Pain and Anxiety Are Independent Factors Associated to Sleep Impairment in Psoriatic Arthritis: A Multicentric Study in 14 Countries
Penelope Palominos, Laura Coates, Charles Kohem et. al.

Nov 12th, 2019 - Background/Purpose: Sleep quality is diminished in patients with psoriatic arthritis (PsA) and close to 40% of PsA patients consider sleep impairment a priority domain.This work analyzed determinants of impaired sleep in patients with PsA. Methods: This was a cross-sectional analysis of an observational study (ReFlap, NCT03119805), which included adult patients with definite PsA with ≥ 2 years ...

Predictors of Advanced Chronic Kidney Disease in Patients with ANCA Vasculitis and Renal Involvement
Gelsomina Alle, John Jaramillo Gallego, Marina Scolnik et. al.

Nov 12th, 2019 - Background/Purpose: The aim of this study was to evaluate the predictors of advanced chronic kidney disease (ACKD) in patients with Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and renal involvement. Methods: Observational retrospective study. We included all patients with biopsy-proven ANCA glomerulonephritis (GN) diagnosed between 2001 and 2016, with at least one year of ...

Patient Perception of Benefit and Risks Associated with Hydroxychloroquine Use in Systemic Lupus Erythematosus (SLE)
Sooyeon Kwon, Jessica Farrell, Sarfaraz Hasni 3 and Shubhasree Banerjee et. al.

Nov 12th, 2019 - Background/Purpose: Hydroxychloroquine (HCQ) is recommended in all patients with systemic lupus erythematosus (SLE).  Studies suggest that a significant proportion of subjects are non-adherent to daily HCQ, leading to poor disease control, increasing morbidity and mortality. One of the main barriers to adherence is reported to be patients’ fear of side effects most notably retinopathy.  The obj...

Provider Variability in Glucocorticoid Prescribing for Patients with Rheumatoid Arthritis and Impact on Chronic Glucocorticoid Use
Michael George, Joshua Baker, Lang Chen et. al.

Nov 12th, 2019 - Background/Purpose: Glucocorticoids are recommended as short-term bridging therapy in patients with rheumatoid arthritis (RA), but as many as 30-40% of patients remain on glucocorticoids chronically. We aimed to measure the variability in the prescribing of glucocorticoids among rheumatologists and determine whether seeing a provider with a greater preference for glucocorticoids was independent...

Pharmacokinetics and Exposure-response of Intravenous Belimumab in Children with Systemic Lupus Erythematosus
Richard Dimelow, Beulah Ji2 and Herbert Struemper, GSK et. al.

Nov 12th, 2019 - Background/Purpose: Belimumab is approved in adults with active SLE and for childhood-onset SLE (cSLE). PLUTO, a Phase 2, placebo-controlled, double-blind trial (114055; NCT01649765), was the first study of belimumab in cSLE. Efficacy, safety, and pharmacokinetics (PK) of intravenous (IV) belimumab 10 mg/kg, plus standard therapy were evaluated. Pediatric and adult belimumab exposures were comp...

Prospective Evaluation of American Academy of Ophthalmology Low Dose Hydroxychloroquine Recommendation in Stable Lupus Nephritis with High-Risk Retinopathy: Lipid Profile and Flare Rates
Tatiana Pedrosa, Sandra G. Pasoto, Emily Yuki et. al.

Nov 12th, 2019 - Background/Purpose: Hydroxychloroquine (HCQ) is the most well established therapy for SLE, as it provides several beneficial properties, such as favorable effects on lipid profile, reduced cardiovascular (CV) risk and reduction in flares. However, one of the main concerns about HCQ use is retinopathy. In this regard, the American Academy of Ophthalmology (AAO) recently recommended the maximum d...

Profile of Renal Function in Patient Suffering from Rheumatoid Arthritis
Denis Choquette, Louis Bessette, Loïc Choquette Sauvageau et. al.

Nov 12th, 2019 - Background/Purpose: Many medications used in the treatment of rheumatoid arthritis (RA) impact renal function. Some of these may be contraindicated in the presence of a certain degree of renal failure or may require dosage adjustment. Product monograph of different molecules such as hydroxychloroquine (HCQ), methotrexate (MTX), sulfasalazine (SSZ), tofacitinib (TOFA) address the issue with diff...

Predictors of Relapse in Giant Cell Arteritis: Data from an International Collaboration
Laure Delaval, Raphael Porcher, Kenneth Warrington et. al.

Nov 12th, 2019 - Background/Purpose: Roughly half of giant-cell arteritis (GCA) patients taking only glucocorticoids (GCs) relapse. The relapse rate seems to reflect, in part, the duration of GC intake, more than the initial dose at induction. However, the GCA-relapse rate varied widely in observational studies and randomized–controlled trials. We aimed to identify factors predictive of GCA relapse based on dat...

Prevalence of Corticosteroid Use in Incidental Vertebral or Hip Fractures
Gurjit Kaeley, Julie Ferm 2 and Lanh Dang, University of Florida et. al.

Nov 12th, 2019 - Background/Purpose: Non-traumatic vertebral and hip fractures are detrimental complications of osteoporosis and those with a previous fracture have double the risk of subsequent fractures. The objective of this quality improvement (QI) project was to determine the baseline characteristics that may have contributed to the vertebral or hip fracture and determine if bone health was optimized subse...

Mortality Predictors in ANCA-associated Vasculitis: Experience of a Brazilian Monocentric Cohort of a Rheumatology Center
Marilia Dagostin, Sergio Nunes, Samuel Shinjo 3 and Rosa Pereira et. al.

Nov 12th, 2019 - Background/Purpose: Mortality of patients with ANCA-associated vasculitis (AAV) is higher than the general population. There are few papers in the literature regarding the factors associated with this unfavorable outcome, most of them in the eastern population or from nephrology centers. To date, there is no study with this approach in Latin-American patients, a miscegenated population. Our obj...

Mitochondrial Contribution to Juvenile Dermatomyositis Pathogenesis
Bhargavi Duvvuri, Lauren Pachman, Richard Moore et. al.

Nov 12th, 2019 - Background/Purpose: Though mainly found intracellularly, we recently observed mitochondrial extrusion upon cell death, contributing to inflammation and organ damage in lupus-prone mice. Of note, mitochondria are immunogenic, promoting development of anti-mitochondrial antibodies (AMAs). Mitochondrial remnants, including DNA, are observed in the circulation of many systemic diseases, including l...

Medication Necessity and Concerns Beliefs Are Distinct, Interactive Predictors of Treatment Adherence in Rheumatoid Arthritis
George Karpouzas, Elizabeth Hernandez, Lorena Ruiz et. al.

Nov 12th, 2019 - Background/Purpose: Medication adherence is instrumental for the successful management of rheumatoid arthritis (RA) to a goal of remission. Awareness of medication necessity and concerns regarding its use influence adherence and respectively foster or undermine the achievement of treatment goals. We here explored the unique and interactive roles of patient beliefs about the necessity of RA medi...

