×
Application of Bayesian Statistics to Support Approval of Intravenous Belimumab in Children with Systemic Lupus Erythematosus in the United States
https://acrabstracts.org/abstract/application-of-bayesian-statistics-to-support-approval-of-intravenous-belimumab-in-children-with-systemic-lupus-erythematosus-in-the-united-states/
Ginto Pottackal, James Travis, Rosemarie Neuner et. al.

Nov 13th, 2019 - Background/Purpose: In April 2019, FDA approved the first treatment, intravenous (IV) belimumab (BEL), specifically for children 5 to 17 years of age with active, seropositive SLE receiving standard care (SOC). The approval was supported by a single post-marketing required randomized, controlled trial (NCT01649765) that evaluated the efficacy, safety and pharmacokinetics (PK) of 10 mg/kg IV BEL...

Access to Care and Diagnostic Delays in Juvenile Dermatomyositis
https://acrabstracts.org/abstract/access-to-care-and-diagnostic-delays-in-juvenile-dermatomyositis/
Jessica Neely, Susan Kim, Hugh Sturrock 2 and Julia Shalen et. al.

Nov 13th, 2019 - Background/Purpose: Factors associated with diagnostic delay in Juvenile Dermatomyositis (JDM) are not known.  We hypothesized that limited access to pediatric rheumatologists can lead to delay in the diagnosis of JDM and worse outcomes. We investigated demographic factors, including access to care, associated with diagnostic delays and clinical outcomes of subjects with JDM in the Childhood Ar...

An Integrated Gut Microbiomic and Plasma Metabolomic Analysis in Patients with Four Systemic Autoimmune Diseases
https://acrabstracts.org/abstract/an-integrated-gut-microbiomic-and-plasma-metabolomic-analysis-in-patients-with-four-systemic-autoimmune-diseases/
Chiara Bellocchi, Álvaro Fernández-Ochoa, Gaia Montanelli et. al.

Nov 13th, 2019 - Background/Purpose: Gut microbiota may be relevant in the regulation of immune processes and in the development of systemic autoimmune diseases (SADs). A reduction of microbiota diversity and a selective decrease of commensal pro-regolatory bacteria have been observed in systemic lupus erythematosus (SLE), Sjogren syndrome (SJS) and primary anti-phosholipid syndrome (PAPS). None studies have be...

Antimicrobial Use Is High in Patients with Rheumatoid Arthritis, and Further Increases with First-Line TNFi Therapy – Nationwide Results from Iceland
https://acrabstracts.org/abstract/antimicrobial-use-is-high-in-patients-with-rheumatoid-arthritis-and-further-increases-with-first-line-tnfi-therapy-nationwide-results-from-iceland/
Aron H Bjornsson, Olafur Palsson, Mar Kristjansson et. al.

Nov 13th, 2019 - Background/Purpose: Severe infections, frequently resulting in hospitalization, are a well-known adverse effects of tumor necrosis factor inhibitors (TNFi). However, studies regarding outpatient treated infections are needed. Our objective was to investigate the use of antimicrobials (antibiotics, antifungals and antivirals; excluding antimycobacterials) in patients with rheumatoid arthritis (R...

The Effects of Leisure Time Sitting and Sitting at Work on Worsening Radiographic Knee Osteoarthritis over Two Years: Data from the Osteoarthritis Initiative
https://acrabstracts.org/abstract/the-effects-of-leisure-time-sitting-and-sitting-at-work-on-worsening-radiographic-knee-osteoarthritis-over-two-years-data-from-the-osteoarthritis-initiative/
Dana Voinier, Tuhina Neogi, Hiral Master et. al.

Nov 13th, 2019 - Background/Purpose: Sitting is associated with many poor health outcomes, which may include knee osteoarthritis (OA). When the knee is subject to minimal load, knee cartilage becomes thinner and may be more susceptible to damage. Thus, people who spend more time in sitting, whether during leisure time or during work, may be at greater risk for worsening structural damage in the knee. We examine...

