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About 203 results

ALLMedicine™ Complement Deficiencies Center

Research & Reviews  95 results

The prognostic roles of hypogammaglobulinemia and hypocomplementemia in newly diagnosed...
https://doi.org/10.1080/10428194.2020.1832673
Leukemia & Lymphoma; Pan BH, Kong YL et. al.

Oct 16th, 2020 - Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of lymphoma. Our retrospective study included 553 newly diagnosed DLBCL patients from May 2009 to October 2019. The relationships between hypogammaglobulinemia, hypocomplementemia and...

Bacterial infections in a pediatric cohort of primary and acquired complement deficienc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513499
Pediatric Rheumatology Online Journal; Al-Shaikhly T, Hayward K et. al.

Sep 25th, 2020 - Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complement defects, patients with transiently l...

Meningococcaemia causing necrotizing cellulitis associated with acquired complement def...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240913
BMC Infectious Diseases; Pletschette Z, De Groote E et. al.

May 21st, 2020 - Neisseria meningitidis has rarely been described as an agent of necrotic soft tissue infection. We report a case of a septic shock with necrotizing cellulitis due to Neisseria meningitidis serogroup W, treated by urgent extensive surgical debridem...

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel ...
https://doi.org/10.4049/jimmunol.1901473
Journal of Immunology (Baltimore, Md. : 1950); Skopelja-Gardner S, Colonna L et. al.

Apr 2nd, 2020 - Lupus nephritis (LN) is a major contributor to morbidity and mortality in lupus patients, but the mechanisms of kidney damage remain unclear. In this study, we introduce, to our knowledge, novel models of LN designed to resemble the polygenic natu...

European Society for Immunodeficiencies (ESID) and European Reference Network on Rare P...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253377
Journal of Clinical Immunology; Brodszki N, Frazer-Abel A et. al.

Feb 17th, 2020 - This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the inna...

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Clinicaltrials.gov  103 results

The prognostic roles of hypogammaglobulinemia and hypocomplementemia in newly diagnosed...
https://doi.org/10.1080/10428194.2020.1832673
Leukemia & Lymphoma; Pan BH, Kong YL et. al.

Oct 16th, 2020 - Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of lymphoma. Our retrospective study included 553 newly diagnosed DLBCL patients from May 2009 to October 2019. The relationships between hypogammaglobulinemia, hypocomplementemia and...

Bacterial infections in a pediatric cohort of primary and acquired complement deficienc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513499
Pediatric Rheumatology Online Journal; Al-Shaikhly T, Hayward K et. al.

Sep 25th, 2020 - Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complement defects, patients with transiently l...

Meningococcaemia causing necrotizing cellulitis associated with acquired complement def...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240913
BMC Infectious Diseases; Pletschette Z, De Groote E et. al.

May 21st, 2020 - Neisseria meningitidis has rarely been described as an agent of necrotic soft tissue infection. We report a case of a septic shock with necrotizing cellulitis due to Neisseria meningitidis serogroup W, treated by urgent extensive surgical debridem...

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel ...
https://doi.org/10.4049/jimmunol.1901473
Journal of Immunology (Baltimore, Md. : 1950); Skopelja-Gardner S, Colonna L et. al.

Apr 2nd, 2020 - Lupus nephritis (LN) is a major contributor to morbidity and mortality in lupus patients, but the mechanisms of kidney damage remain unclear. In this study, we introduce, to our knowledge, novel models of LN designed to resemble the polygenic natu...

European Society for Immunodeficiencies (ESID) and European Reference Network on Rare P...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253377
Journal of Clinical Immunology; Brodszki N, Frazer-Abel A et. al.

Feb 17th, 2020 - This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the inna...

see more →

News  5 results

Fast Five Quiz: Refresh Your Knowledge on Key Aspects of Sepsis
https://reference.medscape.com/viewarticle/897550_2

Jun 6th, 2018 - Risk factors for severe sepsis and septic shock include the following: Extremes of age (<10 years and >70 years) Primary diseases (eg, liver cirrhosis, alcoholism, diabetes, cardiopulmonary diseases, solid malignancy, and hematologic malignancy) I...

ACIP recommends changes to 2016 adult immunization schedule
https://www.mdedge.com/infectiousdisease/article/103719/infectious-diseases/acip-recommends-changes-2016-adult-immunization
Deepak Chitnis

Oct 21st, 2015 - The Advisory Committee on Immunization Practices (ACIP) has unanimously approved a series of changes to the adult immunization schedule for several vaccines. The changes, which must next be approved by the director of the Centers for Disease Contr.

ACIP OKs Meningitis Vaccine (Menveo) for High-Risk Infants
https://www.medscape.com/viewarticle/813066

Oct 22nd, 2013 - The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP) voted today to recommend (13 yes, 1 no, 1 abstain) the meningococcal conjugate vaccine MenACWY-CRM (Menveo, Novartis Vaccines) for use in infants ...

ACIP OKs Meningitis Vaccine (Menveo) for High-Risk Infants
https://www.staging.medscape.com/viewarticle/813066

Oct 22nd, 2013 - The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP) voted today to recommend (13 yes, 1 no, 1 abstain) the meningococcal conjugate vaccine MenACWY-CRM (Menveo, Novartis Vaccines) for use in infants ...

Targeting the Complement System in Bacterial Meningitis
https://www.medscape.com/viewarticle/920918_6

Conclusion There is a multitude of evidence that confirms the importance of complement system activation in bacterial meningitis. Patients with genetic complement deficiencies, and/or lower complement levels in the CSF tend to have favourable outc...

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