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Live Zoster Vaccine Safe in People on TNF Inhibitors
https://www.medscape.com/viewarticle/921734

Nov 25th, 2019 - NEW YORK (Reuters Health) - Patients with rheumatic diseases who are on tumor-necrosis-factor inhibitor (TNFi) therapy can safely receive the live varicella zoster vaccine, without risking vaccine-related infection, a new study suggests. "Because patients with rheumatic diseases are at higher risk for reactivation of herpes zoster, also known as shingles, prevention of this painful condition is...

The Trick of Treating Cancer in Autoimmune Diseases
https://www.medscape.com/viewarticle/921742

Nov 21st, 2019 - ATLANTA — "Immunotherapy operates on this very simple principle: a patient's cancer can be eradicated if we can just instruct the immune system to eradicate it," said Ryan Sullivan, MD, associate director of the melanoma program at Massachusetts General Hospital in Boston. "But for patients with autoimmune disease, it comes with a catch." Immunotherapy helps a patient's immune system locate and...

Atmospheric and Environmental Changes Tied to Organ-Specific Lupus Flares
https://www.medscape.com/viewarticle/921471

Nov 19th, 2019 - NEW YORK (Reuters Health) - Changes in atmospheric and environmental factors may contribute to organ-specific disease exacerbation in patients with systemic lupus erythematosus (SLE), according to a new study. The study found "strong associations between atmospheric variables and fine particulate matter concentration over the 10 days prior to a patient visit and organ-specific lupus flares at t...

Personal Goals Crucial in Virtual Reality Physical Training
https://www.medscape.com/viewarticle/921558

Nov 18th, 2019 - ATLANTA — Virtual reality can help patients with movement issues, but only if it is done correctly and tailored to individual patients, said Robert Ferguson, a neurorehabilitation clinical specialist who focuses on such therapy. Clinicians "are reading the research and they are applying it wrong," he explained. "The evidence suggests that it's not about the virtual reality, it's about how you u...

Few Serious Infections in Babies Exposed to Non-TNF-inhibitor Biologics or Tofacitinib
https://www.medscape.com/viewarticle/921317

Nov 18th, 2019 - NEW YORK (Reuters Health) - Children born to mothers with chronic inflammatory diseases who took non-tumor-necrosis-factor inhibitor (TNFi) biologics or tofacitinib while pregnant appear to be at low risk of developing serious infections, a new analysis suggests. "Our findings help to address the important knowledge gap in biologic and small-molecule drug safety in pregnancy and our data are re...

Arthritis Risk Underestimated in Children With Down Syndrome
https://www.medscape.com/viewarticle/921501

Nov 17th, 2019 - The prevalence of arthritis in children with Down syndrome is at least two times greater than previously reported, findings from a new study suggest, but the diagnosis is often missed or significantly delayed. There are several reasons for this, including a lack of awareness on the part of clinicians and parents that children with Down syndrome can be at high risk for what's known as arthropath...

The 'Silver Lining' of the Opioid Crisis: More Pain Research
https://www.medscape.com/viewarticle/921497

Nov 17th, 2019 - Congress has appropriated almost a billion dollars in 2018 and 2019 so that the National Institutes of Health (NIH) can address the opioid epidemic. About half of that money is to address pain management, reported Charles Helmick, MD, who works on the NIH Helping to End Addiction Long-term (HEAL) initiative, which supports research into pain. "Reducing prescribed opioids means addressing arthri...

New Guidelines Underway for Gout and Vasculitis
https://www.medscape.com/viewarticle/921433

Nov 14th, 2019 - ATLANTA — A first look at new guidelines for the treatment of gout was presented here at the American College of Rheumatology (ACR) 2019 Annual Meeting. A key update is to use a treat-to-target strategy with urate-lowering therapy for all patients with gout. The draft guidelines recommend starting patients on a low-dose urate-lowering medication, then increasing the dose to reach and maintain a...

How Old Outcome Surveys Let Young Patients Down
https://www.medscape.com/viewarticle/921422

Nov 14th, 2019 - ATLANTA — Young adults with chronic illnesses are not being asked the right questions on surveys of patient-reported outcome measures, warns an international focus group. Younger adults saw the outcomes on daily functioning as outdated, said Erika Mosor, MSc, from the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, who is president-elect ...

Immune Checkpoints Viable in Cancer Patients With RA
https://www.medscape.com/viewarticle/921272

Nov 12th, 2019 - ATLANTA — Immune checkpoint inhibitors are safe and effective for patients with rheumatoid arthritis who develop malignancies, report investigators. "In the real world, patients with autoimmune conditions are at a higher risk for malignancies" than people in the general population, said Sabina Sandigursky, MD, from the NYU Langone Medical Center in New York City. Sabina Sandigursky "Our study s...

