Mesenchymal Stem Cells in Scleroderma: A Systematic Review
Rossana Mejia-Romero, Natalia Aguilera, Juan Pablo Alzate-Granados et. al.

Nov 12th, 2019 - Background/Purpose: Scleroderma (systemic scleroderma or systemic sclerosis, SSc), is a highly heterogeneous autoimmune disease of unknown etiology, with a high rate of therapeutic failure and a progression of the disease. Although recently it has been noted a decrease in mortality It is still high, therefore SSc treatment is considered a therapeutic challenge. The immunomodulatory capacity of ...

Multi-Organ System Meta-Analytic Approach to Investigating Sarcoidosis
Jihad Aljabban, Saad Syed, Sharjeel Syed et. al.

Nov 12th, 2019 - Background/Purpose: Sarcoidosis (SD) is a granulomatous inflammatory disease with a heterogenous presentation and no definite etiology. SD usually begins in the lungs, skin, or lymph nodes but can involve other organs such as the heart and lacrimal glands. A better understanding of pathogenesis can pave new therapeutic avenues. Methods: We employed the STARGEO platform to tag samples from the G...

Myopenia Is an Independent Risk Factor for Rotator Cuff Tear and Shoulder Dysfunction in Elderly People : Data from NAMGARAM Cohort
Yun-Hong Cheon, Young Sun Suh, Mingyo Kim et. al.

Nov 12th, 2019 - Background/Purpose: Myopenia refers to decline in muscle mass with age, causing significant impairment in the ability to carry out normal daily functions. Rotator cuff tear (RCT) is a localized tendon disease, however, it is known to be related with systemic inflammation. The aim of this study is to determine whether there is correlation between myopenia and RCT in elderly people. In addition, ...

Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)
Michael Bowes, Katherine Kacena, Oras Alabas et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both structural progression and outcomes, largely based on imprecise radiographic assessment. A statistical shape model (SSM), a form of machine learning, identified a characteristic 3D OA bone shape from MR images, enab...

MicroRNA-27a Can Contribute to Interferon Signatures in Systemic Lupus Erythematosus via the Suppression of Tripartite Motif-containing Protein 27
Daiga Kishimoto, Ryusuke Yoshimi, Yosuke Kunishita et. al.

Nov 12th, 2019 - Background/Purpose: Type Ⅰ interferons (IFN) contribute to antiviral innate immune responses. Upon viral infection, pattern recognition receptors trigger TANK-binding kinase 1 (TBK1) activation and lead to activation of the transcription factor IFN regulatory factor (IRF) 3 to induce type Ⅰ IFN production. Because high expression of typeⅠ IFN inducible genes, called IFN signature, is observed i...

MRI-based Textural Analysis of Trabecular Bone: A Novel Method for the Opportunistic Screening of Bone Quality
Jonathan Cheah, Matthew Koff, Ryan Breighner et. al.

Nov 12th, 2019 - Background/Purpose: A major obstacle to the treatment of osteoporosis and prevention of fractures is that many at-risk patients are never screened. Dual energy x-ray absorptiometry (DXA) measurements of bone mineral density, the gold standard for diagnosis of osteoporosis, are only performed in a minority of patients. Therefore, opportunistic methods using imaging obtained for other clinical pu...

Methotrexate Treatment Is Associated with Reduction of Neutrophil Reactive Oxygen Species and CD177 in RA Patients
Urvashi Kaundal, Varun Dhir, Biman Saikia 1 and Aastha Khullar et. al.

Nov 12th, 2019 - Background/Purpose: Methotrexate (MTX) is the gold-standard DMARD in rheumatoid arthritis, however, it is unclear how exactly it works. Its effects on neutrophils may involve reduction in ROS production and neutrophil activation markers like CD177, CD11b and CD64. Methods: This was a single-center cross-sectional study, which recruited patients with rheumatoid arthritis (RA) and healthy control...

Major Salivary Gland Ultrasound: Pilot Study of Findings and Feasibility in Childhood-Onset Systemic Lupus Erythematosus (cSLE)
Joseph McDonald, Patricia Vega-Fernandez 2 and Tracy Ting, Cincinnati Children's Hospital Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Ultrasonography is becoming an increasingly useful tool in evaluating patients in pediatric rheumatology. It is predominantly used for musculoskeletal assessments, however, major salivary gland ultrasound (SGUS) is being used in adults for assessment of primary and secondary Sjögren’s syndrome. Very few studies have been done examining salivary gland ultrasound in children a...

Mediators of Bone Metabolism (DKK1, OPG, Sclerostin and RANKL) in a Cohort of Patients with Elderly-onset Arthritis
Anahy Brandy-Garcia, Melania Martínez-Morillo, Roxana Coras et. al.

Nov 12th, 2019 - Background/Purpose: Patients with elderly-onset arthritis have greater comorbidity than young patients, with a higher incidence of osteoporosis (OP), probably mediated by increased bone resorption. However, there are few data on bone metabolism mediators in this population. Methods: Longitudinal observational study that included patients with elderly-onset arthritis ( > 65 years) without diagno...

Body Composition and Nailfold Videocapillaroscopy Patterns in a Cohort of Systemic Sclerosis Patients
Tomatis Veronica, Sabrina Paolino, Alberto Sulli et. al.

Nov 12th, 2019 - Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease, characterized by microvascular damage and progressive fibrosis. Among clinical complications, abnormal body composition and sarcopenia have been reported in SSc patients (1,2). Nailfold videocapillaroscopy  (NVC) is a safe diagnostic tool to assess microvascular progressive damage and may predict severe organ involvem...

Burden of Disease at Treatment Initiation Among Biologic-Naïve Patients with Oligoarticular versus Polyarticular Psoriatic Arthritis in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry
Alexis Ogdie, Mei Liu, Meghan Glynn et. al.

Nov 12th, 2019 - Background/Purpose: Oligoarticular PsA accounts for ≈50% of PsA worldwide, but only a paucity of data describes disease burden among these patients. The Corrona PsA/SpA Registry, a prospective, US-based, observational cohort study, collects real-world data on PsA patient characteristics and treatment, including oligoarthritis. This analysis characterized patient demographics, clinical character...

Multi-center Analyses on 518 Cases with Rheumatoid Arthritis Developing Lymphoproliferative Disorders (RA-LPD): The Prognostic Factors and the Influence of Anti-rheumatic Drugs on LPD Development
Yoshihiko Hoshida, Shiro Ohshima, Yukihiko Saeki et. al.

Nov 12th, 2019 - Background/Purpose: Lymphoproliferative disorders (LPD) remains as a major problem to resolve among the patients with rheumatoid arthritis (RA). During few decades, rheumatic therapy has dramatically changed with the advent of new disease modifying anti-rheumatic drugs (DMARDs). However, it is unclear whether these drugs relate to LPD developing in the patients withRA. Methods: The current stud...

Men and Black Persons Die at Younger Ages from Systemic Sclerosis: A Nationwide Population-based Study
Ram Raj Singh, Devanshu Singh 2 and Eric Yen, UCLA et. al.

