Safety and Efficacy Results from the Open Label Extension of a Phase 2 Trial of Risankizumab, a Selective IL-23p19 Inhibitor in Patients with Active Psoriatic Arthritis
Kim Papp, Melinda Gooderham, Akimichi Morita et. al.

Nov 13th, 2019 - Background/Purpose: Psoriatic arthritis (PsA) is characterized by peripheral synovitis, enthesitis, dactylitis and spondylitis, and IL-23 is involved in the pathogenesis of these conditions either directly or indirectly. Risankizumab (RZB), a potent humanized IgG1 monoclonal antibody and selective IL23p19 inhibitor, exhibited superior efficacy vs placebo via ACR responses and PASI scores in pat...

Cluster-based Spondyloarthritis Phenotypes Defined at Baseline Are Predictive of Different Severity Outcomes at 5-Year in the DESIR Cohort
Félicie Costantino, Philippe Aegerter, Anna Moltó et. al.

Nov 12th, 2019 - Background/Purpose: The course of axial spondyloarthritis (SpA) is heterogeneous and remains to be better defined. DESIR is a longitudinal French cohort of early undifferentiated axial SpA, allowing to define different disease courses. We recently performed a cluster analysis, based on baseline characteristics and identified 2 SpA clusters: one, characterized by an isolated axial disorder (A fo...

Profiling Behavioral and Psychological Symptoms in Children with Spondyloarthritis and Polyarthritis
Anne McHugh, Avis Chan, Carolyn Herrera et. al.

Nov 12th, 2019 - Background/Purpose: Mental health disorders are thought to be common in patients with rheumatic disease, but studies examining behavioral issues in patients with juvenile idiopathic arthritis (JIA) have shown mixed results. This may be because JIA comprises a heterogeneous group of diseases and few studies examine psychopathology in different subtypes and disease activity states. This study aim...

Patients with Axial Spondyloarthritis Have Abnormal Microarchitecture Despite Normal Areal Bone Mineral Density and Trabecular Bone Score by DXA
Dalit Ashany, Susan Goodman, Haley Tornberg et. al.

Nov 12th, 2019 - Background/Purpose: Axial Spondyloarthritis (axSpA) is characterized by abnormal bone formation that produces syndesmophytes, while paradoxically, inflammation causes increased bone resorption and skeletal fragility. Detection of osteoporosis using DXA can be challenging as syndesmophytes falsely elevate spine areal bone mineral density (aBMD). In contrast, high-resolution peripheral QCT (HRpQC...

Study of Vertebral Fracture Prevalence and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra (SBAC-L1) in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis vs. Cont...
Marine Fauny, Eliane Albuisson, Elodie Bauer et. al.

Nov 12th, 2019 - Background/Purpose: Osteoporosis is a common disease whose prognosis can be seriously impacted by the development of fractures that lead to functional limitations and may even have life-threatening sequelae. This disease is often under-screened, especially in at-risk populations that require multidisciplinary care such as patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). ...

Shared and Differing Risk Factors for PsA, Psoriasis, AS, and RA: A Series of Case-control Studies
Alexis Ogdie, Xingmei Wang, Thorvardur J Love et. al.

Nov 12th, 2019 - Background/Purpose: While a handful of clinical risk factors for the development of inflammatory diseases have been identified, to date, no studies have compared risk factors across multiple inflammatory diseases. The objective of this study was to compare the strength of association of selected potential risk factors for the development of psoriasis, PsA, RA, and AS. Methods: We performed a se...

Comparison of Comorbidity in Spondyloarthritis: Influence on Inflammatory Activity in Patients with Psoriatic Arthritis
Luis Gomez-Lechon, Maria Elisa Acosta, Guadalupe Manzano Canabal et. al.

Nov 12th, 2019 - Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease that is included in the group of spondyloarthritis. Although PsA has its own clinical characteristics, it has a relatively specific comorbidity in relation to the rest of the entities that make up the group. The most frequent comorbidities in PsA are emotional disorders (anxiety and depression) and obesity. Its presence im...

