Cost-effectiveness of Duloxetine for Knee OA Patients Whose Pain Can’t Be Controlled by NSAIDs
James Sullivan, Jeffrey Katz 2 and Elena Losina, Brigham and Women's Hospital et. al.

Nov 13th, 2019 - Background/Purpose: Knee OA is a disabling condition affecting over 14 million adults in the US. NSAIDs provide only short-term pain relief, creating the need for additional pain management. Growing evidence indicates that chronic knee OA pain is associated with centralized pain pathways. Based on these considerations, ACR and OARSI recommend or conditionally recommend the use of duloxetine. Th...

Knee Injury and Transitions Among States of Knee Osteoarthritis in the Johnston County Osteoarthritis Project: A Multi-State Time-To-Event Modeling Approach
Yvonne Golightly, Carolina Alvarez, Liubov Arbeeva et. al.

Nov 13th, 2019 - Background/Purpose: Musculoskeletal injury is a known risk factor for osteoarthritis (OA). Cumulative effects of comorbid conditions on the association of injury and OA have not been previously examined. The purpose of this study was to clarify associations between knee injury and radiographic knee osteoarthritis (rKOA) and determine whether associations vary by sex, race, body mass index (BMI)...

Long-term Clinical and Economic Benefits of a Short-term Physical Activity Intervention Among Inactive Knee Osteoarthritis Patients in US: A Model-based Evaluation
Genevieve Silva, James Sullivan, Jeffrey Katz et. al.

Nov 13th, 2019 - Background/Purpose: The United States (US) knee osteoarthritis (OA) population has low levels of physical activity (PA), despite its well-defined health benefits. Interventions to promote PA are often stymied by concerns of lack of sustainability of intervention efficacy. We sought to evaluate lifetime benefits and cost-effectiveness of a short term (3-year) PA intervention in this population. ...

Dietary Patterns and Symptomatic Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Chang Xu, Nathalie Marchand, Jeffrey Driban et. al.

Nov 13th, 2019 - Background/Purpose: Osteoarthritis (OA) is a major source of disability worldwide yet dietary exposures that might be associated with its progression have not received significant research attention. We aimed to examine the prospective association of major dietary patterns derived by principal component analysis (PCA) with symptomatic progression of knee OA. Methods: From the Osteoarthritis Ini...

Does the Degree of Decline in Walking Speed Predict Mortality Risk Beyond the Present Level of Walking Speed in Knee Osteoarthritis?
Hiral Master, Tuhina Neogi, Lavalley Michael et. al.

Nov 13th, 2019 - Background/Purpose: Slow walking speed (WS) is a risk factor for mortality in well-functioning older adults and speeds slower than (< ) 1.22 meters per second (m/s) are a risk factor for poor health outcomes in knee osteoarthritis (OA). WS is known to decline with age, with some declining faster than other, though it is unclear if the rate of decline in WS is additionally relevant for mortality...

The Effects of Leisure Time Sitting and Sitting at Work on Worsening Radiographic Knee Osteoarthritis over Two Years: Data from the Osteoarthritis Initiative
Dana Voinier, Tuhina Neogi, Hiral Master et. al.

Nov 13th, 2019 - Background/Purpose: Sitting is associated with many poor health outcomes, which may include knee osteoarthritis (OA). When the knee is subject to minimal load, knee cartilage becomes thinner and may be more susceptible to damage. Thus, people who spend more time in sitting, whether during leisure time or during work, may be at greater risk for worsening structural damage in the knee. We examine...

BMI Has Minimal Effect on Reduction of Symptoms in Patients with Osteoarthritis of the Knee Treated with Diclofenac 1% Gel
Joel A. Block, Bharat Patel 2 and Sandy Yacoub Garas, Rush University Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Clinical trials demonstrate that diclofenac sodium gel 1% (DSG 1%), a topical NSAID, provides significantly better pain relief than vehicle placebo for patients with osteoarthritis (OA) of the knee. As patient BMI may affect the systemic availability and the volume of distribution of topical therapeutics, a post-hoc analysis was conducted to determine whether BMI has any cli...

Cross-sectional Associations of Multiple Joint Osteoarthritis in the Osteoarthritis Initiative
Charles Eaton, Mary Roberts, Jeffrey Driban et. al.

Nov 12th, 2019 - Background/Purpose: Multiple joint osteoarthritis (MJOA) may represent a unique phenotype of osteoarthritis related to systemic factors associated with pathologic aging. We tested the hypothesis that metabolic syndrome and its components, frailty and its components and lower levels of bone density are associated with MJOA. Methods: Participants in the Osteoarthritis Initiative (N=3325) had hand...

“If It Was Unicorn Dust I’d Have It Again.” Patient Experiences of Hip Osteoarthritis and Treatments in the Hip Injection Trial
Clare Jinks, Ashley Hawarden, Edward Roddy et. al.

Nov 12th, 2019 - Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of an ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hydrochloride combined with best current treatment (BCT) with (i) BCT alone (primary objecti...

Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Adam Goode, Rebecca Cleveland, David Hu et. al.

