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About 1,227 results

AllMedicine Hypereosinophilic Syndrome Center

Research & Reviews  601 results

The lymphoid variant of hypereosinophilic syndrome: study of 21 patients with CD3-CD4+ ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602413
Medicine Lefèvre G, Copin MC et. al.

Nov 14th, 2014 - The CD3-CD4+ aberrant T-cell phenotype is the most described in the lymphoid variant of hypereosinophilic syndrome (L-HES), a rare form of HES. Only a few cases have been reported, and data for these patients are scarce. To describe characteristic...

Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557265
The New England Journal of Medicine; Kuang FL, Legrand F et. al.

Apr 3rd, 2019 - Hypereosinophilic syndrome is a group of diseases defined by marked eosinophilia in blood or tissue and eosinophil-related clinical manifestations. Benralizumab is a monoclonal antibody against interleukin-5 receptor α, which is expressed on human...

Severe Prolonged Cough as Presenting Manifestation of FIP1L1-PDGFRA+ Chronic Eosinophil...
https://doi.org/10.1159/000446076
Respiration; International Review of Thoracic Diseases; Roufosse F, Heimann P et. al.

May 11th, 2016 - Chronic eosinophilic leukaemia associated with the FIP1L1-PDGFRA fusion gene (F/P+ CEL) is a rare cause of marked persistent hypereosinophilia, arising almost exclusively in male patients. Clinical presentations are heterogeneous with a higher inc...

Clinical features predict responsiveness to imatinib in platelet-derived growth factor ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109366
Allergy Khoury P, Desmond R et. al.

Jan 22nd, 2016 - With the exception of the presence of the FIP1L1-PDGFRA fusion gene, little is known about predictors of imatinib response in clinically-defined hypereosinophilic syndrome (HES). Subjects with FIP1L1-PDGFRA-myeloid neoplasm (FP; n =12), PDGFRA-neg...

CD3-CD4+ lymphoid variant of hypereosinophilic syndrome: nodal and extranodal histopath...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004425
Haematologica Lefèvre G, Copin MC et. al.

Feb 15th, 2015 - The CD3(-)CD4(+) lymphoid variant of hypereosinophilic syndrome is characterized by hypereosinophilia and clonal circulating CD3(-)CD4(+) T cells. Peripheral T-cell lymphoma has been described during this disease course, and we observed in our coh...

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Drugs  1 results see all →

Clinicaltrials.gov  617 results

The lymphoid variant of hypereosinophilic syndrome: study of 21 patients with CD3-CD4+ ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602413
Medicine Lefèvre G, Copin MC et. al.

Nov 14th, 2014 - The CD3-CD4+ aberrant T-cell phenotype is the most described in the lymphoid variant of hypereosinophilic syndrome (L-HES), a rare form of HES. Only a few cases have been reported, and data for these patients are scarce. To describe characteristic...

IMATINIB MESYLATE TABLETS
http://www1.apotex.com/products/us/detail.asp?m=61086

IMATINIB MESYLATE TABLETS ARE INDICATED FOR THE TREATMENT OF: Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase.

Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557265
The New England Journal of Medicine; Kuang FL, Legrand F et. al.

Apr 3rd, 2019 - Hypereosinophilic syndrome is a group of diseases defined by marked eosinophilia in blood or tissue and eosinophil-related clinical manifestations. Benralizumab is a monoclonal antibody against interleukin-5 receptor α, which is expressed on human...

Severe Prolonged Cough as Presenting Manifestation of FIP1L1-PDGFRA+ Chronic Eosinophil...
https://doi.org/10.1159/000446076
Respiration; International Review of Thoracic Diseases; Roufosse F, Heimann P et. al.

May 11th, 2016 - Chronic eosinophilic leukaemia associated with the FIP1L1-PDGFRA fusion gene (F/P+ CEL) is a rare cause of marked persistent hypereosinophilia, arising almost exclusively in male patients. Clinical presentations are heterogeneous with a higher inc...

Clinical features predict responsiveness to imatinib in platelet-derived growth factor ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109366
Allergy Khoury P, Desmond R et. al.

Jan 22nd, 2016 - With the exception of the presence of the FIP1L1-PDGFRA fusion gene, little is known about predictors of imatinib response in clinically-defined hypereosinophilic syndrome (HES). Subjects with FIP1L1-PDGFRA-myeloid neoplasm (FP; n =12), PDGFRA-neg...

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News  5 results

CHMP recommends approval of generic imatinib
https://www.mdedge.com/hematology-oncology/article/185423/cythemias/chmp-recommends-approval-generic-imatinib?channel=50519
HT Staff

Sep 18th, 2017 - Photo by Patrick Pelletier Imatinib tablet cut with a pill splitter The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended granting marketing authorization for Imatinib Teva B. V.

AACR: Gleevec Effective in Rare Myeloproliferative Disorder
https://www.medpagetoday.com/hematologyoncology/hematology/2977

Apr 2nd, 2006 - Action Points Be aware that this study found Gleevec effective and safe in patients with idiopathic hypereosinophilic syndrome (HES) who have a translocation between the FIP1L1 and PDGFR genes. This is an off-label use of Gleevec. This study was p...

Child With Severe Atopic Dermatitis
https://www.medscape.com/viewarticle/465529

Dec 23rd, 2003 - Question I have a 3-year-old girl with severe atopic dermatitis. Pharmacia CAP shows several positive reactions (class 4, 5, and 6) to foods and mites. She has IgE over 2000 and a peripheral eosinophil count of 2600. No asthma. Except for one supe...

T670X KIT Mutations in Gastrointestinal Stromal Tumors: Making Sense of Missense
https://www.medscape.com/viewarticle/589273

Abstract and Introduction Abstract Background: Chronic myeloid leukemia, gastrointestinal stromal tumors (GISTs), and idiopathic hypereosinophilic syndrome are associated with pathological deregulation of the tyrosine kinases BCR-ABL, KIT, and PDG...

Hypereosinophilic Syndrome: Diagnosis and Treatment
https://www.medscape.com/viewarticle/561214

Abstract and Introduction Purpose of review: Hypereosinophilic syndrome is increasingly recognized as a heterogeneous group of disorders, in some cases with precisely defined pathogenesis, which has led to changes in diagnostic approaches and ther...

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Patient Education  3 results see all →