The Preparation and Recovery Experience from Total Knee Replacement of Patients with Osteoarthritis: A Qualitative Study
Iris Navarro-Millan, Sarah Young, Geyanne Lui et. al.

Nov 12th, 2019 - Background/Purpose: Up to 30% of patients may have persistent pain post-total knee arthroplasty (TKA). One possible approach to improve these outcomes is to optimize muscle strength, physical condition, and mental preparation before surgery. Our purpose was to elicit patients’ experiences with TKA with the goal of understanding the utility and logistics of implementing a pre-habilitation progra...

Relation of Intra-Articular Knee Mineralization on CT to Knee Pain in People with or at Risk of Knee Osteoarthritis
Tuhina Neogi, John Lynch, Mohamed Jarraya et. al.

Nov 12th, 2019 - Background/Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA), particularly in end-stage disease. It is possible that low-grade inflammation related to crystals may contribute to knee pain, including pain fluctuation. However, in prior studies, results on this matter have been conflicting. Detection of chondrocalcinosis has relied on radiographs to ...

Restricting Activity to Evade Knee Symptoms Is Associated with Worse Physical Function and Radiographic Osteoarthritis
Louise Thoma, Jason Jakiela, Hiral Master et. al.

Nov 12th, 2019 - Background/Purpose: Activity restriction (i.e. limiting or avoiding normal activity) is a common strategy to reduce, and sometimes eliminate, knee symptoms. Knee symptoms, such as pain, aching, or stiffness, may be indicative of knee osteoarthritis (OA), thus are a common reason that individuals seek health care services. One concern is that activity restriction may indicate in deteriorating fu...

Optimal Threshold of Walking Speed Predictive of Mortality Risk over 9 Years in Knee Osteoarthritis: Data from Osteoarthritis Initiative
Hiral Master, Tuhina Neogi, Lavalley Michael et. al.

Nov 12th, 2019 - Background/Purpose: Knee osteoarthritis (OA) is associated with mortality, and walking difficulty is known to mediate this relationship. However, little is known about what specific aspects of walking difficulty increase mortality risk. We investigated the relationship of walking speed, as a measure of walking difficulty, to mortality and studied what thresholds that best discriminate risk of m...

Opioids Use Among Medicare Beneficiaries with Knee Osteoarthritis: Prevalence and Correlates of Chronic Use
Elena Losina, Shuang Song 2 and Jeffrey Katz, Brigham and Women's Hospital and Harvard Medical School et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) of the knee is prevalent among Medicare beneficiaries. Effective pain control is critical for managing this chronic disease. In the last decade, opioids became widely available for persons with knee OA. We sought to identify knee OA patients that use opioids chronically and occasionally, and determine factors associated with greater risk of occasional and...

Impact of Eliminating the Bouted Minutes Requirement in the New 2018 Physical Activity Guidelines for Americans on Gender Disparity in Guideline Attainment for Persons with or at High Risk of Knee ...
Alison Chang, Jing Song, Julia (Jungwha) Lee et. al.

Nov 12th, 2019 - Background/Purpose: The 2018 Physical Activity (PA) Guidelines no longer require PA to occur in bouts of ≥ 10 minutes for meeting the weekly 150-min moderate-to-vigorous PA (MVPA) recommendations. In persons with lower limb joint symptoms, attaining 60-min weekly MVPA is linked to maintaining disability-free status over 4 years.  This benchmark serves as an achievable intermediate step toward m...

Reference Curves for the Knee Injury and Osteoarthritis Outcome Score in the Middle-aged Dutch Population
Marieke Loef, Féline PB Kroon, Stephan Böhringer et. al.

Nov 12th, 2019 - Background/Purpose: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire is a widely used patient-reported outcome tool, developed to evaluate short- and long-term knee symptoms and function. Previous studies evaluating knee complaints in the general population have shown that individuals in the general population do not report the best possible score on knee-specific questionn...

Relation of MRI-detected Structural Damage in the Knee to Anterior Knee Pain: The MOST Study
Joshua Stefanik, Tuhina Neogi, Mohamed Jarraya et. al.

Nov 12th, 2019 - Background/Purpose: Discordance between knee osteoarthritis (OA) and knee pain is common yet not well understood. Specifically, anterior knee pain (AKP) is widely held to be associated with patellofemoral (PF) joint structural damage. However, little is known about the relation of MRI-detected structural damage to AKP. A key challenge to identifying determinants of AKP relates to the high inter...

What Are the Prescribing Trends and Satisfaction Levels with Analgesics for Osteoarthritis as Reported by US Rheumatogists, Orthopaedic Surgeons, and Primary Care Physicians?
Thomas Schnitzer, Rebecca Robinson, Lars Viktrup et. al.

Nov 12th, 2019 - Background/Purpose: To describe patterns of care and physician satisfaction with prescribed treatments for osteoarthritis (OA). Methods: Data were collected from February-May 2017 using US Adelphi Disease Specific Programme, a cross-sectional survey of 81 (52.9%) primary care physicians (PCP), 35 (22.9%) rheumatologists (RHEUM), and 37 (24.2%) orthopedic surgeons (ORTHO). Specialties were compa...

Fibrates as Drugs with Senolytic and Autophagic Activity for Osteoarthritis Treatment
Uxia Nogueira-Recalde, Irene Lorenzo-Gomez, Francisco J. Blanco et. al.

Nov 12th, 2019 - Background/Purpose: . Increasing evidence suggest that osteoarthritis (OA) is associated with hallmarks of ageing, including cellular senescence or defective autophagy, that could promote disease onset. The objective of this study was to identify small molecules with senolytic and pro-autophagy activity to prevent cartilage degeneration and OA. Methods: Senescence and defective autophagy were i...