Nov 12th, 2019 - Background/Purpose: Systemic sclerosis (SSc) is more common in women than men, but men tend to have a faster disease progression than women. However, conflicting results with regards to sex differences in SSc mortality have been reported. A few studies found standardized mortality ratios for SSc to be similar between men and women, whereas others found SSc standardized mortality ratios to be hi...

Methotrexate Liver Toxicity in a Large Randomized Controlled Trial
Daniel Solomon, Nina Paynter, Anna Rutherford et. al.

Nov 12th, 2019 - Background/Purpose: Liver test abnormalities are known to predict liver pathology in patients using methotrexate (MTX). Monitoring guidelines for MTX suggest frequent assessment of liver tests (AST and ALT). The frequency of liver test abnormalities and liver pathology (liver AEs) in patients using MTX varies substantially in prior studies and there are sparse placebo-controlled data on these i...

Stabilization of Patellar Bone-Shape Correlates Significantly with Reduced Knee Pain Frequency After IA TPX-100 in Subjects with Bilateral Patellofemoral OA
Dawn McGuire, Michael Bowes, Alan Brett et. al.

Nov 12th, 2019 - Background/Purpose: Based on data from the Osteoarthritis Initiative (OAI), MRI-based analyses of bone shape changes in the knee predict symptomatic and radiographic progression of knee OA and risk of joint replacement (Neogi 2013; Barr 2016).  In a 12-month, double-blind, placebo-controlled trial of MRI-confirmed bilateral patellofemoral OA, TPX-100, administered in 4 weekly injections (200 mg...

Sarcopenia and the Likelihood of Incident Knee Osteoarthritis and Knee Pain Among Older Adults in the Health ABC Study
James Andrews, Laura Gold, Michael Nevitt et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) disproportionately affects older adults.  Sarcopenia, or reduced muscle mass and strength, is strongly associated with reduced physical function and poor clinical outcomes among older adults. Prior studies of knee OA and sarcopenia used varied measures of muscle mass and strength, and results are conflicting. We tested whether two components of sarcopenia...

Study of Vertebral Fracture Prevalence and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra (SBAC-L1) in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis vs. Cont...
Marine Fauny, Eliane Albuisson, Elodie Bauer et. al.

Nov 12th, 2019 - Background/Purpose: Osteoporosis is a common disease whose prognosis can be seriously impacted by the development of fractures that lead to functional limitations and may even have life-threatening sequelae. This disease is often under-screened, especially in at-risk populations that require multidisciplinary care such as patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). ...

Screening for Hepatitis B Surface Antigen and Core Antibody Prior to Administration of Rituximab in Rheumatology Patients
Robyn Moran, Jenna Beatty, Jon Ternus 1 and Megan Krause et. al.

Nov 12th, 2019 - Background/Purpose: Rituximab is used to treat a variety of rheumatic diseases. In 2015, the American Gastroenterological Association (AGA) categorized rituximab as high-risk in terms of hepatitis B virus (HBV) reactivation. Specifically, patients that are hepatitis B surface antigen (HBsAg) negative and total hepatitis B core antibody (anti-HBc) positive or HBsAg and anti-HBc positive are at h...

Survival Trends in Giant Cell Arteritis: A Population-based Cohort Study
Thomas Garvey, Cynthia Crowson, Matthew Koster et. al.

Nov 12th, 2019 - Background/Purpose: To investigate survival trends in patients with giant cell arteritis (GCA) diagnosed over a 60-year period. Methods: We assembled a population-based incidence cohort of patients with GCA diagnosed between 1950 and 2009 based on American College of Rheumatology 1990 GCA classification criteria. Patients aged ≥ 50 years with elevation of erythrocyte sedimentation rate or C-rea...

Serum Myositis Specific/associate Autoantibodies Help Identify Early Connective Tissue Diseases Relevant Interstitial Lung Diseases: A Medical Center Experience
Chieh-Yu Cheng, Wei-Han Ju, Tony Szu-Hsien Lee et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung diseases (ILD), a heterogeneous group of pulmonary disorders, originated from idiopathic causes or secondary to certain etiologies, such as infectious diseases, drugs, or connective tissue diseases (CTD). Common causes of CTD associated ILD (CTD-ILD) include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositi...

Safety of Biological DMARD in Patients with Interstitial Lung Disease from a Chilean Cohort of Patients with Rheumatoid Arthritis
Silvana Saavedra, Karen Vergara, Claudia Hernandez et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis (RA) that may be related to the inflammatory process itself, to infectious complications, and/or to the therapy. Biological disease‐modifying antirheumatic drugs (bDMARD) have dramatically improved the outcome of RA, but an increasing number of reports have described  the potential lu...

Shared and Differing Risk Factors for PsA, Psoriasis, AS, and RA: A Series of Case-control Studies
Alexis Ogdie, Xingmei Wang, Thorvardur J Love et. al.

Nov 12th, 2019 - Background/Purpose: While a handful of clinical risk factors for the development of inflammatory diseases have been identified, to date, no studies have compared risk factors across multiple inflammatory diseases. The objective of this study was to compare the strength of association of selected potential risk factors for the development of psoriasis, PsA, RA, and AS. Methods: We performed a se...

Static and Longitudinal Construct Validity of PROMIS CAT and Profile29 for Assessing Pain Interference, Physical Function and Fatigue in Psoriatic Arthritis
Ana-Maria Orbai, Jamie Perin, Albert W Wu et. al.

Nov 12th, 2019 - Background/Purpose: Pain, physical function and fatigue are outcomes reported as having the greatest importance to people with psoriatic arthritis (PsA)1,2. We assessed these outcomes in participants in a longitudinal PsA study using Patient Reported Outcomes Measurement Information System (PROMIS) measures, which have not been used before in PsA, concomitantly with measures of PsA-specific dis...

Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis
Anna Montgomery, Shang-Yang Chen, Philip Homan et. al.

Nov 12th, 2019 - Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized. Methods: Using single cell RNA-sequencing (scRNA-seq), we uncovered 4 distinct subsets of mouse synovial macrophages during steady state distinguishable by expressions of CX3CR1 and MHCII. Results: M...

Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
Kevin Ong, Maria Runa, Wilson Ngai et. al.

Nov 12th, 2019 - Background/Purpose: Some concerns have been raised about subsequent severe acute localized reactions (SALR) (flares, pseudoseptic reactions, etc.) following hyaluronic acid (HA) injections for pain relief of knee osteoarthritis (OA). SALR has been speculated to be possibly related to the crosslink of hylan or an allergic reaction to hyaluronan of avian origin, but similar reactions have been re...

Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain
Christopher Yohn, Robert O'Brien, Stephanie Lussier et. al.

Nov 12th, 2019 - Background/Purpose: Background/Purpose:  Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A in response to various cellular stressors.  Senescent cells secrete factors collectively referred to as the Senescence Associated Secretory Phenotype (SASP) that are proinflammatory and degradative i...

Safety Results of 50% Enrollment from a Multicenter, Randomized, Double‑blind, Placebo‑controlled Study to Assess the Efficacy and Safety of Repository Corticotropin Injection in Patients with Syst...
Anca Askanase, Dharani Munirathinam, Enxu Zhao et. al.