Modifiable Factors Associated with Response to Treatment in Early Rheumatoid Arthritis
Zoe Brown, Robert Metcalf, Jana Bednarz et. al.

Nov 12th, 2019 - Background/Purpose: Among the potentially modifiable prognostic factors in RA, there is evidence for associations with smoking history, BMI and dietary fish oil supplementation. An integrated examination of these lifestyle factors as predictors of RA outcomes was undertaken in a single early RA cohort receiving standardised algorithm-directed treat-to-target DMARD therapy. Methods: Consecutive ...

Metabolic Changes Induced by Anti-Malondialdehyde Antibodies Promote Osteoclast Development
Koji Sakurabas, Akilan Krishnamurthy, Cheng Xu et. al.

Nov 12th, 2019 - Background/Purpose: Malondialdehyde (MDA) is highly reactive compound produced by lipid-peroxidation in situations associated with oxidative stress. MDA can irreversibly modify proteins (e.g. lysine, arginine and histidine residues), which can lead to the generation of immunogenic neo-epitopes that are recognized by autoantibodies. In fact, anti-MDA IgG antibodies are significantly increased in...

Myositis-specific and -associated Antibodies in Systemic Sclerosis: Prevalence and Clinical Associations
Amélie Leurs, Sylvain Dubucquoi, François Machuron et. al.

Nov 12th, 2019 - Background/Purpose: In systemic sclerosis (SSc) and idiopathic inflammatory myopathies (IIM), auto-antibodies are used in daily practice as potent biomarkers of clinical phenotypes. This study aimed at estimating the prevalence of myositis-specific (MSA) and myositis-associated (MAA) autoantibodies in SSc, and studying their clinical associations. Methods: We realized a cross-sectional, observa...

Modeling-Based Bone Formation Persists in the Femoral Neck Despite Remodeling Inhibition in Subjects Treated with Denosumab
David Dempster, Peter Butler, Mathias Bostrom et. al.

Nov 12th, 2019 - Background/Purpose: Denosumab (DMAb) is a potent antiresorptive agent, but findings in non-human primates suggest that modeling-based bone formation (MBBF) may persist despite DMAb treatment (Ominsky JBMR 2015). This study assessed whether MBBF in the femoral neck (FN) is preserved in the context of inhibited remodeling-based bone formation (RBBF) in subjects receiving DMAb (NCT02576652). Metho...

Mitochondrial DNA: A Potential Trigger of Cyclic GMP-AMP Synthase Activation in Systemic Lupus Erythematosus
Jie An, Bhargavi Duvvuri, Xizhang Sun et. al.

Nov 12th, 2019 - Background/Purpose: Approximately 70% of patients with Systemic Lupus Erythematosus (SLE) show a striking Type I Interferon (IFN-I) signature in peripheral blood. Although we have some understanding of how this signature can be generated in vitro (by immune complex activation of Toll-Like Receptors, TLRs), we have little understanding of mechanisms operative in SLE patients. Cyclic GMP-AMP (cGA...

Multi-vendor Multi-site T1ρ and T2 Quantification of Knee Cartilage
Jeehun Kim, Kenji Mamoto, Richard Lartey et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by deterioration of articular cartilage in the joints. MRI T1ρ and T2 relaxation times have been proposed as potential biomarkers for early detection of cartilage degeneration. However, few studies examined their reliability in a multi-site multi-vendor setting, which is critical for future large-scale trials ...

Major Stressors in the Year Prior to Diagnosis Affects RA Characteristics at Presentation and 1 Year
Nicole Andersen, Orit Schieir, Marie-France Valois et. al.

Nov 12th, 2019 - Background/Purpose: Although many RA patients attribute their disease onset to recent life events, results from retrospective studies remain unclear. We compared characteristics of newly diagnosed RA patients who did and did not report significant stressful life events (+stress) in year prior to diagnosis at baseline and 12 months. Methods: Data were from early RA patients (symptoms < 1 year) e...

Management of Patients with Incident Rheumatoid Arthritis in Rheumatology Clinical Practice
isabel Hernandez Rodriguez, Zulema Rosales Rosado, pia Lois et. al.

Nov 12th, 2019 - Background/Purpose: Treatment of Rheumatoid Arthritis (RA) has changed drastically in the last two decades in strategies and objectives, as well as in therapeutic options, especially with the use of the disease modifying drugs (DMARD), both synthetic and biological. The data on the management of these patients under clinical trial conditions are abundant but it is necessary to expand our knowle...

Mucosal-associated Invariant T Cells Can Be Therapeutically Targeted in Lupus
Goh Murayama, Asako Chiba, Tomohiro Mizuno et. al.

Nov 12th, 2019 - Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. Previously, we reported that the activated status of MAIT cells correlated with disease activity in patients with systemic lupus erythematosus (SLE), and MAIT...

Metabolic Syndrome and Early Arthritis: Frequency, Association with Antibodies Profile and Disease Activity
Francisco Guiñazú, Carla Gobbi, Paula Alba et. al.

Nov 12th, 2019 - Background/Purpose: The Metabolic Syndrome (MetS) is an independent factor of cardiovascular morbidity and mortality and most studies show that its prevalence is higher in established Rheumatoid Arthritis (RA) than in the general population, which would be associated with systemic inflammatory activity. Few studies have evaluated this association in patients with Early Arthritis (EA) with diffe...

Mononuclear Leukocyte DNA Methylome Imprinting of Networked Signaling and Immunity Regulatory Pathways in Gout
Zengmiao Wang, Ying Zhao, Amanda Phipps-Green et. al.

Nov 12th, 2019 - Background/Purpose: Gout encompasses acute arthritis flares mediated by innate autoinflammatory responses to urate crystals, chronic granulomatous tophi, and synovitis promoting bone erosion and soft tissue damage. Here, we probed gout mediators in the circulating mononuclear leukocyte (PBMC) DNA methylome. Methods: PBMC DNA converted by Na+ bisulfite modification was hybridized to Illumina Inf...

MDA Versus DAPSA: Applicability in a Real World
rafaela Gonçalves, Lays Martins, henrique mariz et. al.

Nov 12th, 2019 - Background/Purpose: Background/Purpose: Psoriatic arthritis (PsA) is a progressive, chronic, and potentially irreversible inflammatory disorder. Systematic clinical follow-up of PsA patients is necessary to maintain and adjusting the proposed therapy. There are two different disease activity composite index suggested by Treat To Target (1). MDA (2) defines a state of illness and includes joint ...

Magnetic Resonance Imaging of Knee Joint Protection Following an Intra-Articular Injection of Lipid-Based Dexamethasone Sodium Phosphate Sustained Release Formulation on Subjects with Knee Osteoart...
Sheue-Fang Shih, Carl Brown, Tien-Tzu Tai 1 and Wing Chuang et. al.

Nov 12th, 2019 - Background/Purpose: The most commonly used intra-articular (IA) corticosteroid for osteoarthritis (OA) is triamcinolone acetonide (TA), but its potential chondrotoxicity restricts injection frequency to 3-4 injections per year. TLC599 is a liposomal formulation of dexamethasone sodium phosphate (DSP) designed for intra-articular injection in the treatment of knee osteoarthritis (OA). Based on a...

