Jun 24th, 2019 - Atopic dermatitis is a chronic, itchy skin condition that is very common in children but may occur at any age. It is also known as eczema and atopic eczema and was formerly known as Besnier prurigo. It is the most common form of dermatitis. Atopic dermatitis usually occurs in people who have an 'atopic tendency'. This means they may develop any or all of three closely linked conditions; atop...
Wallace, D.,et al
Dec 18th, 2017 - The Joint Task Force on Practice Parameters, which comprises representatives of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), formed a workgroup to review evidence and provide guidance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in patients aged 12 years or older.
Jul 31st, 2017 - Allergic rhinitis (AR) is a prevalent disorder responsible for a significant and often underappreciated health burden for individuals and society (see Burden of Disease section). Guidelines to improve care for patients with AR have been evolving in an effort to respond to the introduction of new treatment approaches, to address the availability of additional studies that compare treatment optio.
Michael D. Seidman
Feb 1st, 2015 - Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall.
Nov 30th, 2012 - Atopic dermatitis (AD) is often the first manifestation ofallergic disease. Most patients with AD will also have anotheratopic disorder, such as allergic rhinitis, asthma, or foodallergy.
JAMA Scadding GW, Calderon MA et. al.
Feb 14th, 2017 - Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placeb...
The Journal of Allergy and Clinical Immunology; Roduit C, Frei R et. al.
Feb 10th, 2014 - The role of dietary factors in the development of allergies is a topic of debate, especially the potential associations between infant feeding practices and allergic diseases. Previously, we reported that increased food diversity introduced during the first year of life reduced the risk of atopic dermatitis. In this study we investigated the association between the introduction of food during t...
The Journal of Allergy and Clinical Immunology; Bergmann KC, Demoly P et. al.
Jan 6th, 2014 - Preliminary studies have suggested the efficacy of sublingual tablets of house dust mite (HDM) extracts in adults with allergic rhinitis. We sought to assess the efficacy and safety of 2 doses of HDM sublingual tablets over 1 treatment year and the subsequent immunotherapy-free year. Adults with HDM-associated allergic rhinitis were randomized in a double-blind, placebo-controlled study to rece...
Lancet (London, England); Chalmers JR, Haines RH et. al.
Feb 22nd, 2020 - Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. We did a multicentre, pragmatic, parallel-group, randomised controlled trial in 12 hospitals and four primary care sites across the UK. Families were approached via antenatal or postnatal services for recruitment of term infants (at least 3...
ORALAIR® is an allergen extract indicated as immunotherapy for the treatment of grass pollen-induced allergic rhinitis
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Annals of Internal Medicine; Wallace DV, Dykewicz MS et. al.
Nov 28th, 2017 - The Joint Task Force on Practice Parameters, which comprises representatives of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), formed a workgroup to review evidence and provide guidance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in patients aged 12 years or olde...
Alimentary Pharmacology & Therapeutics; von Arnim U, Wex T et. al.
Feb 23rd, 2016 - Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. Helicobacter pylori (H. pylori) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and H. pylori may play a protect...
Pediatrics Skoner DP, Berger WE et. al.
Jan 27th, 2015 - Inadequate designs and conflicting results from previous studies prompted the US Food and Drug Administration to publish guidelines for the design of clinical trials evaluating the effects of orally inhaled and intranasal corticosteroids on the growth of children. This study conformed to these guidelines to evaluate the effect of triamcinolone acetonide aqueous nasal spray (TAA-AQ) on the growt...
The Journal of Allergy and Clinical Immunology; Natarajan M, Hsu AP et. al.
May 28th, 2018 - Aspergillosis, eosinophilic esophagitis, and allergic rhinitis in signal transducer and activator of transcription 3 haploinsufficiency.|2018|Natarajan M,Hsu AP,Weinreich MA,Zhang Y,Niemela JE,|
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Dykewicz MS, Wallace DV et. al.
Nov 6th, 2017 - Treatment of seasonal allergic rhinitis: An evidence-based focused 2017 guideline update.|2017|Dykewicz MS,Wallace DV,Baroody F,Bernstein J,Craig T,|diagnosis,epidemiology,therapy,diagnosis,epidemiology,therapy,epidemiology,
International Forum of Allergy & Rhinology; Hamizan AW, Rimmer J et. al.
