Yoga Improves Fatigue and Mental Health in Rheumatoid Arthritis: Preliminary Results of a Randomized Controlled Trial
Silva Pukšić, Joško Mitrović, Melanie-Ivana Čulo et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) patients perceive reduced health-related quality of life (HRQOL) through functional disability, pain, increased fatigue and impaired psychological functioning. Previous trials demonstrated that Yoga, a mind-body therapy, can enhance both physical and mental health in various chronic conditions including RA. The primary objective of the study was to ...

Comparison of the Management and Prognosis of Pneumonia in Patients with and Those Without Rheumatoid Arthritis Using the Japanese Diagnosis Procedure Combination Database
Eishi Uechi1 and Kiyohide Fushimi, Tomishiro Central Hospital, Tomigusuku city et. al.

Nov 12th, 2019 - Background/Purpose: Pneumonia is a common cause of death not only in the general population but also in patients with rheumatoid arthritis (RA). In particular, patients with RA have an increased risk for pneumonia due to rheumatoid lung disease and the use of some DMARDs. No studies have assessed differences in the management and prognosis of pneumonia in patients with RA compared to the genera...

Consensus Statement and Recommendations on Methotrexate Use in Combined Therapy with Biological or Targeted Synthetic Disease Modifying Drugs in Patients with Rheumatoid Arthritis
Jesus Tornero, Mercedes Alperi-López, Ivan Castellvi et. al.

Nov 12th, 2019 - Background/Purpose: Our aim was to develop recommendations for the management of methotrexate (MTX) when considering the combination with biological (b) or targeted synthetic (ts) disease modifying drugs (DMARDs) in rheumatoid arthritis (RA). Methods: Methodological procedures included nominal discussion group, systematic literature review, and Delphi survey for agreement. A panel of 11 expert ...

Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet
francesca cedola, Roxana Coras, Marta Fernandez-Bustamante et. al.

Nov 12th, 2019 - Background/Purpose: RA patients often inquire about dietary interventions to improve disease control, as they perceive quick changes in pain and/or swelling after consumption of certain foods. Of particular interest is the influence of diet on modifying circulating pro/anti-inflammatory oxylipins and how this relationship affects pain/inflammation. Here, we determine the effect of a 2-week anti...

Comparison of Healthcare Resource Utilization (HCRU) and Costs of Type 2 Diabetes Mellitus (T2DM)-Related Complications in TNFi-Experienced Medicare Beneficiaries with Rheumatoid Arthritis (RA) and...
Vardhaman Patel, Zulkarnain Pulungan, Anne Shah et. al.

Nov 12th, 2019 - Background/Purpose: Patients with RA experienced an increase in the whole-body insulin sensitivity and a reduction in HbA1c levels from treatment with abatacept, which is a type of targeted DMARD (tDMARD).1 Abatacept is often used in tumor necrosis factor inhibitor (TNFi)-experienced patients; however, comparative impact of tDMARDs on type 2 diabetes mellitus (T2DM) related outcomes is lacking....

Comparing Patient and Provider Perspectives on Long Term Biologic Use and Tapering in Stable, Well-Controlled Rheumatoid Arthritis
Patrick Webster, Nicole Wilson, Christina Payne et. al.

Nov 12th, 2019 - Background/Purpose: The 2015 American College of Rheumatology (ACR) and 2013 European League Against Rheumatology (EULAR) guidelines for management of rheumatoid arthritis (RA) conditionally recommend consideration of tapering biologic regimen in stable RA patients in remission with due consideration of patients’ values and preferences. Given the paucity of data on perspectives, in this study w...

Comparative Analysis of Clinical, Laboratory and Therapeutic Strategies Among Blacks with Rhupus, SLE and RA
Naureen Kabani, Joshy Pathiparampil, Madina Abduraimova et. al.

