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Abstract P1-17-07: Preclinical characterization of neratinib in a blood-brain barrier co-culture model: Therapeutic implications for breast cancers with brain metastases
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-17-07

Oct 9th, 2018 - Background: Breast cancer patients who develop brain metastases have poor prognosis/short overall survival. Human epidermal growth factor receptor 2 (HER2) +ive breast cancer have an increased propensity for brain metastases. Currently, these metastases have limited therapeutic options. The endothelial cells forming the blood-brain barrier (BBB) are highly specialized to allow precise control o...

Abstract P5-09-03: Intrinsic heterogeneity of triple-negative breast cancer cells triggers vascular mimicry in 3D matrigel matrix environment
http://cancerres.aacrjournals.org/content/78/4_Supplement/P5-09-03

Jan 10th, 2019 - Within the same tumor microenvironment phenotypic and functional heterogeneity arise among cancer cells as a consequence of genetic change, environmental differences, and reversible epigenetic changes in cellular properties. However, it is thought that cancer stem cells are drivers of drug resistance and metastasis. Individual tumor cells growing in culture also display heterogeneity in their i...

Abstract P5-01-02: Quantitative assessment of tumor response to neoadjuvant chemotherapy in women with locoregional invasive breast cancer using Tc99m sestamibi molecular breast imaging - prelimina...
http://cancerres.aacrjournals.org/content/78/4_Supplement/P5-01-02

May 15th, 2018 - Purpose: To report preliminary data in a pilot study evaluating the ability of Tc99m sestamibi Molecular Breast Imaging (MBI) to predict response and assess residual disease at the completion of neoadjuvant chemotherapy (NAC) in breast cancer patients. Materials and Methods: Patients with localized, invasive breast cancer (T1-T4, N0-N3, M0) planned for NAC were enrolled in this prospective IRB ...

Abstract P2-01-05: Comprehensive analysis of genomic alterations in tumor tissue associated with presence of various subpopulations of circulating tumor cells (CTCs) in primary breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P2-01-05

May 14th, 2018 - Background: CTCs play a major role in tumor dissemination and progression, and represent one of the key components of the metastatic cascade. The aim of this study was to identify signaling pathways associated with presence of CTCs in primary breast cancer (PBC) patients using a comprehensive genomics approach. Methods: This translational study included 78 patients with PBC. CTCs were detected ...

Abstract P5-10-01: Cellular senescence within HER2-amplified breast cancer: Potential implications for breast cancer immune surveillance and HER2-targeted therapy resistance
http://cancerres.aacrjournals.org/content/78/4_Supplement/P5-10-01

Jan 11th, 2019 - Background:Oncogene-induced senescence is considered as a barrier to tumor progression that arrests cells at risk for malignant transformation. Nevertheless, numerous findings demonstrate that senescent cells may also have the opposite function and promote tumor progression through the release of multiple factors called the senescence-associated secretory phenotype or senescence secretome. It i...

Abstract P6-03-11: Differences in serum miRNA signatures in women with pathology-confirmed breast cancer, benign breast diseases and healthy individuals with no cancer history
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-03-11

May 18th, 2018 - [INTRODUCTION] Mammography is the principal non-invasive imaging method of screening for breast cancer around the world. Mammography has been shown to be effective in reducing breast cancer deaths in randomized studies (Tabar et al., 2011 and Duffy et al., 2002). However, screening mammography can result in false positives that require subsequent interventions such as biopsy or interval repeat ...

Abstract P5-10-02: High expression of BAD, PUMA, BOK and TRADD mRNA is associated with higher overall survival in ER+ and PR+ breast cancer patients
http://cancerres.aacrjournals.org/content/78/4_Supplement/P5-10-02

Jan 12th, 2019 - Background: Apoptosis signalling is controlled by a complex interaction of pro- and anti-apoptotic BCL2 proteins and its dysregulation is believed to be a major contributor to therapy responses and resistance in cancer. We previously demonstrated that inhibition of cell death in cancer cell is associated to poor outcome in colorectal cancer (Lindner et al., Cancer Res, 2012) and to lower cell d...

Abstract P6-03-07: An automated DNA methylation assay (QM-MSP) for rapid breast cancer diagnosis in underdeveloped countries
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-03-07

May 26th, 2018 - BACKGROUND: Underdeveloped countries reported 882,900 new cases of breast cancer and 324,000 deaths in 2012, likely to be a gross underestimation according to recent reports. Often, mammography screening is not available, primary care services are limited, and pathology and treatment services are available only in the regional hospitals. Because of the lack of access to diagnostic and treatment...

Abstract P1-17-04: Clinical presentation and outcome of leptomeningeal metastasis in patients with breast cancer in relation to histology and tumor subtypes
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-17-04

Oct 14th, 2018 - Background: Among solid tumors, breast cancer (BC) is one of the most common cause of leptomeningeal metastases. Leptomeningeal disease (LMD) typically carries a devastating prognosis; however, disease presentation and prognostic factors are still uncertain. The aim of this study was to characterize clinical features of LMD in relation to BC histology and subtypes. Patients and Methods:104 pati...