Jul 20th, 2017 - The diagnosis of allergic rhinitis (AR) is based on cutaneous and serological assessment to determine immunoglobulin E (IgE)-mediated disease. However, discrepancies between these tests and nasal provocation exist. Patients diagnosed as non-allergic rhinitis (NAR) but with positive nasal allergen provocation test (NAPT) may represent a local allergic condition or entopy, still suitable to aller...
Allergy and Asthma Proceedings; Fajt ML, Rosenberg SL et. al.
Jul 2nd, 2017 - Allergen immunotherapy (AIT) is an effective treatment option for allergic rhinitis. Although conventional AIT takes 6 months to reach maintenance dosing, rush AIT accelerates the build-up period and reaches the maintenance dose months earlier. However, accelerated schedules of AIT carry an increased risk of systemic reactions (SR). We aimed to describe a novel 1-day, eight-step modified enviro...
The Journal of Allergy and Clinical Immunology; Peters RL, Koplin JJ et. al.
May 18th, 2017 - The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse. This study aimed to report the updated prevalence of food allergy at age 1 year from th...
Allergy Hellings PW, Klimek L et. al.
May 5th, 2017 - This EAACI position paper aims at providing a state-of-the-art overview on nonallergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as nonallergic noninfectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of a minimum of two nasal symptom...
Allergy and Asthma Proceedings; Nayak AS, Berger WE et. al.
Apr 26th, 2017 - Pharmacologic treatment is a mainstay of allergy therapy and many caregivers use over-the-counter antihistamines for the treatment of seasonal allergic rhinitis (SAR) symptoms in children. To assess the efficacy and safety of cetirizine 10 mg syrup versus loratadine 10 mg syrup versus placebo syrup in a randomized double-blind study of children, ages 6-11 years, with SAR. This randomized, doubl...
Current Allergy and Asthma Reports; Posa D, Hofmaier S et. al.
Apr 21st, 2017 - Allergenic molecules of the house dust mite (HDM) are crucially important indoor allergens, contributing to allergic rhinitis and asthma around the globe. In the past years, recombinant molecules for diagnostics opened new pathways to investigate individual sensitization profiles and new chances for the prevention and treatment of HDM allergy. This review summarizes the latest findings on the e...
BMC Complementary and Alternative Medicine; Kim HI, Hong SH et. al.
Mar 31st, 2017 - Allergic diseases including allergic rhinitis, asthma, and atopic dermatitis are increasing worldwide. Common medications used to treat these inflammatory disorders are anti-histamines and corticosteroids, but they have their own limitations such as short duration and severe side effects. Thus, interest in complementary and alternative medicine is continually growing. Here, we investigate the a...
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology; Zhang GQ, Liu B et. al.
Oct 29th, 2016 - It has been suggested that n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have anti-inflammatory properties and may reduce the risk of allergic disease. Fish is a great source of n-3 LC-PUFAs. However, the effect of fish on allergic disease remains controversial. PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) a...
The Journal of Allergy and Clinical Immunology; Durham SR, Creticos PS et. al.
Aug 16th, 2016 - Data comparing the treatment effect of allergy immunotherapy and pharmacotherapy are lacking. We sought to indirectly compare the treatment effect of sublingual immunotherapy (SLIT)-tablets with pharmacotherapy for seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR). Pooled data from randomized, double-blind, placebo-controlled trials for the clinical development programs of ...
The Journal of Allergy and Clinical Immunology; Nolte H, Bernstein DI et. al.
Aug 15th, 2016 - The house dust mite (HDM) sublingual immunotherapy (SLIT) tablet (MK-8237; Merck & Co, Kenilworth, NJ/ALK-Abelló, Hørsholm, Denmark) has demonstrated beneficial effects on allergic rhinoconjunctivitis and asthma outcomes in European trials. This is the first trial to assess the efficacy/safety of HDM SLIT-tablets in North American subjects with HDM-induced allergic rhinitis with or without conj...
Expert Opinion on Drug Safety; González-Núñez V, Bachert C et. al.
