https://acrabstracts.org/abstract/safety-and-efficacy-results-from-the-open-label-extension-of-a-phase-2-trial-of-risankizumab-a-selective-il-23p19-inhibitor-in-patients-with-active-psoriatic-arthritis/
Kim Papp, Melinda Gooderham, Akimichi Morita et. al.
Nov 13th, 2019 - Background/Purpose: Psoriatic arthritis (PsA) is characterized by peripheral synovitis, enthesitis, dactylitis and spondylitis, and IL-23 is involved in the pathogenesis of these conditions either directly or indirectly. Risankizumab (RZB), a potent humanized IgG1 monoclonal antibody and selective IL23p19 inhibitor, exhibited superior efficacy vs placebo via ACR responses and PASI scores in pat...
https://acrabstracts.org/abstract/associations-of-socioeconomic-status-with-rheumatoid-arthritis-ra-progression-in-african-americans-with-early-disease/
Rebecca Cleveland, Emma Astrike-Davis, Beth Jonas 1 and Leigh Callahan et. al.
Nov 13th, 2019 - Background/Purpose: In prior cross-sectional analyses of African Americans (AA) with RA, we observed that low education, income and home ownership were associated with clinical damage and patient reported outcomes (PROs) among those with mean disease duration of 7.8 years. However, when restricted to those with disease duration of < 2 years, associations with PROs remained, but were no longer o...
https://acrabstracts.org/abstract/anakinra-treatment-in-patients-with-familial-mediterranean-fever-a-single-center-experience-2/
Serdal Ugurlu, Bugra Han Egeli, Bilgesu Ergezen et. al.
Nov 13th, 2019 - Background/Purpose: The main goal of Familial Mediterranean Fever (FMF) treatment is to prevent attacks and subclinical inflammation. Mainstay of treatment is colchicine; however, 5-10% of patients are unresponsive to colchicine even in maximum tolerated dosage. Anakinra has been proven to be effective in controlled trials in terms of attack frequency and subclinical inflammation in colchicine ...
https://acrabstracts.org/abstract/advances-in-treatment-of-rheumatoid-arthritis-acpa-positive-patients-benefited-more-than-acpa-negative-patients-25-year-results-of-a-longitudinal-cohort-study/
Xanthe ME Matthijssen, Ellis Niemantsverdriet, Thomas Huizinga 2 and Annette van der Helm-van Mil et. al.
Nov 13th, 2019 - Background/Purpose: The last 25 years, treatment of rheumatoid arthritis (RA) has changed considerably. Although clinically relevant joint damage has become infrequent, it is less established to what extent other long-term outcomes have improved. Moreover, anti-citrullinated anti-bodies (ACPA)-positive and ACPA-negative disease subsets were discovered and it is unknown they have benefited equal...
https://acrabstracts.org/abstract/a-randomised-open-labelled-clinical-trial-to-investigate-synovial-mechanisms-determining-response-resistance-to-rituximab-versus-tocilizumab-in-rheumatoid-arthritis-patients-failing-tnf-inhibitor-t/
Frances humby, Maya H. Buch, Patrick Durez et. al.
Nov 13th, 2019 - Background/Purpose: Although biologic therapies have transformed the outlook for rheumatoid arthritis (RA), the lack of a major treatment response in over 50% of patients, the potential side effects and the high cost of these drugs have highlighted the need to define predictive markers of response and to stratify patients according to therapeutic outcome. B-cells are pivotal to RA pathogenesis,...
https://acrabstracts.org/abstract/transcriptomic-meta-analysis-of-lupus-affected-tissues-reveals-shared-immune-metabolic-and-biochemical-dysregulation/
Kathryn Kingsmore, Sarah Heuer, Erika Hubbard et. al.
Nov 13th, 2019 - Background/Purpose: Systemic lupus erythematosus (SLE) affects various organs and tissues, but whether pathologic processes in each organ are distinct or whether dysregulated molecular functions are found in common in all tissues is not known. We, therefore, conducted a meta-analysis of gene expression profiles in four affected SLE tissues to identify commonly dysregulated pathways. Methods: Ge...
https://acrabstracts.org/abstract/the-use-and-safety-of-rituximab-in-connective-tissue-disease-associated-interstitial-lung-disease/
Christopher Mesa, Snehaja Yadlapati 1 and Myriam Guevara, Louisiana State University Health Science Center et. al.