Can Biologics “Prevent” the Development of Psoriatic Arthritis in Psoriasis Patients? Data from a Large University Hospital Cohort in Argentina
Luciano Fernando Lo Giudice, Maria Laura Acosta Felquer, Luis Daniel Mazzuoccolo et. al.

Nov 12th, 2019 - Background/Purpose: As psoriasis (Pso) commonly precedes psoriatic arthritis (PsA), an important unanswered question is whether treatment of Pso might influence the development of PsA in patients with psoriasis. The objective of this study was to analyze the incidence of PsA in a large cohort of patients with PsO according to different treatments, with the hypothesis that treatment with biologi...

Distinctive Pattern of LTBI Screening Parameters in Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA) in Endemic Areas
Andrea Shimabuco, Ana Cristina de Medeiros Ribeiro, Renata Miossi et. al.

Nov 12th, 2019 - Background/Purpose: Despite late tuberculosis infection (LTBI) screening before anti-TNF treatment, TB reactivation/new exposure in endemic areas remains a relevant problem. The specific analysis of Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA) screening parameters has not been evaluated previously and may provide clues to improve risk assessment for these diseases. Our objective is...

Description and Prevalence of Spondyloarthritis in Unselected Patients with Psoriasis, Acute Anterior Uveitis, and Inflammatory Bowel Disease Presenting with Undiagnosed Back Pain
Walter P. Maksymowych, Raj Carmona, Jonathan Chan et. al.

Nov 12th, 2019 - Background/Purpose: There is limited prospective data as to the frequency of axial spondyloarthritis (axSpA) in unselected patients referred to rheumatologists with undiagnosed back pain who have presented with acute anterior uveitis (AAU), psoriasis, or colitis to their respective specialists. It is also unclear which clinical features discriminate between axSpA and non-specific causes of back...

Alcohol Consumption as a Predictor of the Progression of Spinal Structural Damage in Axial Spondyloarthritis: Data from the Catholic Axial Spondyloarthritis COhort (CASCO)
Hong Ki Min, Seung-Ki Kwok 2 and Sang-Heon Lee, Konkuk university medical center et. al.

Nov 12th, 2019 - Background/Purpose: The purpose of the present study was to demonstrate the predicting factors of spinal structural damage in axial spondyloarthritis (axSpA) in a prospective cohort study. Methods: AxSpA patients were enrolled from a single tertiary hospital in a prospective cohort. Baseline data were collected, and 2 year follow-up radiographic data were collected. We analyzed the progression ...

AxSpA Patients with Symptom Onset < 30 Years Have More Structural Lesions on MRI of the Sacroiliac Joints When Fulfilling the Modified New York Criteria
Manouk de Hooge, Ann-Sophie De Craemer, Thomas Renson et. al.

Nov 12th, 2019 - Background/Purpose: The modified New York criteria (mNY) combine clinical symptoms with radiographic sacroiliitis on conventional pelvic radiographs (X-SI) classifying radiographic axial SpA patients (r-axSpA). AxSpA is known to typically start in the third era of life but there is a diagnostic delay of ±7 years. As the mNY criteria classify the most typical and severe expression of axSpA it is...

Treatment Preferences in Patients with Axial Spondyloarthritis
Dafne Capelusnik, Emilce Schneeberger, Leonela Lysseth Macias Oviedo et. al.

Nov 12th, 2019 - Background/Purpose: Due to the increasing tendency of involving patients in decisions regarding their health care and knowing the need for further research on patients’ preferences about treatment and adherence, the aim of this study was to evaluate the treatment preferences of patients with Axial Spondyloarthritis (axSpA) and to identify the factors associated with their choice. Methods: Patie...

Ixekizumab in Non-Radiographic Axial Spondyloarthritis: Primary Results from a Phase 3 Trial
Atul Deodhar, Désirée van der Heijde, Lianne Gensler et. al.