Aug 8th, 2016 - Rupatadine is a second-generation H1-antihistamine with dual affinity for histamine H1 and PAF receptors. Rupatadine is indicated for the treatment of allergic rhinitis and urticaria. A Medline search was conducted to identify preclinical and clinical studies of rupatadine. This was supplemented with additional articles obtained from online sources. The focus of this review is on the safety pro...
American Journal of Rhinology & Allergy; Paz Lansberg M, DeTineo M et. al.
Jul 27th, 2016 - Allergic rhinitis is a common disorder that leads to a negative impact on quality of life. Multiple options are available for treatment of the symptoms, but preventing the reaction should be an effective strategy. We tested a nasal spray that contained microcrystalline cellulose designed to limit airborne allergens from penetrating the nasal mucosa (nasal blocker) and, therefore, prevent the in...
Pediatric Dermatology; Chuh A, Zawar V et. al.
Jun 24th, 2016 - To investigate whether Gianotti-Crosti syndrome (GCS) in children is associated with atopy. The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the pre...
Find studies, dosing instructions and the safety and tolerability profile for GRASTEK®. View Safety Info & Boxed Warning.
Immunology and Allergy Clinics of North America; Nelson HS, Makatsori M et. al.
Nov 30th, 2015 - Subcutaneous immunotherapy and sublingual immunotherapy are effective for allergic rhinitis and allergic asthma and with some support for use in selected patients with atopic dermatitis. The sequence of immunologic responses is the same, irrespective of the route of administration, and similar disease modification has been demonstrated. However, there are differences between the two approaches....
Respiratory Medicine; Maio S, Baldacci S et. al.
Nov 28th, 2015 - Few epidemiological surveys on general population samples estimated changes in prevalence of respiratory symptoms/diseases over a long time interval; our study aims to quantify the temporal changes in the prevalence rates of asthma, allergic rhinitis and Chronic Obstructive Pulmonary Disease (COPD) after 25 years from baseline. A general population sample participated in 3 cross-sectional surve...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Meltzer EO, Ratner PH et. al.
Nov 12th, 2015 - Over-the-counter phenylephrine hydrochloride (PEH) is used for relief of nasal congestion caused by allergic rhinitis; however, data to support its efficacy are lacking. The US Food and Drug Administration recommended clinical trials to evaluate the efficacy and safety of PEH in patients with this condition. To evaluate the efficacy and safety of PEH 30-mg modified-release (MR) tablets in patie...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Maloney J, Prenner BM et. al.
Nov 10th, 2015 - Sublingual immunotherapy (SLIT) tablets could be an important alternative to subcutaneous immunotherapy for house dust mite (HDM) allergy in children. To characterize the safety, tolerability, and duration of local adverse events (AEs) of an HDM SLIT tablet (MK-8237; Merck, ALK Abellò, and Torii) in North American children 12 to 17 years old with HDM allergic rhinitis with and without conjuncti...
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology; Ludman S, Jafari-Mamaghani M et. al.
Nov 4th, 2015 - There is limited information regarding the onset and sensitization patterns of pollen food syndrome (PFS) in children. The aim was to explore this within children referred to a specialist allergy clinic at a London Tertiary Hospital. A total of 54 patients with seasonal allergic rhinitis (SAR) were enrolled in equal numbers in three age groups; 0-5, 6-10, 11-15 years. Families completed a quest...
Lancet (London, England); Weidinger S, Novak N
Sep 17th, 2015 - Atopic dermatitis (also known as atopic eczema) is a chronic inflammatory skin disease that is characterised by intense itching and recurrent eczematous lesions. Although it most often starts in infancy and affects two of ten children, it is also highly prevalent in adults. It is the leading non-fatal health burden attributable to skin diseases, inflicts a substantial psychosocial burden on pat...
The Journal of Allergy and Clinical Immunology; Schmitt J, Schwarz K et. al.
Sep 15th, 2015 - Allergic rhinitis (AR) is a main risk factor for the development of asthma. Two randomized open-label trials indicated that allergy immunotherapy (AIT) prevents the onset of asthma in patients with AR. However, these trials have methodological limitations, and it is unclear to what extent this experimental efficacy translates into clinical effectiveness. We sought to investigate the effectivene...
International Archives of Allergy and Immunology; Inuo C, Kondo Y et. al.
