PET/CT Vascular Findings at Baseline and Six Months in Patients with Newly Diagnosed Giant Cell Arteritis
Anthony Sammel, Edward Hsiao, Geoff Schembri et. al.

Nov 12th, 2019 - Background/Purpose: PET/CT is a useful modality to diagnose GCA but there is limited knowledge as to how inflammatory vascular findings evolve on follow-up scans. This cohort study aimed to determine the change and clinical significance in vascular wall tracer (FDG) uptake in GCA patients from diagnosis to six-months. Methods: This study included a subset of patients from the previously reporte...

Preexisting Autoimmune Disease and Rheumatic Immune-Related Adverse Events Associated with Cancer Immunotherapy: A Case Series from the Canadian Research Group of Rheumatology in Immuno-Oncology (C...
Linda Laaouad, Janet Roberts, Daniel Ennis et. al.

Nov 12th, 2019 - Background/Purpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by harnessing the immune system to fight cancer, but are associated with significant immune-related adverse events (irAEs). Limited data is available on the safety of ICIs in patients with preexisting autoimmune diseases and on concomitant use of immunosuppressive drugs. CanRIO is a network of Canadian rh...

Pain Chronification and the Important Role of Non-disease Specific Symptoms in Patients with Systemic Sclerosis
Caroline Evers, Suzana Jordan, Britta Maurer et. al.

Nov 12th, 2019 - Background/Purpose: Pain is a frequent, yet inadequately explored challenge in patients with systemic sclerosis (SSc). The aim of this study was to conduct an extensive pain assessment, examining pain chronification and its association with disease manifestation. Methods: Consecutive SSc patients attending their annual assessment in the Department of Rheumatology, Zurich, Switzerland were inclu...

Predictors of Advanced Chronic Kidney Disease in Patients with ANCA Vasculitis and Renal Involvement
Gelsomina Alle, John Jaramillo Gallego, Marina Scolnik et. al.

Nov 12th, 2019 - Background/Purpose: The aim of this study was to evaluate the predictors of advanced chronic kidney disease (ACKD) in patients with Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and renal involvement. Methods: Observational retrospective study. We included all patients with biopsy-proven ANCA glomerulonephritis (GN) diagnosed between 2001 and 2016, with at least one year of ...

Predictors of Relapse in Giant Cell Arteritis: Data from an International Collaboration
Laure Delaval, Raphael Porcher, Kenneth Warrington et. al.

Nov 12th, 2019 - Background/Purpose: Roughly half of giant-cell arteritis (GCA) patients taking only glucocorticoids (GCs) relapse. The relapse rate seems to reflect, in part, the duration of GC intake, more than the initial dose at induction. However, the GCA-relapse rate varied widely in observational studies and randomized–controlled trials. We aimed to identify factors predictive of GCA relapse based on dat...

Prevalence of Corticosteroid Use in Incidental Vertebral or Hip Fractures
Gurjit Kaeley, Julie Ferm 2 and Lanh Dang, University of Florida et. al.

Nov 12th, 2019 - Background/Purpose: Non-traumatic vertebral and hip fractures are detrimental complications of osteoporosis and those with a previous fracture have double the risk of subsequent fractures. The objective of this quality improvement (QI) project was to determine the baseline characteristics that may have contributed to the vertebral or hip fracture and determine if bone health was optimized subse...

Mortality Predictors in ANCA-associated Vasculitis: Experience of a Brazilian Monocentric Cohort of a Rheumatology Center
Marilia Dagostin, Sergio Nunes, Samuel Shinjo 3 and Rosa Pereira et. al.

Nov 12th, 2019 - Background/Purpose: Mortality of patients with ANCA-associated vasculitis (AAV) is higher than the general population. There are few papers in the literature regarding the factors associated with this unfavorable outcome, most of them in the eastern population or from nephrology centers. To date, there is no study with this approach in Latin-American patients, a miscegenated population. Our obj...

Mitochondrial Contribution to Juvenile Dermatomyositis Pathogenesis
Bhargavi Duvvuri, Lauren Pachman, Richard Moore et. al.

Nov 12th, 2019 - Background/Purpose: Though mainly found intracellularly, we recently observed mitochondrial extrusion upon cell death, contributing to inflammation and organ damage in lupus-prone mice. Of note, mitochondria are immunogenic, promoting development of anti-mitochondrial antibodies (AMAs). Mitochondrial remnants, including DNA, are observed in the circulation of many systemic diseases, including l...

Myositis-specific and -associated Antibodies in Systemic Sclerosis: Prevalence and Clinical Associations
Amélie Leurs, Sylvain Dubucquoi, François Machuron et. al.

Nov 12th, 2019 - Background/Purpose: In systemic sclerosis (SSc) and idiopathic inflammatory myopathies (IIM), auto-antibodies are used in daily practice as potent biomarkers of clinical phenotypes. This study aimed at estimating the prevalence of myositis-specific (MSA) and myositis-associated (MAA) autoantibodies in SSc, and studying their clinical associations. Methods: We realized a cross-sectional, observa...

Modeling-Based Bone Formation Persists in the Femoral Neck Despite Remodeling Inhibition in Subjects Treated with Denosumab
David Dempster, Peter Butler, Mathias Bostrom et. al.

Nov 12th, 2019 - Background/Purpose: Denosumab (DMAb) is a potent antiresorptive agent, but findings in non-human primates suggest that modeling-based bone formation (MBBF) may persist despite DMAb treatment (Ominsky JBMR 2015). This study assessed whether MBBF in the femoral neck (FN) is preserved in the context of inhibited remodeling-based bone formation (RBBF) in subjects receiving DMAb (NCT02576652). Metho...

