Bone Mineral Density and Microarchitecture Among Chinese Patients with Rheumatoid Arthritis
Shangyi Jin, Evelyn Hsieh, Weibo Xia et. al.

Nov 12th, 2019 - Background/Purpose: To evaluate alterations of bone mineral density and microarchitecture in patients with rheumatoid arthritis (RA). We also aimed to identify potential factors associated with these alterations. Methods: In this case-control study, patients with RA were recruited from the PUMC Hospital site of the Chinese Registry of rhEumatoiD arthrITis (CREDIT). The primary outcomes were hig...

Biomarkers Identified by Serum Inflammatory Profile Analysis to Predict Biologic Treatment Response in Rheumatoid Arthritis Patients
Chary Lopez-Pedrera, Nuria Barbarroja, Carlos Perez-Sanchez et. al.

Nov 12th, 2019 - Background/Purpose: Biologic disease modifying antirheumatic drugs (b-DMARDs) have revolutionized the management of Rheumatoid Arthritis (RA). Despite this success, a high percentage of the patients undergoing biologic treatment respond insufficiently. There is thus an urgent need to identify effective biomarkers to guide treatment selection. The aim of this study was to identify several specif...

Bone Health: An Independent Predictor of Coronary Artery Disease
Lilian Bizzocchi, Maria Salgado, Bhavin Chokshi et. al.

Nov 12th, 2019 - Background/Purpose: An association between low bone mineral density (BMD) and cardiovascular events has been shown. The calcification process observed in atherosclerosis and bone mineralization have a common pathogenesis pathway. Bone health parameters are not yet incorporated in the cardiovascular risk assessment scale. The objective of our study was to look for an association between standard...

Cytokine and Autoantibody Profiles During Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
Ioannis Parodis, Emil Åkerström, Christopher Sjöwall et. al.

Nov 12th, 2019 - Background/Purpose: The anti-BAFF monoclonal belimumab is approved for the treatment of systemic lupus erythematosus (SLE) since 2011. Effects of belimumab on anti-double stranded (ds)DNA levels, as well as serum levels of B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), both belonging to the tumour necrosis factor (TNF) ligand superfamily, have been demonstrated in ...

Characterization of DOCK8 as a Novel Gene Associated with Macrophage Activation Syndrome
Mingce Zhang, Remy Cron, Devin Absher et. al.

Nov 12th, 2019 - Background/Purpose: Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis (HLH), is a life threatening condition that commonly presents with unremitting fever and shock like multi-organ dysfunction (MOD). Laboratory studies show pancytopenia, elevated liver enzymes, elevated ferritin, and hemophagocytosis. Familial forms of HLH result from homozygous d...

Circulating Mitochondrial Danger-Associated Molecular Patterns as Novel Biomarkers of Disease Activity and Inflammation in Rheumatoid Arthritis
Bhargavi Duvvuri1 and Christian Lood, University of Washington, Seattle

Nov 12th, 2019 - Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease causing erosive and disabling joint damage. We recently found that mitochondria are extruded upon formation of neutrophil extracellular traps (NETs). The extruded mitochondria can be a source of danger-associated molecular patterns (DAMPs) that include highly unmethylated CpG motif content, oxidized mitochondria...

Course of Progressive Lung Fibrosis in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) in the EUSTAR Database
Anna-Maria Hoffmann-Vold, Yannick Allanore, Margarida Alves et. al.

Nov 12th, 2019 - Background/Purpose: The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is heterogeneous; some patients may experience rapid decline in lung function, while others have relatively stable disease. Large patient registries, such as The European Scleroderma Trials and Research (EUSTAR) database, can assist in mapping the trajectory of SSc-ILD and identifying patients at...

Clonal Expansion of a Specific Subset of Cytotoxic CD4+T Cells and Tissue Apoptosis in Patients with IgG4-related Disease
Cory Perugino, Naoki Kaneko, Jesper Kers et. al.

