×
Combined Trajectories of Fatigue and Disease Activity in an Inception Cohort of Lupus Patients over 10 Years
https://acrabstracts.org/abstract/combined-trajectories-of-fatigue-and-disease-activity-in-an-inception-cohort-of-lupus-patients-over-10-years/
Mitra Moazzami, Vibeke Strand, Jiandong Su 3 and Zahi Touma et. al.

Nov 13th, 2019 - Background/Purpose: Fatigue is very common in SLE patients. We aim to: 1) determine if different trajectories of fatigue associate with specific latent classes of disease activity and 2) define the patient characteristics and associated factors in different latent classes. Methods: This is a retrospective analysis on a prospectively collected dataset from an inception cohort and followed from 1...

Clinical Subsets in Giant Cell Arteritis
https://acrabstracts.org/abstract/clinical-subsets-in-giant-cell-arteritis/
K Bates Gribbons, Cristina Ponte, Anthea Craven et. al.

Nov 13th, 2019 - Background/Purpose: Giant cell arteritis (GCA) is a clinically heterogeneous disease.  Disease subsets based upon cranial versus extracranial artery involvement have been proposed.  The study objective was to determine if GCA subsets are associated with distinct clinical profiles or merely reflective of differential diagnostic assessment. Methods: Patients were included from a large internation...

Complement Protein CL-K1 at High Concentrations Protects Against the Development of Lupus Nephritis
https://acrabstracts.org/abstract/complement-protein-cl-k1-at-high-concentrations-protects-against-the-development-of-lupus-nephritis/
Anne Troldborg, Anne Voss, Søren Werner Karlsjov Hansen et. al.

Nov 13th, 2019 - Background/Purpose: Nephritis is a severe manifestation of systemic lupus erythematosus (SLE) that develops in 30 to 50 percent of the patients. At the time of diagnosis, it is not possible to predict which patients will develop nephritis. CL-K1 (collectin kidney-1, collectin-11) is a soluble C-type lectin, with collagenous stalks like C1q, that through recognition of suitably spaced patterns o...

Citrulline Reactive B Cells Are Present in the Lungs of Early Untreated RA
https://acrabstracts.org/abstract/citrulline-reactive-b-cells-are-present-in-the-lungs-of-early-untreated-ra/
Vijay Joshua, Malena Loberg-Haarhaus, Heidi Wähämaa et. al.

Nov 13th, 2019 - Background/Purpose: Structural changes, increased tissue citrullination, signs of local inflammation and anti-citrullinated protein autoantibodies (ACPA) are present in the pulmonary compartment of early untreated seropositive rheumatoid arthritis (RA). These findings provide evidence of a potential role for the lungs in generation and initiation of RA-associated autoimmunity. Here we aimed to ...

Comparison of Arterial Patterns of Disease in Takayasu’s Arteritis and Giant Cell Arteritis
https://acrabstracts.org/abstract/comparison-of-arterial-patterns-of-disease-in-takayasus-arteritis-and-giant-cell-arteritis/
K Bates Gribbons, Cristina Ponte, Anthea Craven et. al.

Nov 13th, 2019 - Background/Purpose: Current classification criteria differentiate between Takayasu’s arteritis (TAK) and giant cell arteritis (GCA), the two most common forms of large-vessel vasculitis, based primarily on clinical assessment, yet patients with TAK and GCA may differ in patterns of arterial disease.  This study aimed to use computer-based algorithms to determine if patterns of arterial disease ...

Cell-bound Complement Activation Products in Combination with Low Complement C3 or C4 Have Superior Diagnostic Performance in Systemic Lupus Erythematosus
https://acrabstracts.org/abstract/cell-bound-complement-activation-products-in-combination-with-low-complement-c3-or-c4-have-superior-diagnostic-performance-in-systemic-lupus-erythematosus/
Sonali Narain, Daniel Wallace, Chaim Putterman et. al.

Nov 13th, 2019 - Background/Purpose: Cell-bound complement activation products (CB-CAPs) are stable forms of classical complement activation ex-vivo, with high sensitivity and specificity for systemic lupus erythematosus  (SLE). We sought to compare the performance of CB-CAPs to the gold standard low complement C3 or C4 in distinguishing SLE from other rheumatic diseases and healthy individuals. Methods: Multip...

Dietary Patterns and Symptomatic Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative
https://acrabstracts.org/abstract/dietary-patterns-and-symptomatic-progression-of-knee-osteoarthritis-data-from-the-osteoarthritis-initiative/
Chang Xu, Nathalie Marchand, Jeffrey Driban et. al.

Nov 13th, 2019 - Background/Purpose: Osteoarthritis (OA) is a major source of disability worldwide yet dietary exposures that might be associated with its progression have not received significant research attention. We aimed to examine the prospective association of major dietary patterns derived by principal component analysis (PCA) with symptomatic progression of knee OA. Methods: From the Osteoarthritis Ini...