Mitochondrial DNA: A Potential Trigger of Cyclic GMP-AMP Synthase Activation in Systemic Lupus Erythematosus
Jie An, Bhargavi Duvvuri, Xizhang Sun et. al.

Nov 12th, 2019 - Background/Purpose: Approximately 70% of patients with Systemic Lupus Erythematosus (SLE) show a striking Type I Interferon (IFN-I) signature in peripheral blood. Although we have some understanding of how this signature can be generated in vitro (by immune complex activation of Toll-Like Receptors, TLRs), we have little understanding of mechanisms operative in SLE patients. Cyclic GMP-AMP (cGA...

Multi-vendor Multi-site T1ρ and T2 Quantification of Knee Cartilage
Jeehun Kim, Kenji Mamoto, Richard Lartey et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by deterioration of articular cartilage in the joints. MRI T1ρ and T2 relaxation times have been proposed as potential biomarkers for early detection of cartilage degeneration. However, few studies examined their reliability in a multi-site multi-vendor setting, which is critical for future large-scale trials ...

Mobile Responsive App – Useful Additional Tool for Data Collection in the German Pregnancy Register Rhekiss?
Jutta Richter, Christina Bungartz, Anja Weiß et. al.

Nov 12th, 2019 - Background/Purpose: The German pregnancy register Rhekiss is designed as a nationwide, web-based longitudinal observational register established in 2015. The register follows women with inflammatory rheumatic disease prospectively from child wish through pregnancy until two years postpartum. During the observation, information on clinical and laboratory parameters, disease activity, comorbiditi...

Meta-Analysis Examining the Clinical Significance of Monitoring of Hydroxychloroquine Levels in SLE
Shivani Garg, Rachna Unnithan, Karen Hansen et. al.

Nov 12th, 2019 - Background/Purpose: Despite the pivotal role hydroxychloroquine (HCQ) plays in treating SLE, less than 50% of patients take HCQ as prescribed. Nonadherence versus lack of effect to HCQ are difficult to distinguish, underscoring the importance of measuring HCQ blood levels to assess adherence. Despite this, information and consensus on the clinical impact of incorporating routine testing of HCQ ...

Multimodal Edema Management After Total Knee Arthroplasty: A Pilot Study
Joel Carmichael, Michael Bade 1 and Jennifer Stevens-Lapsley, University of Colorado Anschutz Medical Campus et. al.

Nov 12th, 2019 - Background/Purpose: The ideal treatment of swelling after TKA is unclear. The purpose of this pilot study was to determine the feasibility and initial efficacy of a multimodal edema management (MEM) program including inelastic gradient compression garment, manual lymph drainage massage and home exercise for patients presenting with swelling after TKA. Methods: This was a prospective pilot study...

Maintained Benefit in Health-Related Quality of Life of Patients with Giant Cell Arteritis Treated with Tocilizumab Plus Prednisone Tapering: Results from the Open-Label, Long-Term Extension of a P...
John Stone, Jian Han, Sebastian Unizony et. al.

Nov 12th, 2019 - Background/Purpose: Patients with giant cell arteritis (GCA) treated with tocilizumab (TCZ) plus prednisone tapering achieved higher rates of sustained glucocorticoid (GC)-free remission and had lower cumulative GC doses than patients treated with prednisone tapering alone in part 1 of the 52-week, double-blind GiACTA trial.1 During therapy, patients who received weekly TCZ reported improvement...

Musculoskeletal Ultrasound Enhances the Evaluation of Checkpoint Inhibitor Associated Musculoskeletal Immune Related Adverse Events
Mazen Nasrallah, Sara Schoenfeld, Mark Matza et. al.

Nov 12th, 2019 - Background/Purpose: Cancer immunotherapy with monoclonal antibodies that antagonize molecular checkpoint pathways in immune activation, the PD-1/PDL1 axis and CTLA-4, have revolutionized the treatment of solid cancers. These therapies however are limited by immune related adverse events (irAEs), including inflammatory arthritis (irIA). Presentations can be subtle, and recognition delayed. Here ...

Minocycline for Refractory Calcinosis in Systemic Sclerosis: A Single-Centre Observational Cohort Study
Carmen Fonseca, Voon Ong 2 and Christopher Denton, UCL Medical School et. al.

Nov 12th, 2019 - Background/Purpose: Calcinosis represents a major challenge for patients with systemic sclerosis (SSc) for which there is no standard therapy. Minocycline has been proposed for treatment of refractory calcinosis in SSc (1,2). We assessed the possible benefit and adverse events (AE) of minocycline in cohort of SSc patients with calcinosis. Methods: We reviewed patients with SSc, attending a larg...

Autoantibodies from Sjögren’s Syndrome Enhance NLRP3 Inflammasome Activation and IL-18 Production in Human Salivary Gland Cell Line A-253
Cheng-Han Wu, Ko Jen Li, Chia-Li Yu 3 and Song-Chou Hsieh et. al.

Nov 12th, 2019 - Background/Purpose: Primary Sjögren’s syndrome (SS) is a chronic autoimmune epithelitis characterized by the presence of autoantibodies against SS-related antigen A (SSA) and lymphocytic infiltration of exocrine glands. The underlying mechanisms in the initiation and perpetuation of SS remain to be fully elucidated. Recently, the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflamma...

Automated Diagnosis Extraction from Electronic Medical Records with Machine Learning Classifiers
Tjardo Maarseveen, Thomas Huizinga, Marcel J.T. Reinders et. al.

Nov 12th, 2019 - Background/Purpose: The use of Electronic Medical Records (EMR) for research purposes has led to an increasing interest in Natural Language Processing (NLP) for text classification. Little preparation is required as the NLP-methods are capable of automatically interpreting the data. Classification is often accomplished with naïve word-matching. An alternative to word-matching is the usage of a ...