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About 20,873 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  7,270 results

Three nervous system-specific expressed genes are potential biomarkers for the diagnosi...
https://doi.org/10.1186/s12920-023-01441-x
BMC Medical Genomics; Liao Y, Cai H et. al.

Jan 29th, 2023 - Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease in adults. However, ALS, especially sporadic ALS (sALS), is difficult to diagnose due to the lack of biomarkers. We used the bioinformatics technology to find the pot...

Perceived benefits from peer-support among family caregivers of people with amyotrophic...
https://doi.org/10.1111/jep.13808
Journal of Evaluation in Clinical Practice; Olesen LK, la Cour K et. al.

Jan 28th, 2023 - Family caregivers of persons with amyotrophic lateral sclerosis and cognitive and/or behavioural impairments (PALS/CIs) experience various challenges and needs, including emotional and practical support from peers. Various forms of peer-support ha...

Mechanistic insights into the conformational switch in profilin-1 subject to collective...
https://doi.org/10.1016/j.ijbiomac.2023.123403
International Journal of Biological Macromolecules; Muneeswaran G, Lee JY

Jan 28th, 2023 - Mutations and histidine (His) tautomerism in profilin-1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS). The conformational changes in PFN1 caused by the collective effects of G117V mutation and His tautomeric isomers εε, εδ, δε, an...

Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and...
https://doi.org/10.1177/0271678X231153281
Journal of Cerebral Blood Flow and Metabolism : Official ... Steinruecke M, Lonergan RM et. al.

Jan 28th, 2023 - There is strong evidence for blood-brain and blood-spinal cord barrier dysfunction at the early stages of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Since impairment of the blood-central nervous system barrier ...

An evaluation of the combination of sodium phenylbutyrate and taurursodiol for the trea...
https://doi.org/10.1080/14737175.2023.2174018
Expert Review of Neurotherapeutics; Sun Y, Li X et. al.

Jan 28th, 2023 - Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative motor neuron disease. Despite the overwhelming need for effective therapeutics for ALS, riluzole and edaravone were the only two FDA-approved disease-modifying t...

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Guidelines  3 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  18 results see all →

Clinicaltrials.gov  547 results

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
https://clinicaltrials.gov/ct2/show/NCT04394871

Jan 27th, 2023 - Objective: Amyotrophic lateral sclerosis type 4 (ALS4) is an inherited form of motor neuron disease caused by mutation in the senataxin (SETX) gene. The main goal of this study will be to collect clinical and molecular biomarkers from patients wit...

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
https://clinicaltrials.gov/ct2/show/NCT03225144

Jan 27th, 2023 - Objectives The primary objective is to evaluate patients referred with a diagnosis of frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), or related adult-onset neurodegenerative disorders to assess patient eligibility for ongoing ...

COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry
https://clinicaltrials.gov/ct2/show/NCT04559009

Jan 26th, 2023 - The purpose of this registry is to assess the incidence and prevalence of COVID-19 in ALS patients, the effect of COVID-19 on ALS disease trajectory, and the impact, if any, of edaravone, riluzole and other concomitant medication used in ALS like ...

Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis
https://clinicaltrials.gov/ct2/show/NCT04953286

Jan 26th, 2023 - Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting the motor neuron. Currently, there is no diagnostic test and no examination that can predict the evolution of this pathology. The search for diagnostic and ...

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation
https://clinicaltrials.gov/ct2/show/NCT01925196

Jan 26th, 2023 - Objective The primary objective of this study is to characterize the natural history of disease in patients who carry a repeat expansion in the C9ORF72 gene, which causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The s...

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News  483 results

Viruses Tied to Subsequent Dementia, Other Neurodegenerative Diseases
https://www.medpagetoday.com/neurology/generalneurology/102872

Jan 30th, 2023 - At least 22 viral illnesses were linked with an increased risk of subsequent neurodegenerative disease, NIH researchers found. Using data from the U.K. and Finland, Mike Nalls, PhD, of the NIH Center for Alzheimer's and Related Dementias, and co-a...

'Concerning' Gonorrhea Strain; DeSantis Targets Trans Students; Pandemic Is Over?
https://www.medpagetoday.com/infectiousdisease/stds/102714

Jan 20th, 2023 - Note that some links may require subscriptions. The CDC and Massachusetts health officials are investigating "concerning" new cases of drug-resistant gonorrhea. (CBS News) Israel has no data linking Pfizer's updated COVID vaccine with risk for str...

High Drug Costs Exclude Most Neurology Patients From Cutting-Edge Treatment
https://www.medscape.com/viewarticle/984953

Dec 2nd, 2022 - Because of high out-of-pocket costs of new-to-market neurologic drugs that are of similar benefit as older agents, only a small percentage of patients with neurologic disorders have access to these cutting-edge medications, new research shows. "Ou...

Trending Clinical Topic: Vitamin B12
https://www.medscape.com/viewarticle/983670

Nov 11th, 2022 - Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share them with us on Twitter or Facebook.  The potentia...

Amyotrophic Lateral Sclerosis (ALS)
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/336726

Learn about this progressive disease attacks the nerve cells that control voluntary movement.

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Patient Education  28 results see all →