Exploring Possible Predictors of Physical Activity in Knee Replacement Patients
Brandy Tanenbaum, Aileen Davis, Deborah Kennedy 3 and Junaid Bhatti et. al.

Nov 12th, 2019 - Background/Purpose: Following total knee replacement (TKR), patients do not achieve recommended physical activity for overall health. The implications of physical inactivity on individuals and the healthcare system are substantial and well documented, yet why these patients do not achieve recommended levels are not well understood. The concept of physical literacy – if people have the knowledge...

Erosive Hand Osteoarthritis, Metabolic Syndrome and Knee Osteoarthritis: A Cross-sectional Study Using Data from the PROCOAC Cohort
Natividad Oreiro, Ignacio Rego-Pérez, Maria T. Silva et. al.

Nov 12th, 2019 - Background/Purpose: Erosive hand osteoarthritis (EOA) is often considered a more severe form of hand OA. However, more data are needed regarding this phenotype to conclude if represents a different subset of hand OA or a different degree of affectation of the same disease. The purpose of this work is to compare the clinical pattern of patients with EOA with those that do not show this phenotype...

Efficacy of a 3-Month Wearable-enabled Physical Activity Counselling Program for People with Knee Osteoarthritis
Hui Xie, Linda Li, Na Lu et. al.

Nov 12th, 2019 - Background/Purpose: Current guidelines emphasize an active lifestyle in the management of knee osteoarthritis (OA), but up to 90% of OA patients are inactive. We previously demonstrated that an 8-week physical therapist (PT)-led counselling intervention, with the use of a consumer-grade wearable device, improved step count and quality of life in people with knee OA, compared to a control [1]. I...

Establishing an in Vitro Model of Hand Osteoarthritis by Generating Induced Pluripotent Stem Cells (iPSc) That Carry Single Nucleotide Polymorphisms Associated with Hand Osteoarthritis Risk
Rocío Castro-Viñuelas, Clara Sanjurjo-Rodríguez, María Piñeiro-Ramil et. al.

Nov 12th, 2019 - Background/Purpose: Knowledge and research results in the field of hand osteoarthritis (hOA) are currently limited, mainly due to the unavailability of tissue samples to develop in vitro studies and lack of animal models of this disease. Cellular in vitro models are important tools to elucidate the molecular mechanisms and pathways that are involved in hOA, but current cell sources present disa...

The Opioid Epidemic: The Rheumatology Response to Management of Chronic Pain
Michael Grant, Alysia Kwiatkowski 1 and Najia Shakoor, Rush University Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Pain is the hallmark symptom of many rheumatologic conditions and chronic pain management is a major part of clinical practice in rheumatology.   Therefore, as the country and medical community evaluate and respond to the opioid epidemic, rheumatologists should be in the forefront of these discussions and response.  In rheumatoid arthritis (RA), chronic opioid use doubled fr...

Regulation of Interleukin-1β (IL-1β)-induced COX-2 Expression and IL-6 and MMP-1 Production in Human OA Synovial Fibroblasts by Guanylate Binding Protein 5
Mahamudul Haque, Madeline McDougal, Anil Singh 1 and Salahuddin Ahmed et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a chronic degenerative joint disease caused by synovial inflammation and cartilage degradation primarily driven by interleukin-1beta (IL-1β). Studies suggest that TNF-stimulated gene 6 (TSG6) plays an important role in reducing IL-1β-induced tissue destruction in arthritis. In the present study, we evaluated the role of guanylate binding protein 5 (GBP...

Reporting of Adverse Events in Randomized Controlled Trials of Therapeutic Exercise for Knee Osteoarthritis: A Systematic Review
Johan vonHeideken 1 and Maura D. Iversen, Karolinska Institutet, Stockholm et. al.

