Computer Vision Applied to Dual Energy Computed Tomography Images for Precise Calcinosis Cutis Quantification in Patients with Systemic Sclerosis
Anita Chandrasekaran, Imran Omar, Zhicheng Fu et. al.

Nov 12th, 2019 - Background/Purpose: Calcinosis cutis, found in both systemic sclerosis (SSc) and juvenile dermatomyositis patients, can be extensive and debilitating. Potential treatments have been identified, but a standardized and validated method for precise and accurate whole-body calcinosis cutis burden quantification is necessary to allow for valid clinical trials. Dual energy computed tomography (DECT) ...

Current Smoking Status Increases the Risk of Axial Psoriatic Arthritis: An Explanation to Smoking Paradox
Dilek Solmaz, Umut Kalyoncu, Ilaria Tinazzi et. al.

Nov 12th, 2019 - Background/Purpose: Smoking has been shown to be associated with an increased risk of psoriatic arthritis (PsA) in the general population, but there are controversies among patients with psoriasis. We hypothesize that smoking is a risk factor for axial PsA specifically, similar to axial spondyloarthritis, more than the other PsA phenotypes. Methods: PsArt-ID (Psoriatic Arthritis- International ...

Checkpoint Inhibitor-Associated Arthritis: Phenotype, Steroid Dose, Serology and Survival
Karmela Kim Chan, Aidan Tirpack, Caroline Benson et. al.

Nov 12th, 2019 - Background/Purpose: Previous studies suggest that steroid dose1and rheumatoid factor positivity2 impact cancer survival in checkpoint inhibitor (CI)-treated patients (with CI-associated hypophysitis, and in all-comers with non-small cell lung cancer patients respectively).  In this study we describe CI-associated arthritis phenotypes in patients enrolled in a CI registry, and measure the impact...

Cardiovascular Treatment and the Incidence of Giant Cell Arteritis (GCA) – a Population-Based Case-Control Study
Aladdin Mohammad, Pavlos Stamatis 1 and Aleksandra Turkiewicz, Lund University et. al.

Nov 12th, 2019 - Background/Purpose: The aetiology of giant cell arteritis (GCA) is largely unknown. We aimed to evaluate ACE-inhibitors (ACE-i), angiotensin II receptor blockers (ARBs), beta-blocking agents, calcium antagonists, diuretics or other cardiovascular drugs as risk factors for incident GCA. Methods: We included 574 biopsy-proven GCA cases diagnosed between Jan 1st2006 and Oct 31st2015 in the Skåne r...

Clinical Study of Peripheral Blood Lymphocyte Subsets in Patients with Rheumatoid Arthritis Complicated with Osteoporosis
Ting Cheng, Sheng-xiao Zhang, Xiao-qing Liu et. al.

Nov 12th, 2019 - Background/Purpose: Rheumatoid arthritis(RA) is an autoimmune disease mainly manifested by aggressive polyarthritis.The incidence of osteoporosis(OP) has risen and the risk of fracture has further increased in parallel with the prolongation of the disease course,which seriously affects the prognosis and the quality of patients’lives.The purpose of this study is to investigate the incidence of O...

Combined Detection of Cytokines and Biomarkers Improve the Diagnostic Performance of Bacteria Infection in Rheumatoid Arthritis
Yan Qin, Xiangcong Zhao 1 and Jing Luo, the Second Hospital of Shanxi Medical University et. al.

Nov 12th, 2019 - Background/Purpose: Patients with rheumatoid arthritis (RA) suffer a high susceptibility to infection, and many inflammatory cytokines are prognostic in RA, but currently the role of cytokines in identifying infection individuals is rarely studied. We assessed the performance of serum inflammatory cytokines to discriminate bacteria infection from non-infections in RA, and setted up a bioscore s...

Color Doppler Ultrasound for the Diagnosis of Giant Cell Arteritis in Montreal: A Canadian Single Center Experience
Jean-Paul Makhzoum, Meriem Belhocine, Michelle Goulet et. al.