Multidisciplinary Unit of Psoriatic Arthritis: Clinical Results
Clara Pérez-Velásquez, Oihane Ibarguengoitia-Barrena, David Montero-Seisdedos et. al.

Nov 12th, 2019 - Background/Purpose: The multidisciplinary unit of psoriatic arthritis (PsA) are attractive to improve the early diagnosis and optimize the management of complex patients with PsA. There are published data about different models, activity data and patient satisfaction in this kind os unit. To evaluate its effectiveness, we also need to know the clinical results of patients with PsA who visit the...

Mobile Responsive App – Useful Additional Tool for Data Collection in the German Pregnancy Register Rhekiss?
Jutta Richter, Christina Bungartz, Anja Weiß et. al.

Nov 12th, 2019 - Background/Purpose: The German pregnancy register Rhekiss is designed as a nationwide, web-based longitudinal observational register established in 2015. The register follows women with inflammatory rheumatic disease prospectively from child wish through pregnancy until two years postpartum. During the observation, information on clinical and laboratory parameters, disease activity, comorbiditi...

Methotrexate Discontinuation and Dose Decreases After Therapy with Tocilizumab: Results from the Corrona Rheumatoid Arthritis Registry
Dimitrios Pappas, Taylor Blachley, Steve Zlotnick et. al.

Nov 12th, 2019 - Background/Purpose: Methotrexate (MTX) is frequently prescribed with biologic disease-modifying antirheumatic drugs. Evidence has shown that tocilizumab (TCZ) monotherapy is effective in the treatment of patients with rheumatoid arthritis (RA).1,2 Similar outcomes have been shown in patients responding to TCZ combination therapy who discontinued MTX or remained on combination therapy.3 The purp...

Major Histocompatibility Antigen HLA-DQB1*0601 Is Associated with Rheumatoid Arthritis Among Indians in a Replication Study: Evidence of Gene-Environment Interaction with LPG Stove Use
Able Lawrence, Anshul Dhar, Swayam Prakash et. al.

Nov 12th, 2019 - Background/Purpose: Shared epitope smoking interaction does not fully explain MHC association in Rheumatoid Arthritis (RA). We have previously shown HLA-DQB1*0601 (DQ6.1) to be a susceptibility allele in India1. It has a restricted geographic distribution being common in Japan, India and parts of middle-east while absent in Africa and western Europe (Fig 1 heat map of DQ6.1 distribution). In Pr...

Meta-Analysis Examining the Clinical Significance of Monitoring of Hydroxychloroquine Levels in SLE
Shivani Garg, Rachna Unnithan, Karen Hansen et. al.

Nov 12th, 2019 - Background/Purpose: Despite the pivotal role hydroxychloroquine (HCQ) plays in treating SLE, less than 50% of patients take HCQ as prescribed. Nonadherence versus lack of effect to HCQ are difficult to distinguish, underscoring the importance of measuring HCQ blood levels to assess adherence. Despite this, information and consensus on the clinical impact of incorporating routine testing of HCQ ...

Multimodal Edema Management After Total Knee Arthroplasty: A Pilot Study
Joel Carmichael, Michael Bade 1 and Jennifer Stevens-Lapsley, University of Colorado Anschutz Medical Campus et. al.

Nov 12th, 2019 - Background/Purpose: The ideal treatment of swelling after TKA is unclear. The purpose of this pilot study was to determine the feasibility and initial efficacy of a multimodal edema management (MEM) program including inelastic gradient compression garment, manual lymph drainage massage and home exercise for patients presenting with swelling after TKA. Methods: This was a prospective pilot study...

Methionine Commits Immunometabolism and Epigenetic Regulation of BACH2 Loci in B Cells, Resulting in Biases Toward Plasmablast Differentiation in the Pathogenesis of SLE
Mingzeng Zhang, Shigeru Iwata, Maiko Hajime et. al.

Nov 12th, 2019 - Background/Purpose: Amino acids play an important role in various metabolic processes. However, the role of amino acid metabolism in the regulation of human B cell function remains elusive. To determine the role of essential amino acids in human B cell differentiation and relevance to the pathogenesis of SLE. Methods:  In the in vitro arm of the study, purified CD19+B cells from healthy donors ...

Maintained Benefit in Health-Related Quality of Life of Patients with Giant Cell Arteritis Treated with Tocilizumab Plus Prednisone Tapering: Results from the Open-Label, Long-Term Extension of a P...
John Stone, Jian Han, Sebastian Unizony et. al.

Nov 12th, 2019 - Background/Purpose: Patients with giant cell arteritis (GCA) treated with tocilizumab (TCZ) plus prednisone tapering achieved higher rates of sustained glucocorticoid (GC)-free remission and had lower cumulative GC doses than patients treated with prednisone tapering alone in part 1 of the 52-week, double-blind GiACTA trial.1 During therapy, patients who received weekly TCZ reported improvement...

Musculoskeletal Ultrasound Enhances the Evaluation of Checkpoint Inhibitor Associated Musculoskeletal Immune Related Adverse Events
Mazen Nasrallah, Sara Schoenfeld, Mark Matza et. al.

Nov 12th, 2019 - Background/Purpose: Cancer immunotherapy with monoclonal antibodies that antagonize molecular checkpoint pathways in immune activation, the PD-1/PDL1 axis and CTLA-4, have revolutionized the treatment of solid cancers. These therapies however are limited by immune related adverse events (irAEs), including inflammatory arthritis (irIA). Presentations can be subtle, and recognition delayed. Here ...

Management of Cutaneous Manifestations of Lupus Erythematosus: A Systematic Review
Jessica Fairley, Shereen Oon, Amanda Saracino 3 and Mandana Nikpour et. al.

Nov 12th, 2019 - Background/Purpose: Cutaneous lupus erythematosus (CLE), occurring with or without systemic lupus erythematosus (SLE), is a group of inflammatory skin diseases that can be very debilitating, causing significant psychological distress, and in some cases scarring. We sought to comprehensively present the evidence for different treatment modalities in patients with cutaneous manifestations of lupu...

MRI of the Wrist in Early Rheumatoid Arthritis After 1-year Treat-to-target Strategy
Fan Xiao, Jacky Ka Ko, Jiang Yue et. al.

Nov 12th, 2019 - Background/Purpose: Background: There are two types of remission in rheumatoid arthritis. The first, and most commonly applied, is clinical remission. Imaging remission is another aspect to consider given that (a) the correlation between clinical and imaging at presentation is only modest, (b) imaging can show subclinical inflammation not evident clinically and (c) imaging evidence of inflammat...

Multimorbidity May Worsen Fatigue in Patients with Rheumatoid Arthritis
John Davis, Elena Myasoedova, Tina Gunderson 1 and Cynthia Crowson et. al.

