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The role of the IAC Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy ...
https://doi.org/10.1111/cyt.13085
Cytopathology : Official Journal of the British Society F... Sundar PM, Shanmugasundaram S et. al.

Dec 7th, 2021 - Stratification of breast lesions for appropriate management is achieved through an integration of clinical examination, imaging, and fine needle aspiration biopsy (FNAB). The current study aimed to evaluate the combined effectiveness of Breast Imaging- Reporting and Data System (BI-RADS); a widely used system with the International Academy of Cytology (IAC) Yokohama System for Reporting Breast ...

Patient-Friendly Summary of the ACR Appropriateness Criteria Asymptomatic Patient at Ri...
https://doi.org/10.1016/j.jacr.2021.09.031
Journal of the American College of Radiology : JACR; Hahn E, Jhala K

Dec 6th, 2021 - Patient-Friendly Summary of the ACR Appropriateness Criteria Asymptomatic Patient at Risk for Coronary Artery Disease.|2021|Hahn E,Jhala K,|

ACR TI-RADS and ATA ultrasound classifications are helpful for the management of thyroi...
https://doi.org/10.3233/CH-211304
Clinical Hemorheology and Microcirculation; Cao J, Huang W et. al.

Dec 6th, 2021 - To compare the application value of the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) and the American Thyroid Association (ATA) guidelines in the risk stratification of thyroid isthmic nodules. A total of 315 patients with thyroid isthmic nodules (315 nodules) confirmed by surgical pathology or fine-needle aspiration biopsy (FNAB) were selected in this...

The P4 study: Subsequent pregnancy maternal physiology after hypertensive and normotens...
https://doi.org/10.1016/j.preghy.2021.10.004
Pregnancy Hypertension; Kennedy R, Roberts L et. al.

Dec 6th, 2021 - Hypertensive disorders of pregnancy are associated with subsequent increased risk of cardiometabolic disease. Adverse cardiometabolic measures are noted soon after hypertensive versus normotensive pregnancy (NP); to what degree these persist into a subsequent pregnancy (SP) is unknown. This study aimed to assess women's physiology early in SP after hypertensive pregnancy (HP: preeclampsia or ge...

"Rheumatology is Amazing": ACR Presidential Address.
https://doi.org/10.1002/art.42039
Arthritis & Rheumatology (Hoboken, N.J.); Karp DR

Dec 4th, 2021 - "Rheumatology is Amazing": ACR Presidential Address.|2021|Karp DR,|

A framework for validating open-source pulse sequences.
https://doi.org/10.1016/j.mri.2021.11.014
Magnetic Resonance Imaging; Tong G, Gaspar AS et. al.

Dec 4th, 2021 - Open-source pulse sequence programs offer an accessible and transparent approach to sequence development and deployment. However, a common framework for testing, documenting, and sharing open-source sequences is still needed to ensure sequence usability and repeatability. We propose and demonstrate such a framework by implementing two sequences, Inversion Recovery Spin Echo (IRSE) and Turbo Spi...

Rheumatoid Arthritis Highlights From ACR 2021
https://www.mdedge.com/rheumatology/article/249124/acr-2021-rheumatoid-arthritis/rheumatoid-arthritis-highlights-acr-2021
Stanley B. Cohen, MD

Dec 3rd, 2021 - Rheumatologist Stanley B. Cohen from UT Southwestern Medical School offers insight on key findings in rheumatoid arthritis (RA) presented at ACR 2021.

Systemic Lupus Erythematosus Updates at ACR 2021: Novel Agents and Combination Regimens
https://www.mdedge.com/rheumatology/article/249175/systemic-lupus-erythematosus-updates-acr-2021-novel-agents-and
Joan Merrill, MD

Dec 3rd, 2021 - Dr Joan Merrill, of the Oklahoma Medical Research Foundation in Oklahoma City, reviews updates on several treatment options for systemic lupus erythematosus that were presented at the 2021 ACR Convergence. Dr Merrill begins by sharing data from a phase 2 study in which she and her colleagues investigated the efficacy and safety data for iberdomide.

Population pharmacokinetics and exposure-response modeling analyses of guselkumab in pa...
https://doi.org/10.1111/cts.13197
Clinical and Translational Science; Chen Y, Miao X et. al.

Dec 3rd, 2021 - Guselkumab is an anti-interleukin-23 human monoclonal antibody effective in treating psoriatic arthritis (PsA). To characterize the pharmacokinetics (PKs) and exposure-response relationship of guselkumab in PsA, population PKs, and exposure-response modeling, analyses were conducted using data from pivotal phase III studies of subcutaneous guselkumab in patients with PsA. The observed serum con...

Interobserver Variability of Ultrasound Features Based on American College of Radiology...
https://doi.org/10.1097/RUQ.0000000000000512
Ultrasound Quarterly; Özel A, Türkyılmaz Mut D et. al.

Dec 3rd, 2021 - The aim of this study is to evaluate the variability of selecting the ultrasound features used in American College of Radiology Thyroid Imaging Reporting and Data System (ACR-TIRADS) and in assigning the ACR-TIRADS level in a single center among radiologists and radiology residents. The study cohort consisted of 108 thyroid nodules in 102 patients who had definite cytology results after thyroid...

Chronic kidney disease, physical activity, and cognitive function in older adults- resu...
https://doi.org/10.1093/ndt/gfab338
Nephrology, Dialysis, Transplantation : Official Publicat... Chu NM, Hong J et. al.