Nov 12th, 2019 - Background/Purpose: Repository corticotropin injection (RCI) is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH1-39) analogues and other pituitary peptides that stimulates endogenous corticosteroid (CS) production and is an agonist for all 5 melanocortin receptors. RCI is approved by the US FDA for the treatment of acute exacerbations or as maintenance therapy in patien...

Skin Disease Activity and Autoantibody Phenotype Are Major Determinants of Blood Interferon Signatures in Dermatomyositis
Mika Tabata, Kavita Sarin, Karen Page et. al.

Nov 12th, 2019 - Background/Purpose: Interferon (IFN) signaling is upregulated in dermatomyositis (DM) and thought to play a role in pathogenesis. An IFN gene signature in peripheral blood of DM patients correlates with skin disease and may predict disease activity. However, studies have not analyzed how IFN signaling differs across DM subtypes or how it is influenced by multiple organ system involvement. Autoa...

Transitions in Lumbar Spine Osteoarthritis: The Johnston County Osteoarthritis Project
Adam Goode, David Hu, Rebecca Cleveland et. al.

Nov 12th, 2019 - Background/Purpose: Spine osteoarthritis (SOA) has been defined by the presence of: 1) disc space narrowing (DSN) and vertebral osteophytes (OST), or 2) facet joint OA (FOA). Anatomical differences between these structures suggest they may have different etiologies. Furthermore, a current clinical paradigm is that SOA leads to lumbar spine instability and subsequent FOA, suggesting a transition...

The Need for Personalized, Non-Pharmacological Intervention Programmes in Autoimmune Connective Tissue Disorders: Results of a EULAR-Funded Scoping Review with a Nested, Descriptive Meta-Analysis
Valentin Ritschl, Ricardo Ferreira, Rúben Fernandes et. al.

Nov 12th, 2019 - Background/Purpose: Autoimmune Connective Tissue Disorders (CTDs), including Mixed Connective Tissue Disorders (MCTD), systemic sclerosis (SSc) and systemic lupus erythematous (SLE) can lead to Raynaud phenomenon, involvement of internal organs, pain in joints, skin abnormalities and muscle weakness. Consequently, people with CTDs experience limitations in activities of daily life and restricti...

Tuberculin Skin Test and Quantiferon®-TB Gold In-Tube Test for Latent Tuberculosis Before Biologic Treatments: Lower Agreement Rate in Spondyloarthropathies Compared to Rheumatoid Arthritis
Ufuk İlgen, Sezin Turan, Hakan Emmungil et. al.

Nov 12th, 2019 - Background/Purpose: Screening for and the treatment of latent tuberculosis is recommended in patients with inflammatory arthritides prior to biologic treatments, particularly the TNF inhibitors. The aim of this study is to evaluate the performance of tuberculin skin test (TST) with respect to Quantiferon®-TB Gold In-Tube test (QFT-GIT) in patients with rheumatoid arthritis (RA) and spondyloarth...

The Positivity for Anti-centromere Antibody Makes Distinct Clinical Features in Primary Sjogren’s Syndrome : Data from a Prospective Korean Nation-wide Cohort
Youngjae Park, Jennifer Lee, Jung Hee Koh et. al.

Nov 12th, 2019 - Background/Purpose: To clarify clinical features of primary Sjogren’s syndrome (SS) patients who show the positivity for anti-centromere antibody in Korea. Methods: We assessed 318 patients who met 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for primary SS. All patients were selected from the Korean Initiative of Primary Sjogren...

The Cumulative Burden of Damage for Patients with Eosinophilic Granulomatosis with Polyangiitis
Irena Doubelt, David Cuthbertson, Gunnar Tomasson et. al.

Nov 12th, 2019 - Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by asthma and other manifestations of vasculitis, some of which can be life-threatening, cause major organ damage, or become chronic. Data on damage in EGPA is limited, mainly due to the rarity of the disease. This study aimed at describing damage in patients with EGPA enrolled in the Vasculitis Clinical R...

Test-Retest Reliability and Validity of a Mobile Health Application to Automate the 30 Seconds Chair Stand Test – Preliminary Data to Create a Contemporary Instrument for Randomized Clinical Trials
Lucas Dantas, Matthew Harkey, André Dantas et. al.

Nov 12th, 2019 - Background/Purpose: Contemporary technologies offer potential solutions to improve and automate data collection of randomized clinical trials by transitioning assessments from the clinic to the real-world. Mobile health (mHealth) applications (Apps) associated with smartphone embedded sensors offer the possibility to automate objective physical function tests by tracking, recording, and analyzi...

The Effects of Message Framing on Patients’ Perceptions and Willingness to Switch to a Biosimilar
Chiara Gasteiger, Annie Jones, Maria Kleinstauber et. al.

Nov 12th, 2019 - Background/Purpose: Patients may hold negative perceptions towards biosimilars which can create barriers to their uptake. Physicians also report uncertainty in how best to explain biosimilars. The aim of this study was to measure the effect of differently framed explanations on patients’ perceptions of and willingness to switch to a biosimilar. Methods: Ninety-six patients with rheumatic diseas...

Treat to Target Is Not Linked to Best Myocardial Strain Indices: Is There Really a Myocardial Dysfunction Directly Associated with Disease Activity?
Alisson Pugliesi, Hugo Nourani, José Roberto Matos Souza 1 and Manoel Bertolo et. al.

Nov 12th, 2019 - Background/Purpose: The risk of developing heart failure (HF) is twice as high in the RA population. It is hypothesized that, in addition to the atherosclerotic ischemic component and the traditional risk factors, there is a mechanism of cardiotoxicity related to the inflammatory pathways. A few previous studies indicate an association between disease activity and myocardial dysfunction, but th...

Too Soon to Say: Promising Results from a Community-Delivered RCT Examining Work-Related Outcomes of the Chronic Disease Self-Management Program
Kristina Theis, Teresa Brady 2 and Shawn Kneipp, Centers for Disease Control and Prevention et. al.

Nov 12th, 2019 - Background/Purpose: More than two-thirds of U.S. adults with arthritis are working-age (< 65), and arthritis is a leading cause of work disability. The Chronic Disease Self-Management Program (CDSMP) has evidence for improving physical and mental health outcomes, but few studies specifically address employment. We examined work-related outcomes following participation in CDSMP. Methods: From 6/...

Treatment Delays Associated with Prior Authorization for Infusible Medications: A Cohort Study
Zachary Wallace, Tyler Harkness, Xiaoqing Fu et. al.

Nov 12th, 2019 - Background/Purpose: Prior authorizations (PA) are commonly required by health payers as cost-containment strategies for expensive medications, including infused biologics. In rheumatology, these medications are frequently prescribed to treat rare conditions that can be organ- or life-threatening and for which few or no medications have regulatory approval because of their relative scarcity. Inf...

The Effectiveness of anti-IL-6 Therapy to Elderly-onset Rheumatoid Arthritis
Takayasu Ando, Takeshi Suzuki, Yutaka Gotou 1 and Kimito Kawahata et. al.

