Persistence of B Cell-rich Synovitis Following Conventional Synthetic Disease Modifying Anti-Rheumatic Drug Treatment in Early Rheumatoid Arthritis Is Associated with Radiographic Progression Indep...
Felice Rivellese, Gloria Lliso-Ribera, Alessandra Nerviani et. al.

Nov 13th, 2019 - Background/Purpose: Synovial B cell aggregates in patients with early Rheumatoid Arthritis (RA) have been associated with disease severity and radiographic progression. Here, we analysed the presence of B cells and their association with clinical outcomes in matched synovial biopsies pre- and post- treatment with conventional synthetic Disease Modifying anti-Rheumatic Drug (scDMARDs). Methods: ...

Prevalence of Systemic Lupus Erythematosus in the United States: Preliminary Estimates from a Meta-Analysis of the Centers for Disease Control and Prevention Lupus Registries
Emily Somers, Lu Wang, W Joseph McCune et. al.

Nov 13th, 2019 - Background/Purpose: The heterogeneity of the clinical manifestations of systemic lupus erythematosus (SLE) and lack of a diagnostic test make SLE difficult for epidemiologists to study. The Centers for Disease Control and Prevention (CDC) supported five population-based SLE surveillance registries, using harmonized methodology, to better estimate incidence and prevalence of SLE in diverse areas...

Perturbation of the Human Gut Microbiome by Methotrexate Contributes to the Resolution of Inflammation and Autoimmune Disease
Renuka Nayak, Margaret Alexander, Kye Stapleton-Grey et. al.

Nov 13th, 2019 - Background/Purpose: The trillions of microorganisms (microbiota) found within the human gut play a critical role in shaping the immune system, yet these complex microbial communities are also highly sensitive to numerous environmental factors. While much of the focus to date has been on dietary intake, emerging data has begun to suggest that the use of pharmaceutical drugs, even those that are ...

Predictors to Develop Definite Systemic Sclerosis (SSc): Results from an International Multicentre Study on Very Early DiagnOsis of Systemic Sclerosis (VEDOSS)
Silvia Bellando-Randone, Gemma Lepri, Dorte Huscher et. al.

Nov 13th, 2019 - Background/Purpose: The very early diagnosis of SSc is a challenge today. The aim of the VEDOSS project was to study in an at-risk population, the clinical signs that could predict the progression toward a definite SSc. Methods: Patients with Raynaud phenomenon (RP), with or without anti-nuclear antibodies (abs) (ANA) were recruited for this longitudinal, observational study. Fulfilling the 201...

Hypoxia Resistant Pathogenic B Cells Accumulate in the RA Synovial Tissue in a CXCR3 Dependent Manner
Achilleas Floudas, Candice Low, Monika Biniecka et. al.

Nov 13th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown and complex aetiology with severe detrimental effects for the patient’s quality of life. While autoantibodies have been used extensively for the diagnosis of RA, no clear mechanism of action towards disease pathogenesis and progression has been identified. Importantly, both seropositive and ser...

High Resolution 3D Fast Spin-Echo T1 Black-Blood Imaging for the Diagnosis of Giant Cell Arteritis
Christine rodriguez, Wagih Ben Hassen, Pierre Seners et. al.

Nov 13th, 2019 - Background/Purpose: Giant cell arteritis (GCA) is the most common form of vasculitis of large arteries affecting people older than 50 years. Temporal artery biopsy (TAB) is still considered as the gold standard for GCA diagnosis but it is invasive and its sensitivity ranges from 39 to 86%.Color Doppler Ultrasonography and PET-scanner have been proposed as alternative methods for GCA diagnosis b...

EHR treat-to-target prompts spur RA medication management decisions
Jeff Craven

Nov 12th, 2019 - ATLANTA – Opportunities to escalate or deescalate medications for patients with rheumatoid arthritis via an electronic health record at the point of care led rheumatologists at the Geisinger Medical Center in Danville, Pa. , to increase the number of such decisions in their practice.

B-cell-poor RA responds better to tocilizumab than to rituximab
Sharon Worcester

Nov 12th, 2019 - ATLANTA – Tocilizumab proved more effective than rituximab in B-cell-poor but not in B-cell-rich patients with RA who have had an inadequate response to disease-modifying antirheumatic drugs (DMARDs) and tumor necrosis factor inhibition in the randomized, open-label, 48-week, phase 4 R4-RA trial. Sharon Worcester/MDedge News Dr.

Even low-dose steroids increase DMARD infection risk
MDedge Rheumatology; M. Alexander Otto

Nov 12th, 2019 - ATLANTA – Concomitant use of even low-dose steroids increases the risk of serious infections with antirheumatic drugs, according to a review of 170,357 Medicare patients by investigators at the University of Pennsylvania, Philadelphia. Dr.

Bromodomain Inhibitor, I-BET762 Inhibits Production of Pro-inflammatory in Rheumatoid Arthritis Fibroblast-like Synoviocytes and Differentiation of Osteoclast
Ra Ham Kim, Hyun Jung Yoo, Shin Eui Kang et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by joint inflammation and bone destruction. The fibroblast-like synoviocyte(FLS) contributes to the pathogenesis of RA through cellular proliferation and production of cytokines or chemokines. Recently, blockade of the bromodomain and extra-terminal domain (BET) family protein was reported to be a pote...

Cracks in Your Referral Process? Find Your Sustainable Solution Here
Sheetal Vora, Amanda Moyer, Lynn Kalhagen et. al.

