About 4,195 results

ALLMedicine™ Allergic Asthma Center

Research & Reviews  1,542 results

Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK...
Immunity, Inflammation and Disease; Xu C, Song Y et. al.

Aug 4th, 2021 - Pterostilbene (Pts) may be used for allergic asthma treatment. The AMPK/Sirt1 and Nrf2/HO-1 pathways are potential targets for asthma treatement. However, the relationship between Pts and AMPK/Sirt1 and Nrf2/HO-1 pathways in asthma is unclear. Her...

Mast cell chymase affects the functional properties of primary human airway fibroblasts...
The Journal of Allergy and Clinical Immunology; Zhao XO, Lampinen M et. al.

Aug 1st, 2021 - Mast cells have a profound impact on allergic asthma. Under such conditions, mast cells undergo degranulation, resulting in the release of exceptionally large amounts of mast cell-restricted proteases. However, the role of these proteases in asthm...

COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE the...
The European Respiratory Journal; Weckmann M, Bahmer T et. al.

Jul 31st, 2021 - Asthma is a heterogeneous syndrome substantiating the urgent requirement for endotype-specific biomarkers. Dysbalance of fibrosis and fibrolysis in asthmatic lung tissue leads to reduced levels of the inflammation-protective collagen 4 (COL4A3). T...

Omalizumab-associated eosinophilic granulomatosis with polyangiitis: cause or coincidence?
BMJ Case Reports; Carson LN, Pradhan A et. al.

Jul 31st, 2021 - Omalizumab is an anti-IgE monoclonal antibody used in severe allergic asthma. Herein, we describe a case of eosinophilic granulomatosis with polyangiitis, which manifested 3 months after initiation of omalizumab therapy, while maintenance corticos...

Local inflammation enables a basophil-neuronal circuITCH in atopic dermatitis.
Allergy López-Sanz C, Jimenéz-Saiz R et. al.

Jul 29th, 2021 - Allergic inflammation is often the result of a dysregulated Th2 immune response, IgE production, and the release of allergic mediators such as histamine or leukotrienes (LTs) by basophils and mast cells (MCs). Allergic diseases can manifest as acu...

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Guidelines  2 results

EAACI Guidelines on Allergen Immunotherapy: House dust mite-driven allergic asthma.
Allergy Agache I, Lau S et. al.

May 17th, 2019 - Allergen immunotherapy (AIT) has been in use for the treatment of allergic disease for more than 100 years. Asthma treatment relies mainly on corticosteroids and other controllers recommended to achieve and maintain asthma control, prevent exacerb...

Asthma management: A new phenotype-based approach using presence of eosinophilia and al...
Allergy Terl M, Sedlák V et. al.

Mar 23rd, 2017 - Asthma is a heterogeneous disease. The Czech Pneumology and Allergology Societies commissioned 10 experts to review the literature and create joint national guidelines for managing asthma, reflecting this heterogeneity. The aim was to develop an e...

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Drugs  13 results see all →

Clinicaltrials.gov  63 results

Mite Asthma Pediatric Immunotherapy Trial

Jan 6th, 2020 - The trial aims to demonstrate efficacy of the HDM SLIT-tablet versus placebo as add-on treatment in children and adolescents (5-17 years) with HDM allergic asthma based on clinically relevant asthma exacerbations. Additionally, the trial will inve...

Role of Montelukast in Asthma and Allergic Rhinitis Patients

Jan 3rd, 2020 - Montelukast is a potent and selective blocker of the CysLT1 receptor. Accordingly, a recent study has shown that Montelukast can improve symptoms of seasonal allergic rhinitis and asthma in patients with both diseases. For treatment of asthma, Mon...

Immune Dysfunction in Allergic Asthma

Sep 27th, 2019 - Subjects with mild allergic asthma are examined before, immediately after and 2 months after a course of treatment with anti-IgE. The following are examined: Allergen skin tests, allergen induced asthma, peripheral blood basophils, pulmonary bronc...

Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization

Mar 26th, 2019 - This is a 24 week double-blind study consisting of up to 11 office visits for people 18 years of age with aspirin exacerbated respiratory disease (AERD). 21 subjects will participate and will be randomized 2:1 to receive Xolair (Omalizumab) or pla...

A Safety and Efficacy Study of Intranasal GSK2245035 in Adults With Allergic Asthma

Oct 16th, 2018 - GSK2245035 belongs to a novel class of agonist drugs targeted at toll like receptors (TLR). T-helper cell 2 (Th2) driven inflammation is a key patho-physiological mechanism in allergic asthma. The clinical manifestations and inflammatory pathways ...

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News  56 results

Fast Five Quiz: Allergic Asthma Management

May 14th, 2021 - Allergic asthma is an increasingly prevalent chronic respiratory disease that imposes a significant burden on individuals, resulting in substantial healthcare costs, impairments to quality of life, and increased morbidity and mortality. The World ...

Fast Five Quiz: Allergic Asthma Management

May 14th, 2021 - Allergic asthma is an increasingly prevalent chronic respiratory disease that imposes a significant burden on individuals, resulting in substantial healthcare costs, impairments to quality of life, and increased morbidity and mortality. The World ...

Asthma Not an Independent Predictor of COVID-19 Outcome

Mar 3rd, 2021 - NEW YORK (Reuters Health) - Asthma is not an independent risk factor for hospitalization or more severe illness from SARS-CoV-2 infection and allergic asthma may actually be protective, according new research. There has been conflicting data regar...

Rapid Weight Gain in an Excessively Sleepy Girl With Asthma

Oct 9th, 2020 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills us...

Large Study Links Asthma, Allergic Rhinitis to Severe COVID-19

Aug 27th, 2020 - NEW YORK (Reuters Health) - People with allergic rhinitis and asthma may be slightly more prone to contracting COVID-19 and considerably more to developing severe disease when infected, according to a nationwide cohort study from South Korea. The ...

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Patient Education  2 results see all →