Nov 12th, 2019 - Background/Purpose:  In daily practice, our rheumatologist has experienced different clinical feature of elderly-onset rheumatoid arthritis (EORA) compared with younger-onset RA (YORA). In EORA patients, serological marker of inflammation, like C-reactive protein, tend to be higher than that of YORA. And previous report suggested that significantly higher level of serum interleukin-6 (IL-6) and...

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3-Year-Prospective Study from a Referral Center of Lung Transplantation
Sara Remuzgo-Martínez, Diana Prieto-Peña, Mónica Calderón-Goercke et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung disease (ILD) occurs in approximately 15% of patients with autoimmune diseases (AD) [1]. Its presence is associated with an increased risk of morbidity and mortality [2].  In the present study, we aimed to determine the frequency of ILD associated with AD (AD-ILD) among patients sent for assessment to a clinic of lung transplantation from a referral center....

A Phase 2a Study of MEDI5872 (AMG557), a Fully Human Anti-ICOS Ligand Monoclonal Antibody in Patients with Primary Sjögren’s Syndrome
Xavier Mariette, Michele Bombardieri, Ilias Alevizos et. al.

Nov 12th, 2019 - Background/Purpose: The interaction of inducible T cell costimulatory ligand (ICOSL) and the ICOS receptor is key in the pathogenesis of primary Sjögren’s syndrome (pSS). MEDI5872 interferes with this pathway by binding to ICOSL. We evaluated the safety and efficacy of MEDI5872 in patients (pts) with pSS. Methods: We conducted a Phase 2a, randomized, placebo (PBO)-controlled study (NCT02334306)...

A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200...
Michael Billard, John Todhunter, Margaret Fleming et. al.

Nov 12th, 2019 - Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal risk (e.g., NSAIDs), liver risk (e.g., acetaminophen) or addiction risk (e.g., opiates), and can safely provide long-lasting pain relief after a brief course of treatment. The Sponsor has clinically shown that topi...

A Phase I, Randomized, Double-blind, Placebo-controlled, Single Center, Single-dose Escalation to Investigate the Safety, Tolerability, and Pharmacodynamics of Subcutaneously Administered DEN-181 i...
Amee Sonigra, Hendrik Nel, Nishta Ramnoruth et. al.

Nov 12th, 2019 - Background/Purpose: Antigen-specific immunological tolerance strategies leverage the natural process of antigen presentation by dendritic cells (DCs) to regulate pathogenic T cells and B cells. We developed a nanoparticulate liposome formulation that encapsulates autoantigenic peptide and NF-kB inhibitor, 1,25 dihydroxycholecalciferol (calcitriol), to target DCs. In mouse models of autoimmune a...

A Phase 2, Open-label Extension Study to Evaluate Long-term Safety of Anifrolumab in Adults with Systemic Lupus Erythematosus
W. Winn Chatham, Richard Furie, Amit Saxena et. al.

Nov 12th, 2019 - Background/Purpose: Anifrolumab is a fully human, IgG1κ monoclonal antibody that binds to the type I IFN receptor and inhibits activity of all type I IFNs.1 In the MUSE phase 2b randomized controlled trial (Study 1013, NCT01438489), anifrolumab demonstrated an acceptable safety profile and efficacy on a range of clinical endpoints in patients with moderate to severe SLE. An open-label extension...

The Paradoxical Effect of Depression on Psoriatic Arthritis Outcomes in a Combined Psoriasis-Psoriatic Arthritis Center
Rebecca Haberman, Samrachana Adhikari, Deborah Ramirez et. al.

Nov 12th, 2019 - Background/Purpose: Psoriatic arthritis (PsA) is a heterogenous inflammatory disease affecting skin, joints, and other domains. While psychiatric diseases (i.e., depression and anxiety) are known comorbidities, little is known about their impact on disease severity and patient reported outcomes (PROs). The objective of this study was to characterize the prevalence of psychiatric comorbidities i...

Shared Decision Making in Routine Clinical Practice: An Assessment of Audio-recorded Consultations with Rheumatoid Arthritis Patients
Elke Mathijssen, Johanna Vriezekolk 2 and Bart van den Bemt, Sint Maartenskliniek et. al.

Nov 12th, 2019 - Background/Purpose: International guidelines for rheumatoid arthritis (RA) treatment emphasize that all treatment decisions should be made through a shared decision making (SDM) process between clinicians and patients (1,2). Observations of routine clinical practice are needed to obtain insight into the actual implementation of SDM. The aim of this study was to assess the level of SDM in RA tre...

The Expression of the Interferon Inducible Gene SERPING1 Is Reduced by Rituximab and Correlates with Clinical Response in Systemic Lupus Erythematosus
Liliana Santos Ribeiro, Mariea Parvaz, Su-Ann Yeoh 2 and Michael Ehrenstein et. al.

Nov 12th, 2019 - Background/Purpose: Abnormalities in B cells and the interferon alpha (IFN) pathway have been separately implicated in the pathogenesis of systemic lupus erythematosus (SLE). B cell depletion therapy with rituximab is used to treat SLE but clinical response varies between patients. We hypothesized that the IFN inducible gene response may explain the difference in clinical responses to rituximab...

Knowledge, Needs and Expectations Among Systemic Lupus Erythematosus: Preliminary Results from the INTEGRATE Pilot Project
Valentina Lorenzoni, Ilaria Palla, Elena Elefante et. al.

Nov 12th, 2019 - Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease characterized by multi-organ involvement and a complex clinical picture, with a wide range of manifestations with and unpredictable relapsing and remitting course. Evidence suggests that discordance between patients and physicians could negatively affect patient care, adherence to treatment and outcomes of ...

Knowledge of Cardiovascular Disease Risk Among Patients with Rheumatoid Arthritis
Juan Bande, María Medina, Julia Sosa et. al.

Nov 12th, 2019 - Background/Purpose: Patients with rheumatoid arthritis (RA) have a significantly higher risk of cardiovascular disease (CVD) than general population. The Heart Disease Fact Questionnaire (HDFQ-RA 1 and 2) is a self-reported questionnaire that assesses the knowledge of general CVD risk and more specifically the related with RA and its treatment. The aim of this study was to validate the Spanish ...

Large Vessel Vasculitis: Diagnosis Is Very Frequent with Ultrasound Examination and Shows Responsiveness to Treatment
Eugenio de Miguel, Irene Monjo, Elisa Fernández et. al.

Nov 12th, 2019 - Background/Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly. In the EULAR recommendations of 2018 for the use of imaging in GCA, color Doppler ultrasound (CDUS)  is recognized as the first diagnostic tool to be performed in centers with experience and OMERACT 2018 definitions and reliability of elemental ultrasound lesion of GCA have been published. Toda...

Long-Term Efficacy and Safety of Сanakinumab in Children with Systemic Juvenile Idiopathic Arthritis
Ekaterina Alexeeva, Rina Denisova, Tatyana Dvoryakovskaya et. al.

Nov 12th, 2019 - Background/Purpose: Canakinumab (CAN) is an efficacious option for treatment of systemic juvenile idiopathic arthritis (sJIA). However, it is still disputable whether long-term therapy is efficacious and drug-free remission can be achieved. This study aimed to analyze the efficacy and safety of long-term CAN treatment in children. Methods: Nineteen patients aged 2.3–15.6 years who had started C...

