Major Stressors in the Year Prior to Diagnosis Affects RA Characteristics at Presentation and 1 Year
Nicole Andersen, Orit Schieir, Marie-France Valois et. al.

Nov 12th, 2019 - Background/Purpose: Although many RA patients attribute their disease onset to recent life events, results from retrospective studies remain unclear. We compared characteristics of newly diagnosed RA patients who did and did not report significant stressful life events (+stress) in year prior to diagnosis at baseline and 12 months. Methods: Data were from early RA patients (symptoms < 1 year) e...

Management of Patients with Incident Rheumatoid Arthritis in Rheumatology Clinical Practice
isabel Hernandez Rodriguez, Zulema Rosales Rosado, pia Lois et. al.

Nov 12th, 2019 - Background/Purpose: Treatment of Rheumatoid Arthritis (RA) has changed drastically in the last two decades in strategies and objectives, as well as in therapeutic options, especially with the use of the disease modifying drugs (DMARD), both synthetic and biological. The data on the management of these patients under clinical trial conditions are abundant but it is necessary to expand our knowle...

Metabolic Syndrome and Early Arthritis: Frequency, Association with Antibodies Profile and Disease Activity
Francisco Guiñazú, Carla Gobbi, Paula Alba et. al.

Nov 12th, 2019 - Background/Purpose: The Metabolic Syndrome (MetS) is an independent factor of cardiovascular morbidity and mortality and most studies show that its prevalence is higher in established Rheumatoid Arthritis (RA) than in the general population, which would be associated with systemic inflammatory activity. Few studies have evaluated this association in patients with Early Arthritis (EA) with diffe...

Methotrexate Discontinuation and Dose Decreases After Therapy with Tocilizumab: Results from the Corrona Rheumatoid Arthritis Registry
Dimitrios Pappas, Taylor Blachley, Steve Zlotnick et. al.

Nov 12th, 2019 - Background/Purpose: Methotrexate (MTX) is frequently prescribed with biologic disease-modifying antirheumatic drugs. Evidence has shown that tocilizumab (TCZ) monotherapy is effective in the treatment of patients with rheumatoid arthritis (RA).1,2 Similar outcomes have been shown in patients responding to TCZ combination therapy who discontinued MTX or remained on combination therapy.3 The purp...

Major Histocompatibility Antigen HLA-DQB1*0601 Is Associated with Rheumatoid Arthritis Among Indians in a Replication Study: Evidence of Gene-Environment Interaction with LPG Stove Use
Able Lawrence, Anshul Dhar, Swayam Prakash et. al.

Nov 12th, 2019 - Background/Purpose: Shared epitope smoking interaction does not fully explain MHC association in Rheumatoid Arthritis (RA). We have previously shown HLA-DQB1*0601 (DQ6.1) to be a susceptibility allele in India1. It has a restricted geographic distribution being common in Japan, India and parts of middle-east while absent in Africa and western Europe (Fig 1 heat map of DQ6.1 distribution). In Pr...

MRI of the Wrist in Early Rheumatoid Arthritis After 1-year Treat-to-target Strategy
Fan Xiao, Jacky Ka Ko, Jiang Yue et. al.

Nov 12th, 2019 - Background/Purpose: Background: There are two types of remission in rheumatoid arthritis. The first, and most commonly applied, is clinical remission. Imaging remission is another aspect to consider given that (a) the correlation between clinical and imaging at presentation is only modest, (b) imaging can show subclinical inflammation not evident clinically and (c) imaging evidence of inflammat...

Multimorbidity May Worsen Fatigue in Patients with Rheumatoid Arthritis
John Davis, Elena Myasoedova, Tina Gunderson 1 and Cynthia Crowson et. al.

Nov 12th, 2019 - Background/Purpose: Fatigue is a pervasive problem for many patients with rheumatoid arthritis (RA) that often persists despite treatment with effective disease-modifying therapies. Recent studies have suggested that patients with RA have a high burden of multimorbidity, which could affect their disease experiences and treatment outcomes. We sought to determine whether multimorbidity is associa...

