About 220 results

ALLMedicine™ Complement Deficiencies Center

Research & Reviews  72 results

Physiology and pathology of the C3 amplification cycle: A retrospective.
Immunological Reviews; Peters K

Nov 22nd, 2022 - The C3 "Tickover" hypothesis, a mechanism whereby the host maintains constant surveillance of potential invading pathogens, targeting them for elimination through amplified C3b generation and C3-dependent effector mechanisms, was proposed by the l...

Meningococcemia Workup

Aug 5th, 2022 - Approach Considerations Definitive diagnosis of meningococcal infection requires culture of meningococci from blood, spinal fluid, joint fluid, or, occasionally, from skin lesions. The laboratory findings in the early stages of meningococcal disea...

Moyamoya Disease Associated with a Deficiency of Complement Component 6.
Journal of Stroke and Cerebrovascular Diseases : the Offi... Kato M, Kudo Y et. al.

Jun 20th, 2022 - Complement component 6 (C6) deficiency is a very rare genetic defect that leads to significantly diminished synthesis, secretion, or function of C6. In the current report, we demonstrate a previously undescribed, homozygous missense mutation in ex...

The yin and the yang of early classical pathway complement disorders.
Clinical and Experimental Immunology; Sullivan KE

Jun 2nd, 2022 - The classical pathway of the complement cascade has been recognized as a key activation arm, partnering with the lectin activation arm and the alternative pathway to cleave C3 and initiate the assembly of the terminal components. While deficiencie...

Screening for Immunodeficiencies in Children With Invasive Pneumococcal Disease: Six-ye...
The Pediatric Infectious Disease Journal; Bijker EM, Bateman EAL et. al.

Apr 15th, 2022 - A previous study showed that investigation of children with invasive pneumococcal disease (IPD) revealed an immunodeficiency in up to 10% of cases. Following this report, we implemented a protocol to investigate children with IPD, to assess the pr...

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Clinicaltrials.gov  3 results

Systematic Search for Primary Immunodeficiency in Adults With Infections

Sep 18th, 2020 - Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections - especially upper and lo...

Safety, Tolerability and Immunogenicity of 4CMenB Vaccine(2 Doses) in Adults With an Immunodeficiency

Mar 4th, 2020 - The meningococcal quadrivalent conjugate vaccine (MenACWY) and the licenced multicomponent MenB vaccine (Bexsero®) have already been included in the Italian childhood immunization programme and recommendations for high risk categories have been al...

Safety and Immunogenicity of Novartis Meningococcal B Vaccine When Administered to Immunocompromised Children and Adolescents Compared to Healthy Subjects.

Feb 15th, 2017 - The study aims at evaluating the safety and immunogenicity of rMenB+OMV NZ when administered to subjects from 2 to 17 years of age with increased risk of meningococcal disease because either of primary or secondary complement deficiencies or of as...

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News  13 results

Study supports meningococcal B vaccine in children with rare diseases
Randy Dotinga

Aug 1st, 2018 - A new study, the first of its kind, provided support for guidelines suggesting that the capsular meningococcal B vaccine be given to children with three rare conditions that boost infection risk. ©Micah Young/istockphoto.

Fast Five Quiz: Refresh Your Knowledge on Key Aspects of Sepsis

Jun 7th, 2018 - Risk factors for severe sepsis and septic shock include the following: Extremes of age (<10 years and >70 years) Primary diseases (eg, liver cirrhosis, alcoholism, diabetes, cardiopulmonary diseases, solid malignancy, and hematologic malignancy) I...

Fast Five Quiz: Do You Know Current Vaccination Recommendations?

Aug 22nd, 2016 - A single dose of meningococcal vaccine ACWY (ie, Menactra or Menveo) vaccine at age 11 through 12 years, with a booster dose at age 16 years, is recommended for routine vaccination. Meningococcal vaccination with conjugate ACWY vaccine is indicate...

ACIP recommends changes to 2016 adult immunization schedule
Deepak Chitnis

Oct 21st, 2015 - The Advisory Committee on Immunization Practices (ACIP) has unanimously approved a series of changes to the adult immunization schedule for several vaccines. The changes, which must next be approved by the director of the Centers for Disease Contr.

New Meningococcal B Vaccines: Who Gets Them and When?

Aug 20th, 2015 - Hello. I'm Dr Sandra Fryhofer. Welcome to Medicine Matters. The topic: the new Advisory Committee on Immunization Practices (ACIP) meningococcal B (MenB) vaccination recommendation. Here's why it matters. The good news is that meningococcal diseas...

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