorders and autism spectrum disorders among the children born to SLE mothers. However, i...

Results of the Open-label, Non-randomized 52-Week Study to Evaluate Treatment Holidays and Rebound Phenomenon After Treatment with Belimumab in Patients with SLE
Sang-Cheol Bae, Richard Dimelow, Beulah Ji et. al.

Nov 12th, 2019 - Background/Purpose: Belimumab is approved as add-on therapy in active, autoantibody-positive SLE. Safety and efficacy up to 13 years has been reported in adults, but potential for rebound upon temporary discontinuation of belimumab has not been investigated. This study (BEL116027; NCT02119156) assessed the impact of temporary withdrawal of intravenous (IV) belimumab. Methods: In this 52-week op...

Optimal Hydroxychloroquine Drug Levels in Pregnant Women with Systemic Lupus Erythematosus
Stephen Balevic, Michael Cohen-wolkowiez, Amanda Eudy et. al.

Nov 12th, 2019 - Background/Purpose: Pregnancies in women with systemic lupus erythematosus (SLE) often result in preterm birth. Active disease during pregnancy significantly increases the risks for these poor outcomes. Hydroxychloroquine (HCQ) reduces disease activity and flares in SLE, however, low serum levels may lead to treatment failure. Therefore, our objective is to evaluate HCQ levels during pregnancy ...

Proton Pump Inhibitor Induced Subacute Cutaneous Lupus Erythematosus: Clinical Characteristics and Outcomes – Case Control Study
Abdulrahman Alrashid, Yih Jia Poh, David D'Cruz et. al.

Nov 12th, 2019 - Background/Purpose: Drug induced subacute cutaneous lupus erythematosus has rarely been described. There is a growing literature reporting the association between proton pump inhibitor (PPI) use and subacute cutaneous lupus erythematosus (SCLE). To compare the clinical characteristics of a cohort of patients with proton pump inhibitor induced subacute cutaneous lupus erythematosus, their clinic...

Pharmacotherapies Targeting Type 2 SLE Symptoms
Raeann Whitney, Amanda Eudy, Megan Clowse et. al.

Nov 12th, 2019 - Background/Purpose: We propose categorizing lupus activity to better align with patient experience: Type 1 SLE activity includes classic symptoms such as arthritis and nephritis; Type 2 includes widespread pain, fatigue, depression, sleep disturbance, and perceived cognitive dysfunction. We previously found that only 53% of our patients with active Type 2 SLE received direct treatment for these...

Response Gene to Complement -32 Exerts Proinflammatory and Profibrotic Effects in Immune Complex Gediated Glomerulonephritis
Vinh Nguyen, Alexandru Tatomir, Horea Rus et. al.

Nov 12th, 2019 - Background/Purpose: Response Gene to Complement (RGC)-32 is a cell cycle regulator widely expressed in normal tissues, multiple tumors and  a variety of cell lines. RGC-32 is induced by TGF-β in fibroblasts, astrocytes and human renal proximal tubular cells and mediates TGF-β dependent profibrotic pathways.  In immune cells, RGC-32 is upregulated preferentially in murine and human Th17 cells an...

Pregnancy in Patients with Systemic Lupus Erythematosus After Cyclophosphamide Therapy
Mitali Sen, Anu Kurl, Tejal Vashi 2 and Arezou Khosroshahi et. al.

Nov 12th, 2019 - Background/Purpose: Systemic lupus erythematosus (SLE) predominantly affects females of reproductive age. Cyclophosphamide, an alkylating agent, labelled category D for pregnancy, is used for induction in treatment of severe manifestations of lupus. Previous studies have shown increased rate of primary ovarian insufficiency causing infertility in patients who have received cyclophosphamide. But...

Inhibition of Neutrophil Elastase Reduces Autoantibody Levels and Renal Inflammation in Murine Lupus
Gautam Sule, Kristen Gilley, Andrew Fernandes et. al.