Nov 12th, 2019 - Background/Purpose: Early diagnosis for rheumatic conditions is crucial for children to achieve the best functional outcomes. Access to care is difficult due to the volume of referrals and paucity of pediatric rheumatologists. This compelling need to expediently triage dire and complex rheumatology referrals has been painfully demonstrated in our clinic. When this project was initiated there wa...

Beyond Genes—a Multi-omic Analysis of Monozygotic Twins Discordant for Rheumatoid Arthritis
Julia Manasson, Jeremy Sokolove, Lauren Lahey et. al.

Nov 12th, 2019 - Background/Purpose: Although a number of genetic factors, including susceptibility alleles, have been identified in rheumatoid arthritis (RA), the concordance rate in monozygotic (MZ) twins is only 15% (Silman AJ et al, Br J Rheumatol 1993). Given this relatively low rate, environmental factors (including smoking, the microbiome and others) likely play a significant role in disease pathogenesis...

Baseline Characteristics Associated with Sustained SDAI Remission Following Treatment with Abatacept in Combination with MTX Compared with Abatacept Placebo in Combination with MTX in ACPA Positive...
Paul Emery, Yoshiya Tanaka, Vivian Bykerk et. al.

Nov 12th, 2019 - Background/Purpose: The Phase IIIb Assessing Very Early Rheumatoid arthritis Treatment (AVERT)-2 trial (NCT02504268) is evaluating SC abatacept (ABA) + MTX versus ABA placebo (PBO) + MTX in adults with early RA.1 AVERT-2 was designed to demonstrate that ABA + MTX could achieve higher rates of SDAI remission versus ABA PBO + MTX and to test a clinically meaningful withdrawal strategy. Identifyin...

BATF2 Contributes to Interferon Dysregulation in SLE Keratinocytes
Jessica Turnier, Celine Berthier, Lam Tsoi et. al.

Nov 12th, 2019 - Background/Purpose: Skin inflammation can drive systemic disease in SLE, thus it is essential to understand the key regulators of the aberrant inflammatory response in lupus skin. We have previously identified BATF2 as a transcription factor that is highly overexpressed in lupus keratinocytes following type I IFN exposure. The objective of this study was to determine the role of BATF2 in regula...

Bone Mineral Density in Psoriatic Arthritis: Results from a Longitudinal Study
Timothy Kwok, Justine (Yang) Ye, Daniel Pereira 2 and Dafna Gladman et. al.

Nov 12th, 2019 - Background/Purpose: Evidence thus far on the effect of psoriatic arthritis (PsA) on bone mineral density (BMD) has been inconsistent. There is also insufficient guidance surrounding BMD testing in PsA patients. The purpose of this study was to determine BMD in the PsA population, factors associated with having BMD testing performed, and the effect of PsA clinical activity on BMD. Methods: : Thi...

Bone Microstructure of Patients with Rheumatoid Arthritis: A HR-pQCT Study
Ikuko Tanaka, Takashi Kato, Hiroaki Mizuno et. al.

Nov 12th, 2019 - Background/Purpose: In rheumatoid arthritis (RA), it has been reported that osteoclast are activated by immune complexes, anti-CCP antibodies (ACPAs), and inflammatory cytokines. The purpose of this study was to investigate the relationship between bone microstructure and joint involvement by imaging the distal radius using HR-pQCT. Methods: Subjects were 127 female patients with RA, who were e...

Body Mass Index and Systemic Corticosteroid Use as Indicators of Disease Burden and Their Influence on the Safety Profile of Certolizumab Pegol Across Indications
Vivian Bykerk, Andrew Blauvelt, Jeffrey Curtis et. al.

Nov 12th, 2019 - Background/Purpose: Certolizumab pegol (CZP) is an anti-TNF drug approved for rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), psoriasis (PSO) and Crohn’s disease (CD). Older age, comorbidities and corticosteroid (CS) use have been linked to increased risk of serious infectious events (SIEs) in CZP-treated patients (pts) with RA.1 However, the impact of ove...

Bone Mineral Density and Microarchitecture Among Chinese Patients with Rheumatoid Arthritis
Shangyi Jin, Evelyn Hsieh, Weibo Xia et. al.

Nov 12th, 2019 - Background/Purpose: To evaluate alterations of bone mineral density and microarchitecture in patients with rheumatoid arthritis (RA). We also aimed to identify potential factors associated with these alterations. Methods: In this case-control study, patients with RA were recruited from the PUMC Hospital site of the Chinese Registry of rhEumatoiD arthrITis (CREDIT). The primary outcomes were hig...

Biomarkers Identified by Serum Inflammatory Profile Analysis to Predict Biologic Treatment Response in Rheumatoid Arthritis Patients
Chary Lopez-Pedrera, Nuria Barbarroja, Carlos Perez-Sanchez et. al.

Nov 12th, 2019 - Background/Purpose: Biologic disease modifying antirheumatic drugs (b-DMARDs) have revolutionized the management of Rheumatoid Arthritis (RA). Despite this success, a high percentage of the patients undergoing biologic treatment respond insufficiently. There is thus an urgent need to identify effective biomarkers to guide treatment selection. The aim of this study was to identify several specif...

Bone Health: An Independent Predictor of Coronary Artery Disease
Lilian Bizzocchi, Maria Salgado, Bhavin Chokshi et. al.

Nov 12th, 2019 - Background/Purpose: An association between low bone mineral density (BMD) and cardiovascular events has been shown. The calcification process observed in atherosclerosis and bone mineralization have a common pathogenesis pathway. Bone health parameters are not yet incorporated in the cardiovascular risk assessment scale. The objective of our study was to look for an association between standard...