The Role of Alterations in the Splicing Machinery in the Pathogenesis of Lupus: Does It Impact Lupus Nephritis?
https://acrabstracts.org/abstract/the-role-of-alterations-in-the-splicing-machinery-in-the-pathogenesis-of-lupus-does-it-impact-lupus-nephritis/
Chary Lopez-Pedrera, Alejandro Ibañez-Costa, Mª Ángeles Aguirre-Zamorano et. al.

Nov 13th, 2019 - Background/Purpose: The aim of this study was to evaluate whether alterations in the splicing machinery of immune cells could influence the development and activity of the disease and the kidney involvement in systemic lupus erythematosus (SLE) patients. Methods: Monocytes, lymphocytes and neutrophils from 43 SLE patients and 34 healthy donors (HD) were purified by immunomagnetic selection. The...

Risk of 30-day Readmission and Adverse Events After Primary Hip or Knee Arthroplasty: A Comparison of Patients with Rheumatoid Arthritis versus Osteoarthritis Using the Nationwide Readmission Database
https://acrabstracts.org/abstract/risk-of-30-day-readmission-and-adverse-events-after-primary-hip-or-knee-arthroplasty-a-comparison-of-patients-with-rheumatoid-arthritis-versus-osteoarthritis-using-the-nationwide-readmission-database/
Ali Yazdanyar, Anthony Donato, Kathleen McElwee et. al.

Nov 13th, 2019 - Background/Purpose: To assess the risk of 30-day readmission, mortality, and adverse events among adults with Rheumatoid Arthritis as compared to Osteoarthritis after primary hip or knee arthroplasty. Methods: We identified index hospitalizations with a principal procedure of primary HA or KA using a nationally representative U.S. sample, the Nationwide Readmission Database (2010-2013).  Exclud...

Prospective Demonstration That Attainment of the Lupus Low Disease Activity State Is Associated with Improved Health Related Quality of Life
https://acrabstracts.org/abstract/prospective-demonstration-that-attainment-of-the-lupus-low-disease-activity-state-is-associated-with-improved-health-related-quality-of-life/
Vera Golder, Molla Huq, Rangi Kandane-Rathnayake et. al.

Nov 13th, 2019 - Background/Purpose: The Lupus Low Disease Activity State (LLDAS) is a treatment endpoint for SLE that has been shown in prospective validation studies to be associated with protection against disease flares and damage accrual. In addition to improved physician-measured outcomes, attainment of treatment endpoints should also result in improvement in patient-reported outcomes such as health relat...

Rilonacept in Recurrent Pericarditis: Efficacy and Safety Data from an Ongoing Phase 2 Pilot Clinical Trial
https://acrabstracts.org/abstract/rilonacept-in-recurrent-pericarditis-efficacy-and-safety-data-from-an-ongoing-phase-2-pilot-clinical-trial/
Allan Klein, David Lin, Paul Cremer et. al.

Nov 13th, 2019 - Background/Purpose: Recurrent pericarditis (RP) is characterized by the recurrence of pericarditis signs and symptoms after a symptom-free period of ≥4 to 6 weeks and affects 20-30 % of acute pericarditis patients. IL-1α/β, mediators of the inflammatory process, predominate in recurrent pericarditis (RP). Methods: Participants with symptomatic or corticosteroid (CS)-dependent idiopathic or post...

Rituximab as Rescue Therapy in Treatment-Refractory CTD-ILD
https://acrabstracts.org/abstract/rituximab-as-rescue-therapy-in-treatment-refractory-ctd-ild/
Julia Sun, Charles Oshinsky, Nicole Garcia et. al.

Nov 13th, 2019 - Background/Purpose: Interstitial lung disease (ILD) is the leading cause of mortality and carries significant morbidity in connective tissue disease (CTD). Corticosteroids are often used as first line therapy, yet the use of additional immunosuppressive (IS) agents remains largely empiric. In this study we evaluated the effect of Rituximab (RTX) as rescue therapy on lung function in a cohort of...