Nov 12th, 2019 - Background/Purpose: Fatigue is a pervasive problem for many patients with rheumatoid arthritis (RA) that often persists despite treatment with effective disease-modifying therapies. Recent studies have suggested that patients with RA have a high burden of multimorbidity, which could affect their disease experiences and treatment outcomes. We sought to determine whether multimorbidity is associa...

Metabolic Regulation in Cybrids Obtained from Healthy and Osteoarthritic (OA) Patients: Impaired Metabolic Flexibility in OA Process
Andrea Dalmao-Fernández, Jenny Lund, Tamara Hermida-Gómez et. al.

Nov 12th, 2019 - Background/Purpose: Background: Osteoarthritis (OA) is the most frequent joint disease.The OA is a heterogeneous disorder. With acceptance of the joint as an organ, the pathogenesis of OA has been viewed as a complex process that involves all the joint structures. There are several metabolic pathways involved in cell metabolism, including glycolysis, tricarboxylic acid (TCA) cycle and fatty aci...

Minocycline for Refractory Calcinosis in Systemic Sclerosis: A Single-Centre Observational Cohort Study
Carmen Fonseca, Voon Ong 2 and Christopher Denton, UCL Medical School et. al.

Nov 12th, 2019 - Background/Purpose: Calcinosis represents a major challenge for patients with systemic sclerosis (SSc) for which there is no standard therapy. Minocycline has been proposed for treatment of refractory calcinosis in SSc (1,2). We assessed the possible benefit and adverse events (AE) of minocycline in cohort of SSc patients with calcinosis. Methods: We reviewed patients with SSc, attending a larg...

Autoantibodies from Sjögren’s Syndrome Enhance NLRP3 Inflammasome Activation and IL-18 Production in Human Salivary Gland Cell Line A-253
Cheng-Han Wu, Ko Jen Li, Chia-Li Yu 3 and Song-Chou Hsieh et. al.

Nov 12th, 2019 - Background/Purpose: Primary Sjögren’s syndrome (SS) is a chronic autoimmune epithelitis characterized by the presence of autoantibodies against SS-related antigen A (SSA) and lymphocytic infiltration of exocrine glands. The underlying mechanisms in the initiation and perpetuation of SS remain to be fully elucidated. Recently, the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflamma...

Association of Rheumatic Autoimmune Disease, Including Rheumatoid Arthritis, with Post-Traumatic Stress Disorder but Not Traumatic Brain Injury in Veterans
Biji Kurien, Calin Prodan 2 and Robert Scofield, Oklahoma Medical Research Foundation et. al.

Nov 12th, 2019 - Background/Purpose: Autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus, are 2- to 3-fold more common among those with post-traumatic stress disorder (PTSD) than among matched controls.  In US Armed Service personnel, PTSD is more prevalent among individuals with mild traumatic brain injury (TBI).  For both PTSD and TBI there are immune changes that might p...

Automated Diagnosis Extraction from Electronic Medical Records with Machine Learning Classifiers
Tjardo Maarseveen, Thomas Huizinga, Marcel J.T. Reinders et. al.

Nov 12th, 2019 - Background/Purpose: The use of Electronic Medical Records (EMR) for research purposes has led to an increasing interest in Natural Language Processing (NLP) for text classification. Little preparation is required as the NLP-methods are capable of automatically interpreting the data. Classification is often accomplished with naïve word-matching. An alternative to word-matching is the usage of a ...

Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative
Alejandro Duran-Sotuela, Mercedes Fernandez-Moreno, María E. Vázquez-Mosquera et. al.

Nov 12th, 2019 - Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in the risk of suffering rapid progressive knee OA in patients from the Osteoarthritis Initiative (OAI). Methods: Caucasian patients from the OAI were classified into three groups based on previous criteria: i) Rapid progressors (R...

Musculoskeletal Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy: Single Center Experience
Didem Saygin, Melissa Bastacky, Gerard Mascara et. al.

Nov 12th, 2019 - Background/Purpose: Immune checkpoint inhibitors (ICI) are new anti-cancer agents used for lung cancer, melanoma, renal cell and urothelial carcinoma, and head and neck cancers. They activate anti-tumor immunity which hampers self-tolerance leading to many immune related adverse events (irAE) commonly affecting the skin, endocrine organs and GI tract. Historically, rheumatologists report limite...

Muscle Involvement Revealed by 18F-PET-CT in Polymyalgia Rheumatica
Daniel WENDLING, Maxime SONDAG, Nicolas GIRAUD et. al.

Nov 12th, 2019 - Background/Purpose: Imaging techniques in polymyalgia rheumatica (PMR) have revealed mainly bursitis, tenosynovitis, capsulitis and enthesitis. This is also the case for 18F-FDG-PET-CT. This technique, which has shown its interest for the diagnosis of PMR, allows an assessment of the metabolic activity of the entire musculoskeletal system and in particular of muscle structures. The aim of this ...

MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh, Frank Roemer, Erin Ashbeck et. al.

Nov 12th, 2019 - Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint tissues, different ordinal grades and joint subregions or locations. Our objective was to compare 8 different representations of MOAKS in terms of prediction performance for time to incident...

Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Kenya Terabe, Nobunori Takahashi, Yoshifumi Ohashi et. al.

Nov 12th, 2019 - Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic (OA), bovine as well as bovine or OA cartilage explants [1]. This was a somewhat counterintuitive observation because we have also demonstrated that the overexpression of HAS2 (HAS2-OE) exe...

Mining Social Media Data to Investigate Patient Perceptions Regarding DMARD Pharmacotherapy for Rheumatoid Arthritis
Chanakya Sharma, Samuel Whittle, Pari Delir Haghighi et. al.

Nov 12th, 2019 - Background/Purpose: Our hypothesis is that patients have a positive opinion regarding the newer, biologic DMARDs and a negative sentiment towards the conventional synthetic agents. We sought to analyse discussions on social media platforms regarding DMARDs so understand the collective sentiment expressed towards these medications.  Methods: Treato data analytics were utilised to download all av...

Methotrexate Intolerance: A Qualitative Descriptive Study of the Adult Rheumatoid Arthritis Patients’ Perspectives
Elizabeth Salt, Mary Kay Rayens, Leslie Crofford 3 and Jamie Studts et. al.

Nov 12th, 2019 - Background/Purpose: An estimated 11% to 33% of persons taking methotrexate for rheumatoid arthritis (RA) are reported to be at least moderately intolerant to this medication. The published literature has largely measured methotrexate intolerance using a scale composed of four domains: abdominal pain, nausea, vomiting and behavioral symptoms. These symptoms largely ignore the definition of “into...

Mesenchymal Stem Cells in Scleroderma: A Systematic Review
Rossana Mejia-Romero, Natalia Aguilera, Juan Pablo Alzate-Granados et. al.

Nov 12th, 2019 - Background/Purpose: Scleroderma (systemic scleroderma or systemic sclerosis, SSc), is a highly heterogeneous autoimmune disease of unknown etiology, with a high rate of therapeutic failure and a progression of the disease. Although recently it has been noted a decrease in mortality It is still high, therefore SSc treatment is considered a therapeutic challenge. The immunomodulatory capacity of ...