Nov 12th, 2019 - Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis  predict the incidence and worsening of lumbar spine disc space narrowing (DSN), facet joint OA (FOA), osteophytes (OST), and spondylolisthesis. Methods: These analyses used baseline (2006-2010) and follow-up (2013-2015) data from the Johnston County OA Project. Paire...

Magnetic Resonance Imaging of Knee Joint Protection Following an Intra-Articular Injection of Lipid-Based Dexamethasone Sodium Phosphate Sustained Release Formulation on Subjects with Knee Osteoart...
Sheue-Fang Shih, Carl Brown, Tien-Tzu Tai 1 and Wing Chuang et. al.

Nov 12th, 2019 - Background/Purpose: The most commonly used intra-articular (IA) corticosteroid for osteoarthritis (OA) is triamcinolone acetonide (TA), but its potential chondrotoxicity restricts injection frequency to 3-4 injections per year. TLC599 is a liposomal formulation of dexamethasone sodium phosphate (DSP) designed for intra-articular injection in the treatment of knee osteoarthritis (OA). Based on a...

Metabolic Regulation in Cybrids Obtained from Healthy and Osteoarthritic (OA) Patients: Impaired Metabolic Flexibility in OA Process
Andrea Dalmao-Fernández, Jenny Lund, Tamara Hermida-Gómez et. al.

Nov 12th, 2019 - Background/Purpose: Background: Osteoarthritis (OA) is the most frequent joint disease.The OA is a heterogeneous disorder. With acceptance of the joint as an organ, the pathogenesis of OA has been viewed as a complex process that involves all the joint structures. There are several metabolic pathways involved in cell metabolism, including glycolysis, tricarboxylic acid (TCA) cycle and fatty aci...

Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative
Alejandro Duran-Sotuela, Mercedes Fernandez-Moreno, María E. Vázquez-Mosquera et. al.

Nov 12th, 2019 - Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in the risk of suffering rapid progressive knee OA in patients from the Osteoarthritis Initiative (OAI). Methods: Caucasian patients from the OAI were classified into three groups based on previous criteria: i) Rapid progressors (R...

MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh, Frank Roemer, Erin Ashbeck et. al.

Nov 12th, 2019 - Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint tissues, different ordinal grades and joint subregions or locations. Our objective was to compare 8 different representations of MOAKS in terms of prediction performance for time to incident...

Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Kenya Terabe, Nobunori Takahashi, Yoshifumi Ohashi et. al.

Nov 12th, 2019 - Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic (OA), bovine as well as bovine or OA cartilage explants [1]. This was a somewhat counterintuitive observation because we have also demonstrated that the overexpression of HAS2 (HAS2-OE) exe...

Myopenia Is an Independent Risk Factor for Rotator Cuff Tear and Shoulder Dysfunction in Elderly People : Data from NAMGARAM Cohort
Yun-Hong Cheon, Young Sun Suh, Mingyo Kim et. al.

Nov 12th, 2019 - Background/Purpose: Myopenia refers to decline in muscle mass with age, causing significant impairment in the ability to carry out normal daily functions. Rotator cuff tear (RCT) is a localized tendon disease, however, it is known to be related with systemic inflammation. The aim of this study is to determine whether there is correlation between myopenia and RCT in elderly people. In addition, ...

Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)
Michael Bowes, Katherine Kacena, Oras Alabas et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both structural progression and outcomes, largely based on imprecise radiographic assessment. A statistical shape model (SSM), a form of machine learning, identified a characteristic 3D OA bone shape from MR images, enab...

Stabilization of Patellar Bone-Shape Correlates Significantly with Reduced Knee Pain Frequency After IA TPX-100 in Subjects with Bilateral Patellofemoral OA
Dawn McGuire, Michael Bowes, Alan Brett et. al.

Nov 12th, 2019 - Background/Purpose: Based on data from the Osteoarthritis Initiative (OAI), MRI-based analyses of bone shape changes in the knee predict symptomatic and radiographic progression of knee OA and risk of joint replacement (Neogi 2013; Barr 2016).  In a 12-month, double-blind, placebo-controlled trial of MRI-confirmed bilateral patellofemoral OA, TPX-100, administered in 4 weekly injections (200 mg...

Sarcopenia and the Likelihood of Incident Knee Osteoarthritis and Knee Pain Among Older Adults in the Health ABC Study
James Andrews, Laura Gold, Michael Nevitt et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) disproportionately affects older adults.  Sarcopenia, or reduced muscle mass and strength, is strongly associated with reduced physical function and poor clinical outcomes among older adults. Prior studies of knee OA and sarcopenia used varied measures of muscle mass and strength, and results are conflicting. We tested whether two components of sarcopenia...

Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain
Christopher Yohn, Robert O'Brien, Stephanie Lussier et. al.

Nov 12th, 2019 - Background/Purpose: Background/Purpose:  Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A in response to various cellular stressors.  Senescent cells secrete factors collectively referred to as the Senescence Associated Secretory Phenotype (SASP) that are proinflammatory and degradative i...