Nov 13th, 2019 - Background/Purpose: Interstitial Lung Disease (ILD) is the most common lung manifestation in Connective Tissue Diseases (CTD). It is present in most types of CTD, such as: Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc), Systemic Lupus Erythematous (SLE), Inflammatory Myositis (IM), Mixed Connective Tissue Disease (MCTD), Sjogren Syndrome and Sarcoid. Despite it being so common, treatment h...
https://acrabstracts.org/abstract/effects-of-filgotinib-on-anemia-thrombocytopenia-and-leukopenia-results-from-a-phase-3-study-in-patients-with-active-rheumatoid-arthritis-and-prior-inadequate-response-or-intolerance-to-biological-d/
Mark Genovese, Kenneth Kalunian, Jacques-Eric Gottenberg et. al.
Nov 13th, 2019 - Background/Purpose: Anemia, thrombocytopenia and leukopenia in RA patients treated with non-Janus Kinase 1 (JAK1) selective inhibitors may be due to inhibition of hematopoietic growth factors signaling through JAK2. Therefore, we investigated the extent of anemia, thrombocytopenia and leukopenia in patients with active RA with a prior inadequate response/intolerance to biological DMARD (bDMARD)...
https://acrabstracts.org/abstract/efficacy-and-safety-of-intravenous-belimumab-in-children-with-systemic-lupus-erythematosus-an-across-trial-comparison-with-the-adult-belimumab-studies/
Antonio Nino, Damon L Bass, Gina Eriksson et. al.
Nov 13th, 2019 - Background/Purpose: Belimumab (BEL) is the first treatment approved for children with systemic lupus erythematosus (SLE) from 5 years of age and older.1 This approval was based on the PLUTO trial (NCT01649765), which was designed to assess the safety and efficacy of BEL in children with SLE.2 Additional evidence to support the consistency of effect of BEL in children included an across-trial co...
https://acrabstracts.org/abstract/efficacy-and-safety-of-low-dose-il-2-in-rebuilting-immunity-re-equilibrium-of-psoriatic-arthritis-patients/
Jia Wang, Yu-fei Hao, Sheng-xiao Zhang et. al.
Nov 13th, 2019 - Background/Purpose: Psoriatic arthritis (PsA) is a T lymphocytes-mediated inflammatory condition. Although regulatory T cells (Tregs) isolated from blood and psoriatic skin have been showed a functional deficiency in suppressing effector T-cells in PsA, absolute quantitative status of peripheral Treg or Th17 cells is still unclear. On the other hand, recent studies have revealed that low-dose I...
https://acrabstracts.org/abstract/endothelial-protein-c-receptor-and-scavenger-receptor-class-b-type-1-negatively-regulate-vascular-inflammation-and-are-major-autoantigens-in-takayasu-arteritis/
Tomoyuki Mutoh, Tsuyoshi Shirai, Tomonori Ishii et. al.
Nov 13th, 2019 - Background/Purpose: Takayasu arteritis (TAK) is a chronic vasculitis which predominantly affects large vessels. Although anti-endothelial cell antibodies (AECA) had been reported to be involved in vascular inflammation in TAK, their target antigens remained unclear. We had constructed an expression cloning system for specific identification of cell-surface antigens, which we named SARF. The aim...
https://acrabstracts.org/abstract/efficacy-and-safety-of-the-selective-interleukin-1-receptor-associated-kinase-4-inhibitor-pf-06650833-in-patients-with-active-rheumatoid-arthritis-and-inadequate-response-to-methotrexate/
Spencer I Danto, Negin Shojaee, Ravi Shankar P Singh et. al.
Nov 13th, 2019 - Background/Purpose: Adaptive and innate immune pathways are involved in inflammation and pathogenesis of rheumatoid arthritis (RA). Toll-like receptor (TLR) stimulation activates the innate immune system, and may be involved in the pro-inflammatory response to ACPA protein complexes found in severe RA.1 Interleukin (IL) receptor-associated kinase 4 (IRAK4) is a key signal transducer downstream ...
https://acrabstracts.org/abstract/systemic-lupus-erythematous-risk-alleles-drive-autoimmune-features-in-a-population-without-diagnosed-autoimmune-diseases/
April Barnado, Lee Wheless, Leslie Crofford 2 and Joshua Denny et. al.
Nov 13th, 2019 - Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous disease with > 100 known risk alleles. Some of these risk alleles associate with ACR SLE criteria such as renal disease. We examined if nine of these SLE risk alleles would identify autoimmune features in a population without diagnosed autoimmune diseases. Methods: We investigated subjects from BioVU, a databank that link...
https://acrabstracts.org/abstract/the-effect-of-rheumatoid-arthritis-and-biologics-on-the-acquisition-of-subsequent-diseases-and-adverse-events-a-matched-longitudinal-population-study/
Mark Tatangelo, George Tomlinson, Edward Keystone et. al.