Nov 12th, 2019 - Background/Purpose: Giant Cell Arteritis (GCA) remains challenging to diagnose as false negative temporal artery biopsy (TAB) can occur. Color doppler ultrasonography (CDUS) of the temporal, axillary and carotid arteries is useful when GCA is suspected. A wide range of sensitivities and specificities of CDUS are reported, with better results when performed by a trained sonographer using high re...

Bone Mineral Density of the Spine, Hip, and Distal Radius in Patients with Postmenopausal Osteoporosis
KEN NAKASEKO, Department of Orthopaedic Surgery and Rheumatology Kuwana City Medical Center, kuwana mie et. al.

Nov 12th, 2019 - Background/Purpose: Bone mineral density (BMD) is used for the diagnosis of osteoporosis, predicting future fracture risk, and monitoring osteoporosis treatment. Osteoporosis is defined as BMD of at least 2.5 standard deviations below the young adult mean (YAM) (T-score ≦2.5) according to World Health Organization (WHO) criteria or a BMD of 70% or lower of YAM (YAM% ≦70) according to the Japane...

BMI Has Minimal Effect on Reduction of Symptoms in Patients with Osteoarthritis of the Knee Treated with Diclofenac 1% Gel
Joel A. Block, Bharat Patel 2 and Sandy Yacoub Garas, Rush University Medical Center et. al.

Nov 12th, 2019 - Background/Purpose: Clinical trials demonstrate that diclofenac sodium gel 1% (DSG 1%), a topical NSAID, provides significantly better pain relief than vehicle placebo for patients with osteoarthritis (OA) of the knee. As patient BMI may affect the systemic availability and the volume of distribution of topical therapeutics, a post-hoc analysis was conducted to determine whether BMI has any cli...

Body Composition and Fat Distribution in Patients with Psoriasis or Psoriatic Arthritis
Eric Toussirot, Francois Aubin, maxime Desmarets et. al.

Nov 12th, 2019 - Background/Purpose: Obesity is a leading comorbidity in both psoriasis (Pso) and psoriatic arthritis (PsA) and is associated with common metabolic complications and increased cardiovascular (CV) risk. Obesity is also a risk factor for the onset of these diseases. Body composition and fat distribution have been rarely evaluated in Pso and PsA. In this study, we aimed to characterize the fat mass...

Biological Therapy Is Associated with Faster Recovery and Lower Frequency of Switch Treatment in Patients with Chikungunya Fever
Aline Razolin, Claudia Marques, Laurindo Rocha Jr et. al.

Nov 12th, 2019 - Background/Purpose: Background/purpose. The first chikungunya fever outbreak in Brazil had its peak in the first half of 2016 and many patients with rheumatologic disease using biological disease-modifying antirheumatic drugs (bDMARD) and conventional synthetic disease-modifying antirheumatic drugs therapy (csDMARD) were affected by the disease. Although there was initially concerns about the u...

Baseline Characteristics and Quality of Life Metrics in Non-Infectious Uveitis
Jessica Shantha, Amy Cassedy, Joseph McDonald et. al.

Nov 12th, 2019 - Background/Purpose: Uveitis is a heterogenous group of ocular inflammatory diseases. Underlying disease and treatment can lead to poor quality of life (QOL), depression, and increased health care costs. Our aim is to evaluate overall QOL, vision related QOL, anxiety and depression in a cohort of children with non-infectious uveitis at the Cincinnati Children’s Hospital Medical Center. Methods: ...

BK Polyomavirus Viremia and Viruria in Patients with Autoimmune Connective Tissue Diseases: Impact of Immunosuppressants
Mamatha Katikaneni, Madeline Davis, Carolyn Smith 2 and John Vanchiere et. al.

Nov 12th, 2019 - Background/Purpose: The human polyomaviruses, such as the BK and JC virus, are highly prevalent in humans but appear to cause clinical disease only in immunocompromised patients. BK virus (BKV) is the primary cause of tubulointerstitial nephritis and ureteral stenosis in kidney transplant recipients and hemorrhagic cystitis in bone marrow transplant recipients. Among transplant recipients, it h...

