×
About 130 results

ALLMedicine™ Complement Deficiencies Center

Research & Reviews  46 results

Complement as Prognostic Biomarker and Potential Therapeutic Target in Renal Cell Carci...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703597
Journal of Immunology (Baltimore, Md. : 1950); Reese B, Silwal A et. al.

Nov 8th, 2020 - Preclinical studies demonstrated that complement promotes tumor growth. Therefore, we sought to determine the best target for complement-based therapy among common human malignancies. High expression of 11 complement genes was linked to unfavorabl...

The prognostic roles of hypogammaglobulinemia and hypocomplementemia in newly diagnosed...
https://doi.org/10.1080/10428194.2020.1832673
Leukemia & Lymphoma; Pan BH, Kong YL et. al.

Oct 17th, 2020 - Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of lymphoma. Our retrospective study included 553 newly diagnosed DLBCL patients from May 2009 to October 2019. The relationships between hypogammaglobulinemia, hypocomplementemia and...

Bacterial infections in a pediatric cohort of primary and acquired complement deficienc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513499
Pediatric Rheumatology Online Journal; Al-Shaikhly T, Hayward K et. al.

Sep 26th, 2020 - Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complement defects, patients with transiently l...

Meningococcaemia causing necrotizing cellulitis associated with acquired complement def...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240913
BMC Infectious Diseases; Pletschette Z, De Groote E et. al.

May 22nd, 2020 - Neisseria meningitidis has rarely been described as an agent of necrotic soft tissue infection. We report a case of a septic shock with necrotizing cellulitis due to Neisseria meningitidis serogroup W, treated by urgent extensive surgical debridem...

see more →

Clinicaltrials.gov  1 results

Safety and Immunogenicity of Novartis Meningococcal B Vaccine When Administered to Immunocompromised Children and Adolescents Compared to Healthy Subjects.
https://clinicaltrials.gov/ct2/show/NCT02141516

Feb 15th, 2017 - The study aims at evaluating the safety and immunogenicity of rMenB+OMV NZ when administered to subjects from 2 to 17 years of age with increased risk of meningococcal disease because either of primary or secondary complement deficiencies or of as...

see more →

News  5 results

Fast Five Quiz: Refresh Your Knowledge on Key Aspects of Sepsis
https://reference.medscape.com/viewarticle/897550_2

Jun 7th, 2018 - Risk factors for severe sepsis and septic shock include the following: Extremes of age (<10 years and >70 years) Primary diseases (eg, liver cirrhosis, alcoholism, diabetes, cardiopulmonary diseases, solid malignancy, and hematologic malignancy) I...

ACIP recommends changes to 2016 adult immunization schedule
https://www.mdedge.com/infectiousdisease/article/103719/infectious-diseases/acip-recommends-changes-2016-adult-immunization
Deepak Chitnis

Oct 21st, 2015 - The Advisory Committee on Immunization Practices (ACIP) has unanimously approved a series of changes to the adult immunization schedule for several vaccines. The changes, which must next be approved by the director of the Centers for Disease Contr.

ACIP OKs Meningitis Vaccine (Menveo) for High-Risk Infants
https://www.medscape.com/viewarticle/813066

Oct 23rd, 2013 - The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP) voted today to recommend (13 yes, 1 no, 1 abstain) the meningococcal conjugate vaccine MenACWY-CRM (Menveo, Novartis Vaccines) for use in infants ...

ACIP OKs Meningitis Vaccine (Menveo) for High-Risk Infants
https://www.staging.medscape.com/viewarticle/813066

Oct 23rd, 2013 - The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP) voted today to recommend (13 yes, 1 no, 1 abstain) the meningococcal conjugate vaccine MenACWY-CRM (Menveo, Novartis Vaccines) for use in infants ...

Targeting the Complement System in Bacterial Meningitis
https://www.medscape.com/viewarticle/920918_6

Conclusion There is a multitude of evidence that confirms the importance of complement system activation in bacterial meningitis. Patients with genetic complement deficiencies, and/or lower complement levels in the CSF tend to have favourable outc...

see more →