M. Alexander Otto
Nov 11th, 2019 - ATLANTA – Black race was the single greatest predictor of cardiovascular disease (CVD) events in systemic lupus erythematosus, with black patients having an 18-fold higher risk than white patients from 2 years before to 8 years after diagnosis, according to a review of 336 patients in the Georgia Lupus Registry that was presented at the annual meeting of the American College of Rheumatology. Th.
Nov 11th, 2019 - ATLANTA – Guselkumab improved outcomes in psoriatic arthritis patients regardless of past treatment with tumor necrosis factor inhibitors in the phase 3 DISCOVER-1 trial. The anti-interleukin-23p19 monoclonal antibody is approved in the United States for the treatment of moderate to severe plaque psoriasis (PsO).
Nov 11th, 2019 - ATLANTA – A group of patients using a tumor necrosis factor inhibitor safely received the live-attenuated varicella vaccine Zostavax without any cases of herpes zoster in the first 6 weeks after vaccination in the blinded, randomized, placebo-controlled Varicella Zoster Vaccine (VERVE) trial. Dr.
Nov 10th, 2019 - ATLANTA — Twenty years ago, Kim Schofield was a single mom with a successful career. She was active in her community and her church, she drove her daughter to dance practice, and she'd just bought a house near Atlanta. She had never heard of lupus. That changed one day when her left eye turned red and her vision got blurry. She went to her ophthalmologist, who sent her to a primary care physici...
Nov 9th, 2019 - David Hu, PhD, from the Georgia Institute of Technology in Atlanta, is studying animal biomechanics to inspire clinical innovations that can help humans David Hu, PhD, professor of mechanical engineering and biology at the Georgia Institute of Technology in Atlanta, wonders about everyday things that other people take for granted. How does a dog dry itself? How long does it take to urinate? H...
Nov 5th, 2019 - A computer-based, self-administered test for cognitive impairment could be used to screen for cognitive impairment in adults with systemic lupus erythematosus, new research suggests. In a paper published in Arthritis Care & Research, researchers assessed the validity of the Automated Neuropsychological Assessment Metrics (ANAM) test in 211 adult patients with systemic lupus erythematosus (SLE).
Nov 1st, 2019 - Major new insights into the treatment of psoriatic arthritis (PsA) dominated the headlines during the past year, with a head-to-head trial comparing interleukin (IL)-17A inhibition with tumor necrosis factor (TNF) blockade, another study considering whether methotrexate can improve outcomes with anti-TNF therapy in PsA, and an investigation into the effects of biologic therapy on bone. These br...
Nov 1st, 2019 - African-American patients who underwent total knee arthroplasty were more likely than whites to be discharged to an inpatient or skilled nursing facility after the procedure, and also to be readmitted to an acute care hospital within 90 days, a large retrospective cohort study found. Among 107,768 individuals who had knee replacement surgeries, the likelihood of being discharged to an inpatient...
Oct 23rd, 2019 - A frailty index helped predict future disease damage in patients with systemic lupus erythematosus (SLE), an international group of researchers and experts reported. On a multivariable analysis, each 0.05-point increase in the baseline frailty index developed by the Systemic Lupus International Collaborating Clinics (SLICC) group was associated with a 20% higher rate of later damage accumulatio...
Oct 23rd, 2019 - More than half of patients with rheumatoid arthritis (RA) with persistent moderate-to-high disease activity after 6 months of treatment with a conventional disease-modifying anti-rheumatic drug (DMARD) did not have their therapy escalated, a U.S. registry study found. Among 409 patients enrolled in the Corrona registry from 2014 to 2018 with moderate-to-high disease activity at baseline, and wh...
Oct 15th, 2019 - Intra-articular injections of corticosteroids for relief of the pain of hip or knee osteoarthritis (OA) may have adverse long-term consequences, researchers suggested. These injections are commonly performed and have been "conditionally" recommended by the American College of Rheumatology and "should be considered," according to the Osteoarthritis Research Society International. The American Ac...
Oct 8th, 2019 - Opioid responsiveness To examine whether fibromyalgia survey results correlate with outcomes after knee and hip arthroplasty, Dr. Clauw and colleagues conducted a prospective, observational cohort study that included approximately 500 people.
Sep 30th, 2019 - Ixekizumab (Taltz) was superior to adalimumab (Humira) at 24 weeks in an open-label, ongoing, multicenter head-to-head trial evaluating both skin and joint symptoms in psoriatic arthritis (PsA), investigators reported. On the primary endpoint of the simultaneous achievement of a 50% improvement on the articular criteria of the American College of Rheumatology (ACR50) and a 100% clearing on the ...
Jan 3rd, 2019 - Test your knowledge of the featured topics and findings reported at rheumatology’s annual educational gathering
Dec 19th, 2018 - Eli Lilly and Co. has announced positive results from the phase 3b/4, multicenter, randomized, open-label, parallel-group SPIRIT-H2H trial, which compared ixekizumab (Taltz) with adalimumab (Humira) in patients with psoriatic arthritis who had previously not taken a biologic disease-modifying antirheumatic drug.
Dec 19th, 2018 - CHICAGO – A specific type of natural killer cell has for the first time been implicated as playing a key contributory role in the development of psoriatic arthritis in patients with psoriasis. Bruce Jancin/MDedge News Dr.
Dec 18th, 2018 - A weekly full-body massage may be an effective way to help patients with knee osteoarthritis (OA) manage pain, data from a randomized trial show. "Osteoarthritis is a leading cause of disability and affects more than 30 million people in America," lead author Adam Perlman, MD, program director of the Leadership Program in Integrative Healthcare at Duke University School of Medicine, Durham, Nor...
MDedge Rheumatology; Bruce Jancin
Dec 18th, 2018 - CHICAGO – Canakinumab, a human monoclonal antibody targeting interleukin-1 beta, was associated with an eye-popping 45% relative risk reduction in the rate of total knee or hip replacement in a prespecified secondary analysis of the landmark CANTOS trial, Matthias Schieker, MD, reported at the annual meeting of the American College of Rheumatology. Bruce Jancin/MDedge News Dr.
Dec 18th, 2018 - Teaching in the inpatient setting can be a tall task, hindered by a lack of time, an unpredictable environment and a variety of learners encountered at different levels. But a few techniques—based mainly on understanding who your students are and how they prefer to learn—can make a big difference, an expert said at the 2018 ACR/ARHP Annual Meeting.
Dec 18th, 2018 - Throughout medical training, you have guideposts and guardrails all around you: academic advisors, professors in the classroom, preceptors in the clinic during residency. But once you get a job as a medical faculty member, you’re basically on your own.