Patients’ Journeys Through Giant Cell Arteritis: A Qualitative Study
Jennie Best, Ivan Nunez, Kristina Woodburn et. al.

Nov 12th, 2019 - Background/Purpose: Diagnosis of giant cell arteritis (GCA) is difficult due to multiple presenting symptoms, and access to care may be delayed because often multiple providers are involved in the diagnosis of GCA and disease management. Treatment with high-dose glucocorticoids (GCs) can relieve symptoms and prevent vision loss, but GC-related adverse events are common; GCA often relapses once ...

Prevalence of Anxiety and Depression in a Cohort of Patients with Rheumatic Diseases on Biological Infusions
Alexander Peck, Ella Starobinska, Gilbert Ortega et. al.

Nov 12th, 2019 - Background/Purpose: Studies have shown an increased prevalence of psychologic disorders in rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriatic arthritis, compared to the general population. Of note, the coexistence of anxiety and depression with rheumatic diseases has been linked to worse outcomes and increased health care utilization. Our aim was to ex...

Prevalence of Thyroid Dysfunction with Therapeutic Indication in Patients with Rheumatological Diseases
Sho Fukui, Genki Kidoguchi, Takehiro Nakai et. al.

Nov 12th, 2019 - Background/Purpose: Thyroid dysfunction (TD) is known as a common complication of rheumatological diseases (RD). Treatment for TD is important not only in clinical TD for controlling symptom but also in some patients with subclinical ones especially for cardiovascular events in the future. But the data about prevalence of hypothyroidism or hyperthyroidism requiring treatment and it’s changes wi...

Patients with Axial Spondyloarthritis Have Abnormal Microarchitecture Despite Normal Areal Bone Mineral Density and Trabecular Bone Score by DXA
Dalit Ashany, Susan Goodman, Haley Tornberg et. al.

Nov 12th, 2019 - Background/Purpose: Axial Spondyloarthritis (axSpA) is characterized by abnormal bone formation that produces syndesmophytes, while paradoxically, inflammation causes increased bone resorption and skeletal fragility. Detection of osteoporosis using DXA can be challenging as syndesmophytes falsely elevate spine areal bone mineral density (aBMD). In contrast, high-resolution peripheral QCT (HRpQC...

PET/CT Vascular Findings at Baseline and Six Months in Patients with Newly Diagnosed Giant Cell Arteritis
Anthony Sammel, Edward Hsiao, Geoff Schembri et. al.

Nov 12th, 2019 - Background/Purpose: PET/CT is a useful modality to diagnose GCA but there is limited knowledge as to how inflammatory vascular findings evolve on follow-up scans. This cohort study aimed to determine the change and clinical significance in vascular wall tracer (FDG) uptake in GCA patients from diagnosis to six-months. Methods: This study included a subset of patients from the previously reporte...

Preexisting Autoimmune Disease and Rheumatic Immune-Related Adverse Events Associated with Cancer Immunotherapy: A Case Series from the Canadian Research Group of Rheumatology in Immuno-Oncology (C...
Linda Laaouad, Janet Roberts, Daniel Ennis et. al.

Nov 12th, 2019 - Background/Purpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by harnessing the immune system to fight cancer, but are associated with significant immune-related adverse events (irAEs). Limited data is available on the safety of ICIs in patients with preexisting autoimmune diseases and on concomitant use of immunosuppressive drugs. CanRIO is a network of Canadian rh...

Post-Approval Comparative Safety Study of Tofacitinib and Biologic DMARDs: Five‑Year Results from a US-based Rheumatoid Arthritis Registry
Joel Kremer, Clifton Bingham, Laura Cappelli et. al.

Nov 12th, 2019 - Background/Purpose: Tofacitinib is an oral JAK inhibitor for the treatment of RA. Real‑world data (RWD) complement clinical trial data in assessing long-term safety. We evaluated 5-year adverse event (AE) incidence rates (IRs) in new starters of tofacitinib vs biologic (b)DMARDs using cohorts from the US Corrona RA registry. Methods: This prospective, observational 5-year study in the ongoing U...

Patient Beliefs and Perceptions of Methotrexate for the Treatment of Rheumatoid Arthritis and Psoriatic Arthritis
W. Benjamin Nowell, Elaine Karis, Kelly Gavigan et. al.

Nov 12th, 2019 - Background/Purpose: Methotrexate (MTX) is a frequently used therapy in both Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) due to its beneficial effects in both populations. Despite the well-known benefits of MTX, it is associated with a number of potential side effects and tolerability issues including nausea and fatigue, gastrointestinal toxicity, skin reactions, headaches, mouth sor...

Prescribing Exercise: Facilitators and Barriers to the Successful Implementation of Physical Activity Guidelines in Inflammatory Arthritis
Lauren Freid, Alexis Ogdie 2 and Joshua Baker, Hospital of the University of Pennsylvania et. al.

Nov 12th, 2019 - Background/Purpose: Physical Activity (PA) is beneficial for people with inflammatory arthritis (IA).  In 2018, EULAR published the first recommendations for guiding PA in patients with IA.1These endorsed the American College of Sports Medicine-American Heart Association Public Health Recommendations, which encourage participation in four domains of PA: Aerobic, Resistance, Flexibility, and Bal...

Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Adam Goode, Rebecca Cleveland, David Hu et. al.

Nov 12th, 2019 - Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis  predict the incidence and worsening of lumbar spine disc space narrowing (DSN), facet joint OA (FOA), osteophytes (OST), and spondylolisthesis. Methods: These analyses used baseline (2006-2010) and follow-up (2013-2015) data from the Johnston County OA Project. Paire...

Pain Chronification and the Important Role of Non-disease Specific Symptoms in Patients with Systemic Sclerosis
Caroline Evers, Suzana Jordan, Britta Maurer et. al.

