Body Composition and Fat Distribution in Patients with Psoriasis or Psoriatic Arthritis
Eric Toussirot, Francois Aubin, maxime Desmarets et. al.

Nov 12th, 2019 - Background/Purpose: Obesity is a leading comorbidity in both psoriasis (Pso) and psoriatic arthritis (PsA) and is associated with common metabolic complications and increased cardiovascular (CV) risk. Obesity is also a risk factor for the onset of these diseases. Body composition and fat distribution have been rarely evaluated in Pso and PsA. In this study, we aimed to characterize the fat mass...

Biological Therapy Is Associated with Faster Recovery and Lower Frequency of Switch Treatment in Patients with Chikungunya Fever
Aline Razolin, Claudia Marques, Laurindo Rocha Jr et. al.

Nov 12th, 2019 - Background/Purpose: Background/purpose. The first chikungunya fever outbreak in Brazil had its peak in the first half of 2016 and many patients with rheumatologic disease using biological disease-modifying antirheumatic drugs (bDMARD) and conventional synthetic disease-modifying antirheumatic drugs therapy (csDMARD) were affected by the disease. Although there was initially concerns about the u...

Baseline Characteristics and Quality of Life Metrics in Non-Infectious Uveitis
Jessica Shantha, Amy Cassedy, Joseph McDonald et. al.

Nov 12th, 2019 - Background/Purpose: Uveitis is a heterogenous group of ocular inflammatory diseases. Underlying disease and treatment can lead to poor quality of life (QOL), depression, and increased health care costs. Our aim is to evaluate overall QOL, vision related QOL, anxiety and depression in a cohort of children with non-infectious uveitis at the Cincinnati Children’s Hospital Medical Center. Methods: ...

BK Polyomavirus Viremia and Viruria in Patients with Autoimmune Connective Tissue Diseases: Impact of Immunosuppressants
Mamatha Katikaneni, Madeline Davis, Carolyn Smith 2 and John Vanchiere et. al.

Nov 12th, 2019 - Background/Purpose: The human polyomaviruses, such as the BK and JC virus, are highly prevalent in humans but appear to cause clinical disease only in immunocompromised patients. BK virus (BKV) is the primary cause of tubulointerstitial nephritis and ureteral stenosis in kidney transplant recipients and hemorrhagic cystitis in bone marrow transplant recipients. Among transplant recipients, it h...

Burden of Systemic Lupus Erythematosus Among Korean Women in Childbearing Years Based on the National Health Insurance Service Data
Min Kyung Chung, Jin Su Park, Hyun Sun Lim et. al.

Nov 12th, 2019 - Background/Purpose: Most women with systemic lupus erythematosus (SLE) are diagnosed with the disease in their reproductive ages, but the burden of SLE among women in childbearing years remains incompletely understood. We aimed to investigate the burden of SLE among Korean women in childbearing years in terms of prevalence and incidence of disease, prevalence of comorbidity, medication dispensi...

Bone Metabolism Impairment in Heart Transplant: Results from a Prospective Cohort Study
Luis Seguro, Rosa Pereira, Luciana Seguro et. al.

Nov 12th, 2019 - Background/Purpose: Data on prevention of fractures after heart transplant (HTx) are controversial in the literature. Understanding the effects of HTx on bone may guide appropriate treatment in this high-risk population. Methods: Seventy adult patients submitted to HTx were followed for 12 months. Clinical and laboratory parameters, bone mineral density (BMD), body composition, microarchitectur...

Belatacept in Systemic Lupus Erythematosus (SLE) Kidney Transplant Patients
Irene Carrión-Barberà, Melissa Fajardo, Demetra Tsapepas et. al.

Nov 12th, 2019 - Background/Purpose: Lupus nephritis (LN) ultimately requires renal replacement therapy (RRT) in 10-30% of LN patients. Thirty percent of these patients receive a kidney transplant. Belatacept is a second-generation, selective, T-cell co-stimulator blocker (inhibits CTLA-4) used as an alternative to calcineurin inhibitors (CNI) for maintenance regimens after kidney transplants. The pathogenic re...