Nov 12th, 2019 - Background/Purpose: Rhupus is the overlap of SLE and RA. While a few studies have been conducted among Rhupus patients, no studies have focused on Black population with Rhupus. Our aim was to describe the clinical, laboratory, radiographic and therapeutic profiles of predominantly Black patients with Rhupus and to compare this group with age and sex-matched patients with SLE and with RA. Method...

Contribution of Personality Traits, Psychological Factors and Health Related Quality of Life on Medication Adherence in Patients with RA
Kyung Min Ko, Su-Jin Moon, Jung Hee Koh 1 and Jun-Ki Min et. al.

Nov 12th, 2019 - Background/Purpose: Non-adherence to long-term treatment is important in Rheumatoid arthritis (RA), as it can result in inadequate disease control and make rheumatologist to change the treatment strategy. Personality refers to individual differences in characteristic pattern of thinking, feeling and behaving. However, it is not clear that personality could predict medication non-adherence in pa...

Cardiovascular Risk Factors in Rheumatoid Arthritis: Prevalence, Comparison of Risk Calculators and Subclinical Atherosclerosis in Indian Patients
Hafis Muhammed, Durga P Misra, Sujata Ganguly et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis(RA) patients have increased cardiovascular(CV) risk with no data on CV risk scores in Indian patients.The primary objective was to study prevalence of traditional CV risk factors in RA. Secondary objectives were to assess performances of various CV risk scores with respect to each other and against subclinical atherosclerosis as measured by carotid intim...

Comparison Between Fibromyalgia and Neuropathic Pain in Patients with Established Rheumatoid Arthritis
Yong Gil Hwang, Lei Zhu 1 and Larry Moreland, University of Pittsburgh et. al.

Nov 12th, 2019 - Background/Purpose: Our objectives were (1) to identify similarities and differences of pain symptoms identified by fibromyalgia (FM) and neuropathic pain (NP) screening tool (2) to compare pain qualities and their relationship with rheumatoid arthritis (RA) disease activity. Methods: 169 RA patients enrolled in the University of Pittsburgh Rheumatoid Arthritis Comparative Effectiveness Registr...

Discontinuation of Disease Modifying Drugs in Patients with Incident Rheumatoid Arthritis
pia Lois, Zulema Rosales Rosado, Judit Font Urgelles et. al.

Nov 12th, 2019 - Background/Purpose: Treatment of Rheumatoid Arthritis (RA) has undergone a big change in the last two decades in strategies, objectives and therapeutic options, especially with the use of the Disease Modifying Drugs (DMARDs), both synthetic and biological. We have little information about the management of these drugs in real life conditions so it is necessary to expand our knowledge about disc...

Derivation and Validation of a Biomarker-Based Cardiovascular Risk Prediction Score in Rheumatoid Arthritis
Jeffrey Curtis, Fenglong Xie, Cynthia Crowson et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) patients are at elevated risk for cardiovascular (CV) events, but efficient risk stratification based on CV prediction models is not part of routine clinical practice. We constructed and validated a biomarker-based CV risk prediction model and compared it to alternative risk prediction approaches. Methods: Using Medicare administrative data 2006-201...

Differences in the Phenotypic Landscape and Antigen Specificity of CD4+ T Cells Are Present in CCP+ Subjects Before the Onset of Rheumatoid Arthritis
Virginia Muir, Cliff Rims, Kevin Deane et. al.

Nov 12th, 2019 - Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing rheumatoid arthritis (RA) because of serum anti-citrullinated protein antibody (ACPA) positivity in absence of arthritis at baseline, and is focused on defining how they transition from at-risk to classifiable disease. One potential mechanism is the ex...

DNA Methylation of the Dual Specificity Phosphatase 22 (DUSP22) Gene Promoter in Plasma and Medication Use in Rheumatoid Arthritis (RA)
Lissette Delgado-Cruzata, Milena Rodriguez Alvarez, Abhimanyu Amarnani et. al.