Association of Rheumatic Autoimmune Disease, Including Rheumatoid Arthritis, with Post-Traumatic Stress Disorder but Not Traumatic Brain Injury in Veterans
Biji Kurien, Calin Prodan 2 and Robert Scofield, Oklahoma Medical Research Foundation et. al.

Nov 12th, 2019 - Background/Purpose: Autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus, are 2- to 3-fold more common among those with post-traumatic stress disorder (PTSD) than among matched controls.  In US Armed Service personnel, PTSD is more prevalent among individuals with mild traumatic brain injury (TBI).  For both PTSD and TBI there are immune changes that might p...

Mining Social Media Data to Investigate Patient Perceptions Regarding DMARD Pharmacotherapy for Rheumatoid Arthritis
Chanakya Sharma, Samuel Whittle, Pari Delir Haghighi et. al.

Nov 12th, 2019 - Background/Purpose: Our hypothesis is that patients have a positive opinion regarding the newer, biologic DMARDs and a negative sentiment towards the conventional synthetic agents. We sought to analyse discussions on social media platforms regarding DMARDs so understand the collective sentiment expressed towards these medications.  Methods: Treato data analytics were utilised to download all av...

Methotrexate Intolerance: A Qualitative Descriptive Study of the Adult Rheumatoid Arthritis Patients’ Perspectives
Elizabeth Salt, Mary Kay Rayens, Leslie Crofford 3 and Jamie Studts et. al.

Nov 12th, 2019 - Background/Purpose: An estimated 11% to 33% of persons taking methotrexate for rheumatoid arthritis (RA) are reported to be at least moderately intolerant to this medication. The published literature has largely measured methotrexate intolerance using a scale composed of four domains: abdominal pain, nausea, vomiting and behavioral symptoms. These symptoms largely ignore the definition of “into...

Methotrexate Treatment Is Associated with Reduction of Neutrophil Reactive Oxygen Species and CD177 in RA Patients
Urvashi Kaundal, Varun Dhir, Biman Saikia 1 and Aastha Khullar et. al.

Nov 12th, 2019 - Background/Purpose: Methotrexate (MTX) is the gold-standard DMARD in rheumatoid arthritis, however, it is unclear how exactly it works. Its effects on neutrophils may involve reduction in ROS production and neutrophil activation markers like CD177, CD11b and CD64. Methods: This was a single-center cross-sectional study, which recruited patients with rheumatoid arthritis (RA) and healthy control...

Mediators of Bone Metabolism (DKK1, OPG, Sclerostin and RANKL) in a Cohort of Patients with Elderly-onset Arthritis
Anahy Brandy-Garcia, Melania Martínez-Morillo, Roxana Coras et. al.

Nov 12th, 2019 - Background/Purpose: Patients with elderly-onset arthritis have greater comorbidity than young patients, with a higher incidence of osteoporosis (OP), probably mediated by increased bone resorption. However, there are few data on bone metabolism mediators in this population. Methods: Longitudinal observational study that included patients with elderly-onset arthritis ( > 65 years) without diagno...

Multi-center Analyses on 518 Cases with Rheumatoid Arthritis Developing Lymphoproliferative Disorders (RA-LPD): The Prognostic Factors and the Influence of Anti-rheumatic Drugs on LPD Development
Yoshihiko Hoshida, Shiro Ohshima, Yukihiko Saeki et. al.

Nov 12th, 2019 - Background/Purpose: Lymphoproliferative disorders (LPD) remains as a major problem to resolve among the patients with rheumatoid arthritis (RA). During few decades, rheumatic therapy has dramatically changed with the advent of new disease modifying anti-rheumatic drugs (DMARDs). However, it is unclear whether these drugs relate to LPD developing in the patients withRA. Methods: The current stud...