Comparison of Medication New User Definitions in Multi-Specialty EMR Data
Jeffrey Curtis, Lang Chen, Narender Annapureddy et. al.

Nov 12th, 2019 - Background/Purpose: New user designs are typically preferred in pharmacoepidemiology to avoid bias. The optimal implementation of a new user design in electronic medical record (EMR) data, where the concept of ‘enrollment’ does not necessarily exist, has not been well studied. Methods: We used data from PCORnet, a large U.S. comparative effectiveness research network consisting of multiple EMR ...

Cluster Analysis for Classification of Japanese Antineutrophil Cytoplasmic Antibody-associated Vasculitis: Subgroup Analysis of Nationwide Cohort Studies
Haruki Watanabe, Ken-ei Sada, Masayoshi Harigai 3 and Hirofumi Makino et. al.

Nov 12th, 2019 - Background/Purpose: The predominance of myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA) and interstitial lung disease (ILD) have been reported as characteristics of Japanese patients with ANCA-associated vasculitis (AAV) recently. A previous report using cluster analysis showed that the importance of ANCA type and renal involvement in Western countries. Because of the considerable di...

Coronary Artery Disease in a Population-Based Cohort of Biopsy-Proven Giant Cell Arteritis in Southern Sweden
Pavlos Stamatis, Moman Mohammad, Peter Merkel et. al.

Nov 12th, 2019 - Background/Purpose: The aim of this study was to estimate the incidence rate and prevalence of coronary artery diseases (CAD) in patients with temporal artery positive giant cell arteritis (TAB+GCA) from a defined population in southern Sweden, and to describe characteristics of CAD in this sample. Methods: The study cohort consisted of 1202 patients (71.9% women) diagnosed with TAB+GCA between...

Characteristics of Psoriasis Patients with Subclinical Signs of Musculoskeletal Involvement Detected by Fluorescence Optical Imaging and Confirmed by MRI-assessment
Michaela Koehm, Sarah Ohrndorf, Tanja Rossmanith et. al.

Nov 12th, 2019 - Background/Purpose: Psoriasis (Pso) is one of the most common chronic inflammatory skin diseases in Europe. Psoriatic arthritis (PsA) is closely associated to Pso whereas the skin manifestation appears usually years before PsA-related symptoms emerge. Up to 30% of Pso patients develop PsA, but there is no clear correlation between disease duration of Pso and PsA development. Therefore, biomarke...

Co-morbidities in Patients with OA and RA: Results from a Large US Rheumatic Disease Registry
Sofia Pedro, Rebecca Schumacher, Alyssa Dominique et. al.

Nov 12th, 2019 - Background/Purpose: The burden of co-morbid conditions can impact the overall quality of life in patients with RA and OA. However, the presence of common co-morbidities in inflammatory and degenerative arthritis is not well described. We sought to compare overlapping co-morbidities in the two patient groups. Methods: We identified patients with physician-diagnosed OA and RA in FORWARD, The Nati...

Combined First-Trimester Serum BAFF and sFlt-1 Levels as an Early Biomarker of Spontaneous Abortion
Hindi Stohl, Ning Yu 2 and William Stohl, Harbor-UCLA Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Immunologic, angiogenic, and anti-angiogenic factors have been associated with spontaneous abortion (SAB), yet early identification of those pregnant women who ultimately undergo SAB remains very limited. B-cell activating factor (BAFF; a vital B cell survival factor), a proliferation-inducing ligand (APRIL; a vital plasma cell survival factor), placental growth factor (PlGF...

Comparison of Single and Dual Latent Tuberculosis Screening Strategies Before the Initiation of Biologic and Targeted Therapy in Rheumatological Patients in Hong Kong
Yan Ki Tang, Ho So, Weng Nga Virginia Lao et. al.