Multi-Organ System Meta-Analytic Approach to Investigating Sarcoidosis
Jihad Aljabban, Saad Syed, Sharjeel Syed et. al.

Nov 12th, 2019 - Background/Purpose: Sarcoidosis (SD) is a granulomatous inflammatory disease with a heterogenous presentation and no definite etiology. SD usually begins in the lungs, skin, or lymph nodes but can involve other organs such as the heart and lacrimal glands. A better understanding of pathogenesis can pave new therapeutic avenues. Methods: We employed the STARGEO platform to tag samples from the G...

Myopenia Is an Independent Risk Factor for Rotator Cuff Tear and Shoulder Dysfunction in Elderly People : Data from NAMGARAM Cohort
Yun-Hong Cheon, Young Sun Suh, Mingyo Kim et. al.

Nov 12th, 2019 - Background/Purpose: Myopenia refers to decline in muscle mass with age, causing significant impairment in the ability to carry out normal daily functions. Rotator cuff tear (RCT) is a localized tendon disease, however, it is known to be related with systemic inflammation. The aim of this study is to determine whether there is correlation between myopenia and RCT in elderly people. In addition, ...

Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)
Michael Bowes, Katherine Kacena, Oras Alabas et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both structural progression and outcomes, largely based on imprecise radiographic assessment. A statistical shape model (SSM), a form of machine learning, identified a characteristic 3D OA bone shape from MR images, enab...

MicroRNA-27a Can Contribute to Interferon Signatures in Systemic Lupus Erythematosus via the Suppression of Tripartite Motif-containing Protein 27
Daiga Kishimoto, Ryusuke Yoshimi, Yosuke Kunishita et. al.

Nov 12th, 2019 - Background/Purpose: Type Ⅰ interferons (IFN) contribute to antiviral innate immune responses. Upon viral infection, pattern recognition receptors trigger TANK-binding kinase 1 (TBK1) activation and lead to activation of the transcription factor IFN regulatory factor (IRF) 3 to induce type Ⅰ IFN production. Because high expression of typeⅠ IFN inducible genes, called IFN signature, is observed i...

MRI-based Textural Analysis of Trabecular Bone: A Novel Method for the Opportunistic Screening of Bone Quality
Jonathan Cheah, Matthew Koff, Ryan Breighner et. al.

Nov 12th, 2019 - Background/Purpose: A major obstacle to the treatment of osteoporosis and prevention of fractures is that many at-risk patients are never screened. Dual energy x-ray absorptiometry (DXA) measurements of bone mineral density, the gold standard for diagnosis of osteoporosis, are only performed in a minority of patients. Therefore, opportunistic methods using imaging obtained for other clinical pu...

Methotrexate Treatment Is Associated with Reduction of Neutrophil Reactive Oxygen Species and CD177 in RA Patients
Urvashi Kaundal, Varun Dhir, Biman Saikia 1 and Aastha Khullar et. al.

Nov 12th, 2019 - Background/Purpose: Methotrexate (MTX) is the gold-standard DMARD in rheumatoid arthritis, however, it is unclear how exactly it works. Its effects on neutrophils may involve reduction in ROS production and neutrophil activation markers like CD177, CD11b and CD64. Methods: This was a single-center cross-sectional study, which recruited patients with rheumatoid arthritis (RA) and healthy control...

Major Salivary Gland Ultrasound: Pilot Study of Findings and Feasibility in Childhood-Onset Systemic Lupus Erythematosus (cSLE)
Joseph McDonald, Patricia Vega-Fernandez 2 and Tracy Ting, Cincinnati Children's Hospital Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Ultrasonography is becoming an increasingly useful tool in evaluating patients in pediatric rheumatology. It is predominantly used for musculoskeletal assessments, however, major salivary gland ultrasound (SGUS) is being used in adults for assessment of primary and secondary Sjögren’s syndrome. Very few studies have been done examining salivary gland ultrasound in children a...

Mediators of Bone Metabolism (DKK1, OPG, Sclerostin and RANKL) in a Cohort of Patients with Elderly-onset Arthritis
Anahy Brandy-Garcia, Melania Martínez-Morillo, Roxana Coras et. al.

Nov 12th, 2019 - Background/Purpose: Patients with elderly-onset arthritis have greater comorbidity than young patients, with a higher incidence of osteoporosis (OP), probably mediated by increased bone resorption. However, there are few data on bone metabolism mediators in this population. Methods: Longitudinal observational study that included patients with elderly-onset arthritis ( > 65 years) without diagno...

Body Composition and Nailfold Videocapillaroscopy Patterns in a Cohort of Systemic Sclerosis Patients
Tomatis Veronica, Sabrina Paolino, Alberto Sulli et. al.

Nov 12th, 2019 - Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease, characterized by microvascular damage and progressive fibrosis. Among clinical complications, abnormal body composition and sarcopenia have been reported in SSc patients (1,2). Nailfold videocapillaroscopy  (NVC) is a safe diagnostic tool to assess microvascular progressive damage and may predict severe organ involvem...

Burden of Disease at Treatment Initiation Among Biologic-Naïve Patients with Oligoarticular versus Polyarticular Psoriatic Arthritis in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry
Alexis Ogdie, Mei Liu, Meghan Glynn et. al.

Nov 12th, 2019 - Background/Purpose: Oligoarticular PsA accounts for ≈50% of PsA worldwide, but only a paucity of data describes disease burden among these patients. The Corrona PsA/SpA Registry, a prospective, US-based, observational cohort study, collects real-world data on PsA patient characteristics and treatment, including oligoarthritis. This analysis characterized patient demographics, clinical character...

Multi-center Analyses on 518 Cases with Rheumatoid Arthritis Developing Lymphoproliferative Disorders (RA-LPD): The Prognostic Factors and the Influence of Anti-rheumatic Drugs on LPD Development
Yoshihiko Hoshida, Shiro Ohshima, Yukihiko Saeki et. al.

Nov 12th, 2019 - Background/Purpose: Lymphoproliferative disorders (LPD) remains as a major problem to resolve among the patients with rheumatoid arthritis (RA). During few decades, rheumatic therapy has dramatically changed with the advent of new disease modifying anti-rheumatic drugs (DMARDs). However, it is unclear whether these drugs relate to LPD developing in the patients withRA. Methods: The current stud...

Men and Black Persons Die at Younger Ages from Systemic Sclerosis: A Nationwide Population-based Study
Ram Raj Singh, Devanshu Singh 2 and Eric Yen, UCLA et. al.

Nov 12th, 2019 - Background/Purpose: Systemic sclerosis (SSc) is more common in women than men, but men tend to have a faster disease progression than women. However, conflicting results with regards to sex differences in SSc mortality have been reported. A few studies found standardized mortality ratios for SSc to be similar between men and women, whereas others found SSc standardized mortality ratios to be hi...

Methotrexate Liver Toxicity in a Large Randomized Controlled Trial
Daniel Solomon, Nina Paynter, Anna Rutherford et. al.