Five Year Structural Changes in Patients with Meniscal Tear and Osteoarthritis from an RCT of Arthroscopic Partial Meniscectomy vs. Physical Therapy
Swastina Shrestha, Jeffrey Katz, Elena Losina 3 and Jamie Collins et. al.

Nov 12th, 2019 - Background/Purpose: Meniscal tear is an independent risk factor of structural progression in OA; Arthroscopic partial meniscectomy (APM) is also associated with progression, though it is unclear if APM confers additional risk beyond that of the underlying meniscal tear. The goal of this study was to evaluate changes in knee MRI findings over 60 months in patients with meniscal tear and OA treat...

Is There an Association of Serum LDL, HDL and Total Cholesterol with the Development of Knee Osteoarthritis?
Jessica Barlow, Xianbang Sun, Michael Nevitt et. al.

Nov 12th, 2019 - Background/Purpose: Recent data have suggested an association between elevated serum cholesterol levels, particularly low density lipoprotein (LDL), and the development of osteoarthritis (OA).  Within the joint, circulating LDL is taken up by the synovium and oxidized, activating macrophages and leading to the release of inflammatory mediators.  Further, mice with high LDL levels have high rate...

Inhibition of CD44 Intracellular Domain Production Suppresses Bovine Articular Chondrocyte De-differentiation Induced by Excessive Mechanical Stress Loading
Yasumori Sobue, Nobunori Takahashi, Naoki Ishiguro 2 and Toshihisa Kojima et. al.

Nov 12th, 2019 - Background/Purpose: CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. Excessive mechanical stress loading is a risk factor for OA, but the molecular mechanism underlying the relationship is unclear. We hypothesized that mechanical stress-induced enhancement of CD44-ICD production plays an important role in the de-differentiation of chondrocytes and OA. This study a...

Impact of Hypothetical Changes in the Use of Analgesics on the Burden of Osteoarthritis: A Population-based Microsimulation Study
Jacek Kopec, Eric Sayre, Anya Okhmatovskaia et. al.

Nov 12th, 2019 - Background/Purpose: Analgesics are the cornerstone of medical treatment of osteoarthritis (OA) but are associated with serious side effects. A more optimal use of analgesics in OA is one strategy to reduce the population health burden of OA. The purpose of this simulation study was to assess the impact of hypothetical changes in the use of analgesics on the quality-adjusted life years (QALYs) a...

24-hour Activity Profiling in People Living with Arthritis: Habits Matter
Lynne Feehan, Linda Li, Na Lu 2 and Hui Xie et. al.

Nov 12th, 2019 - Background/Purpose: Current practices promoting change in physical activity classify individuals as being more or less active. However, across 24-hours people spend time in different types of activities including sleeping. Variations in 24-hour activity may have implications for a person’s health and well-being and may influence how a person responds to interventions that promote physical activ...

A Flexion Contracture Is a Risk Factor for Radiographic Progression and Earlier Need for Arthroplasty in Knee Osteoarthritis: Data from the Osteoarthritis Initiative
T Mark Campbell1 and Dennis McGonagle, Elisabeth Bruyere Hospital, Ottawa et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis. Knee OA is often accompanied by a knee flexion contracture (FC), but the impact of FC on OA-related outcomes is not well-described. We evaluated whether the presence and/or severity of a knee FC were risk factors for increased OA incidence, clinical outcomes, radiographic progression and the need for and time to total...

A Drug Repurposing Story: New Therapeutic Tools Ready to Block Innate Immune Responses in Osteoarthritis
Eloi Franco-Trepat, Ana Alonso-Pérez, Maria Guillán-Fresco et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatic diseases, also known as musculoskeletal pathologies, are steadily rising their prevalence. This worldwide phenomenon is depriving our society of their life quality and has become a grave economic burden. Among musculoskeletal pathologies, osteoarthritis (OA) stands as the major rheumatic disease, in fact, the World Health Organization (WHO) included OA within the T...

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Doses of the Anti-ADAMTS-5 Nanobody®, M6495, in Healthy Male Subjects: A Phase I, Placebo-Controlled, First-in-Human ...
Hans Guehring, Torben Balchen, Kosalaram Goteti et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a serious disease characterized by progressive joint failure and cartilage degeneration. In OA, ADAMTS-5 protease is upregulated, resulting in enhanced cleavage of joint cartilage aggrecan into fragments (e.g. the aggrecan neo-epitope family [ARGS]) and subsequent stimulation of synovial inflammation. M6495 is an anti-catabolic, bivalent, bifunctional ...

Stopping NSAIDs for Arthritis Pain (SNAP): A Randomized Withdrawal Trial Comparing NSAIDs to Cognitive Behavioral Therapy
Liana Fraenkel, Eugenia Buta, Joseph Goulet et. al.

Nov 12th, 2019 - Background/Purpose: NSAIDs are associated with uncertain long-term benefits and significant toxicity in patients with knee osteoarthritis (OA). Our objective was to evaluate if discontinuing NSAIDs and engaging in a telephone-based cognitive behavioral therapy (CBT) program is non-inferior to continuing NSAIDs. Methods: Patients in 4 medical centers, taking NSAIDs for knee OA pain on most days ...

Abaloparatide Followed by Alendronate on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis and Osteoarthritis
Nancy Lane, Richard Weiss, Bruce Mitlak et. al.

Nov 12th, 2019 - Background/Purpose: Osteoporosis (OP) and osteoarthritis (OA) are often comorbid conditions in the elderly, with prevalence of OP in patients with OA reported as high as 30%. Previous studies have found significantly higher baseline BMD in OA patients than their non-OA counterparts, despite an increased risk for fracture, potentially contributing to delayed diagnosis and treatment in this popul...