Remission in Patients with Rheumatoid Arthritis Receiving Triple Therapy Compared to Biological Therapy – A Swedish Nationwide Register Study
https://acrabstracts.org/abstract/remission-in-patients-with-rheumatoid-arthritis-receiving-triple-therapy-compared-to-biological-therapy-a-swedish-nationwide-register-study/
Hanna Källmark, Jon Einarsson, Jan-Åke Nilsson 3 and Meliha Kapetanovic et. al.

Nov 13th, 2019 - Background/Purpose: Current treatment guidelines for rheumatoid arthritis (RA) recommend a treat-to-target approach with early treatment initiation of disease-modifying antirheumatic drugs (DMARDs), most commonly methotrexate (MTX), and treatment escalation in case of insufficient response. In this scenario, similar efficacy of biological DMARDs (bDMARDs)  + MTX compared to conventional triple ...

Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Phase 2b Study to Demonstrate the Safety and Efficacy of Tildrakizumab, a High-Affinity Anti–Interleukin-23P19 Monoclonal Antibody, in P...
https://acrabstracts.org/abstract/randomized-double-blind-placebo-controlled-multiple-dose-phase-2b-study-to-demonstrate-the-safety-and-efficacy-of-tildrakizumab-a-high-affinity-anti-interleukin-23p19-monoclonal-antibody/
Philip Mease, Saima Chohan, Ferran J. García Fructuoso et. al.

Nov 13th, 2019 - Background/Purpose: Tildrakizumab (TIL), a high-affinity anti–interleukin-23p19 monoclonal antibody, is approved for moderate-to-severe plaque psoriasis treatment and is under investigation for PsA. This study evaluated the 24-week efficacy and safety results from a randomized, double-blind, placebo-controlled, multiple-dose, phase 2b TIL study in patients with active PsA (NCT02980692). Methods...

From a Potential Solution to Part of the Problem: Analysis of Spending and Price Trends for Brand-Name and Generic Colchicine and Other Gout Medications
https://acrabstracts.org/abstract/from-a-potential-solution-to-part-of-the-problem-analysis-of-spending-and-price-trends-for-brand-name-and-generic-colchicine-and-other-gout-medications/
Natalie McCormick, Zachary Wallace, Chio Yokose et. al.

Nov 13th, 2019 - Background/Purpose: Gout affects >4 million US adults aged ≥ 65 years, but little is known about the scale and drivers of public spending on gout medications, including colchicine.  Used for decades, its price rose drastically after one brand-name form (Colcrys) was granted market exclusivity from 2011-2014, as part of the FDA Unapproved Drugs Initiative. We quantified changes in total spending...

Factors Associated with Cardiac Dysfunction in a Longitudinal Follow-Up of Neonatal Lupus
https://acrabstracts.org/abstract/factors-associated-with-cardiac-dysfunction-in-a-longitudinal-follow-up-of-neonatal-lupus-2/
Amit Saxena, Peter Izmirly, Rebecca Bomar et. al.

Nov 13th, 2019 - Background/Purpose: Cardiac manifestations of neonatal lupus (NL) have been associated with significant morbidity and mortality, however there has been minimal information on long-term outcomes of affected individuals.  This study was initiated to evaluate the presence of and risk factors associated with cardiac dysfunction in NL after birth in multiple age groups to improve counseling, further...

Evaluation of the Transcriptome of Non-Lesional, Non-Sun Exposed Skin in Patients with Lupus Nephritis
https://acrabstracts.org/abstract/evaluation-of-the-transcriptome-of-non-lesional-non-sun-exposed-skin-in-patients-with-lupus-nephritis/
Hemant Suryawanshi, Robert Clancy, Evan Der et. al.

Nov 13th, 2019 - Background/Purpose: The impact of renal injury in lupus nephritis (LN) is widespread with consequences to resident cells in other tissue beds, even non-lesional, non-sun exposed skin. Faithful reflection of a relevant renal tissue pathway in a more readily accessible compartment would allow for less invasive diagnostic alternatives. While ongoing studies are exploiting single cell RNA sequencin...