Nov 12th, 2019 - Background/Purpose: Liver test abnormalities are known to predict liver pathology in patients using methotrexate (MTX). Monitoring guidelines for MTX suggest frequent assessment of liver tests (AST and ALT). The frequency of liver test abnormalities and liver pathology (liver AEs) in patients using MTX varies substantially in prior studies and there are sparse placebo-controlled data on these i...

Stabilization of Patellar Bone-Shape Correlates Significantly with Reduced Knee Pain Frequency After IA TPX-100 in Subjects with Bilateral Patellofemoral OA
Dawn McGuire, Michael Bowes, Alan Brett et. al.

Nov 12th, 2019 - Background/Purpose: Based on data from the Osteoarthritis Initiative (OAI), MRI-based analyses of bone shape changes in the knee predict symptomatic and radiographic progression of knee OA and risk of joint replacement (Neogi 2013; Barr 2016).  In a 12-month, double-blind, placebo-controlled trial of MRI-confirmed bilateral patellofemoral OA, TPX-100, administered in 4 weekly injections (200 mg...

Sarcopenia and the Likelihood of Incident Knee Osteoarthritis and Knee Pain Among Older Adults in the Health ABC Study
James Andrews, Laura Gold, Michael Nevitt et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) disproportionately affects older adults.  Sarcopenia, or reduced muscle mass and strength, is strongly associated with reduced physical function and poor clinical outcomes among older adults. Prior studies of knee OA and sarcopenia used varied measures of muscle mass and strength, and results are conflicting. We tested whether two components of sarcopenia...

Study of Vertebral Fracture Prevalence and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra (SBAC-L1) in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis vs. Cont...
Marine Fauny, Eliane Albuisson, Elodie Bauer et. al.

Nov 12th, 2019 - Background/Purpose: Osteoporosis is a common disease whose prognosis can be seriously impacted by the development of fractures that lead to functional limitations and may even have life-threatening sequelae. This disease is often under-screened, especially in at-risk populations that require multidisciplinary care such as patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). ...

Screening for Hepatitis B Surface Antigen and Core Antibody Prior to Administration of Rituximab in Rheumatology Patients
Robyn Moran, Jenna Beatty, Jon Ternus 1 and Megan Krause et. al.

Nov 12th, 2019 - Background/Purpose: Rituximab is used to treat a variety of rheumatic diseases. In 2015, the American Gastroenterological Association (AGA) categorized rituximab as high-risk in terms of hepatitis B virus (HBV) reactivation. Specifically, patients that are hepatitis B surface antigen (HBsAg) negative and total hepatitis B core antibody (anti-HBc) positive or HBsAg and anti-HBc positive are at h...

Survival Trends in Giant Cell Arteritis: A Population-based Cohort Study
Thomas Garvey, Cynthia Crowson, Matthew Koster et. al.

Nov 12th, 2019 - Background/Purpose: To investigate survival trends in patients with giant cell arteritis (GCA) diagnosed over a 60-year period. Methods: We assembled a population-based incidence cohort of patients with GCA diagnosed between 1950 and 2009 based on American College of Rheumatology 1990 GCA classification criteria. Patients aged ≥ 50 years with elevation of erythrocyte sedimentation rate or C-rea...

Serum Myositis Specific/associate Autoantibodies Help Identify Early Connective Tissue Diseases Relevant Interstitial Lung Diseases: A Medical Center Experience
Chieh-Yu Cheng, Wei-Han Ju, Tony Szu-Hsien Lee et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung diseases (ILD), a heterogeneous group of pulmonary disorders, originated from idiopathic causes or secondary to certain etiologies, such as infectious diseases, drugs, or connective tissue diseases (CTD). Common causes of CTD associated ILD (CTD-ILD) include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositi...

Safety of Biological DMARD in Patients with Interstitial Lung Disease from a Chilean Cohort of Patients with Rheumatoid Arthritis
Silvana Saavedra, Karen Vergara, Claudia Hernandez et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis (RA) that may be related to the inflammatory process itself, to infectious complications, and/or to the therapy. Biological disease‐modifying antirheumatic drugs (bDMARD) have dramatically improved the outcome of RA, but an increasing number of reports have described  the potential lu...

Shared and Differing Risk Factors for PsA, Psoriasis, AS, and RA: A Series of Case-control Studies
Alexis Ogdie, Xingmei Wang, Thorvardur J Love et. al.

Nov 12th, 2019 - Background/Purpose: While a handful of clinical risk factors for the development of inflammatory diseases have been identified, to date, no studies have compared risk factors across multiple inflammatory diseases. The objective of this study was to compare the strength of association of selected potential risk factors for the development of psoriasis, PsA, RA, and AS. Methods: We performed a se...

Static and Longitudinal Construct Validity of PROMIS CAT and Profile29 for Assessing Pain Interference, Physical Function and Fatigue in Psoriatic Arthritis
Ana-Maria Orbai, Jamie Perin, Albert W Wu et. al.

Nov 12th, 2019 - Background/Purpose: Pain, physical function and fatigue are outcomes reported as having the greatest importance to people with psoriatic arthritis (PsA)1,2. We assessed these outcomes in participants in a longitudinal PsA study using Patient Reported Outcomes Measurement Information System (PROMIS) measures, which have not been used before in PsA, concomitantly with measures of PsA-specific dis...

Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis
Anna Montgomery, Shang-Yang Chen, Philip Homan et. al.

Nov 12th, 2019 - Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized. Methods: Using single cell RNA-sequencing (scRNA-seq), we uncovered 4 distinct subsets of mouse synovial macrophages during steady state distinguishable by expressions of CX3CR1 and MHCII. Results: M...

Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
Kevin Ong, Maria Runa, Wilson Ngai et. al.

Nov 12th, 2019 - Background/Purpose: Some concerns have been raised about subsequent severe acute localized reactions (SALR) (flares, pseudoseptic reactions, etc.) following hyaluronic acid (HA) injections for pain relief of knee osteoarthritis (OA). SALR has been speculated to be possibly related to the crosslink of hylan or an allergic reaction to hyaluronan of avian origin, but similar reactions have been re...

Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain
Christopher Yohn, Robert O'Brien, Stephanie Lussier et. al.

Nov 12th, 2019 - Background/Purpose: Background/Purpose:  Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A in response to various cellular stressors.  Senescent cells secrete factors collectively referred to as the Senescence Associated Secretory Phenotype (SASP) that are proinflammatory and degradative i...

Safety Results of 50% Enrollment from a Multicenter, Randomized, Double‑blind, Placebo‑controlled Study to Assess the Efficacy and Safety of Repository Corticotropin Injection in Patients with Syst...
Anca Askanase, Dharani Munirathinam, Enxu Zhao et. al.

Nov 12th, 2019 - Background/Purpose: Repository corticotropin injection (RCI) is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH1-39) analogues and other pituitary peptides that stimulates endogenous corticosteroid (CS) production and is an agonist for all 5 melanocortin receptors. RCI is approved by the US FDA for the treatment of acute exacerbations or as maintenance therapy in patien...