Dual Neutralization of IL-17A and IL-17F with Bimekizumab in Patients with Active Psoriatic Arthritis: Disease Activity and Remission in a 48-Week Phase 2b, Randomized, Double‑Blind, Placebo-Contro...
https://acrabstracts.org/abstract/dual-neutralization-of-il-17a-and-il-17f-with-bimekizumab-in-patients-with-active-psoriatic-arthritis-disease-activity-and-remission-in-a-48-week-phase-2b-randomized-double%e2%80%91blind-placebo-c/
Philip Mease, Laure Gossec, Laura Coates et. al.

Nov 13th, 2019 - Background/Purpose: The ultimate goal of therapy in patients with psoriatic arthritis (PsA) is clinical remission, defined as ‘the absence of clinical and laboratory evidence of significant inflammatory disease activity’.1,2 Since many patients with PsA may not achieve clinical remission, treatment recommendations recognise minimal or low disease activity as an important alternative treatment t...

Does the Degree of Decline in Walking Speed Predict Mortality Risk Beyond the Present Level of Walking Speed in Knee Osteoarthritis?
https://acrabstracts.org/abstract/does-the-degree-of-decline-in-walking-speed-predict-mortality-risk-beyond-the-present-level-of-walking-speed-in-knee-osteoarthritis/
Hiral Master, Tuhina Neogi, Lavalley Michael et. al.

Nov 13th, 2019 - Background/Purpose: Slow walking speed (WS) is a risk factor for mortality in well-functioning older adults and speeds slower than (< ) 1.22 meters per second (m/s) are a risk factor for poor health outcomes in knee osteoarthritis (OA). WS is known to decline with age, with some declining faster than other, though it is unclear if the rate of decline in WS is additionally relevant for mortality...

Deriving Accurate Prednisone Dosing from Electronic Health Records: Analysis of a Natural Language Processing Tool for Complex Prescription Instructions
https://acrabstracts.org/abstract/deriving-accurate-prednisone-dosing-from-electronic-health-records-analysis-of-a-natural-language-processing-tool-for-complex-prescription-instructions/
Francine Castillo, Adrienne Strait, Michael Evans et. al.

Nov 13th, 2019 - Background/Purpose: Prednisone is commonly used to treat rheumatic diseases, yet few comparative effectiveness studies on different dosing regimens are available. Electronic health records (EHR) and prescriptions are potential data sources for such research. However, a barrier to this work is organizing non-standardized prednisone “sigs”, or free-text instructions within a prescription, into a ...

DMARD-free Remission in Established Rheumatoid Arthritis: 2 Year Results of the TARA Trial
https://acrabstracts.org/abstract/dmard-free-remission-in-established-rheumatoid-arthritis-2-year-results-of-the-tara-trial/
Elise van Mulligen, Angelique Weel, Martijn Kuijper et. al.

Nov 13th, 2019 - Background/Purpose: In rheumatoid arthritis (RA) disease outcomes  have improved enormously in the last  decades. Due to early initiation of therapy, a treat-to-target approach and a growing arsenal of disease-modifying antirheumatic drugs (DMARDs) and biologicals, RA patients are in sustained remission more often. This raises the subsequent questions whether treatment should be continued, tape...

Application of Bayesian Statistics to Support Approval of Intravenous Belimumab in Children with Systemic Lupus Erythematosus in the United States
https://acrabstracts.org/abstract/application-of-bayesian-statistics-to-support-approval-of-intravenous-belimumab-in-children-with-systemic-lupus-erythematosus-in-the-united-states/
Ginto Pottackal, James Travis, Rosemarie Neuner et. al.

Nov 13th, 2019 - Background/Purpose: In April 2019, FDA approved the first treatment, intravenous (IV) belimumab (BEL), specifically for children 5 to 17 years of age with active, seropositive SLE receiving standard care (SOC). The approval was supported by a single post-marketing required randomized, controlled trial (NCT01649765) that evaluated the efficacy, safety and pharmacokinetics (PK) of 10 mg/kg IV BEL...

Access to Care and Diagnostic Delays in Juvenile Dermatomyositis
https://acrabstracts.org/abstract/access-to-care-and-diagnostic-delays-in-juvenile-dermatomyositis/
Jessica Neely, Susan Kim, Hugh Sturrock 2 and Julia Shalen et. al.

Nov 13th, 2019 - Background/Purpose: Factors associated with diagnostic delay in Juvenile Dermatomyositis (JDM) are not known.  We hypothesized that limited access to pediatric rheumatologists can lead to delay in the diagnosis of JDM and worse outcomes. We investigated demographic factors, including access to care, associated with diagnostic delays and clinical outcomes of subjects with JDM in the Childhood Ar...

An Integrated Gut Microbiomic and Plasma Metabolomic Analysis in Patients with Four Systemic Autoimmune Diseases
https://acrabstracts.org/abstract/an-integrated-gut-microbiomic-and-plasma-metabolomic-analysis-in-patients-with-four-systemic-autoimmune-diseases/
Chiara Bellocchi, Álvaro Fernández-Ochoa, Gaia Montanelli et. al.

Nov 13th, 2019 - Background/Purpose: Gut microbiota may be relevant in the regulation of immune processes and in the development of systemic autoimmune diseases (SADs). A reduction of microbiota diversity and a selective decrease of commensal pro-regolatory bacteria have been observed in systemic lupus erythematosus (SLE), Sjogren syndrome (SJS) and primary anti-phosholipid syndrome (PAPS). None studies have be...