Aug 25th, 2015 - Some patients with Japanese cedar pollen (JCP)-induced allergic rhinitis develop pollen-food allergy syndrome (PFAS) as a reaction to tomato fruit. Pollen allergen-specific subcutaneous immunotherapy (SCIT) is reportedly beneficial for some associated food allergies; however, the reported changes in food allergen-specific immunoglobulin (Ig)E and IgG4 levels are inconsistent. Here, we investiga...
The Journal of Allergy and Clinical Immunology; Demoly P, Emminger W et. al.
Aug 21st, 2015 - The SQ HDM SLIT-tablet (ALK) has been developed for treatment of house dust mite (HDM)-induced respiratory allergic disease. This trial investigated the efficacy and safety of the SQ HDM SLIT-tablet in adults with moderate-to-severe HDM-induced allergic rhinitis (AR). The trial was a randomized, double-blind, placebo-controlled phase III trial conducted in 12 European countries including 992 ad...
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology; Potter P, Mitha E et. al.
Aug 12th, 2015 - Recommendations in current guidelines for the treatment of chronic spontaneous urticaria (CSU) in infants and children are mostly based on extrapolation of data obtained in adults. This study reports the efficacy and safety of rupatadine, a modern H1 and PAF antagonist recently authorized in Europe for children with allergic rhinitis and CSU. A double-blind, randomized, parallel-group, multicen...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Ram G, Lee J et. al.
Aug 3rd, 2015 - Evidence supports a possible link between eosinophilic esophagitis (EoE) and environmental aeroallergens, which can manifest as seasonal exacerbation of esophageal eosinophilia. Few studies have examined this link in pediatric patients with EoE. To identify the proportion of patients with seasonal induced esophageal eosinophilia. A retrospective chart review was conducted of all patients diagno...
American Journal of Rhinology & Allergy; Liu SC, Lu HH et. al.
Jul 14th, 2015 - The transient receptor potential channel melastatin 8 (TRPM8) has been proposed to be a cold receptor. However, its distribution and physiologic role in the nose is not yet fully explored. We investigated the expression of TRPM8 in human nasal mucosa and its function when using the TRPM8 agonist. Immunohistochemistry was used to study TRPM8 receptors in the nasal mucosa from patients with and t...
American Journal of Rhinology & Allergy; Berger WE, Meltzer EO
Jul 1st, 2015 - Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR) by providing direct delivery of medication to the nasal mucosa, reducing the potential for systemic adverse effects, decreasing burden of disease, and improving quality of life. To review currently available intranasal sprays indicated for maintenance therapy of AR in the United States: intranasal antihistamines (I...
Annals of Nutrition & Metabolism; Nutten S
Apr 30th, 2015 - Atopic dermatitis (AD) is a chronic inflammatory skin disease posing a significant burden on health-care resources and patients' quality of life. It is a complex disease with a wide spectrum of clinical presentations and combinations of symptoms. AD affects up to 20% of children and up to 3% of adults; recent data show that its prevalence is still increasing, especially in low-income countries....
International Forum of Allergy & Rhinology; Zajac AE, Adams AS et. al.
Apr 22nd, 2015 - Probiotics have proven beneficial in a number of immune-mediated and allergic diseases. Several human studies have evaluated the efficacy of probiotics in allergic rhinitis; however, evidence for their use has yet to be firmly established. The current systematic review seeks to synthesize the results of available randomized trials. In a systematic review and meta-analysis, the Medline, EMBASE, ...
International Journal of Pediatric Otorhinolaryngology; Yen HR, Liang KL et. al.
Feb 23rd, 2015 - Allergic rhinitis (AR) is a common allergic disorder in children, some of whom seek complementary treatments, including acupuncture and Chinese herbs. Little, however, is known about the treatment of pediatric AR with traditional Chinese medicine (TCM). To characterize TCM use in pediatric AR, we conducted a nationwide population-based study. We screened one million randomly sampled beneficiari...
The Journal of Allergy and Clinical Immunology; Nolte H, Maloney J et. al.
Jan 31st, 2015 - The magnitude of effect of sublingual immunotherapy for house dust mite (HDM)-induced allergic rhinitis with or without conjunctivitis is uncertain, partly because there are few well-controlled trials with well-defined doses. We sought to determine the dose-related efficacy and onset of action of the HDM sublingual immunotherapy tablet MK-8237 (Merck/ALK-Abelló) using the Vienna Challenge Chamb...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Ratner P, Van Bavel J et. al.