Nov 12th, 2019 - Background/Purpose: CONSORT guidelines recommend the reporting of adverse events (AEs) and drop outs, along with a description of each. However, the application of these guidelines in clinical trials of exercise is unknown. This study aimed to identify how AEs and drop outs are reported in clinical trials of therapeutic exercise for adults with KOA. Methods: Cochrane Library, EMBASE, MEDLINE, a...

Subcutaneous Tanezumab versus NSAID for the Treatment of Osteoarthritis: Joint Safety Events in a Randomized, Double-Blind, Active-Controlled, 80-Week, Phase-3 Study
Marc C. Hochberg, John Carrino, Thomas Schnitzer et. al.

Nov 12th, 2019 - Background/Purpose: Tanezumab, a monoclonal antibody inhibiting nerve growth factor (NGF), is under investigation for the treatment of chronic pain conditions. In prior osteoarthritis (OA) studies, intravenous tanezumab was effective and generally well tolerated, and the risk of increased joint damage required further assessment. This study was conducted to evaluate the efficacy and safety of s...

Surgical and Medical Weight Loss Threshold Dictates Decreases in Knee Osteoarthritis Pain but Not Reductions in Inflammatory Biomarkers
Fernando Bomfim, Shannon Chen, Stephen Zak et. al.

Nov 12th, 2019 - Background/Purpose: Weight loss in obese patients can reduce knee osteoarthritis (OA) pain, even when physical therapy and intra-articular injections have failed. The impacts of either non-surgical or surgical weight loss on knee OA pain have been reported separately, but few studies have assessed them conjointly.  While the decrease in mechanical load helps, the contribution of metabolic chang...

Use of Minimal Important Difference (MID) in Randomized Clinical Trials of Pain in Osteoarthritis
Lavalley Michael, Matthew Parkes, Daniel White et. al.

Nov 12th, 2019 - Background/Purpose: Minimal important differences (MID), based on within-subject evaluation of attaining  an improvement in a continuous outcome such as a pain scale, are important for evaluating the magnitude of treatment effects in randomized clinical trials (RCT) in OA. While designed to assess whether an individual’s improvement achieved a meaningful threshold, MID has often been used to ga...

Understanding Knee Function and Symptom Management in Individuals with Risk Factors for Knee Osteoarthritis
Jason Jakiela, Daniel White, Hiral Master et. al.

Nov 12th, 2019 - Background/Purpose: Worse knee function and frequent use of knee symptom management strategies are common in people with symptomatic knee osteoarthritis (SxOA). There are several risk factors for SxOA, with the most common being overweight/obese (OW/OB) or having a previous knee injury/surgery (KISHx). Prior to the onset of SxOA, individuals likely are not seeking care, however the presence of ...

Trends in Prescribing of NSAIDs and Opioids Among Osteoarthritis Patients in British Columbia, Canada, 1998-2014
Jacek Kopec, Jolanda Cibere, Na Lu et. al.

Nov 12th, 2019 - Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are commonly prescribed for patients with osteoarthritis (OA). However, both types of medication are associated with serious side effects. As a result, guidelines for the treatment of OA have changed substantially over the past 2 decades. Our purpose in this study was to describe the trends in prescribing of NSAIDs (...

The Rat Homolog to FX201, a Gene Therapy in Development for the Treatment of Osteoarthritis, Demonstrates Dose-Dependent Decreases in the Severity of Cartilage and Bone Lesions Following Anterior C...
Rebecca Senter, Rogely Boyce, Monika Chabicovksy et. al.

Nov 12th, 2019 - Background/Purpose: Acute injury to the anterior cruciate ligament (ACL) is a common cause of posttraumatic OA in humans, and ACL transection (ACLT) in rats is an established animal model of traumatic injury-induced OA. FX201, a helper-dependent adenovirus (HDAd)-based intra-articular (IA) gene therapy candidate designed to induce the production of an Interleukin (IL)-1 receptor antagonist (IL-...