Dec 2nd, 2021 - Cognitive impairment is common among persons with chronic kidney disease (CKD) due in part to reduced kidney function. Given that physical activity (PA) is known to mitigate cognitive decline, we examined whether associations between CKD stage and global/domain-specific cognitive function differs by PA. We leveraged 3,223 participants (aged≥60years) enrolled in National Health and Nutrition Exa...

Evaluation of SIGLEC1 in the diagnosis of suspected systemic lupus erythematosus.
https://doi.org/10.1093/rheumatology/keab875
Rheumatology (Oxford, England); Zorn-Pauly L, von Stuckrad ASL et. al.

Dec 2nd, 2021 - To evaluate and compare the diagnostic accuracy of SIGLEC1, a surrogate marker of type I IFN, with established biomarkers in an inception cohort of systemic lupus erythematosus (SLE). SIGLEC1 was analyzed by flow cytometry in 232 patients referred to our institution with suspected SLE between October 2015 and September 2020. SLE was confirmed in 76 of 232 patients (32.8%) according to the 2019 ...

Tofacitinib Yields Rapid and Sustained Improvement in Juvenile Idiopathic Arthritis
https://www.medscape.com/viewarticle/963672

Nov 29th, 2021 - NEW YORK (Reuters Health) - Tofacitinib significantly reduces the number of flares in children with polyarticular course juvenile idiopathic arthritis (JIA), according to the first phase-3 clinical trial to assess the efficacy of a Janus kinase (JAK) inhibitor in JIA. JIA is a heterogeneous group of chronic conditions with no known cause that develop before age 16 years, the study team explains...

Epidemiology of Childhood-Onset Systemic Lupus Erythematosus: A Population-Based Study.
https://doi.org/10.1002/acr.24827
Arthritis Care & Research; Valenzuela-Almada MO, Hocaoglu M et. al.

Nov 27th, 2021 - To characterize the incidence and prevalence of childhood onset systemic lupus erythematosus (cSLE), and to estimate the proportion of patients who are diagnosed with SLE during childhood. A cohort of patients with incident cSLE in 1976 to 2018 from a US 8-county region were identified based on comprehensive medical record review. All cases met the European League Against Rheumatism (EULAR)/Ame...

Gout during the SARS-CoV-2 pandemic: increased flares, urate levels and functional impr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613459
Clinical Rheumatology; García-Maturano JS, Torres-Ordaz DE et. al.

Nov 26th, 2021 - Gout is the most common inflammatory arthritis, but was not considered in most COVID-19 and rheumatic diseases reports. Our aim was to describe changes in clinical data, treatment, function and quality of life for gout patients during COVID-19 pandemic. Prospective, descriptive and analytical study of 101 consecutive gout (ACR/EULAR 2015) patients from our clinic evaluated during pandemic by ph...

NICE Updates Recommendation on the Management of Diabetes
https://www.medscape.com/viewarticle/963686

Nov 26th, 2021 - NICE has issued updated guidance on the management of type 2 diabetes (T2D) in adults, which include new recommendations on the treatment of T2D in patients with chronic kidney disease (CKD). The 2021 recommendations advise that patients with CKD and T2D and an albumin-to-creatinine ratio (ACR) of 3 mg/mmol or more should be offered an angiotensin receptor blocker (ARB) or an angiotensin‑conver...

Axial spondyloarthritis survey raises importance of discussing treatment changes
https://www.mdedge.com/rheumatology/article/249092/spondyloarthropathies/axial-spondyloarthritis-survey-raises-importance
Jeff Evans

Nov 24th, 2021 - More than half of patients with axial spondyloarthritis in a survey of ArthritisPower Registry participants said they discussed a change in treatment with their doctor at their most recent visit, and these discussions were about changing medication or increasing the dose in more than two-thirds of instances. The cross-sectional survey, published in ACR Open Rheumatology, is believed to be the f.

Health-Related Quality of Life and fatigue are associated with a higher work productivi...
https://doi.org/10.1177/09612033211052485
Lupus Reategui-Sokolova C, Gamboa-Cárdenas RV et. al.

Nov 23rd, 2021 - Objectives: This study aims to determine the factors associated with absenteeism, presenteeism, and overall work impairment in patients with systemic lupus erythematosus (SLE).Methods: A total of 133 consecutive working patients with SLE were assessed between October 2017 and December 2018, using a standardized data collection form. Sociodemographic, disease, and work-related variables were col...

PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1...
https://doi.org/10.18632/aging.203699
Aging Zhang H, Xiang D et. al.

Nov 21st, 2021 - To observe the inhibitory effects of the peroxisome proliferator-activated receptor alpha (PPARα) agonist palmitoylethanolamide (PEA) on inflammatory responses and oxidative stress injury in rats with spinal cord injury (SCI). The SCI rat model was established using modified Allen's method and the changes in rats' joint motion were observed by Basso, Beattie and Bresnahan locomotor rating scale...

Identifying mindfulness and acceptance as mediators between negative affect, functional...
https://www.ncbi.nlm.nih.gov/pubmed/34796836
Clinical and Experimental Rheumatology; Maurel S, Sáez-Francàs N et. al.

Nov 20th, 2021 - Fibromyalgia (FM) is a prevalent disabling condition characterised by chronic widespread pain. It is considered a complex illness in which the prognosis is conditioned by affective and cognitive mediators still largely unknown in FM. To investigate the correlation between psychological variables (acceptance, negative affect, and mindfulness) and functional disability or physical impact, anxiety...