Jan 27th, 2015 - Allergic rhinitis (AR) is an inflammatory condition of the nasal mucosa characterized by symptoms of nasal discharge, itching, sneezing, and congestion. Ocular symptoms are commonly associated with AR and include itching or burning, tearing or watering, and redness. Intranasal corticosteroids are a mainstay of treatment, and their effect on nasal symptoms is well described. To demonstrate that ...
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology; Campo P, Rondón C et. al.
Dec 16th, 2014 - Local allergic rhinitis (LAR) is characterized by the presence of a nasal Th2 inflammatory response with local production of specific IgE antibodies and a positive response to a nasal allergen provocation test (NAPT) without evidence of systemic atopy. The prevalence has been shown to be up to 25% in subjects affected with rhinitis with persistence, comorbidity and evolution similar to allergic...
Allergy Smith H, Horney D et. al.
Nov 25th, 2014 - It is widely believed that in patients with allergic rhinitis and asthma, avoidance of specific triggers can help improve symptom control and reduce need for medication. Whilst most patients with asthma or rhinitis are sensitized to airborne allergens, primary care diagnostic and management decisions are often made without either obtaining a detailed history of the patient's allergic triggers o...
Journal of Psychosomatic Research; Chen MH, Su TP et. al.
Oct 4th, 2014 - Previous studies have found a temporal concordance in the increased prevalence of atopic diathesis/atopic diseases, attention-deficit hyperactivity disorder (ADHD), and autistic spectrum disorder (ASD) worldwide. But, the temporal association among these 3 distinct diseases is unknown. 14,812 atopic subjects diagnosed with any atopic disease (asthma, atopic dermatitis, allergic rhinitis, or all...
Current Allergy and Asthma Reports; Kern J, Bielory L
Oct 1st, 2014 - CAM is any therapeutic intervention that exists outside traditional allopathic medicine. The utilization in the US population is increasing up to 4 out of 10 patients in some surveys. Given this increasing prevalence, it is essential that clinicians have the resources to advise their patients in the utilizations, benefits, and potential harms of these alternative therapies. Recent literature wa...
American Journal of Rhinology & Allergy; Zhang CS, Xia J et. al.
Sep 9th, 2014 - Perennial allergic rhinitis (PAR) has a high and increasing prevalence worldwide. Ear acupressure (EAP) is a noninvasive semi-self-administered form of acupuncture. Previous studies indicated that EAP could be effective and safe for AR symptom management. However, there was insufficient evidence to confirm this. This study investigated whether EAP, a noninvasive clinical alternative to acupunct...
The Journal of Allergy and Clinical Immunology; Bartemes KR, Kephart GM et. al.
Aug 30th, 2014 - In mice, group 2 innate lymphoid cells (ILC2s) likely mediate helminth immunity, inflammation, and tissue repair and remodeling. However, the involvement of ILC2s in human diseases, such as asthma, is not well understood. The goals of this study were to investigate whether peripheral blood specimens can be used to monitor innate type 2 immunity in human subjects and to examine whether ILC2s are...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Nolte H, Amar N et. al.
May 19th, 2014 - MK-3641 is a short ragweed sublingual tablet under investigation for immunotherapy of ragweed pollen-induced allergic rhinitis. To characterize the safety and tolerability of a ragweed sublingual tablet (Merck/ALK-Abelló) in ragweed-allergic adults with or without conjunctivitis. Data from 4 randomized, double-blinded, placebo-controlled trials of MK-3641 (2 28-day and 2 52-week trials) were ev...
The Journal of Allergy and Clinical Immunology; Mosbech H, Deckelmann R et. al.
May 6th, 2014 - Investigations meeting current standards are limited for the effect of house dust mite (HDM) allergy immunotherapy in asthmatic patients. This trial investigated the efficacy and safety of a standardized quality (SQ; allergen standardization method proprietary to the trial sponsor) HDM SLIT-tablet (ALK, Hørsholm, Denmark) in adults and adolescents with HDM respiratory allergic disease. This pub...