Nov 12th, 2019 - Background/Purpose: In IgG4-related disease (IgG4-RD), both activated B cells and CD4+ cytotoxic T lymphocytes (CD4+CTLs) expand clonally, accumulate in tissues, likely recognize distinct epitopes on the same protein antigens, and thus, work together to contribute to fibrosis. We have previously reported that CD4+CTLs synthesize IL-1β and TGF-β in disease tissues, indicating that they are react...

Changes in Fecal Microbiota Composition After Fecal Microbiota Transplantation in Systemic Sclerosis
Anna Maria Hoffmann-Vold, Håvard Fretheim, Brian Chung et. al.

Nov 12th, 2019 - Background/Purpose: In the double-blind, placebo-controlled 16-week pilot including 10 systemic sclerosis (SSc) patients with upper and lower gastrointestinal (GI) symptoms we found that fecal microbiota transplantation (FMT) with commercially-available anaerobic cultivated human intestinal microbiota (ACHIM) reduced lower GI symptoms. Here, we aimed to determine relative abundance of gut micro...

Clinical Evidence Supporting Therapeutic Potential of Activating the Immune Checkpoint Receptor BTLA in SLE
Matthew Linnik, Adam Godzik, Lukasz Jaroszewski et. al.

Nov 12th, 2019 - Background/Purpose: Background/Purpose:  Immune checkpoint inhibitors have demonstrated durable benefit in some cancer patients.  However, checkpoint inhibitors are also associated with new onset autoimmune adverse events.  The link between checkpoints and autoimmune disease suggests that activating immune checkpoint receptors might be useful in treating autoimmune diseases like SLE.  As the ro...

Comparison of Patient Self-reported Data to Physician-driven Cohorts in Patients with Eosinophilic Granulomatosis with Polyangiitis
Irena Doubelt, Jason Springer, Tanaz Kermani et. al.

Nov 12th, 2019 - Background/Purpose: Aligning perspectives of patients and physicians in the diagnosis and management of diseases is imperative, particularly in rare, chronic diseases such as vasculitis. We sought to compare patient-reported vs. physician-reported clinical manifestations, treatments, and outcomes in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Methods: Retrospective, comp...

Computer Vision Applied to Dual Energy Computed Tomography Images for Precise Calcinosis Cutis Quantification in Patients with Systemic Sclerosis
Anita Chandrasekaran, Imran Omar, Zhicheng Fu et. al.

Nov 12th, 2019 - Background/Purpose: Calcinosis cutis, found in both systemic sclerosis (SSc) and juvenile dermatomyositis patients, can be extensive and debilitating. Potential treatments have been identified, but a standardized and validated method for precise and accurate whole-body calcinosis cutis burden quantification is necessary to allow for valid clinical trials. Dual energy computed tomography (DECT) ...

Current Smoking Status Increases the Risk of Axial Psoriatic Arthritis: An Explanation to Smoking Paradox
Dilek Solmaz, Umut Kalyoncu, Ilaria Tinazzi et. al.

Nov 12th, 2019 - Background/Purpose: Smoking has been shown to be associated with an increased risk of psoriatic arthritis (PsA) in the general population, but there are controversies among patients with psoriasis. We hypothesize that smoking is a risk factor for axial PsA specifically, similar to axial spondyloarthritis, more than the other PsA phenotypes. Methods: PsArt-ID (Psoriatic Arthritis- International ...

Checkpoint Inhibitor-Associated Arthritis: Phenotype, Steroid Dose, Serology and Survival
Karmela Kim Chan, Aidan Tirpack, Caroline Benson et. al.

Nov 12th, 2019 - Background/Purpose: Previous studies suggest that steroid dose1and rheumatoid factor positivity2 impact cancer survival in checkpoint inhibitor (CI)-treated patients (with CI-associated hypophysitis, and in all-comers with non-small cell lung cancer patients respectively).  In this study we describe CI-associated arthritis phenotypes in patients enrolled in a CI registry, and measure the impact...