Nov 12th, 2019 - Background/Purpose: The Dual Specificity Phosphatase 22 (DUSP22) gene expression has been shown to be regulated via DNA methylation of its promoter. In addition, aberrant DNA methylation of DUSP22 in lymphocytes has been observed in RA patients and it has been linked to erosive disease. Global DNA hypomethylation of lymphocyte cell subpopulations from RA patients was reversed after  methotrexat...

Differential Methylation of Peripheral Blood Adaptive Immune Cells in Individuals at High Risk for RA and with Early RA Compared with Controls Identifies Pathways Important in Transition to Arthritis
Rizi Ai, David Boyle, Deepa Hammaker et. al.

Nov 12th, 2019 - Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing RA because of serum anti-citrullinated protein antibody positivity in absence of arthritis, and is focused on defining how they transition from at-risk to classifiable disease. One potential mechanism is through alterations in epigenetics patterns in a...

DMARD-naïve Rheumatoid Arthritis (RA) Patients Have Greater RAPID3 Improvement over 6 Months After 1st Visit Than Patients Who Were Treated Previously Treated with DMARDs, Although Baseline RAPID3 ...
Theodore Pincus, jaquelin Chua, Joel Block 2 and Isabel Castrejon et. al.

Nov 12th, 2019 - Background/Purpose: A study of patients with RA at their first visit to an academic rheumatology site indicated an unexpected observation that 75% of patients had a history of prior treatment with either glucocorticoids or disease modifying antirheumatic drug (DMARD) agents, while only 25% were DMARD-naïve (1).  Therefore, we analyzed a hypothesis that DMARD-naïve RA patients would have greater...

Depression and Subsequent Risk for Incident Seronegative Rheumatoid Arthritis Among Women
Jeffrey Sparks, Susan Malspeis, Jill Hahn et. al.

Nov 12th, 2019 - Background/Purpose: Depression is associated with elevated systemic inflammation and risk of several chronic diseases including lupus, psoriasis, and inflammatory bowel disease. However, the association between depression and subsequent risk for developing RA is less clear. Therefore, we hypothesized that depression may increase RA risk. Since depression may develop in the period prior to clini...

Disease Flares of Rheumatoid Arthritis During Pregnancy: What Is the Impact of Stopping bDMARDs at the Beginning of Pregnancy?
Maria Chiara Gerardi, Laura Andreoli, Antía García-Fernández et. al.

Nov 12th, 2019 - Background/Purpose: During pregnancy, patients with rheumatoid arthritis (RA) can experience flares that might influence pregnancy outcomes. We aimed at assessing disease course during pregnancy and identifying possible risk factors of disease flares. Methods: Data about RA patients prospectively followed in a pregnancy clinic were retrospectively collected before conception and during each tri...

Distribution and Predictors of Whole Blood Hydroxychloroquine Levels in Clinical Rheumatology Practices in the United States
Thierry Dervieux, Kelley Brady, Don Thomas et. al.

Nov 12th, 2019 - Background/Purpose: Therapeutic drug monitoring of whole blood Hydroxychloroquine (HCQ) can help identify patients at risk of flares due to underexposure (e.g. severe non-adherence, < 200 ng/ml) or alternatively those with heightened risk of retinal toxicity due to overexposure (e.g. HCQ >1733 ng/ml) (Petri M et al. Arthritis Rheumatol. 2018). Our purpose was to report and evaluate factors asso...

Differences in Fracture Risk Assessment (FRAX) and Osteoporosis Treatment Cutoffs with and Without Bone Mineral Density Are Greater in Anti-Cyclic Citrullinated Peptide Positive Rheumatoid Arthritis
Katherine Wysham, Jonathan Graf, Mary Margaretten et. al.

Nov 12th, 2019 - Background/Purpose: FRAX (Fracture Risk Assessment Tool) is the most commonly used tool to estimate 10-year fracture risk. FRAX estimates are performed with and without bone mineral density (BMD) measures; the BMD-adjusted FRAX (BMD-FRAX) provides a more sensitive estimate. In the United States, if FRAX major osteoporotic fracture (MOF) risk is ≥20% or the hip fracture risk is ≥3% or the T-scor...