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About 4,430 results

ALLMedicine™ Acromegaly Center

Research & Reviews  1,449 results

Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess
https://clinicaltrials.gov/ct2/show/NCT03882034

Sep 23rd, 2022 - Study Description: Growth hormone excess is a rare and potentially lethal condition associated with hypersecretion of growth hormone (GH), usually by a pituitary tumor or hyperplasia. When it occurs prior to the complete fusion of growth plates, i...

Predictive factors of somatostatin receptor ligand response in acromegaly - a prospecti...
https://doi.org/10.1210/clinem/dgac512
The Journal of Clinical Endocrinology and Metabolism; Ilie MD, Tabarin A et. al.

Sep 23rd, 2022 - Somatostatin receptor ligands (SRLs) are the cornerstone medical treatments for acromegaly, however many patients remain unresponsive to SRLs. Well-established predictive markers of response are needed. We aimed to explore the relationship between...

Predictors of postoperative biochemical remission in lower Knosp grade growth hormone-s...
https://doi.org/10.1007/s40618-022-01873-9
Journal of Endocrinological Investigation; Zhang S, Chen J et. al.

Sep 21st, 2022 - Growth hormone-secreting pituitary adenomas (GH-PAs) with a low Knosp grade are typically associated with a good postoperative biochemical remission (BR) rate. However, a proportion of patients do not achieve remission. In this study, we aimed to ...

IVIVC of Octreotide in PLGA-Glucose Microsphere Formulation, Sandostatin® LAR.
https://doi.org/10.1208/s12249-022-02359-w
AAPS PharmSciTech; Song JS, Kim SY et. al.

Sep 20th, 2022 - In vitro-in vivo correlation (IVIVC) analysis reveals a relationship between in vitro release and in vivo pharmacokinetic response of the drug of interest. Sandostatin LAR Depot (SLD) for endocrine tumors and acromegaly is a sustained-release form...

Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly.
https://doi.org/10.1055/a-1913-7900
Experimental and Clinical Endocrinology & Diabetes : Offi... Peng G, Li X et. al.

Sep 9th, 2022 - To investigate the clinical characteristics and associated factors of colonic polyps in patients with acromegaly. Clinical characteristics and colonoscopy findings of 86 acromegaly patients who received treatment were retrospectively reviewed, and...

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Guidelines  5 results

Italian Society for the Study of Diabetes (SID)/Italian Endocrinological Society (SIE) ...
https://doi.org/10.1016/j.numecd.2016.02.001
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Baroni MG, Giorgino F et. al.

Feb 26th, 2016 - Hyperglycemia is a common feature associated with states of increased growth hormone secretion and glucocorticoid levels. The purpose of these guidelines is to assist clinicians and other health care providers to take evidence-based therapeutic de...

Expert consensus document: A consensus on the medical treatment of acromegaly.
https://doi.org/10.1038/nrendo.2014.21
Nature Reviews. Endocrinology; Giustina A, Chanson P et. al.

Feb 26th, 2014 - In March 2013, the Acromegaly Consensus Group met to revise and update guidelines for the medical treatment of acromegaly. The meeting comprised experts skilled in the medical management of acromegaly. The group considered treatment goals covering...

American Association of Clinical Endocrinologists medical guidelines for clinical pract...
https://www.ncbi.nlm.nih.gov/pubmed/21846616
Endocrine Practice : Official Journal of the American Col... Katznelson L, Atkinson JL et. al.

Aug 24th, 2011 - American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly--2011 update.|2011|Katznelson L,Atkinson JL,Cook DM,Ezzat SZ,Hamrahian AH,|diagnosis,therapy,standards,trends,...

AME Position Statement on clinical management of acromegaly.
https://www.ncbi.nlm.nih.gov/pubmed/19923883
Journal of Endocrinological Investigation; Cozzi R, Baldelli R et. al.