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology; Portelli MA, Hodge E et. al.
Apr 28th, 2014 - An increasing proportion of the worldwide population is affected by allergic diseases such as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment options are needed particularly for severe, refractory disease. Allergic diseases are complex and development involves both environmental and genetic factors. Although the existence of a genetic component for alle...
American Journal of Rhinology & Allergy; DeYoung K, Wentzel JL et. al.
Apr 10th, 2014 - Immunotherapy (IT) has been well established as an effective treatment for allergic rhinitis (AR), but little is known about the benefits of IT on clinical outcomes of comorbid chronic rhinosinusitis (CRS). The goal of this publication is to systematically review the literature regarding outcomes of IT in patients with atopic CRS. A systematic review of the literature was conducted including st...
BMC Complementary and Alternative Medicine; Ortiz M, Witt CM et. al.
Apr 8th, 2014 - In a large randomised trial in patients with seasonal allergic rhinitis (SAR), acupuncture was superior compared to sham acupuncture and rescue medication. The aim of this paper is to describe the characteristics of the trial's participating physicians and to describe the trial intervention in accordance with the STRICTA (Standards for Reporting Interventions in Controlled Trials of Acupuncture...
Allergy Yilmaz O, Bakirtas A et. al.
Mar 21st, 2014 - During an asthma exacerbation, pulmonary function test parameters (PFTs) return to their baseline values within a few weeks. Factors affecting the recovery of PFTs other than the severity of exacerbation are not well known. The primary aim of the study was to determine the risk factors for recovery of PFTs > 7 days after a moderate to severe asthma exacerbation in children. Children who had mod...
Pediatric Neurology; Lin WY, Muo CH et. al.
Mar 18th, 2014 - Febrile convulsions and allergic rhinitis are both common childhood disorders and both are considered as generally benign disorders. Yet, especially in the case of allergic rhinitis, adverse effects on school performance and limited socialization are found. The relationship between febrile convulsions and allergic rhinitis has not been previously reported; thus, this article seeks to explore th...
PLoS Medicine; Saulyte J, Regueira C et. al.
Mar 12th, 2014 - Allergic rhinitis, allergic dermatitis, and food allergy are extremely common diseases, especially among children, and are frequently associated to each other and to asthma. Smoking is a potential risk factor for these conditions, but so far, results from individual studies have been conflicting. The objective of this study was to examine the evidence for an association between active smoking (...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Maloney J, Bernstein DI et. al.
Jan 28th, 2014 - In North America, few studies have evaluated sublingual immunotherapy for allergic rhinitis with or without conjunctivitis (AR/C); pediatric data are sparse. The authors report findings from the largest published immunotherapy trial yet conducted in adults and children. To evaluate grass sublingual immunotherapy tablet (MK-7243) treatment in subjects with AR/C. North American subjects (5-65 yea...
The Journal of Allergy and Clinical Immunology; Rondón C, Campo P et. al.
Dec 17th, 2013 - Local allergic rhinitis (LAR) is a common disease that affects 25.7% of the rhinitis population and more than 47% of patients previously diagnosed with nonallergic rhinitis. Whether LAR is the first step in the natural history of allergic rhinitis (AR) with systemic atopy or a consistent entity is unknown. The aim was to evaluate the natural history of a population with LAR of recent onset and ...
Clinics in Dermatology; Ramos-E-Silva M, Sampaio AL et. al.
Dec 9th, 2013 - Atopic dermatitis and seborrheic dermatitis are multifactorial dermatitides that are known collectively as endogenous dermatitis. Both conditions can affect the face, but they have clinical, epidemiological, and physiopathological peculiarities that distinguish them from each other. These two diseases are very common all around the world. Atopic dermatitis is associated with xerosis and increas...
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology; Dondi A, Tripodi S et. al.
Nov 18th, 2013 - Pollen-induced allergic rhinoconjunctivitis (AR) is highly prevalent and rapidly evolving during childhood. General practitioners may not be fully aware of the nature and severity of symptoms experienced by patients and might underestimate the prevalence of moderate or severe disease. Thus, the relevance of early diagnosis and intervention may be overlooked. To investigate the severity of polle...
Respiratory Medicine; Aasbjerg K, Torp-Pedersen C et. al.