Abstract P6-02-01: Perceived life expectancy, multimorbidity, and breast cancer screening in older women
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-02-01

May 30th, 2018 - Objective: Screening mammography (SM) benefits are maximal in women who have a several years' life expectancy. Perceived life expectancy (PLE), however, can be compromised by older age, and/or poor health. Prior studies have shown low rates of SM in younger and/or healthier women, while women who are older and/or those presenting with multimorbidity (MM) continue to undergo screening. The resul...

Abstract P3-17-02: Influence of non-measurable disease on progression-free survival in patients with metastatic breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P3-17-02

Oct 15th, 2018 - Background: Progression free-survival (PFS) is the dominant endpoint in phase 3 randomized controlled trials (RCTs) in women with metastatic breast cancer (MBC), and requires the ability to measure target lesions. It is unknown whether treatment effect on PFS is consistent among patients with measurable and non-measurable disease. Methods: We searched MEDLINE, EMBASE and COCHRANE for phase 3 RC...

Abstract P6-10-04: “Disparities in breast cancer: A multi-institutional comparative analysis focusing on American Hispanics”
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-10-04

May 31st, 2018 - Background: Breast cancer (BC) is the leading cause of cancer death in Hispanic/Latina women nationwide. Hispanic women are more likely to be presented with advanced disease and might have adverse prognosis. Further, the Hispanics of Mexican-American origin might reflect different clinico-pathological characteristics as opposed to other Hispanics and ethnic groups. No previous largest studies c...

Abstract P3-17-03: Concordance of real world progression free survival (PFS) on endocrine therapy as first line treatment for metastatic breast cancer using electronic health record with proper qua...
http://cancerres.aacrjournals.org/content/78/4_Supplement/P3-17-03

Oct 16th, 2018 - Background: There is growing interest to assess treatment effect with clinical endpoints that are reflective of real world clinical practice based on data systemically collected from the electronic health record (EHR). This study compared real world PFS (rwPFS) among a cohort of female patients (pts) treated with letrozole (LET) monotherapy as first-line therapy for metastatic breast cancer (MB...

Abstract P6-10-07: Differences in genome-wide DNA methylation levels in breast milk by race and lactation duration
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-10-07

Jun 7th, 2018 - Introduction: Identifying biomarkers of breast cancer risk among young women would have value in developing effective screening and prevention strategies at early ages. We have proposed that DNA methylation analysis of breast milk may provide breast cancer risk information among young women, and could possibly provide etiologic clues related to the higher rates of early onset cancers among Afri...

Abstract P6-05-03: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-05-03

Jan 16th, 2019 - Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it is unclear whether loss of these ubiquitously important functions fully explains the cell lineage-specific tumorigenesis. In vitro studies implicate BRCA1 in elimination of R-loops, D...

Abstract P4-06-18: Clinical application of multigene panel testing and genetic counseling for hereditary/familial breast cancer risk assessment: Prospective single center study
http://cancerres.aacrjournals.org/content/78/4_Supplement/P4-06-18

Jun 8th, 2018 - Background The identification of individuals at elevated risk for hereditary cancers has allowed the development of consensus recommendations for cancer screening and prevention. The introduction of multigene panels may identify more individuals with breast cancer gene mutations than does testing for BRCA1/2 alone. Therefore, the multigenerational panel increase the need for genetic counseling ...

Abstract P6-05-02: Targeting vesicular trafficking machinery for breast cancer therapeutics
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-05-02

Jan 17th, 2019 - The Rab GTPase family is a key regulator of vesicular import, transport and export. Deregulation of vesicular trafficking promotes undesirable intercellular cross talk via exosomes that contribute to cancer pathophysiology. Preclinical and clinical studies underscore a role for exosomes and their cargo in breast cancer development, progression, metastasis, and resistance to therapy. While many ...

Abstract P4-06-06: Frequency of mutations in multi-gene panel testing of 3,011 breast cancer patients
http://cancerres.aacrjournals.org/content/78/4_Supplement/P4-06-06

Jun 15th, 2018 - Objectives: Here, we describe the characteristics of 3,011 individuals with a self-reported diagnosis of breast cancer who received a multi-gene panel genetic test for hereditary cancer risk. Methods: These 3,011 patients were referred physician order for a multi-gene, next generation sequencing panel for hereditary cancer risk. Analysis was limited to 19 genes associated with hereditary breast...

Abstract P1-08-02: Breast tumor-specific MHC-II expression drives a unique pattern of adaptive resistance to antitumor immunity through MHC-II receptor checkpoint engagement
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-08-02

Oct 19th, 2018 - Background: We have previously shown that some breast cancers express major histocompatibility complex II (MHC-II), correlating with enhanced immune infiltration. In other tumor types, we have shown that MHC-II expression on tumor cells predicts clinical response to checkpoint inhibition. We sought to determine the direct effects of MHC-II on anti-tumor immunity and characterize mechanisms of i...

Abstract P5-23-05: Prognostic value of PD-L1 expression in male breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P5-23-05

Oct 23rd, 2018 - Background Growing evidence have shown promise for targeting programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) signaling in several tumors. In female breast cancer, PD-L1 expression has been correlated with poor clinical outcome. However, whether PD-L1 has any indication for prognosis in male breast cancer (MBC) patients remains unknown. The purpose of this study was to examine the ex...