Jan 23rd, 2010 - AME Position Statement on clinical management of acromegaly.|2010|Cozzi R,Baldelli R,Colao A,Lasio G,Zini M,|diagnosis,economics,epidemiology,therapy,

Guidelines for acromegaly management: an update.
https://doi.org/10.1210/jc.2008-2421
The Journal of Clinical Endocrinology and Metabolism; Melmed S, Colao A et. al.

Feb 12th, 2009 - The Acromegaly Consensus Group reconvened in November 2007 to update guidelines for acromegaly management. The meeting participants comprised 68 pituitary specialists, including neurosurgeons and endocrinologists with extensive experience treating...

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Drugs  27 results see all →

Clinicaltrials.gov  176 results

Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess
https://clinicaltrials.gov/ct2/show/NCT03882034

Sep 23rd, 2022 - Study Description: Growth hormone excess is a rare and potentially lethal condition associated with hypersecretion of growth hormone (GH), usually by a pituitary tumor or hyperplasia. When it occurs prior to the complete fusion of growth plates, i...

Genetic Studies of Insulin and Diabetes
https://clinicaltrials.gov/ct2/show/NCT00001987

Sep 8th, 2022 - Study Description: Insulin is the key hormone responsible for regulating the level of glucose in plasma. In several disease states (e.g., obesity, type 2 diabetes, and acromegaly), the target cells are resistant to insulin action. Insulin resistan...

A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (PATHFNDR-2)
https://clinicaltrials.gov/ct2/show/NCT05192382

Sep 7th, 2022 - A randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with non-pharmacologically treated acromeg...

A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly
https://clinicaltrials.gov/ct2/show/NCT04837040

Sep 7th, 2022 - A randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with acromegaly previously treated with so...

A Study to Evaluate the Long-Term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance)
https://clinicaltrials.gov/ct2/show/NCT04261712

Sep 7th, 2022 - A phase 2, open label, long-term extension study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with acromegaly.

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News  108 results

When to Treat Low Testosterone in Diabetes and Obesity
https://www.medscape.com/viewarticle/977284

Jul 15th, 2022 - Men with type 2 diabetes are at higher risk for testosterone deficiency. And in turn, hypogonadism is commonly associated with metabolic syndrome or type 2 diabetes. However, this does not imply a specific need for action, as Stephan Petersenn, MD...

Practice Guidelines Highlights From the Past Year
https://www.medscape.com/viewarticle/969871

Mar 8th, 2022 - Dr Douglas S. Paauw A 64-year-old woman is evaluated for fever, diarrhea, and abdominal pain. She was diagnosed with Clostridioides difficile 2 months ago and completed a 10-day course of vancomycin. Her stool toxin test is positive for Clostridio...

Practice guidelines highlights from past year
https://www.mdedge.com/internalmedicine/article/252401/infectious-diseases/practice-guidelines-highlights-past-year
Douglas S. Paauw, MD

Mar 3rd, 2022 - A 64-year-old woman is evaluated for fever, diarrhea, and abdominal pain. She was diagnosed with Clostridioides difficile 2 months ago and completed a 10-day course of vancomycin.

Oral Octreotide Shows Promise as Alternative to Injections for Acromegaly
https://www.medscape.com/viewarticle/966233

Jan 10th, 2022 - NEW YORK (Reuters Health) - Many patients with acromegaly may do as well on oral octreotide treatment as they do on injectable somatostatin receptor ligands (iSRLs), an industry-sponsored phase-3 trial suggests. Oral octreotide is the first oral m...

Association of Circulating IGF-I with Common Non-cancerous Conditions
https://www.medscape.com/viewarticle/963018

Nov 15th, 2021 - Takeaway Circulating insulin-like growth factor-I (IGF-I) was associated with several common conditions (other than cancer), including a positive association with carpal tunnel syndrome and inverse associations with varicose veins and iron deficie...

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Patient Education  7 results see all →