Nov 12th, 2019 - Background/Purpose: Screening for latent tuberculosis infection (LTBI) before the initiation of biologic and targeted synthetic disease modifying anti-rheumatic drugs (b/tsDMARDs) is recommended internationally especially in tuberculosis (TB) endemic areas like Hong Kong. However, there is no gold-standard. The local guideline recommends the use of either tuberculin-skin-test (TST) or interfero...

Clinical Impact of Decreasing Hydroxychloroquine Dose According to the 2016 American Academy of Ophthalmology Guidelines in Patients with Systemic Lupus Erythematosus
Nicolle Medina-Cintrón, Ileana Vázquez-Otero, Mariangelí Arroyo-Ávila et. al.

Nov 12th, 2019 - Background/Purpose: Hydroxychloroquine (HCQ) is one of the main drugs used for the treatment of systemic lupus erythematosus (SLE). Nonetheless, HCQ-induced retinal toxicity remains a major concern. To reduce the risk of HCQ-induced retinopathy, in 2016 the American Academy of Ophthalmology recommended a maximum daily HCQ dose of ≤5.0 mg/kg real weight. However, it is uncertain if this recommen...

Cardiovascular Disease in Rheumatoid Arthritis: Risk Factors and the Role of Auto-antibodies
Leticia Ferri, Grace Crocket, Yuting Kuang et. al.

Nov 12th, 2019 - Background/Purpose: Shorter life expectancy in RA patients has in part been associated with an increased incidence of cardiovascular disease (CVD). This literature review summarizes the current understanding of CVD in the RA population, focusing on the role of risk factors and auto-antibodies. Methods: A systematic literature review was conducted by searching MEDLINE, Embase, and Cochrane CENTR...

Contemporary Prescription Opioid Use and Predictors Among Patients with Systemic Lupus Erythematosus
April Jorge, Na Lu 2 and Hyon K. Choi, Massachusetts General Hospital et. al.

Nov 12th, 2019 - Background/Purpose: SLE is a complex illness that can be associated with chronic pain. In recent years, an international opioid epidemic has become a major public health concern and is attributed, in part, to prescription opioids. We assessed contemporary patterns of opioid prescribing among patients with SLE in a general population context and examined potential associations with prescription ...

Complement Component 3 as Biomarker of Cardiometabolic Risk in Rheumatic Diseases: Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis and Systemic Lupus Erythematosus
Ivan Arias de la Rosa, Alejandro Escudero, Maria Dolores Lopez-Montilla et. al.

Nov 12th, 2019 - Background/Purpose: Patients with rheumatic diseases have an increased risk of cardiovascular disease (CVD). Cardiometabolic disease includes an alteration in metabolic organs and CV system that might contribute to the development of CVD. Complement factors have recently been associated with metabolic events such as metabolic syndrome.  Objectives: 1) To evaluate the levels of complement C3 in ...

Changes in B Cell Profile as a Marker of Clinical Remission to TNF Inhibitors in Patients with Rheumatoid Arthritis
Borja Hernández-Breijo, Israel Nieto-Gañán, Cristina Sobrino et. al.

Nov 12th, 2019 - Background/Purpose: According to the EULAR recommendations, the therapeutic objective in patients with rheumatoid arthritis (RA) should be remission. Biological therapies, as TNF inhibitors (TNFi), have allowed to increase remission rates although these are still limited (20-47%). There is still unknown if peripheral blood mononuclear cells (PBMC) play a role as predictors of response in patien...

Characteristics of Patients with Rheumatoid Arthritis Undergoing Primary Total Joint Replacement: A 14-year Trend Analysis (2004-2017)
Shuji Asai, Toshihisa Kojima, Nobunori Takahashi 1 and Naoki Ishiguro et. al.

Nov 12th, 2019 - Background/Purpose: Total joint replacement (TJR) is performed when severe large joint destruction causes functional disability in patients with rheumatoid arthritis (RA). Biologics were approved in Japan for use in patients with RA in July 2003. We hypothesized that newer medications including biologics and more aggressive treatment strategies to suppress disease activity might have led to a d...