Safety of Biological DMARD in Patients with Interstitial Lung Disease from a Chilean Cohort of Patients with Rheumatoid Arthritis
Silvana Saavedra, Karen Vergara, Claudia Hernandez et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis (RA) that may be related to the inflammatory process itself, to infectious complications, and/or to the therapy. Biological disease‐modifying antirheumatic drugs (bDMARD) have dramatically improved the outcome of RA, but an increasing number of reports have described  the potential lu...

Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis
Anna Montgomery, Shang-Yang Chen, Philip Homan et. al.

Nov 12th, 2019 - Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized. Methods: Using single cell RNA-sequencing (scRNA-seq), we uncovered 4 distinct subsets of mouse synovial macrophages during steady state distinguishable by expressions of CX3CR1 and MHCII. Results: M...

Tuberculin Skin Test and Quantiferon®-TB Gold In-Tube Test for Latent Tuberculosis Before Biologic Treatments: Lower Agreement Rate in Spondyloarthropathies Compared to Rheumatoid Arthritis
Ufuk İlgen, Sezin Turan, Hakan Emmungil et. al.

Nov 12th, 2019 - Background/Purpose: Screening for and the treatment of latent tuberculosis is recommended in patients with inflammatory arthritides prior to biologic treatments, particularly the TNF inhibitors. The aim of this study is to evaluate the performance of tuberculin skin test (TST) with respect to Quantiferon®-TB Gold In-Tube test (QFT-GIT) in patients with rheumatoid arthritis (RA) and spondyloarth...

Treat to Target Is Not Linked to Best Myocardial Strain Indices: Is There Really a Myocardial Dysfunction Directly Associated with Disease Activity?
Alisson Pugliesi, Hugo Nourani, José Roberto Matos Souza 1 and Manoel Bertolo et. al.

Nov 12th, 2019 - Background/Purpose: The risk of developing heart failure (HF) is twice as high in the RA population. It is hypothesized that, in addition to the atherosclerotic ischemic component and the traditional risk factors, there is a mechanism of cardiotoxicity related to the inflammatory pathways. A few previous studies indicate an association between disease activity and myocardial dysfunction, but th...

The Effectiveness of anti-IL-6 Therapy to Elderly-onset Rheumatoid Arthritis
Takayasu Ando, Takeshi Suzuki, Yutaka Gotou 1 and Kimito Kawahata et. al.

Nov 12th, 2019 - Background/Purpose:  In daily practice, our rheumatologist has experienced different clinical feature of elderly-onset rheumatoid arthritis (EORA) compared with younger-onset RA (YORA). In EORA patients, serological marker of inflammation, like C-reactive protein, tend to be higher than that of YORA. And previous report suggested that significantly higher level of serum interleukin-6 (IL-6) and...

A Phase I, Randomized, Double-blind, Placebo-controlled, Single Center, Single-dose Escalation to Investigate the Safety, Tolerability, and Pharmacodynamics of Subcutaneously Administered DEN-181 i...
Amee Sonigra, Hendrik Nel, Nishta Ramnoruth et. al.

Nov 12th, 2019 - Background/Purpose: Antigen-specific immunological tolerance strategies leverage the natural process of antigen presentation by dendritic cells (DCs) to regulate pathogenic T cells and B cells. We developed a nanoparticulate liposome formulation that encapsulates autoantigenic peptide and NF-kB inhibitor, 1,25 dihydroxycholecalciferol (calcitriol), to target DCs. In mouse models of autoimmune a...

Shared Decision Making in Routine Clinical Practice: An Assessment of Audio-recorded Consultations with Rheumatoid Arthritis Patients
Elke Mathijssen, Johanna Vriezekolk 2 and Bart van den Bemt, Sint Maartenskliniek et. al.

Nov 12th, 2019 - Background/Purpose: International guidelines for rheumatoid arthritis (RA) treatment emphasize that all treatment decisions should be made through a shared decision making (SDM) process between clinicians and patients (1,2). Observations of routine clinical practice are needed to obtain insight into the actual implementation of SDM. The aim of this study was to assess the level of SDM in RA tre...