Burden of Systemic Lupus Erythematosus Among Korean Women in Childbearing Years Based on the National Health Insurance Service Data
Min Kyung Chung, Jin Su Park, Hyun Sun Lim et. al.

Nov 12th, 2019 - Background/Purpose: Most women with systemic lupus erythematosus (SLE) are diagnosed with the disease in their reproductive ages, but the burden of SLE among women in childbearing years remains incompletely understood. We aimed to investigate the burden of SLE among Korean women in childbearing years in terms of prevalence and incidence of disease, prevalence of comorbidity, medication dispensi...

Bone Metabolism Impairment in Heart Transplant: Results from a Prospective Cohort Study
Luis Seguro, Rosa Pereira, Luciana Seguro et. al.

Nov 12th, 2019 - Background/Purpose: Data on prevention of fractures after heart transplant (HTx) are controversial in the literature. Understanding the effects of HTx on bone may guide appropriate treatment in this high-risk population. Methods: Seventy adult patients submitted to HTx were followed for 12 months. Clinical and laboratory parameters, bone mineral density (BMD), body composition, microarchitectur...

Belatacept in Systemic Lupus Erythematosus (SLE) Kidney Transplant Patients
Irene Carrión-Barberà, Melissa Fajardo, Demetra Tsapepas et. al.

Nov 12th, 2019 - Background/Purpose: Lupus nephritis (LN) ultimately requires renal replacement therapy (RRT) in 10-30% of LN patients. Thirty percent of these patients receive a kidney transplant. Belatacept is a second-generation, selective, T-cell co-stimulator blocker (inhibits CTLA-4) used as an alternative to calcineurin inhibitors (CNI) for maintenance regimens after kidney transplants. The pathogenic re...

Comparison of Medication New User Definitions in Multi-Specialty EMR Data
Jeffrey Curtis, Lang Chen, Narender Annapureddy et. al.

Nov 12th, 2019 - Background/Purpose: New user designs are typically preferred in pharmacoepidemiology to avoid bias. The optimal implementation of a new user design in electronic medical record (EMR) data, where the concept of ‘enrollment’ does not necessarily exist, has not been well studied. Methods: We used data from PCORnet, a large U.S. comparative effectiveness research network consisting of multiple EMR ...

Cluster Analysis for Classification of Japanese Antineutrophil Cytoplasmic Antibody-associated Vasculitis: Subgroup Analysis of Nationwide Cohort Studies
Haruki Watanabe, Ken-ei Sada, Masayoshi Harigai 3 and Hirofumi Makino et. al.

Nov 12th, 2019 - Background/Purpose: The predominance of myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA) and interstitial lung disease (ILD) have been reported as characteristics of Japanese patients with ANCA-associated vasculitis (AAV) recently. A previous report using cluster analysis showed that the importance of ANCA type and renal involvement in Western countries. Because of the considerable di...

Coronary Artery Disease in a Population-Based Cohort of Biopsy-Proven Giant Cell Arteritis in Southern Sweden
Pavlos Stamatis, Moman Mohammad, Peter Merkel et. al.

Nov 12th, 2019 - Background/Purpose: The aim of this study was to estimate the incidence rate and prevalence of coronary artery diseases (CAD) in patients with temporal artery positive giant cell arteritis (TAB+GCA) from a defined population in southern Sweden, and to describe characteristics of CAD in this sample. Methods: The study cohort consisted of 1202 patients (71.9% women) diagnosed with TAB+GCA between...

Characteristics of Psoriasis Patients with Subclinical Signs of Musculoskeletal Involvement Detected by Fluorescence Optical Imaging and Confirmed by MRI-assessment
Michaela Koehm, Sarah Ohrndorf, Tanja Rossmanith et. al.

Nov 12th, 2019 - Background/Purpose: Psoriasis (Pso) is one of the most common chronic inflammatory skin diseases in Europe. Psoriatic arthritis (PsA) is closely associated to Pso whereas the skin manifestation appears usually years before PsA-related symptoms emerge. Up to 30% of Pso patients develop PsA, but there is no clear correlation between disease duration of Pso and PsA development. Therefore, biomarke...