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About 192 results

ALLMedicine Complement Deficiencies Center

Research & Reviews  91 results

Meningococcaemia causing necrotizing cellulitis associated with acquired complement def...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240913
BMC Infectious Diseases; Pletschette Z, De Groote E et. al.

May 21st, 2020 - Neisseria meningitidis has rarely been described as an agent of necrotic soft tissue infection. We report a case of a septic shock with necrotizing cellulitis due to Neisseria meningitidis serogroup W, treated by urgent extensive surgical debridem...

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel ...
https://doi.org/10.4049/jimmunol.1901473
Journal of Immunology (Baltimore, Md. : 1950); Skopelja-Gardner S, Colonna L et. al.

Apr 2nd, 2020 - Lupus nephritis (LN) is a major contributor to morbidity and mortality in lupus patients, but the mechanisms of kidney damage remain unclear. In this study, we introduce, to our knowledge, novel models of LN designed to resemble the polygenic natu...

European Society for Immunodeficiencies (ESID) and European Reference Network on Rare P...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253377
Journal of Clinical Immunology; Brodszki N, Frazer-Abel A et. al.

Feb 17th, 2020 - This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the inna...

Plasma levels of soluble membrane attack complex are elevated despite viral suppression...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857077
Clinical and Experimental Immunology; Schein TN, Blackburn TE et. al.

Aug 28th, 2019 - The complement system is now a therapeutic target for the management of serious and life-threatening conditions such as paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, glomerulonephritis and other diseases caused by comple...

Common Genetic Variants in the Complement System and their Potential Link with Disease ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098274
Journal of Innate Immunity; van den Broek B, van der Flier M et. al.

Jul 3rd, 2019 - Streptococcus pneumoniae and Neisseria meningitidis are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a cruc...

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Clinicaltrials.gov  97 results

Meningococcaemia causing necrotizing cellulitis associated with acquired complement def...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240913
BMC Infectious Diseases; Pletschette Z, De Groote E et. al.

May 21st, 2020 - Neisseria meningitidis has rarely been described as an agent of necrotic soft tissue infection. We report a case of a septic shock with necrotizing cellulitis due to Neisseria meningitidis serogroup W, treated by urgent extensive surgical debridem...

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel ...
https://doi.org/10.4049/jimmunol.1901473
Journal of Immunology (Baltimore, Md. : 1950); Skopelja-Gardner S, Colonna L et. al.

Apr 2nd, 2020 - Lupus nephritis (LN) is a major contributor to morbidity and mortality in lupus patients, but the mechanisms of kidney damage remain unclear. In this study, we introduce, to our knowledge, novel models of LN designed to resemble the polygenic natu...

European Society for Immunodeficiencies (ESID) and European Reference Network on Rare P...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253377
Journal of Clinical Immunology; Brodszki N, Frazer-Abel A et. al.

Feb 17th, 2020 - This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the inna...

Plasma levels of soluble membrane attack complex are elevated despite viral suppression...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857077
Clinical and Experimental Immunology; Schein TN, Blackburn TE et. al.

Aug 28th, 2019 - The complement system is now a therapeutic target for the management of serious and life-threatening conditions such as paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, glomerulonephritis and other diseases caused by comple...

Common Genetic Variants in the Complement System and their Potential Link with Disease ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098274
Journal of Innate Immunity; van den Broek B, van der Flier M et. al.

Jul 3rd, 2019 - Streptococcus pneumoniae and Neisseria meningitidis are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a cruc...

see more →

News  4 results

ACIP recommends changes to 2016 adult immunization schedule
https://www.mdedge.com/infectiousdisease/article/103719/infectious-diseases/acip-recommends-changes-2016-adult-immunization
Deepak Chitnis

Oct 21st, 2015 - The Advisory Committee on Immunization Practices (ACIP) has unanimously approved a series of changes to the adult immunization schedule for several vaccines. The changes, which must next be approved by the director of the Centers for Disease Contr.

Give the MenB Vaccine
https://www.medscape.com/viewarticle/849868

Aug 25th, 2015 - Hi. My name is Paul Offit, and I am talking to you today from the Vaccine Education Center here at The Children's Hospital of Philadelphia. As of January of this year, two new serogroup B meningococcal (MenB) vaccines were licensed for use in adol...

ACIP OKs Meningitis Vaccine (Menveo) for High-Risk Infants
https://www.medscape.com/viewarticle/813066

Oct 22nd, 2013 - The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP) voted today to recommend (13 yes, 1 no, 1 abstain) the meningococcal conjugate vaccine MenACWY-CRM (Menveo, Novartis Vaccines) for use in infants ...

Advances in Meningococcal Immunization
https://www.medscape.com/viewarticle/410092

Introduction According to the CDC, about 3000 cases of meningococcal disease occur every year in the United States, with a case fatality rate of 10%. Although the frequency of meningococcal disease outbreaks has increased during the last decade, m...

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