Long-term Safety of Tildrakizumab in Patients with Moderate-to-Severe Plaque Psoriasis: Incidence of Severe Infections Through 3 Years (148 Weeks) from 2 Phase 3 Trials
Diamant Thaçi, Kristian Reich, Jo Lydie Lambert et. al.

Nov 12th, 2019 - Background/Purpose: Tildrakizumab (TIL) is a high-affinity anti–interleukin-23p19 monoclonal antibody approved for the treatment of moderate-to-severe plaque psoriasis. The objective of this study was to evaluate severe infections in the phase 3 reSURFACE 1 (NCT01722331) and reSURFACE 2 (NCT01729754) trials. Methods: This is a post hoc pooled analysis of adult patients with moderate-to-severe p...

Longitudinal Changes in Health-related Quality of Life in Systemic Sclerosis Treated with Autologous Hematopoietic Stem Cell Transplant Compared to Standard of Care
Nancy Maltez, Mathieu Puyade, Pauline Lansiaux et. al.

Nov 12th, 2019 - Background/Purpose: In severe, early progressive systemic sclerosis (SSc), autologous hematopoietic stem cell transplantation (AHSCT) allows significant improvements in overall and event free survival. The objectives of this study were to quantify the magnitude, domains and duration of improvement in HRQoL in SSc subjects treated with AHSCT compared to standard of care in the setting of routine...

Long-term Survival in Lung Transplantation and Allograft Rejection in Patients with Interstitial Lung Disease Related with Rheumatoid Arthritis: Study from a Single Referral Center
DIANA PRIETO- PENA, Amaya Martinez Meñaca, Mónica Calderón-Goercke et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung disease (ILD) is a leading cause of death in patients with rheumatoid arthritis (RA). In end-stage RA-ILD, lung transplant becomes the only option for these patients. However, there are concerns about worse outcomes and a higher risk of allograft dysfunction in patients with RA after lung transplantation due to the underlying immune dysregulation in this po...

Long Non-coding RNA HOTAIR Induces Myofibroblast Activation in Systemic Sclerosis Through EZH2 Dependent De-repression of NOTCH Signalling Pathway Activation
Christopher Wasson, Giuseppina Abignano, Rebecca Ross et. al.

Nov 12th, 2019 - Background/Purpose: Fibroblasts explanted from affected tissues in Systemic Sclerosis (SSc), conserve their pro-fibrotic phenotype characterised by increased secretion of collagens and other extracellular matrix proteins and comprise a large proportion of a-Smooth Muscle Actin (a-SMA) positive myofibroblasts. Long non-coding RNAs (lncRNAs) within the HOX loci have been described as master epige...

Lysosomal Placement of the Energy Sensors AMPK and mTORC1 Controls Tissue Inflammation in Rheumatoid Arthritis
Zhenke Wen, Ke Jin, Yinyin Li et. al.

Nov 12th, 2019 - Background/Purpose: CD4 T cells from patients with rheumatoid arthritis (RA) are metabolically reprogrammed, diverting glucose away from glycolysis towards the production of biosynthetic precursors. Several of the pro-inflammatory effector functions of such CD4 T cells are metabolically controlled; including T cell longevity, differentiation into Th1 and Th17 cells and the formation of tissue-i...

Natural Disease Progression in Hand Osteoarthritis: Results from a Belgian Ten-years Prospective Cohort Study
Lisa Pardaens, Tine Vanhaverbeke, Jordy Vandercruyssen 1 and Ruth Wittoek et. al.

Nov 12th, 2019 - Background/Purpose: Limited evidence is available about natural disease progression in hand osteoarthritis (HOA).  A previous study of the Ghent HOA cohort showed a positive association between soft tissue swelling, tenderness upon pressure and pain with radiographic progression (1). The aim of the study is to study natural radiographic and clinical disease progression in HOA after 10 years of ...

NMR Spectroscopy Reveals Alterations of Urinary Acetate and Citrate Levels Following Cyclophosphamide Therapy in Patients with Lupus Nephritis
Sujata Ganguly, Umesh Kumar, Anupam Guleria et. al.

Nov 12th, 2019 - Background/Purpose:   Metabolomics, the study of global alterations in small metabolites is a useful tool to look for novel biomarkers. Recently, we reported a reprogramming of the serum metabolomic profile on nuclear magnetic resonance(NMR) spectroscopy following treatment in Lupus Nephritis (LN).(1)We explored urinary parameters using NMR Spectroscopy in patients with biopsy proven proliferat...

Neuromyelitis Optica Overlaps Frequently with Systemic Rheumatic Diseases in African-Americans: Experience at a Large US Academic Medical Center
Michael Belsky, Sunita Dia, Hassan Amer et. al.

Nov 12th, 2019 - Background/Purpose: Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD) are immune-mediated demyelinating disorders of the central nervous system, primarily characterized by optic neuritis and longitudinal extensive transverse myelitis. Antibodies to aquaporin-4 (AQP4-IgG) are highly specific markers of NMOSD. The coexistence of NMOSD with systemic rheumatologic autoi...

Netrin-1 and Its Receptor Unc5B Mediates Tenofovir Induced Bone Loss and Dipyridamole, an Agent That Blocks Adenosine Transporter, Is Able to Modulate the Signal
Aranzazu Mediero, Patricia Llamas-Granda, Bruce Cronstein et. al.

Nov 12th, 2019 - Background/Purpose: Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, a common antiviral in HIV treatment, also leads to increases in bone catabolism markers and decreased bone mineral density (BMD) in children and young adults. In murine models and human cell lines, tenofovir inhibits ATP release and decreases extracellular adenosine levels. We have recentl...

Normalization of Inflammatory Gene Expression and Cellular Markers by Abatacept in the Skin Lesions of Psoriatic Arthritis Patients: A Biopsy Substudy of a Phase III Study
Jennifer Belasco, Sandra Garcet, Mustimbo roberts et. al.

Nov 12th, 2019 - Background/Purpose: Abatacept (ABA), a selective T-cell co-stimulation modulator, has been shown to improve disease activity in patients with psoriatic arthritis (PsA), but its effect on psoriatic inflammation at a molecular level has not been determined. Methods: 40 patients received ABA and 38 received PBO in this substudy of a 24 week, Phase 3, randomized, double blind, placebo (PBO) control...

Novel Somatic Mutations Identified by Whole Genome Sequencing of Rheumatoid Arthritis (RA) Fibroblast-Like Synoviocytes (FLS)
Richard Ainsworth, Deepa Hammaker, David Boyle et. al.

Nov 12th, 2019 - Background/Purpose: Somatic mutations caused by reactive oxygen and nitrogen species in inflamed joints, have been implicated in the destructive nature of RA. Mutation analysis also helps identify mechanisms contributing to the aggressive behavior of RA FLS. However, previous analyses focused on candidate gene approaches. This work represents the first whole genome sequencing study of RA FLS. M...