Cardiovascular Treatment and the Incidence of Giant Cell Arteritis (GCA) – a Population-Based Case-Control Study
Aladdin Mohammad, Pavlos Stamatis 1 and Aleksandra Turkiewicz, Lund University et. al.

Nov 12th, 2019 - Background/Purpose: The aetiology of giant cell arteritis (GCA) is largely unknown. We aimed to evaluate ACE-inhibitors (ACE-i), angiotensin II receptor blockers (ARBs), beta-blocking agents, calcium antagonists, diuretics or other cardiovascular drugs as risk factors for incident GCA. Methods: We included 574 biopsy-proven GCA cases diagnosed between Jan 1st2006 and Oct 31st2015 in the Skåne r...

Clinical Study of Peripheral Blood Lymphocyte Subsets in Patients with Rheumatoid Arthritis Complicated with Osteoporosis
Ting Cheng, Sheng-xiao Zhang, Xiao-qing Liu et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis(RA) is an autoimmune disease mainly manifested by aggressive polyarthritis.The incidence of osteoporosis(OP) has risen and the risk of fracture has further increased in parallel with the prolongation of the disease course,which seriously affects the prognosis and the quality of patients’lives.The purpose of this study is to investigate the incidence of O...

Combined Detection of Cytokines and Biomarkers Improve the Diagnostic Performance of Bacteria Infection in Rheumatoid Arthritis
Yan Qin, Xiangcong Zhao 1 and Jing Luo, the Second Hospital of Shanxi Medical University et. al.

Nov 12th, 2019 - Background/Purpose: Patients with rheumatoid arthritis (RA) suffer a high susceptibility to infection, and many inflammatory cytokines are prognostic in RA, but currently the role of cytokines in identifying infection individuals is rarely studied. We assessed the performance of serum inflammatory cytokines to discriminate bacteria infection from non-infections in RA, and setted up a bioscore s...

Color Doppler Ultrasound for the Diagnosis of Giant Cell Arteritis in Montreal: A Canadian Single Center Experience
Jean-Paul Makhzoum, Meriem Belhocine, Michelle Goulet et. al.

Nov 12th, 2019 - Background/Purpose: Giant Cell Arteritis (GCA) remains challenging to diagnose as false negative temporal artery biopsy (TAB) can occur. Color doppler ultrasonography (CDUS) of the temporal, axillary and carotid arteries is useful when GCA is suspected. A wide range of sensitivities and specificities of CDUS are reported, with better results when performed by a trained sonographer using high re...

Bone Mineral Density of the Spine, Hip, and Distal Radius in Patients with Postmenopausal Osteoporosis
KEN NAKASEKO, Department of Orthopaedic Surgery and Rheumatology Kuwana City Medical Center, kuwana mie et. al.

Nov 12th, 2019 - Background/Purpose: Bone mineral density (BMD) is used for the diagnosis of osteoporosis, predicting future fracture risk, and monitoring osteoporosis treatment. Osteoporosis is defined as BMD of at least 2.5 standard deviations below the young adult mean (YAM) (T-score ≦2.5) according to World Health Organization (WHO) criteria or a BMD of 70% or lower of YAM (YAM% ≦70) according to the Japane...

BMI Has Minimal Effect on Reduction of Symptoms in Patients with Osteoarthritis of the Knee Treated with Diclofenac 1% Gel
Joel A. Block, Bharat Patel 2 and Sandy Yacoub Garas, Rush University Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Clinical trials demonstrate that diclofenac sodium gel 1% (DSG 1%), a topical NSAID, provides significantly better pain relief than vehicle placebo for patients with osteoarthritis (OA) of the knee. As patient BMI may affect the systemic availability and the volume of distribution of topical therapeutics, a post-hoc analysis was conducted to determine whether BMI has any cli...