Oct 4th, 2013 - In Denmark, 23% of the adult population have allergic rhinitis. We have previously demonstrated that a majority of hay fever patients are treated with depot-steroid injections in violation of the guidelines. It has been hypothesised that 1-2 annual depot-steroid injections are not harmful to the patient. Investigate if the depot-steroid treatment of allergic rhinitis instead of immunotherapy in...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Just J, Saint-Pierre P et. al.
Sep 23rd, 2013 - Rules for predicting the course of asthma in wheezy infants have low specificity. To determine if the novel phenotypes-mild early viral wheeze (EVW), atopic multiple-trigger wheeze (MTW), and nonatopic uncontrolled wheeze (NAUW)-have different courses during the preschool period. Part of the prospectively followed Trousseau Asthma Program cohort was phenotyped using cluster analysis with 12 par...
The Journal of Allergy and Clinical Immunology; Chen YY, Khoury P et. al.
Aug 30th, 2013 - Although most patients with hypereosinophilic syndromes (HES) present with clinical signs and symptoms attributable to eosinophilic tissue infiltration, some untreated patients remain asymptomatic or have signs and symptoms, such as allergic rhinitis, for which the relationship to peripheral eosinophilia is unclear (hypereosinophilia of unknown significance [HEUS]). To identify and characterize...
Allergy West CE, Hammarström ML et. al.
Jul 30th, 2013 - Long-term effects of probiotics in primary prevention of allergic disease need further evaluation. We previously reported a reduced cumulative incidence of infant eczema by feeding Lactobacillus paracasei ssp paracasei F19 (LF19) during weaning. Therefore, we assessed effects of LF19 on the prevalence of allergic disease at school age. In a double-blind placebo-controlled trial infants were ran...
Respiratory Medicine; Aydogan M, Eifan AO et. al.
Jul 27th, 2013 - Although sublingual immunotherapy (SLIT) has been demonstrated to be a safe and efficient treatment in children with seasonal allergic rhinitis (AR), there is little evidence on the efficacy of SLIT with house-dust-mite (HDM) extract in children with isolated perennial AR. We sought to assess the clinical efficacy and safety of HDM-SLIT in children with isolated allergic rhinitis-conjunctivitis...
American Journal of Rhinology & Allergy; Li Y, Wang D et. al.
Jul 25th, 2013 - This study evaluates the efficacy and safety of a pollen blocker cream in treatment of perennial allergic rhinitis (PAR) in a Chinese population. A randomized double-blind placebo-controlled, crossover trial was conducted in the Outpatient Department of the Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China. Patients diagnosed with PAR were randomly assigned to receive polle...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Reinhold T, Roll S et. al.
Jun 28th, 2013 - Allergic rhinitis (AR) is a frequent allergic disorder with a significant economic effect on health care costs and productivity. To assess the cost-effectiveness of acupuncture for patients with seasonal AR (SAR) in Germany. The present analysis was part of the Acupuncture in Seasonal Allergic Rhinitis (ACUSAR) trial, a 3-arm randomized, controlled, multicenter trial in patients with SAR, compa...
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Nolte H, Hébert J et. al.
May 27th, 2013 - Ragweed is an important cause of allergic rhinitis with or without conjunctivitis (AR/C) in North America and elsewhere. Allergen immunotherapy enabling safe patient self-administration is considered an unmet clinical need. Allergy immunotherapy tablet (AIT) treatment has shown promising efficacy and safety for grass allergy but has not been assessed for ragweed allergy. To evaluate efficacy an...
The Journal of Allergy and Clinical Immunology; Kiel MA, Röder E et. al.
May 8th, 2013 - Subcutaneous allergen immunotherapy (SCIT) and sublingual allergen immunotherapy (SLIT) are safe and effective treatments of allergic rhinitis, but high levels of compliance and persistence are crucial to achieving the desired clinical effects. Our objective was to assess levels and predictors of compliance and persistence among grass pollen, tree pollen, and house dust mite immunotherapy users...
The Journal of Allergy and Clinical Immunology; Creticos PS, Maloney J et. al.