Nortriptyline in Knee Arthritis (Nortika): A Randomised Controlled Double Blind Trial of Nortriptyline for Pain in Knee Osteoarthritis
Ben Hudson, Leslie Toop, Jonathan Williman et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is the most common joint disease and is a major cause of pain and disability There is currently no cure for OA and management is focused on relief of pain and maintenance of function Tricyclic antidepressants (TCAs) have long been used in other chronic pain conditions, but their analgesic effect in OA has not previously been evaluated. To investigate the ...

National Trends in Hospitalizations and Mortality for Acute Myocardial Infarction in Patients with Rheumatoid Arthritis: Data from National Inpatient Sample 2010-2014
Shraddha Jatwani, Karan Jatwani, Bikramjit Bindra 3 and Karan Chugh et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) has been associated with increased cardiovascular mortality. More intensive treatment with a focus on “treat to target” strategies are being developed, resulting in improved control of inflammation and lower levels of disability. Our literature review suggested that most of the studies were done to assess incident acute myocardial infarction (AMI) b...

No Evidence of an Increased Risk of Serious Infections Among 3 Classes of Biologics for Psoriasis or Psoriatic Arthritis: A Retrospective Real-World Cohort Study
Xintong Li, Kathleen M Andersen, Hsien-Yen Chang et. al.

Nov 12th, 2019 - Background/Purpose: The real-world risk of serious infections associated with interleukin (IL) and tumor necrosis factor-alpha (TNF-α) inhibitors for patients with psoriasis (PsO) and psoriatic arthritis (PsA) is unclear. The objective of this study was to examine whether initiation of IL-17, IL-12/23, or TNF-α, was associated with increased risk of serious infection among PsO and PsA patients....

NADPH Oxidase 4 Regulates the Migration and Invasion of Synoviocytes in Rheumatoid Arthritis Through Pro-angiogenic Factor Secretion
Ha-Reum Lee, Su-Jin Yoo, Chan-Geol Park et. al.

Nov 12th, 2019 - Background/Purpose: Fibroblast-like synoviocytes (FLS) are key effector cells in the pathogenesis of rheumatoid arthritis (RA) through the increased cell migration, degradation of extracellular matrix, and cartilage destruction. Reactive oxygen species (ROS) also have been known to be involved in the initiation and progression of RA, such as secretion of immunoregulatory and pro-angiogenic fact...

National Estimates of Pain Medication Use in Patients with Osteoarthritis
Mohammed Saeed, Capital Health, Trenton et. al.

Nov 12th, 2019 - Background/Purpose: The epidemiology of pain medication use among patients with osteoarthritis is not well explored. Chronic kidney disease (CKD) modifies choice of analgesics. The aim of this study was to explore real world use of pain medications in a nationally representative sample of patients with osteoarthritis. Methods: The CDC’s National Health and Nutrition Examination Survey (NHANES) ...

Natural Killer Cells Gene Expression Can Differentiate Rheumatoid Arthritis Patients from Healthy Controls
Noha Elemam, Mahmood Hachim, Suad Hannawi 2 and Azzam Maghazachi et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent autoimmune diseases (1-3% of the world’s population). RA is a prototypic inflammatory disease, being characterized by an altered state of homeostasis, in which immunological stimulation and unwanted inflammation prevail (Pincus, Brooks et al. 1994). The molecular triggers for the development of RA in healthy subjects are still ...

KL-6 Is a Useful Marker to Monitor the Progression of RA-ILD, but Not to Diagnose or Predict the Development of ILD
Yuta Takamura, Ayae Tanaka, Kazuhiro Kurasawa et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung disease (ILD) is a critical comorbidity in RA. To manage RA-ILD, early diagnosis and monitoring disease progression are important. KL-6 is a marker of disease activity of ILD including CTD-ILD such as scleroderma. However, clinical values of KL-6 in the management of RA remain to be elucidated. The purpose of this study is to determine whether KL-6 elevati...

Large Joint and Lower Extremity Involvement Has Higher Impact on Disease Outcomes in Oligoarticular PsA
Gizem Ayan, Dilek Solmaz, Sibel Bakirci et. al.

Nov 12th, 2019 - Background/Purpose: Joints with different sizes (e.g. small and large joints) and anatomical locations (upper and lower extremities) can be affected in psoriatic arthritis (PsA). Our aim was to explore the effect of these different joint patterns on patient reported outcomes (PROs) in a patient population presenting with mono-oligoarthritis. Methods: PsArt-ID (Psoriatic Arthritis- International...

LOU064: A Highly Selective and Potent Covalent Oral BTK Inhibitor with Promising Pharmacodynamic Efficacy on B Cells for Sjoegren’s Syndrome
Bruno Cenni, Peter End, Maciej Cabanski et. al.

Nov 12th, 2019 - Background/Purpose: Bruton’s Tyrosine Kinase (BTK) is a cytoplasmic tyrosine kinase selectively expressed in B cells, macrophages, mast cells and basophils. The essential role of BTK in B cell antigen receptor and Fc receptor signaling is validated by human and mouse genetics, as well as by preclinical pharmacological intervention. BTK inhibition is expected to positively impact autoimmune dise...

Lower IL-4R in IgD+ Naïve B Cells Is a Pre-disposing Factor for Development of T-bet+ DN2 B Cells in Systemic Lupus Erythematosus
John Mountz, Min Gao, Qi Wu et. al.

Nov 12th, 2019 - Background/Purpose: Studies to date have primarily focused on stimulators that are overexpressed and activate B cells in SLE subjects.  Factors that can maintain B cells in a resting state and may be under-expressed in SLE are largely unknown.  We utilized a combined single-cell B cell transcriptome and high dimensional flow cytometry analysis approach for a coordinated understanding of factors...

Neutrophil Passage Through the Megakaryocyte Cytoplasm via Emperipolesis Modulates Neutrophil Migration
Pierre Cunin, Alexandra Wactor, Li Guo et. al.

Nov 12th, 2019 - Background/Purpose: Emperipolesis (EP) is a little-understood phenomenon referring to the presence neutrophils within megakaryocytes (MKs). We developed methods to study EP in vitro and in vivo, finding that EP is a highly regulated cell-in-cell interaction, requires cytoskeleton rearrangement by neutrophils and MKs, and results in the reciprocal exchange of cell membrane and proteins between b...

Association of a Gout Polygenic Risk Score with Disease Severity Phenotypes Amongst Caucasian Gout Patients in Three Independent Cohorts
Nicholas Sumpter, Tony Merriman, Richard Reynolds et. al.

Nov 12th, 2019 - Background/Purpose: This study aimed to determine whether a polygenic risk score (PRS) based on gout-associated genetic variants is associated with gout disease severity phenotypes such as age at onset, presence of tophi and flare frequency. Methods: A genome wide association study (GWAS) for gout was performed on all genotyped SNPs (single nucleotide polymorphisms) in approximately 500,000 ind...

ACPA Testing and Resultant Treatment Patterns in Patients with Rheumatoid Arthritis: Findings from US Community Rheumatology Practices
Bela Bapat, Andrew J. Klink, Jill Kaufman et. al.