Nov 12th, 2019 - Background/Purpose: Ixekizumab (IXE), a high affinity IL-17A monoclonal antibody, previously showed efficacy in AS/radiographic-axSpA1,2. COAST-X (NCT02757352) is a phase 3 study that assessed efficacy and safety of IXE in patients (pts) with active nr-axSpA and objective signs of inflammation. Methods: COAST-X was a 52-wk, randomized, double-blind, PBO-controlled study enrolling adults with an...

Relationship Between Structural Spine Involvement and the Scanographic Bone Attenuation Coefficient of L1 in a Population of 73 Patients with Ankylosing Spondylitis
Marine Fauny, Frank VERHOEVEN, Edem Allado et. al.

Nov 12th, 2019 - Background/Purpose: Thoracic and/or thoraco-abdomino-pelvic (TAP) Computed Tomography (CT) may be performed during the follow up of patients with ankylosing spondylitis (AS) and are able to assess vertebral fracture and recently to assess bone fragility thought the scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1).    The objective is to evaluate the correlation b...

What Is Axial Spondyloarthritis? A Latent Class and Transition Analysis in the SPACE and DESIR Cohorts
Alexandre Sepriano, Sofia Ramiro, Désirée van der Heijde et. al.

Nov 12th, 2019 - Background/Purpose: Axial spondyloarthritis (axSpA) is a disease with a rather heterogeneous presentation that may be difficult to diagnose. Classification criteria, such as the ASAS criteria, developed and validated against the gold-standard ‘expert diagnosis’, exist,  but may suffer from circularity because features deemed important by experts may have got a too prominent, and therefore biase...

Frailty in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis: Data from a National Claims Database
Sarah Lieber, Mangala Rajan, Sebastian E. Sattui et. al.

Nov 12th, 2019 - Background/Purpose: Frailty, a state of decreased homeostatic reserve, is associated with increased disability and mortality, independent of age. Frailty has been evaluated in large datasets using validated algorithms in the elderly. Although frailty has been investigated in several rheumatic diseases, including RA, to our knowledge, frailty has not been investigated in AS and PsA, which often ...

Efficacy and Safety of Tocilizumab Treatment for Anti–human T Lymphotropic Virus Type I Antibody–positive Rheumatoid Arthritis
Yushiro Endo, Kunihiko Umekita, Hideki Nakamura et. al.

Nov 12th, 2019 - Background/Purpose: The asymptotic individuals with the human T lymphotropic virus type I (HTLV-I) infection rarely develop adult T cell leukemia/lymphoma (ATL) or HTLV-I–associated myelopathy (HAM). In addition, HTLV­1 infection is also associated with rheumatic disease such as HTLV-I–associated arthropathy, rheumatoid arthritis (RA), and Sjogren’s syndrome. The HTLV-I virus infects not only p...

5-years Treatment Effect of TNF Alpha Inhibitor in Early Axial Spondyloarthritis and Associated Factors: An Inverse Probability Weighting Analysis of the DESIR Cohort
Marion Pons, Sylvie Chevret, Karine Briot et. al.

Nov 12th, 2019 - Background/Purpose: Only scarce date is available on the long term treatment effect in a real-life setting (i.e. effectiveness) of TNFi in early axial SpA forms and its predisposing associated factors; furthermore, unbiased evaluation of treatment effect in non-randomized clinical trials is challenging, and new methods have been developed to overcome prescription bias.  The objectives of the st...

Achilles Tendon Enthesitis and Disease Burden in Psoriatic Arthritis and Axial Spondyloarthritis: Baseline Results from a Randomized Controlled Trial
Frank Behrens, Philipp Sewerin, Eugenio de Miguel et. al.

Nov 12th, 2019 - Background/Purpose: Enthesitis is a common feature of Spondyloarthritis (SpA)1. Enthesitis at the Achilles tendon is an important manifestation with impact on function which is often refractory to standard NSAID/corticosteroid treatment1,2. ACHILLES is a double blind, placebo-controlled, multicenter Phase 3 trial designed to investigate the efficacy of secukinumab on enthesitis by clinical as w...