Nov 12th, 2019 - Background/Purpose: Pain is a frequent, yet inadequately explored challenge in patients with systemic sclerosis (SSc). The aim of this study was to conduct an extensive pain assessment, examining pain chronification and its association with disease manifestation. Methods: Consecutive SSc patients attending their annual assessment in the Department of Rheumatology, Zurich, Switzerland were inclu...

Pain and Anxiety Are Independent Factors Associated to Sleep Impairment in Psoriatic Arthritis: A Multicentric Study in 14 Countries
Penelope Palominos, Laura Coates, Charles Kohem et. al.

Nov 12th, 2019 - Background/Purpose: Sleep quality is diminished in patients with psoriatic arthritis (PsA) and close to 40% of PsA patients consider sleep impairment a priority domain.This work analyzed determinants of impaired sleep in patients with PsA. Methods: This was a cross-sectional analysis of an observational study (ReFlap, NCT03119805), which included adult patients with definite PsA with ≥ 2 years ...

Predictors of Advanced Chronic Kidney Disease in Patients with ANCA Vasculitis and Renal Involvement
Gelsomina Alle, John Jaramillo Gallego, Marina Scolnik et. al.

Nov 12th, 2019 - Background/Purpose: The aim of this study was to evaluate the predictors of advanced chronic kidney disease (ACKD) in patients with Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and renal involvement. Methods: Observational retrospective study. We included all patients with biopsy-proven ANCA glomerulonephritis (GN) diagnosed between 2001 and 2016, with at least one year of ...

Patient Perception of Benefit and Risks Associated with Hydroxychloroquine Use in Systemic Lupus Erythematosus (SLE)
Sooyeon Kwon, Jessica Farrell, Sarfaraz Hasni 3 and Shubhasree Banerjee et. al.

Nov 12th, 2019 - Background/Purpose: Hydroxychloroquine (HCQ) is recommended in all patients with systemic lupus erythematosus (SLE).  Studies suggest that a significant proportion of subjects are non-adherent to daily HCQ, leading to poor disease control, increasing morbidity and mortality. One of the main barriers to adherence is reported to be patients’ fear of side effects most notably retinopathy.  The obj...

Provider Variability in Glucocorticoid Prescribing for Patients with Rheumatoid Arthritis and Impact on Chronic Glucocorticoid Use
Michael George, Joshua Baker, Lang Chen et. al.

Nov 12th, 2019 - Background/Purpose: Glucocorticoids are recommended as short-term bridging therapy in patients with rheumatoid arthritis (RA), but as many as 30-40% of patients remain on glucocorticoids chronically. We aimed to measure the variability in the prescribing of glucocorticoids among rheumatologists and determine whether seeing a provider with a greater preference for glucocorticoids was independent...

Pharmacokinetics and Exposure-response of Intravenous Belimumab in Children with Systemic Lupus Erythematosus
Richard Dimelow, Beulah Ji2 and Herbert Struemper, GSK et. al.

Nov 12th, 2019 - Background/Purpose: Belimumab is approved in adults with active SLE and for childhood-onset SLE (cSLE). PLUTO, a Phase 2, placebo-controlled, double-blind trial (114055; NCT01649765), was the first study of belimumab in cSLE. Efficacy, safety, and pharmacokinetics (PK) of intravenous (IV) belimumab 10 mg/kg, plus standard therapy were evaluated. Pediatric and adult belimumab exposures were comp...

Prospective Evaluation of American Academy of Ophthalmology Low Dose Hydroxychloroquine Recommendation in Stable Lupus Nephritis with High-Risk Retinopathy: Lipid Profile and Flare Rates
Tatiana Pedrosa, Sandra G. Pasoto, Emily Yuki et. al.

Nov 12th, 2019 - Background/Purpose: Hydroxychloroquine (HCQ) is the most well established therapy for SLE, as it provides several beneficial properties, such as favorable effects on lipid profile, reduced cardiovascular (CV) risk and reduction in flares. However, one of the main concerns about HCQ use is retinopathy. In this regard, the American Academy of Ophthalmology (AAO) recently recommended the maximum d...

Profile of Renal Function in Patient Suffering from Rheumatoid Arthritis
Denis Choquette, Louis Bessette, Loïc Choquette Sauvageau et. al.

Nov 12th, 2019 - Background/Purpose: Many medications used in the treatment of rheumatoid arthritis (RA) impact renal function. Some of these may be contraindicated in the presence of a certain degree of renal failure or may require dosage adjustment. Product monograph of different molecules such as hydroxychloroquine (HCQ), methotrexate (MTX), sulfasalazine (SSZ), tofacitinib (TOFA) address the issue with diff...

Predictors of Relapse in Giant Cell Arteritis: Data from an International Collaboration
Laure Delaval, Raphael Porcher, Kenneth Warrington et. al.

Nov 12th, 2019 - Background/Purpose: Roughly half of giant-cell arteritis (GCA) patients taking only glucocorticoids (GCs) relapse. The relapse rate seems to reflect, in part, the duration of GC intake, more than the initial dose at induction. However, the GCA-relapse rate varied widely in observational studies and randomized–controlled trials. We aimed to identify factors predictive of GCA relapse based on dat...

Prevalence of Corticosteroid Use in Incidental Vertebral or Hip Fractures
Gurjit Kaeley, Julie Ferm 2 and Lanh Dang, University of Florida et. al.

Nov 12th, 2019 - Background/Purpose: Non-traumatic vertebral and hip fractures are detrimental complications of osteoporosis and those with a previous fracture have double the risk of subsequent fractures. The objective of this quality improvement (QI) project was to determine the baseline characteristics that may have contributed to the vertebral or hip fracture and determine if bone health was optimized subse...