Nov 12th, 2019 - Background/Purpose: Dysregulated neutrophil extracellular trap (NET) release has been proposed as a source of autoantigens in lupus.  Furthermore, it has recently been shown that the onset of lupus nephritis is predicted by a “neutrophil signature” in lupus blood.  Neutrophil elastase (NE) is a serine protease uniquely expressed by neutrophils, which is known to activate matrix metalloproteinas...

Inhibited Expression of Hematopoietic Progenitor Kinase 1 in Tfh Cells Contributes to Autoimmunity in Systemic Lupus Erythematosus
Qing Zhang1 and Huilin Zhang, Department of Dermatology, Second Xiangya Hospital et. al.

Nov 12th, 2019 - Background/Purpose: T follicular helper cells (Tfh cells) are a newly discovered subset of CD4+ T cells, which play a mainly role in inducing B cells to produce antibody. Tfh cells are over activated in systemic lupus erythematosus (SLE) patients, consequently bring about immune damages. Hematopoietic progenitor kinase 1 (HPK1) can inhibit T cell-mediated immune responses, but the role that HPK...

Identifying Subgroups of SLE Patients with Differential Responses to a BLyS Inhibitor: Application of a Machine Learning Algorithm to Clinical Trial Data
Mimi Kim, Kith Pradhan, Peter Izmirly et. al.

Nov 12th, 2019 - Background/Purpose: Given the heterogeneity of systemic lupus erythematosus (SLE), the effect of any intervention is expected to vary. The ability to identify those most and least likely to benefit from a treatment would improve the interpretability of trial outcomes and advance medical care. Conventional subgroup analyses suffer from low power, can encompass only a few variables at a time, and...

Iguratimod Is an Alternative Option for Refractory Lupus Nephritis: A Preliminary Observational Study
Qingran Yan, Chunde Bao, Yuening Kang et. al.

Nov 12th, 2019 - Background/Purpose: Despite significant advances in the management of patients with lupus nephritis (LN), a significant proportion of patients either do not respond to first-line immunosuppressive drugs, or relapse after initial remission. Iguratimod is a novel disease modifying anti-rheumatic drug that has been approved for treating rheumatoid arthritis in East Asia and has shown benefits in l...

Integration of Single Cells from Inflammatory Disease Tissues Reveals Common and Unique Pathogenic Cell States
Fan Zhang, Joseph Mears, ilya Korsunsky et. al.

Nov 12th, 2019 - Background/Purpose: Different autoimmune diseases can co-exist in an individual and share similar genetic associations, autoimmune signaling pathways, and clinical manifestations. However, autoimmune diseases present varied cellular heterogeneities and may be distinguished by their primary target organs or tissues. The immune mechanisms that are shared between similar autoimmune diseases remain...

Effect of Race and Lupus Nephritis on Pregnancy Outcomes in Systemic Lupus Erythematosus: An Individual Participant Meta-analysis
Ravyn Njagu, Amanda Eudy, Stephen Balevic et. al.

Nov 12th, 2019 - Background/Purpose: Individual cohort studies have found that Black and Hispanic women have worse pregnancy outcomes compared to their white counterparts. Additionally, this population of women has a higher prevalence of lupus nephritis. Therefore, this individual participant meta-analysis pooled data from multiple lupus pregnancy cohorts to assess the effect of maternal race and nephritis on p...

Frequency and Early Prediction of Hydroxychloroquine Induced Retinopathy in SLE
Jessica Li, Daniel Goldman 2 and Michelle Petri, Johns Hopkins University School of Medicine et. al.

Nov 12th, 2019 - Background/Purpose: In 2016, the American Academy of Ophthalmology (AAO) published recommendations designed to reduce hydroxychloroquine induced retinopathy via early detection and reduction of hydroxychloroquine dosing from 6.5 mg/kg to less than 5 mg/kg. We prospectively determined the frequency and the predictive role of blood levels of hydroxychloroquine to identify those at greater future ...