Nov 13th, 2019 - Background/Purpose: The direct and indirect effects of rheumatoid arthritis (RA) are difficult to measure in observational studies because: (1) The inflammatory effects of RA are difficult to separate from underlying age-sex related risk of comorbid conditions (2) Long-term large sample follow-up of patients is expensive, arduous, and difficult to standardize (3) Limited methods for selecting a...
https://acrabstracts.org/abstract/predictive-factors-for-treatment-related-mortality-and-event-free-survival-after-autologous-hematopoietic-stem-cell-transplantation-for-systemic-sclerosis-results-of-a-long-term-follow-up-multi-centr/
Sandra van Bijnen, Maaike Boonstra, Els van den Ende et. al.
Nov 13th, 2019 - Background/Purpose: Autologous hematopoietic stemcell transplantation (HSCT) has shown to improve survival of SSc patients with poor prognosis, but is hampered by treatment related mortality (TRM). Better selection of eligible patients could improve outcomes. Objectives: 1. To evaluate event-free survival, TRM and response after HSCT in SSc and 2. To explore patient characteristics that associa...
https://acrabstracts.org/abstract/persistence-of-b-cell-rich-synovitis-following-conventional-synthetic-disease-modifying-anti-rheumatic-drug-treatment-in-early-rheumatoid-arthritis-is-associated-with-radiographic-progression-independ/
Felice Rivellese, Gloria Lliso-Ribera, Alessandra Nerviani et. al.
Nov 13th, 2019 - Background/Purpose: Synovial B cell aggregates in patients with early Rheumatoid Arthritis (RA) have been associated with disease severity and radiographic progression. Here, we analysed the presence of B cells and their association with clinical outcomes in matched synovial biopsies pre- and post- treatment with conventional synthetic Disease Modifying anti-Rheumatic Drug (scDMARDs). Methods: ...
https://acrabstracts.org/abstract/prevalence-of-systemic-lupus-erythematosus-in-the-united-states-preliminary-estimates-from-a-meta-analysis-of-the-centers-for-disease-control-and-prevention-lupus-registries/
Emily Somers, Lu Wang, W Joseph McCune et. al.
Nov 13th, 2019 - Background/Purpose: The heterogeneity of the clinical manifestations of systemic lupus erythematosus (SLE) and lack of a diagnostic test make SLE difficult for epidemiologists to study. The Centers for Disease Control and Prevention (CDC) supported five population-based SLE surveillance registries, using harmonized methodology, to better estimate incidence and prevalence of SLE in diverse areas...
https://acrabstracts.org/abstract/perturbation-of-the-human-gut-microbiome-by-methotrexate-contributes-to-the-resolution-of-inflammation-and-autoimmune-disease/
Renuka Nayak, Margaret Alexander, Kye Stapleton-Grey et. al.
Nov 13th, 2019 - Background/Purpose: The trillions of microorganisms (microbiota) found within the human gut play a critical role in shaping the immune system, yet these complex microbial communities are also highly sensitive to numerous environmental factors. While much of the focus to date has been on dietary intake, emerging data has begun to suggest that the use of pharmaceutical drugs, even those that are ...
https://acrabstracts.org/abstract/predictors-to-develop-definite-systemic-sclerosis-ssc-results-from-an-international-multicentre-study-on-very-early-diagnosis-of-systemic-sclerosis-vedoss/
Silvia Bellando-Randone, Gemma Lepri, Dorte Huscher et. al.
Nov 13th, 2019 - Background/Purpose: The very early diagnosis of SSc is a challenge today. The aim of the VEDOSS project was to study in an at-risk population, the clinical signs that could predict the progression toward a definite SSc. Methods: Patients with Raynaud phenomenon (RP), with or without anti-nuclear antibodies (abs) (ANA) were recruited for this longitudinal, observational study. Fulfilling the 201...
https://acrabstracts.org/abstract/hypoxia-resistant-pathogenic-b-cells-accumulate-in-the-ra-synovial-tissue-in-a-cxcr3-dependent-manner/
Achilleas Floudas, Candice Low, Monika Biniecka et. al.
Nov 13th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown and complex aetiology with severe detrimental effects for the patient’s quality of life. While autoantibodies have been used extensively for the diagnosis of RA, no clear mechanism of action towards disease pathogenesis and progression has been identified. Importantly, both seropositive and ser...