Nov 12th, 2019 - Background/Purpose: Research is redefining RA as a heterogeneous group of diseases distinguished by clinical, biochemical, and genomic markers. ACPA positivity is one such biomarker associated with a clinical profile of early rapidly progressing RA (ERPRA). This study aimed to understand patterns of biomarker testing including ACPA and their impact on treatment patterns in RA patients in the re...

A Pilot Study of the Psychosocial Impact of Undifferentiated Connective Tissue Disease
Juliette Kleinman, Ecem Sevim, Medha Barbhaiya et. al.

Nov 12th, 2019 - Background/Purpose: Despite increased awareness related to the diagnosis and treatment of Undifferentiated Connective Tissue Disease (UCTD), there is a dearth of research on the psychosocial impact of the disease. The objective of this qualitative pilot study was to better understand the psychosocial impact of UCTD on patient well-being. Methods: We identified UCTD patients using the newly esta...

Aggregation of Functional Variants in NOTCH4 Gene Increases SSc Risk
Pravitt Gourh, Sarah Safran, Theresa Alexander et. al.

Nov 12th, 2019 - Background/Purpose: Genetic studies of common variants in scleroderma (systemic sclerosis, SSc) have identified several susceptibility loci increasing SSc risk. Most of these common variants are in the non-coding region and thus have a relatively minor effect size and are not able to fully account for the heritability of SSc. The risk accorded by rare and functional variants is presumed to be h...

Associations of Disease-Modifying Anti-Rheumatic Drug (DMARD) Adherence with Time to First Biologic and Cycle Time on DMARDs, and Healthcare Utilization/Cost in a New RA Patient Cohort
Stephanie Saeli, Joseph Roots, Kelly Shields 2 and Tarun Sharma et. al.

Nov 12th, 2019 - Background/Purpose: Lack of adherence to medications is a well-known problem with chronic conditions, RA included. Nonadherence is associated with decreased quality of life and poorer outcomes. This study explores the effect of adherence to DMARDs on the time to biologic initiation, cycle time on each DMARD, and on healthcare utilization and cost in patients with new-onset RA utilizing a large ...

Association of Periodontitis with Rheumatological Disorders: NHANES III Analysis
Vivekanand Tiwari, Lawrence Brent, Jasim Albandar et. al.

Nov 12th, 2019 - Background/Purpose: The association between periodontal diseases, smoking, and some systemic diseases such as diabetes mellitusis is well established. Periodontitis and rheumatological disorders share common immunological features and there is some evidence of possible association between these diseases. The role of oral dysbiosis from key oral bacteria may play a role in the pathogenesis of au...

Assisted Reproductive Technology in Patients with Inflammatory and Autoimmune Rheumatic Disease
Elisa Trujillo1 and Erika Padrón, Hospital Universitario de Canarias, Santa Cruz de Tenerife et. al.

Nov 12th, 2019 - Background/Purpose: Women with chronic inflammatory and autoimmune diseases increasingly solicit assisted reproductive techniques (ART) due to infertility, but there is little information about success rates of these techniques in such patients. Objective: To analyze pregnancy rates after artificial insemination (AI) and in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) in pati...

A Qualitative Study Evaluating Near-Patient Tools Including a Mobile Application for Earlier RA Referral; Potential to Reduce Chronic Disease Burden
Norma Biln, Simran Chahal, Bruce Clarke 2 and Alison Warner et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) is a chronic, debilitative autoimmune disease. Patients who are treated with disease modifying therapy within 6-12 weeks of symptom onset have better outcomes which leads to a reduced economic burden of disease.1 Technology that enables near-patient blood testing coupled with digital health applications may increase the proportion of patients treate...

ANCA Response upon Rituximab or Cyclophosphamide in ANCA-associated Vasculitis Patients
Laura van Dam, Ebru Dirikgil, Edwin Bredewold et. al.

Nov 12th, 2019 - Background/Purpose: Recent studies have demonstrated that in patients with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) with successful remission-induction (RI) after cyclophosphamide (CYC), maintenance treatment with ANCA-guided rituximab (RTX) improved relapse free survival (RFS). However, current recommended RI treatment is RTX, CYC or a combination of both. As y...

Antimalarial Agents Improve Physical Functioning in Patients with Systemic Lupus Erythematosus
Ioannis Parodis, Sofia Soukka, Alvaro Gomez et. al.

Nov 12th, 2019 - Background/Purpose: Patients with systemic lupus erythematosus (SLE) suffer an impaired health-related quality of life (HRQoL), and the majority of them experience fatigue as a major problem. Traditionally, treatment of SLE has been symptomatic, and antimalarial agents (AMA) are considered a cornerstone of SLE treatment. In previous literature, results regarding the effect of antimalarial agent...

Neutrophil Extracellular Traps Induce Tissue-Invasive Macrophages in Granulomatosis with Polyangiitis Dominated by Ear, Nose and Throat Manifestations
Mitsuhiro Akiyama, Nour Ibrahim, Markus Zeisbrich et. al.

Nov 12th, 2019 - Background/Purpose: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis characterized by acute and chronic tissue destruction in the nose, sinuses, lungs and kidneys. In a subset of patients, tissue inflammation predominantly occurs in the ear, nose, throat and eye (ENT-dominated) manifesting with tissue-invasive and space-consuming lesions, such as saddlenose, septal perforatio...

Giant Cell Arteritis Diagnostic Workup Among Medicare Beneficiaries
Alicia Rodriguez-Pla, Lili Zhou, Erin Ashbeck 3 and C. Kent Kwoh et. al.

Nov 12th, 2019 - Background/Purpose: Giant cell arteritis (GCA) has traditionally been diagnosed by a combination of symptoms, clinical findings, laboratory results, and temporal artery biopsy. More recently, imaging studies have proven to be useful for the diagnosis. The purpose of our study was to describe the diagnostic workup for GCA in clinical practice among Medicare beneficiaries in the United States. Me...

Giant-Cell Arteritis Associated with Myeloproliferative Neoplasms: A Retrospective Case–Control Study
Matthias Papo, Laure Delaval, Hubert de BOYSSON et. al.

Nov 12th, 2019 - Background/Purpose: Giant-cell arteritis (GCA) is a large-vessel vasculitis affecting patients >50 years, whose origin remains widely unelucidated. Recent studies demonstrated that myeloid disease-related somatic mutations were frequent in healthy aged patients, defining the concept of clonal hematopoiesis. Those mutations, especially JAK2V617F, which occur even more frequently in patients with...

Gender Differences in Psoriatic Arthritis – Impact on Tumor Necrosis Factor Inhibitors Persistence and Response
Elsa Vieira-Sousa, Mónica Eusébio, Pedro Ávila-Ribeiro et. al.

Nov 12th, 2019 - Background/Purpose: The impact of gender on tumor necrosis factor inhibitors (TNFi) effectiveness has been poorly studied in Psoriatic Arthritis (PsA) patients. The objective of this work was to study gender differences in persistence and response to a first TNFi in PsA patients. Methods: PsA patients prospectively followed at the Rheumatic Diseases Portuguese Registry (Reuma.pt), treated with ...