Skin Disease Activity and Autoantibody Phenotype Are Major Determinants of Blood Interferon Signatures in Dermatomyositis
Mika Tabata, Kavita Sarin, Karen Page et. al.

Nov 12th, 2019 - Background/Purpose: Interferon (IFN) signaling is upregulated in dermatomyositis (DM) and thought to play a role in pathogenesis. An IFN gene signature in peripheral blood of DM patients correlates with skin disease and may predict disease activity. However, studies have not analyzed how IFN signaling differs across DM subtypes or how it is influenced by multiple organ system involvement. Autoa...

Transitions in Lumbar Spine Osteoarthritis: The Johnston County Osteoarthritis Project
Adam Goode, David Hu, Rebecca Cleveland et. al.

Nov 12th, 2019 - Background/Purpose: Spine osteoarthritis (SOA) has been defined by the presence of: 1) disc space narrowing (DSN) and vertebral osteophytes (OST), or 2) facet joint OA (FOA). Anatomical differences between these structures suggest they may have different etiologies. Furthermore, a current clinical paradigm is that SOA leads to lumbar spine instability and subsequent FOA, suggesting a transition...

The Need for Personalized, Non-Pharmacological Intervention Programmes in Autoimmune Connective Tissue Disorders: Results of a EULAR-Funded Scoping Review with a Nested, Descriptive Meta-Analysis
Valentin Ritschl, Ricardo Ferreira, Rúben Fernandes et. al.

Nov 12th, 2019 - Background/Purpose: Autoimmune Connective Tissue Disorders (CTDs), including Mixed Connective Tissue Disorders (MCTD), systemic sclerosis (SSc) and systemic lupus erythematous (SLE) can lead to Raynaud phenomenon, involvement of internal organs, pain in joints, skin abnormalities and muscle weakness. Consequently, people with CTDs experience limitations in activities of daily life and restricti...

Tuberculin Skin Test and Quantiferon®-TB Gold In-Tube Test for Latent Tuberculosis Before Biologic Treatments: Lower Agreement Rate in Spondyloarthropathies Compared to Rheumatoid Arthritis
Ufuk İlgen, Sezin Turan, Hakan Emmungil et. al.

Nov 12th, 2019 - Background/Purpose: Screening for and the treatment of latent tuberculosis is recommended in patients with inflammatory arthritides prior to biologic treatments, particularly the TNF inhibitors. The aim of this study is to evaluate the performance of tuberculin skin test (TST) with respect to Quantiferon®-TB Gold In-Tube test (QFT-GIT) in patients with rheumatoid arthritis (RA) and spondyloarth...

The Positivity for Anti-centromere Antibody Makes Distinct Clinical Features in Primary Sjogren’s Syndrome : Data from a Prospective Korean Nation-wide Cohort
Youngjae Park, Jennifer Lee, Jung Hee Koh et. al.

Nov 12th, 2019 - Background/Purpose: To clarify clinical features of primary Sjogren’s syndrome (SS) patients who show the positivity for anti-centromere antibody in Korea. Methods: We assessed 318 patients who met 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for primary SS. All patients were selected from the Korean Initiative of Primary Sjogren...

The Cumulative Burden of Damage for Patients with Eosinophilic Granulomatosis with Polyangiitis
Irena Doubelt, David Cuthbertson, Gunnar Tomasson et. al.

Nov 12th, 2019 - Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by asthma and other manifestations of vasculitis, some of which can be life-threatening, cause major organ damage, or become chronic. Data on damage in EGPA is limited, mainly due to the rarity of the disease. This study aimed at describing damage in patients with EGPA enrolled in the Vasculitis Clinical R...

Test-Retest Reliability and Validity of a Mobile Health Application to Automate the 30 Seconds Chair Stand Test – Preliminary Data to Create a Contemporary Instrument for Randomized Clinical Trials
Lucas Dantas, Matthew Harkey, André Dantas et. al.

Nov 12th, 2019 - Background/Purpose: Contemporary technologies offer potential solutions to improve and automate data collection of randomized clinical trials by transitioning assessments from the clinic to the real-world. Mobile health (mHealth) applications (Apps) associated with smartphone embedded sensors offer the possibility to automate objective physical function tests by tracking, recording, and analyzi...

The Effects of Message Framing on Patients’ Perceptions and Willingness to Switch to a Biosimilar
Chiara Gasteiger, Annie Jones, Maria Kleinstauber et. al.

Nov 12th, 2019 - Background/Purpose: Patients may hold negative perceptions towards biosimilars which can create barriers to their uptake. Physicians also report uncertainty in how best to explain biosimilars. The aim of this study was to measure the effect of differently framed explanations on patients’ perceptions of and willingness to switch to a biosimilar. Methods: Ninety-six patients with rheumatic diseas...

Treat to Target Is Not Linked to Best Myocardial Strain Indices: Is There Really a Myocardial Dysfunction Directly Associated with Disease Activity?
Alisson Pugliesi, Hugo Nourani, José Roberto Matos Souza 1 and Manoel Bertolo et. al.

Nov 12th, 2019 - Background/Purpose: The risk of developing heart failure (HF) is twice as high in the RA population. It is hypothesized that, in addition to the atherosclerotic ischemic component and the traditional risk factors, there is a mechanism of cardiotoxicity related to the inflammatory pathways. A few previous studies indicate an association between disease activity and myocardial dysfunction, but th...

Too Soon to Say: Promising Results from a Community-Delivered RCT Examining Work-Related Outcomes of the Chronic Disease Self-Management Program
Kristina Theis, Teresa Brady 2 and Shawn Kneipp, Centers for Disease Control and Prevention et. al.

Nov 12th, 2019 - Background/Purpose: More than two-thirds of U.S. adults with arthritis are working-age (< 65), and arthritis is a leading cause of work disability. The Chronic Disease Self-Management Program (CDSMP) has evidence for improving physical and mental health outcomes, but few studies specifically address employment. We examined work-related outcomes following participation in CDSMP. Methods: From 6/...

Treatment Delays Associated with Prior Authorization for Infusible Medications: A Cohort Study
Zachary Wallace, Tyler Harkness, Xiaoqing Fu et. al.

Nov 12th, 2019 - Background/Purpose: Prior authorizations (PA) are commonly required by health payers as cost-containment strategies for expensive medications, including infused biologics. In rheumatology, these medications are frequently prescribed to treat rare conditions that can be organ- or life-threatening and for which few or no medications have regulatory approval because of their relative scarcity. Inf...

The Effectiveness of anti-IL-6 Therapy to Elderly-onset Rheumatoid Arthritis
Takayasu Ando, Takeshi Suzuki, Yutaka Gotou 1 and Kimito Kawahata et. al.

Nov 12th, 2019 - Background/Purpose:  In daily practice, our rheumatologist has experienced different clinical feature of elderly-onset rheumatoid arthritis (EORA) compared with younger-onset RA (YORA). In EORA patients, serological marker of inflammation, like C-reactive protein, tend to be higher than that of YORA. And previous report suggested that significantly higher level of serum interleukin-6 (IL-6) and...