AstraZeneca Succeeds in Treating Lupus in Late-Stage Study
https://www.medscape.com/viewarticle/921064

Nov 11th, 2019 - (Reuters) - AstraZeneca Plc said on Monday its experimental treatment anifrolumab significantly reduced disease activity in patients with systemic lupus erythematosus (SLE) in its late-stage study TULIP-2 study. The results pit anifrolumab against GlaxoSmithKline Plc's Benlysta (belimumab) - the only new drug approved for lupus in the last 60 years. Benlysta recorded 473 million pounds of globa...

Patient Advocacy a Vital Aspect of Clinical Practice
https://www.medscape.com/viewarticle/921075

Nov 10th, 2019 - ATLANTA — Twenty years ago, Kim Schofield was a single mom with a successful career. She was active in her community and her church, she drove her daughter to dance practice, and she'd just bought a house near Atlanta. She had never heard of lupus. That changed one day when her left eye turned red and her vision got blurry. She went to her ophthalmologist, who sent her to a primary care physici...

Nature Inspires Research Ideas to Improve Medical Care
https://www.medscape.com/viewarticle/921028

Nov 9th, 2019 -   David Hu, PhD, from the Georgia Institute of Technology in Atlanta, is studying animal biomechanics to inspire clinical innovations that can help humans David Hu, PhD, professor of mechanical engineering and biology at the Georgia Institute of Technology in Atlanta, wonders about everyday things that other people take for granted. How does a dog dry itself? How long does it take to urinate? H...

Year in Review: Psoriatic Arthritis
https://www.medpagetoday.com/rheumatology/arthritis/83077

Nov 1st, 2019 - Major new insights into the treatment of psoriatic arthritis (PsA) dominated the headlines during the past year, with a head-to-head trial comparing interleukin (IL)-17A inhibition with tumor necrosis factor (TNF) blockade, another study considering whether methotrexate can improve outcomes with anti-TNF therapy in PsA, and an investigation into the effects of biologic therapy on bone. These br...

Discharge After Knee Replacement: Race Matters
https://www.medpagetoday.com/surgery/orthopedics/83076

Nov 1st, 2019 - African-American patients who underwent total knee arthroplasty were more likely than whites to be discharged to an inpatient or skilled nursing facility after the procedure, and also to be readmitted to an acute care hospital within 90 days, a large retrospective cohort study found. Among 107,768 individuals who had knee replacement surgeries, the likelihood of being discharged to an inpatient...

Frailty Predicts Damage in SLE
https://www.medpagetoday.com/rheumatology/lupus/82915

Oct 23rd, 2019 - A frailty index helped predict future disease damage in patients with systemic lupus erythematosus (SLE), an international group of researchers and experts reported. On a multivariable analysis, each 0.05-point increase in the baseline frailty index developed by the Systemic Lupus International Collaborating Clinics (SLICC) group was associated with a 20% higher rate of later damage accumulatio...

Treatment Still Falls Short in Majority With RA
https://www.medpagetoday.com/rheumatology/arthritis/82887

Oct 23rd, 2019 - More than half of patients with rheumatoid arthritis (RA) with persistent moderate-to-high disease activity after 6 months of treatment with a conventional disease-modifying anti-rheumatic drug (DMARD) did not have their therapy escalated, a U.S. registry study found. Among 409 patients enrolled in the Corrona registry from 2014 to 2018 with moderate-to-high disease activity at baseline, and wh...

Joint Injections: Are They Worth the Risk?
https://www.medpagetoday.com/rheumatology/arthritis/82753

Oct 15th, 2019 - Intra-articular injections of corticosteroids for relief of the pain of hip or knee osteoarthritis (OA) may have adverse long-term consequences, researchers suggested. These injections are commonly performed and have been "conditionally" recommended by the American College of Rheumatology and "should be considered," according to the Osteoarthritis Research Society International. The American Ac...

Consider centralized pain in patients with rheumatic disease
https://www.mdedge.com/surgery/article/209664/pain/consider-centralized-pain-patients-rheumatic-disease/page/0/1?channel=237

Oct 8th, 2019 - Opioid responsiveness To examine whether fibromyalgia survey results correlate with outcomes after knee and hip arthroplasty, Dr. Clauw and colleagues conducted a prospective, observational cohort study that included approximately 500 people.

We Have a Winner: Head-to-Head Study Compares Biologics for PsA
https://www.medpagetoday.com/rheumatology/arthritis/82499

Sep 30th, 2019 - Ixekizumab (Taltz) was superior to adalimumab (Humira) at 24 weeks in an open-label, ongoing, multicenter head-to-head trial evaluating both skin and joint symptoms in psoriatic arthritis (PsA), investigators reported. On the primary endpoint of the simultaneous achievement of a 50% improvement on the articular criteria of the American College of Rheumatology (ACR50) and a 100% clearing on the ...