Apr 29th, 2013 - In North America and Europe, millions of patients experience symptoms of allergic rhinitis with or without conjunctivitis (AR/C) on exposure to ragweed pollen. The disease burden can be significant, with most patients relying on symptomatic medications without disease-modifying potential. However, novel sublingual immunomodulatory treatment options may potentially play an important role if effi...
Allergy Lohia S, Schlosser RJ et. al.
Apr 17th, 2013 - Given the relationship between allergic rhinitis (AR) and asthma, it can be hypothesized that reducing inflammation in the upper airway with intranasal corticosteroid (INCS) medications may improve asthma outcomes. The goal of this study was to perform a systematic review with meta-analysis of the efficacy of INCS medications on asthma outcomes in patients with AR and asthma. Asthma-specific ou...
Human Vaccines & Immunotherapeutics; Rosewich M, Lee D et. al.
Apr 15th, 2013 - The prevalence of seasonal allergic rhinitis in the western world is high and increasing. Besides considerably affecting physical and psychosocial aspects of patients' lives, allergic rhinitis is often associated with allergic asthma and may aggravate this condition over time. Specific immunotherapy is currently the only approved therapy that can modify the underlying disease process and induce...
American Journal of Rhinology & Allergy; Agondi RC, Barros MT et. al.
Apr 8th, 2013 - Rhinosinusitis is highly prevalent in patients with common variable immunodeficiency (CVID), and probably allergic rhinitis (AR) may be masked by a history of repeated respiratory infections. The diagnosis of AR is based on the patient's symptoms and detection of specific immunoglobulin E (IgE) to aeroallergens. This study was designed to identify rhinitis of probable allergic cause in patients...
Annals of Internal Medicine; Brinkhaus B, Ortiz M et. al.
Feb 19th, 2013 - Chinese translation Acupuncture is frequently used to treat seasonal allergic rhinitis (SAR) despite limited scientific evidence. To evaluate the effects of acupuncture in patients with SAR. Randomized, controlled multicenter trial. (ClinicalTrials.gov: NCT00610584) 46 specialized physicians in 6 hospital clinics and 32 private outpatient clinics. 422 persons with SAR and IgE sensitization to b...
The Journal of Allergy and Clinical Immunology; Hankin CS, Cox L et. al.
Feb 4th, 2013 - Research demonstrates significant health care cost savings conferred by allergen-specific immunotherapy (AIT) to US children with allergic rhinitis (AR). We sought to examine whether AIT-related cost benefits conferred to US children with AR similarly extend to adults. A retrospective (1997-2009) Florida Medicaid claims analysis compared mean 18-month health care costs of patients with newly di...
American Journal of Otolaryngology; Albu S, Florian IS
Feb 4th, 2013 - The aim of this cross-sectional trial was to identify the bacterial flora and to quantify the level of bacterial presence in healthy adult frontal sinus cavities. Ninety five consecutive patients undergoing craniotomy of the anterior cranial fossa were enrolled. All patients were evaluated preoperatively by a sino-nasal questionnaire, nasal endoscopy and CT scan. Exclusion criteria were patient...
Allergy Choi SM, Park JE et. al.
Dec 20th, 2012 - The aim of this study was to evaluate the efficacy and safety of acupuncture in the treatment for allergic rhinitis. This study was a multicenter, randomized, parallel-controlled study. Participants were randomized to either the active acupuncture, sham acupuncture, or waitlist groups. The active and sham acupuncture groups received acupuncture treatment three times per week for 4 weeks. In the...
American Journal of Rhinology & Allergy; Abdulrahman H, Hadi U et. al.
Dec 18th, 2012 - Chronic respiratory diseases such as asthma and allergic rhinitis (AR) are a major public health problem in developing countries including those in the Middle East. However, to date, there is a paucity of information related to physician-diagnosed AR in this region. The Allergies in Middle East Survey was undertaken to help clarify and broaden the understanding of physician-diagnosed AR across ...
The Journal of Allergy and Clinical Immunology; Nwaru BI, Takkinen HM et. al.
Nov 27th, 2012 - Emerging evidence questions current recommendations on the timing of infant feeding for the prevention of childhood allergies. The evidence for asthma is inconclusive. We sought to investigate the associations between the duration of breast-feeding and timing of introduction of complementary foods and the development of asthma and allergies by the age of 5 years. Data were analyzed for 3781 con...