Antimicrobial Use Is High in Patients with Rheumatoid Arthritis, and Further Increases with First-Line TNFi Therapy – Nationwide Results from Iceland
https://acrabstracts.org/abstract/antimicrobial-use-is-high-in-patients-with-rheumatoid-arthritis-and-further-increases-with-first-line-tnfi-therapy-nationwide-results-from-iceland/
Aron H Bjornsson, Olafur Palsson, Mar Kristjansson et. al.

Nov 13th, 2019 - Background/Purpose: Severe infections, frequently resulting in hospitalization, are a well-known adverse effects of tumor necrosis factor inhibitors (TNFi). However, studies regarding outpatient treated infections are needed. Our objective was to investigate the use of antimicrobials (antibiotics, antifungals and antivirals; excluding antimycobacterials) in patients with rheumatoid arthritis (R...

The Effects of Leisure Time Sitting and Sitting at Work on Worsening Radiographic Knee Osteoarthritis over Two Years: Data from the Osteoarthritis Initiative
https://acrabstracts.org/abstract/the-effects-of-leisure-time-sitting-and-sitting-at-work-on-worsening-radiographic-knee-osteoarthritis-over-two-years-data-from-the-osteoarthritis-initiative/
Dana Voinier, Tuhina Neogi, Hiral Master et. al.

Nov 13th, 2019 - Background/Purpose: Sitting is associated with many poor health outcomes, which may include knee osteoarthritis (OA). When the knee is subject to minimal load, knee cartilage becomes thinner and may be more susceptible to damage. Thus, people who spend more time in sitting, whether during leisure time or during work, may be at greater risk for worsening structural damage in the knee. We examine...

The Role of Alterations in the Splicing Machinery in the Pathogenesis of Lupus: Does It Impact Lupus Nephritis?
https://acrabstracts.org/abstract/the-role-of-alterations-in-the-splicing-machinery-in-the-pathogenesis-of-lupus-does-it-impact-lupus-nephritis/
Chary Lopez-Pedrera, Alejandro Ibañez-Costa, Mª Ángeles Aguirre-Zamorano et. al.

Nov 13th, 2019 - Background/Purpose: The aim of this study was to evaluate whether alterations in the splicing machinery of immune cells could influence the development and activity of the disease and the kidney involvement in systemic lupus erythematosus (SLE) patients. Methods: Monocytes, lymphocytes and neutrophils from 43 SLE patients and 34 healthy donors (HD) were purified by immunomagnetic selection. The...

Risk of 30-day Readmission and Adverse Events After Primary Hip or Knee Arthroplasty: A Comparison of Patients with Rheumatoid Arthritis versus Osteoarthritis Using the Nationwide Readmission Database
https://acrabstracts.org/abstract/risk-of-30-day-readmission-and-adverse-events-after-primary-hip-or-knee-arthroplasty-a-comparison-of-patients-with-rheumatoid-arthritis-versus-osteoarthritis-using-the-nationwide-readmission-database/
Ali Yazdanyar, Anthony Donato, Kathleen McElwee et. al.

Nov 13th, 2019 - Background/Purpose: To assess the risk of 30-day readmission, mortality, and adverse events among adults with Rheumatoid Arthritis as compared to Osteoarthritis after primary hip or knee arthroplasty. Methods: We identified index hospitalizations with a principal procedure of primary HA or KA using a nationally representative U.S. sample, the Nationwide Readmission Database (2010-2013).  Exclud...

Prospective Demonstration That Attainment of the Lupus Low Disease Activity State Is Associated with Improved Health Related Quality of Life
https://acrabstracts.org/abstract/prospective-demonstration-that-attainment-of-the-lupus-low-disease-activity-state-is-associated-with-improved-health-related-quality-of-life/
Vera Golder, Molla Huq, Rangi Kandane-Rathnayake et. al.

Nov 13th, 2019 - Background/Purpose: The Lupus Low Disease Activity State (LLDAS) is a treatment endpoint for SLE that has been shown in prospective validation studies to be associated with protection against disease flares and damage accrual. In addition to improved physician-measured outcomes, attainment of treatment endpoints should also result in improvement in patient-reported outcomes such as health relat...

Rilonacept in Recurrent Pericarditis: Efficacy and Safety Data from an Ongoing Phase 2 Pilot Clinical Trial
https://acrabstracts.org/abstract/rilonacept-in-recurrent-pericarditis-efficacy-and-safety-data-from-an-ongoing-phase-2-pilot-clinical-trial/
Allan Klein, David Lin, Paul Cremer et. al.

Nov 13th, 2019 - Background/Purpose: Recurrent pericarditis (RP) is characterized by the recurrence of pericarditis signs and symptoms after a symptom-free period of ≥4 to 6 weeks and affects 20-30 % of acute pericarditis patients. IL-1α/β, mediators of the inflammatory process, predominate in recurrent pericarditis (RP). Methods: Participants with symptomatic or corticosteroid (CS)-dependent idiopathic or post...