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Abstract P6-09-05: Factors associated with the uptake of risk-reducing surgeries among Hispanic women at high risk of breast and ovarian cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-09-05

Apr 17th, 2019 - Background: BRCA mutation carriers have an increased lifetime risk of breast and ovarian cancer. Although risk-reducing surgeries have documented utility, social factors, cultural beliefs and access to healthcare may be barriers among the Hispanic population to the uptake of risk-reducing practices. We aimed to describe the uptake of risk-reducing mastectomy (RRM) and risk-reducing salpingo-oop...

Abstract P6-09-01: Risk-reducing oophorectomy and breast cancer risk across the spectrum of familial risk using a prospective family study cohort (ProF-SC)
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-09-01

Apr 16th, 2019 - Background: Whether risk-reducing salpingo oophorectomy (RRSO) reduces breast cancer risk in addition to reducing ovarian cancer risk is controversial with some arguing that the previous evidence of a reduction in breast cancer risk from RRSO was due to bias. Evidence from independent prospective cohorts of high-risk women is needed to resolve this controversy. Methods: Using a prospective fami...

Abstract P6-03-09: Internal mammary lymph node biopsy during free flap breast reconstruction: Accurate oncologic staging leads to change in adjuvant therapies
http://cancerres.aacrjournals.org/content/78/4_Supplement/P6-03-09

Apr 15th, 2019 - Introduction: Accurate breast cancer staging, including nodal status, is essential for optimal management of adjuvant therapies leading to improved disease-specific and overall survival. Lymphatic drainage of the breast is known to involve both axillary and internal mammary (IM) lymph node basins. While IM nodal metastases represent advanced cancer stage, sampling is not routinely advocated due...

Abstract P2-03-03: A multicenter clinical study of Xpert® breast cancer STRAT4 demonstrates high concordance with central lab ER, PgR, HER2, and Ki67 IHC and HER2 FISH tests in FFPE breast tumor ti...
http://cancerres.aacrjournals.org/content/78/4_Supplement/P2-03-03

Apr 14th, 2019 - The Xpert® Breast Cancer STRAT4 (STRAT4) is a CE-IVD marked, semi-quantitative, cartridge-based RT-qPCR assay for the detection of ESR1, PGR, ERBB2 (HER2), and MKi67 mRNAs from formalin fixed, paraffin embedded (FFPE) breast tumors. The assay is fast (< 2 hrs), reproducible, robust, and easy to perform. The aim of this multicenter clinical study was to assess the performance characteristics of ...

Abstract P2-03-01: Analytical validation of a standardized scoring protocol for Ki67 assessed on breast excision whole sections: An international multicenter collaboration
http://cancerres.aacrjournals.org/content/78/4_Supplement/P2-03-01

Apr 13th, 2019 - Aims: (i) Determine whether between-observer reproducibility for Ki67 when assessed on whole sections according to a standardized scoring protocol is adequate for clinical application. (ii) Compare between-observer reproducibility of Ki67 scores assessed on hot-spots to scores using a global method that averages across a tissue section. Background: The nuclear proliferation biomarker Ki67 has m...

Abstract P2-03-11: The immune microenvironment of HER2-positive ductal carcinoma in situ of the breast
http://cancerres.aacrjournals.org/content/78/4_Supplement/P2-03-11

Apr 12th, 2019 - Background: Ductal carcinoma in situ (DCIS) consists of a heterogeneous group of tumors that can be subclassified based on their molecular profile similar to invasive breast carcinomas. DCIS ducts are often surrounded by an inflammatory infiltrate, yet few studies have focused on this inflammatory response in the different subtypes of DCIS. The role of the immune microenvironment in tumor progr...

Abstract P2-02-06: Biomarker analysis by next generation circulating tumor DNA (ctDNA) sequencing in patients with advanced breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P2-02-06

Apr 11th, 2019 - Background: Next-generation sequencing is of increasing interest to identify specific targets for both drug development and treatment. The study of metastatic cancer is complicated by lack of tissue and the potential for change in biology over treatment. We evaluated ctDNA in patients with advanced breast cancer to explore the relationship between specific DNA mutations and prognosis as well as...

Abstract P1-04-01: A novel oncolytic herpes simplex virus, GD116, has enhanced antitumour efficacy in human breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-04-01

Apr 10th, 2019 - Background: Oncolytic herpes simplex virus-1 (oHSV-1) vectors are promising new therapeutic agents for cancer. For the nuerovirulence of ICP34.5 protein, the encoding gene named γ34.5 is deleted in all oHSV-1 mutants currently in clinical trials. However, the deletion of γ34.5 also promotes the interferon-induced shutoff of virual protein synthesis, and attenuates the virus replication in cance...

Abstract P1-01-08: DPYSL3 modulates proliferation and migration in claudin-low breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-08

Apr 9th, 2019 - Cancer is often driven by deregulated protein kinases pathways including breast cancer. To profile the kinome at the protein level we are developing a kinase pulldown (KiP) proteomic platform that uses multiple kinase inhibitors conjugated to sepharose beads for protein kinase profiling. Mass spectrometry-base tryptic peptide sequencing is used to identify and quantify the kinome in an unbiased...

Abstract P1-01-03: Preclinical evidence that distant metastases occur via the lymphatic route
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-03

Apr 8th, 2019 - Cancer that metastasizes beyond the lymph nodes is almost invariably terminal. Therefore, understanding how cancer metastasizes is a critical aspect to understanding and eventually preventing cancer spreading from tissue to tissue. A major question that remains controversial is whether cancer cells that metastasize to the LNs are able to physically leave the LNs to colonize distant tissues. Mor...