The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3-Year-Prospective Study from a Referral Center of Lung Transplantation
Sara Remuzgo-Martínez, Diana Prieto-Peña, Mónica Calderón-Goercke et. al.

Nov 12th, 2019 - Background/Purpose: Interstitial lung disease (ILD) occurs in approximately 15% of patients with autoimmune diseases (AD) [1]. Its presence is associated with an increased risk of morbidity and mortality [2].  In the present study, we aimed to determine the frequency of ILD associated with AD (AD-ILD) among patients sent for assessment to a clinic of lung transplantation from a referral center....

A Phase 2a Study of MEDI5872 (AMG557), a Fully Human Anti-ICOS Ligand Monoclonal Antibody in Patients with Primary Sjögren’s Syndrome
Xavier Mariette, Michele Bombardieri, Ilias Alevizos et. al.

Nov 12th, 2019 - Background/Purpose: The interaction of inducible T cell costimulatory ligand (ICOSL) and the ICOS receptor is key in the pathogenesis of primary Sjögren’s syndrome (pSS). MEDI5872 interferes with this pathway by binding to ICOSL. We evaluated the safety and efficacy of MEDI5872 in patients (pts) with pSS. Methods: We conducted a Phase 2a, randomized, placebo (PBO)-controlled study (NCT02334306)...

A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200...
Michael Billard, John Todhunter, Margaret Fleming et. al.

Nov 12th, 2019 - Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal risk (e.g., NSAIDs), liver risk (e.g., acetaminophen) or addiction risk (e.g., opiates), and can safely provide long-lasting pain relief after a brief course of treatment. The Sponsor has clinically shown that topi...

A Phase I, Randomized, Double-blind, Placebo-controlled, Single Center, Single-dose Escalation to Investigate the Safety, Tolerability, and Pharmacodynamics of Subcutaneously Administered DEN-181 i...
Amee Sonigra, Hendrik Nel, Nishta Ramnoruth et. al.

Nov 12th, 2019 - Background/Purpose: Antigen-specific immunological tolerance strategies leverage the natural process of antigen presentation by dendritic cells (DCs) to regulate pathogenic T cells and B cells. We developed a nanoparticulate liposome formulation that encapsulates autoantigenic peptide and NF-kB inhibitor, 1,25 dihydroxycholecalciferol (calcitriol), to target DCs. In mouse models of autoimmune a...

A Phase 2, Open-label Extension Study to Evaluate Long-term Safety of Anifrolumab in Adults with Systemic Lupus Erythematosus
W. Winn Chatham, Richard Furie, Amit Saxena et. al.

Nov 12th, 2019 - Background/Purpose: Anifrolumab is a fully human, IgG1κ monoclonal antibody that binds to the type I IFN receptor and inhibits activity of all type I IFNs.1 In the MUSE phase 2b randomized controlled trial (Study 1013, NCT01438489), anifrolumab demonstrated an acceptable safety profile and efficacy on a range of clinical endpoints in patients with moderate to severe SLE. An open-label extension...

The Paradoxical Effect of Depression on Psoriatic Arthritis Outcomes in a Combined Psoriasis-Psoriatic Arthritis Center
Rebecca Haberman, Samrachana Adhikari, Deborah Ramirez et. al.

Nov 12th, 2019 - Background/Purpose: Psoriatic arthritis (PsA) is a heterogenous inflammatory disease affecting skin, joints, and other domains. While psychiatric diseases (i.e., depression and anxiety) are known comorbidities, little is known about their impact on disease severity and patient reported outcomes (PROs). The objective of this study was to characterize the prevalence of psychiatric comorbidities i...

Shared Decision Making in Routine Clinical Practice: An Assessment of Audio-recorded Consultations with Rheumatoid Arthritis Patients
Elke Mathijssen, Johanna Vriezekolk 2 and Bart van den Bemt, Sint Maartenskliniek et. al.

Nov 12th, 2019 - Background/Purpose: International guidelines for rheumatoid arthritis (RA) treatment emphasize that all treatment decisions should be made through a shared decision making (SDM) process between clinicians and patients (1,2). Observations of routine clinical practice are needed to obtain insight into the actual implementation of SDM. The aim of this study was to assess the level of SDM in RA tre...

The Expression of the Interferon Inducible Gene SERPING1 Is Reduced by Rituximab and Correlates with Clinical Response in Systemic Lupus Erythematosus
Liliana Santos Ribeiro, Mariea Parvaz, Su-Ann Yeoh 2 and Michael Ehrenstein et. al.

Nov 12th, 2019 - Background/Purpose: Abnormalities in B cells and the interferon alpha (IFN) pathway have been separately implicated in the pathogenesis of systemic lupus erythematosus (SLE). B cell depletion therapy with rituximab is used to treat SLE but clinical response varies between patients. We hypothesized that the IFN inducible gene response may explain the difference in clinical responses to rituximab...

Knowledge, Needs and Expectations Among Systemic Lupus Erythematosus: Preliminary Results from the INTEGRATE Pilot Project
Valentina Lorenzoni, Ilaria Palla, Elena Elefante et. al.

Nov 12th, 2019 - Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease characterized by multi-organ involvement and a complex clinical picture, with a wide range of manifestations with and unpredictable relapsing and remitting course. Evidence suggests that discordance between patients and physicians could negatively affect patient care, adherence to treatment and outcomes of ...

Knowledge of Cardiovascular Disease Risk Among Patients with Rheumatoid Arthritis
Juan Bande, María Medina, Julia Sosa et. al.

Nov 12th, 2019 - Background/Purpose: Patients with rheumatoid arthritis (RA) have a significantly higher risk of cardiovascular disease (CVD) than general population. The Heart Disease Fact Questionnaire (HDFQ-RA 1 and 2) is a self-reported questionnaire that assesses the knowledge of general CVD risk and more specifically the related with RA and its treatment. The aim of this study was to validate the Spanish ...

Large Vessel Vasculitis: Diagnosis Is Very Frequent with Ultrasound Examination and Shows Responsiveness to Treatment
Eugenio de Miguel, Irene Monjo, Elisa Fernández et. al.

Nov 12th, 2019 - Background/Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly. In the EULAR recommendations of 2018 for the use of imaging in GCA, color Doppler ultrasound (CDUS)  is recognized as the first diagnostic tool to be performed in centers with experience and OMERACT 2018 definitions and reliability of elemental ultrasound lesion of GCA have been published. Toda...

Long-Term Efficacy and Safety of Сanakinumab in Children with Systemic Juvenile Idiopathic Arthritis
Ekaterina Alexeeva, Rina Denisova, Tatyana Dvoryakovskaya et. al.

Nov 12th, 2019 - Background/Purpose: Canakinumab (CAN) is an efficacious option for treatment of systemic juvenile idiopathic arthritis (sJIA). However, it is still disputable whether long-term therapy is efficacious and drug-free remission can be achieved. This study aimed to analyze the efficacy and safety of long-term CAN treatment in children. Methods: Nineteen patients aged 2.3–15.6 years who had started C...