The Synthesis of Hydrogen Sulfide Is Impaired in Osteoarthritic Chondrocytes from Diabetic Patients and in Vitro in Cells Under High Glucose Environment
Carlos Vaamonde-García, Tamara Hermida-Gómez, Francisco J. Blanco et. al.

Nov 12th, 2019 - Background/Purpose: A growing number of findings indicates that type 2 diabetes is an independent risk factor of osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Hydrogen sulfide (H2S) plays an important role in the pathogenesis of diabetes and its complications. In relation, we and other authors have observed a protective impact of H2...

What Is the Pathogenic Meaning of Chondrocyte Hypertrophy in Osteoarthritis? Effect of Evc Deletion Through Hedgehog Signaling
Ana Lamuedra, Paula Gratal, Víctor Luis Ruiz-Perez et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is mainly characterized by the progressive damage of articular cartilage, where chondrocytes acquire a hypertrophic-like phenotype. Indian Hedgehog levels are increased in OA cartilage. An induction of Hedgehog (Hh) signaling pathway induces OA-like cartilage lesions, whereas its pharmacological downregulation prevents articular destruction in animal mode...

What Is an Important Difference in Gait Speed in Adults with Knee Osteoarthritis?
Jing Song, David Cella, Abigail Gilbert et. al.

Nov 12th, 2019 - Background/Purpose: Little is known regarding what difference in functional performance measures are clinically significant in individuals with a chronic medical disease. This study examines the important differences in gait speed in adults with knee osteoarthritis. Methods: Functional performance was objectively measured by gait speed using 20-meter and 400-meter walk tests among adults with r...

Preclinical Evaluation of Targeting TGF-beta Signaling and Senescence in ex Vivo Models of Human Knee and Spine Osteoarthritis
Jeroen Geurts, Cordula Netzer, Stefan Schären 2 and Thomas Hugle et. al.

Nov 12th, 2019 - Background/Purpose: The absence of effective disease-modifying drugs remains an important unmet need in the treatment of osteoarthritis. In recent years, novel pharmacological treatments including targeting TGF-beta signaling in subchondral bone (Zhen et al., Nat Med 2013) or senescence of joint tissues (Jeon et al., Nat Med 2017) have demonstrated promising efficacy in experimental osteoarthri...

Protective Effects of Intra-Articular Formulated Liraglutide in Osteoarthritis: Preclinical Studies
Francis Berenbaum, Coralie Meurot, Margot Vieubled et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease affecting millions of individuals worldwide. Its development has been reported to be associated with cartilage degradation and inflammatory responses leading to pain, swelling and reduced function. Liraglutide, a Glucagon-Like-Peptide 1 Receptor (GLP-1R) agonist, is clinically used as a subcutaneous treatment for type 2 dia...

Inhibition of Choline Kinase Alpha Improves Synovitis and Cartilage Damage in Animal Models of Osteoarthritis
Roxana Coras, Leening P Liu, Serena Z Shi et. al.

Nov 12th, 2019 - Background/Purpose: Osteoarthritis (OA) is a disease of the whole joint, affecting cartilage, ligaments, menisci, bone and synovial tissue. We previously found that choline kinase alpha (ChoK) expression was upregulated in human OA synovial and cartilage tissues, and inhibition of ChoK decreased production of proinflammatory cytokines by OA synovial fibroblasts and inhibited chondrocyte catabol...

Identification of Distinct Lipidomic Profiles in Synovial Membranes from Inflammatory Arthritis by Mass Spectrometry Imaging
Beatriz Rocha, Berta Cillero-Pastor, Cristina Ruiz-Romero et. al.

Nov 12th, 2019 - Background/Purpose: Early diagnosis of inflammatory arthritis is associated with improved patient outcomes. However, accurate diagnosis can be challenging because of their complexity and heterogeneous nature. Synovitis is a common pathological event undergoing arthritis which causes severe histological changes in the synovium. In this work, we evaluated the lipid signature of the synovium from ...