Abstract P1-01-17: Characterization of novel ESR1 (c.749T>C; p.Met250Thr) mutation in enhancing cellular invasiveness of breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-17

Apr 7th, 2019 - Emerging evidence has revealed that the mutations in estrogen receptor alpha (ERα) gene (ESR1) is frequently observed in ER+ metastatic breast cancer, and is associated with the aggressively invasive and metastatic phenotype in advanced breast cancer due to the resistance of endocrine therapy. In our previous study, we have identified three novel mutations of ESR1, including ESR1 G74R, D230H an...

Abstract P1-01-12: Expression of autophagy related genes impacts clinical outcomes of human breast carcinoma and is associated with estrogen and progestin receptor status
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-12

Apr 6th, 2019 - The dual role of autophagy in breast cancer initiation, progression and responsiveness to various therapies is the focus of extensive studies. Our goal is to assess the relationship of expression of certain autophagy related genes in primary breast carcinomas to predict risk of recurrence. Our hypothesis includes the caveat that unique gene expression subsets will be deciphered by utilizing Las...

Abstract P1-01-09: BMP4 suppresses the progression of breast cancer through altered expression of metastasis regulating genes
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-09

Apr 5th, 2019 - Metastasis is a lethal manifestation of cancer, the development of which is the major cause of death in cancer patients. During a search for metastasis-regulating elements, an inverse correlation was identified between the in vivo tumor expression of bone morphogenetic protein-4 (BMP4) and spontaneous metastasis in a panel of isogenic mammary tumors of varying metastatic capacity. BMP4 is an es...

Abstract P1-01-05: Wnt5a induces ROR1 to associate with cortactin, which undergoes tyrosine phosphorylation, and enhances migration of breast cancer cells
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-05

Apr 4th, 2019 - Background: ROR1is an evolutionarily conserved, oncoembryonic surface-antigen expressed in breast cancer. Previously, we found that ROR1 can serve as a receptor for Wnt5a, which can induce non-canonical Wnt signaling that enhances cancer-cell migration. Recently we found that Wnt5a could induce ROR1 to complex with a cytoskeletal protein designated HS1, which recruited ARHGEF1, enhanced activat...

Abstract P1-01-04: Mutational profiling of breast cancer brain metastases – matched pair analysis of next generation sequencing between primary breast cancer and later developed brain metastases
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-04

Apr 3rd, 2019 - Background: Despite increased survival in patients with advanced breast cancer, breast cancer brain metastases (BCBM), remains a final frontier with a mean survival of 3-12 months. The biology facilitating BCBM is not fully understood. Aims: To compare gene expression profiles in primary BC, and later diagnosed, surgically removed BCBM. Material and Methods: A total of 58 BCBM and 46 breast tum...

Abstract P1-01-16: Detection of disseminated tumor cells in DCIS patients impacts local recurrence
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-16

Apr 2nd, 2019 - Background Recently it was shown that tumor cell dissemination is an early event in breast cancer progression (Hosseini et al., Nature 2016). This has been backed up by an assessment of over 100,000 patients with in situ carcinoma (DCIS), where some patients developed distant metastases and died from breast cancer without presenting with local invasive recurrence (Narod et al., JAMA Oncology 20...

Abstract P1-01-07: Clinical and histological characteristics of peritoneal metastases of invasive lobular breast cancer
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-07

Apr 1st, 2019 - Introduction: In previously reported autopsy series, peritoneal metastases have been detected in up to 40% of patients with invasive lobular breast cancer (ILC). Despite modern diagnostic techniques such as high-resolution ultrasound, it remains a challenge to differentiate ovarian cancer from metastatic breast cancer with peritoneal manifestation before or during surgery. The goal of this anal...

Abstract P1-01-19: The role of S100A7 in microbiota mediated inflammation and breast cancer progression
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-19

Mar 31st, 2019 - Introduction While it is accepted that inflammation is a key component of cancer development, the intricate mechanism linking the two are not fully defined. Unparalleled progress has been underway to provide better understanding of this mechanism. We investigate the role of bacterial microbiota in promoting an inflammatory environment through the induction of the pro-inflammatory molecule, S100...

Abstract P1-01-21: The levels of sphingosine-1-phosphate and its related gene expressions in breast cancer patients
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-21

Mar 30th, 2019 - Background: The bioactive lipid mediator sphingosine-1-phosphate (S1P) has emerged as a key regulatory molecule in cancer progression. We previously demonstrated that S1P is a crucial mediator of breast cancer-induced angiogenesis and lymphangiogenesis, and promote metastasis. Although increasing number of in vitro and in vivo experiments have revealed the importance of S1P in cancer progressio...

Abstract P1-01-06: Targeting the SphK1/S1P/S1PR1 axis that connects obesity, chronic inflammation, and breast cancer metastasis
http://cancerres.aacrjournals.org/content/78/4_Supplement/P1-01-06

Mar 29th, 2019 - Introduction: Obesity with associated inflammation is now recognized as a risk factor for breast cancer and increased incidence of distant metastases. However, the link between obesity and breast cancer progression remains poorly understood. There is growing evidence that sphingosine-1-phosphate (S1P), a pleiotropic bioactive sphingolipid metabolite enriched both in blood and lymphatic fluid is...