Imaging Acquisition Technique Influences Interpretation of Positron Emission Tomography Vascular Activity in Large-Vessel Vasculitis
https://acrabstracts.org/abstract/imaging-acquisition-technique-influences-interpretation-of-positron-emission-tomography-vascular-activity-in-large-vessel-vasculitis/
Kaitlin Quinn, Joel S. Rosenblum, Casey A. Rimland et. al.

Nov 13th, 2019 - Background/Purpose: 18F-flurodeoxyglucose (FDG) positron emission tomography (PET) is one of several imaging modalities used in the assessment of patients with large-vessel vasculitis (LVV).  Conventionally PET images are obtained 1 hour after radiotracer injection; however, delayed imaging may be more sensitive to detect vascular inflammation.    The objectives of this study were to: 1) determ...

Increased CD69+ Tissue-resident Memory T (TRM) Cells and STAT3 Expression in Cutaneous Lupus Erythematosus Patients Recalcitrant to Antimalarials
https://acrabstracts.org/abstract/increased-cd69-tissue-resident-memory-t-trm-cells-and-stat3-expression-in-cutaneous-lupus-erythematosus-patients-recalcitrant-to-antimalarials/
Majid Zeidi, Kristen Chen, Krisha Desai et. al.

Nov 13th, 2019 - Background/Purpose: Cutaneous lupus erythematosus (CLE) is an autoimmune disease with various subsets and clinical manifestations. T lymphocytes are the predominant cell type found in lesional skin, but plasmacytoid dendritic cells (pDCs) and myeloid dendritic cells (mDCs) also play an important role in the pathogenesis. Oral antimalarials, including hydroxychloroquine (HCQ) and quinacrine (QC)...

Interferon Signature Predicts Response to Tofacitinib in Haploinsufficiency of A20
https://acrabstracts.org/abstract/interferon-signature-predicts-response-to-tofacitinib-in-haploinsufficiency-of-a20/
Sarah Blackstone, Daniella Schwartz, Natalia Sampaio Moura et. al.

Nov 13th, 2019 - Background/Purpose: The protein A20, encoded by TNFAIP3, represses signaling upstream of the inflammatory transcription factor nuclear factor (NF)-kB by regulating ubiquitination. Heterozygous loss-of-function mutations in TNFAIP3 cause the systemic autoinflammatory disease Haploinsufficiency of A20 (HA20) [1]. Because no FDA-approved medications directly target NF-kB signaling, current HA20 th...

Improving the Efficiency of Clinical Trial Recruitment Using Electronic Health Record Data, Natural Language Processing, and Machine Learning
https://acrabstracts.org/abstract/improving-the-efficiency-of-clinical-trial-recruitment-using-electronic-health-record-data-natural-language-processing-and-machine-learning/
Tianrun Cai, Fiona Cai, Kumar Dahal et. al.

Nov 13th, 2019 - Background/Purpose: Efficiently identifying eligible patients is an important component of a successful clinical trial.  Billing codes from electronic health record (EHR) data are commonly used to first screen for potential patients, followed by labor-intensive chart review to identify the eligible patients by trial criteria.  The objective of this study was to test whether a machine learning s...

Secukinumab Improves Axial Manifestations in Patients with Psoriatic Arthritis and Inadequate Response to NSAIDs: Primary Analysis of Phase 3 Trial
https://acrabstracts.org/abstract/secukinumab-improves-axial-manifestations-in-patients-with-psoriatic-arthritis-and-inadequate-response-to-nsaids-primary-analysis-of-phase-3-trial/
Xenofon Baraliakos, Laura Coates, Laure Gossec et. al.

Nov 13th, 2019 - Background/Purpose: Secukinumab (SEC) has provided significant and sustained improvement in the signs and symptoms of active psoriatic arthritis (PsA) and ankylosing spondylitis1. Evidence is limited on the efficacy of biologics in the treatment of patients (pts) with PsA having axial manifestations that affect between 30–70% of pts2, particularly as validated classification criteria for this s...