Gut Dysbiosis Is Associated with Measures of Early Vascular Dysfunction in Patients with Rheumatoid Arthritis
Michelle Ormseth, Joseph Solus, Annette Oeser 1 and C. Michael Stein et. al.

Nov 12th, 2019 - Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated cardiovascular disease independent of traditional risk factors. Previous studies demonstrate that the gut microbiome is altered in patients with RA and that the gut microbiota may play a role in development of cardiovascular disease in the general population. We tested the hypothesis that gut dysbiosis is associated wi...

Glucocorticosteroid Usage and Major Organ Damage in Patients with Systemic Lupus Erythematosus – Meta-analyses of Observational Studies Published Between 1979 and 2018
Anselm Mak, Mike W.L.- Cheung, Wai Yee Joanna Leong et. al.

Nov 12th, 2019 - Background/Purpose: The impact of glucocorticoid (GC) use on major organ damage in SLE patients has not been formally studied by amalgamating the relevant data published in the literature over the past 40 years. We aimed to study the association between GC use and the occurrence of major organ damage in SLE patients by performing meta-analyses of observational studies published between 1970 and...

Gathering Patients’ and Physicians’ Perceptions to Improve Outcomes in Systemic Autoimmune Myopathies
Isabela Bertoglio, Glaucia Abrahão, Michelle Remião Ugolini-Lopes et. al.

Nov 12th, 2019 - Background/Purpose: Treat-to-target (T2T) strategy has become the best approach to treat several rheumatic disorders. However, most targets are only based on specialists’ opinions, which may not reflect exactly the main patients’ concerns during treatment. There is evidence that switching to a more patient-centered healthcare system seems to enhance treatment adherence and improve outcomes. The...

Genome-wide Association Study in a Japanese Population Revealed Novel Candidate Genes for Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Masayoshi Harigai, Aya Kawasaki, Naoyuki Tsuchiya et. al.

Nov 12th, 2019 - Background/Purpose: Clinical and serological features of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are different across geographical regions and ethnicities, which strongly indicates significant roles of genetic factors in development of AAV. In AAV patients with Asian ethnicity, MHC and non-MHC genes associated with susceptibility or clinical characteristics of AAV...

Genetics of Longitudinal Kidney Function in Children and Adults with Systemic Lupus Erythematosus
Thai-Son Tang, Declan Webber, Jingjing Cao et. al.

Nov 12th, 2019 - Background/Purpose: Genetics influences kidney function (estimated glomerular filtration rate (eGFR)), systemic lupus erythematosus (SLE) and lupus nephritis (LN) risk. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with eGFR in the general population as well as SLE. However, few loci have been identified and replicated for LN risk, in p...

Genes Associated with Nucleotide Oligomerization Domain-Like Receptor Signaling Pathway Are Upregulated in Discoid Lupus Erythematosus
Irene Calderon, Inhan Lee 2 and Rina Mina, SCDS et. al.

Nov 12th, 2019 - Background/Purpose: Background: Discoid Lupus Erythematosus (DLE) is disfiguring autoimmune skin disorder, associated with defects in the adaptive immune system. The innate immune system is likely involved as seen in the presence of interface dermatitis, observed in viral exanthem, and improvement of DLE using inhibitors to membrane-bound Pattern Recognition Receptors (PRR). Hypothesis: Genes a...

Gene-Expression Analysis of Male and Female SLE Patients Reveals Candidate Pathogenic Pathways
MIKHAIL OLFERIEV, David Fernandez, Dina Greenman et. al.

Nov 12th, 2019 - Background/Purpose: The female predisposition for development of multiple autoimmune diseases is well recognized. The female to male ratio reaches a maximum during the reproductive years among SLE patients, suggesting a link between sexual development and disease. Additional epidemiologic data indicate an effect of sex chromosomes. To gain insight into molecular mechanisms of SLE, we investigat...

Gender Influence on Treatment Effectiveness in Psoriatic Arthritis
Diego Benavent, Chamaida Plasencia, Victoria Navarro-Compán et. al.

Nov 12th, 2019 - Background/Purpose: Gender has been lately suggested as influential in the response to treatment with biological drugs in spondyloarthritis. However, data about the association between gender and treatment response in axial PsA (axPsA) or peripheral PsA (pPsA) are scarce. Objective: to analyze the association between gender and clinical response to biological therapy in patients with axPsA and ...

In Rheumatoid Arthritis, New-onset Prednisone Use Is Associated with a Daily Dose, Cumulative Dose, and Duration-dependent Risk for Cardiovascular Events at 6 Months and 1 Year of Use
Anthony Ocon, George Reed 2 and Joel Kremer, University of Rochester Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease but also affects the cardiovascular (CV) system. Many patients are treated with corticosteroids. Corticosteroid use is associated with increased risk for cardiovascular events (CVE). We hypothesized that patients with RA who initiate corticosteroid therapy would have an increased risk for CVE related to dose a...

Longitudinal Changes in the Nasal Microbiome and Disease Activity in Patients with Granulomatosis with Polyangiitis
Rennie Rhee, Antoine Sreih, Jung-Jin Lee et. al.

Nov 12th, 2019 - Background/Purpose: Microbial organisms have been theorized to contribute to disease activity in granulomatosis with polyangiitis (GPA) but little is known about what changes occur in commensal microbes in association with disease relapse. This longitudinal study examined compositional changes in the nasal microbiome and its association with disease activity in patients with GPA. We hypothesize...

Linking Toll-Like Receptor Signaling and Type I Interferons to Inflammation and Fibrosis in a Macrophage/Fibroblast Model of Congenital Heart Block
Miao Chang, Robert Clancy 1 and Jill Buyon, NYU School of Medicine et. al.

Nov 12th, 2019 - Background/Purpose: Since one of the strongest associations with antibodies (abs) to SSA/Ro (Ro60) is the development of congenital heart block (CHB), this model provides an exceptional opportunity to define novel insights that link maternal abs with an inflammatory cellular response which eventuates in fibrotic replacement of the AV node. We recently compiled risk genes based on an agnostic tr...

Legal Matters: Attitudes Regarding Marijuana for Medical Use Among Patients with Rheumatic and Musculoskeletal Disease
Kelly Gavigan, Shilpa Venkatachalam, Jeffrey Curtis et. al.

Nov 12th, 2019 - Background/Purpose: While there have been significant improvements in quality of life among people living with rheumatic and musculoskeletal disease (RMD) with the introduction of biologics and targeted therapies, patients often seek non-pharmacological alternative and complementary treatments, such as marijuana for medical use (MMU), to help manage their condition and symptoms. An understandin...

Levels of Proinflammatory Cytokines in Rheumatoid Arthritis Patients with Carotid Plaque: A Case-Control Study
Dionicio Galarza-Delgado, Jose Azpiri-Lopez, Iris Colunga-Pedraza et. al.

Nov 12th, 2019 - Background/Purpose: Patients with RA have an augmented cardiovascular mortality up to 50% compared to controls. Chronic inflammation of the disease causes endothelial dysfunction and accelerated atherosclerosis. Key molecular pathways in this process are dependent on cytokines like TNF-α, IL-1, IL-6, among others, which are shared with RA. Increased disease activity could contribute to atherosc...