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About 1,937 results

ALLMedicine™ Hypogammaglobulinemia Center

Research & Reviews  955 results

Helicobacter cinaedi-Associated Refractory Cellulitis in Patients with X-Linked Agammag...
https://doi.org/10.1007/s10875-020-00830-6
Journal of Clinical Immunology; Inoue K, Sasaki S et. al.

Sep 11th, 2020 - X-linked agammaglobulinemia (XLA) is characterized by severe or recurrent infections, hypogammaglobulinemia, and circulating B cell deficiency. The frequent pathogens seen in patients with XLA include Streptococcus pneumoniae, Haemophilus influenz...

Results of a Phase 2 Trial of an Oral CXCR4 Antagonist Mavorixafor for Treatment of WHI...
https://doi.org/10.1182/blood.2020007197
Blood Dale DC, Firkin FC et. al.

Sep 1st, 2020 - Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics and preli...

A systematic literature review of the effects of immunoglobulin replacement therapy on ...
https://doi.org/10.1080/1744666X.2020.1807328
Expert Review of Clinical Immunology; Monleón Bonet C, Waser N et. al.

Aug 11th, 2020 - Secondary immunodeficiency diseases (SID) caused by hematological malignancies (HMs), stem cell transplant (SCT), and associated therapies are mainly characterized by the presence of hypogammaglobulinemia or antibody production deficits. The autho...

Infection during the first year in patients treated with CD19 CAR T cells for diffuse l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405315
Blood Cancer Journal; Wudhikarn K, Palomba ML et. al.

Aug 7th, 2020 - CD19-targeted chimeric antigen receptor (CAR) T cell therapy is an effective treatment for diffuse large B cell lymphoma (DLBCL). In addition to cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS), B cell apla...

Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficie...
https://doi.org/10.1002/eji.202048549
European Journal of Immunology References; Schena F, Penco F et. al.

Jul 24th, 2020 - Adenosine deaminase 2 deficiency (DADA2) is an autoinflammatory disease characterized by inflammatory vasculopathy, early strokes associated often with hypogammaglobulinemia. Pure red cell aplasia, thrombocytopenia, and neutropenia have been repor...

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Drugs  4 results see all →

Clinicaltrials.gov  965 results

Helicobacter cinaedi-Associated Refractory Cellulitis in Patients with X-Linked Agammag...
https://doi.org/10.1007/s10875-020-00830-6
Journal of Clinical Immunology; Inoue K, Sasaki S et. al.

Sep 11th, 2020 - X-linked agammaglobulinemia (XLA) is characterized by severe or recurrent infections, hypogammaglobulinemia, and circulating B cell deficiency. The frequent pathogens seen in patients with XLA include Streptococcus pneumoniae, Haemophilus influenz...

Results of a Phase 2 Trial of an Oral CXCR4 Antagonist Mavorixafor for Treatment of WHI...
https://doi.org/10.1182/blood.2020007197
Blood Dale DC, Firkin FC et. al.

Sep 1st, 2020 - Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics and preli...

A systematic literature review of the effects of immunoglobulin replacement therapy on ...
https://doi.org/10.1080/1744666X.2020.1807328
Expert Review of Clinical Immunology; Monleón Bonet C, Waser N et. al.

Aug 11th, 2020 - Secondary immunodeficiency diseases (SID) caused by hematological malignancies (HMs), stem cell transplant (SCT), and associated therapies are mainly characterized by the presence of hypogammaglobulinemia or antibody production deficits. The autho...

Infection during the first year in patients treated with CD19 CAR T cells for diffuse l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405315
Blood Cancer Journal; Wudhikarn K, Palomba ML et. al.

Aug 7th, 2020 - CD19-targeted chimeric antigen receptor (CAR) T cell therapy is an effective treatment for diffuse large B cell lymphoma (DLBCL). In addition to cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS), B cell apla...

Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficie...
https://doi.org/10.1002/eji.202048549
European Journal of Immunology References; Schena F, Penco F et. al.

Jul 24th, 2020 - Adenosine deaminase 2 deficiency (DADA2) is an autoinflammatory disease characterized by inflammatory vasculopathy, early strokes associated often with hypogammaglobulinemia. Pure red cell aplasia, thrombocytopenia, and neutropenia have been repor...

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News  13 results

Hypogammaglobulinemia and infection risk clarified in MS patients on anti-CD20 agents
https://www.mdedge.com/multiplesclerosishub/article/209320/multiple-sclerosis/hypogammaglobulinemia-and-infection-risk/page/0/1

Oct 2nd, 2019 - Ocrelizumab Tobias Derfuss, MD, provided data on infection rates in the pivotal phase 3 OPERA and ORATIO double-blind clinical trials combined with their long-term, open-label extensions totaling 288 weeks, or nearly 6 years, of follow-up. Serum I.

Plerixafor produced dramatic responses in severe WHIM syndrome
https://www.mdedge.com/familymedicine/article/192393/anemia/plerixafor-produced-dramatic-responses-severe-whim-syndrome
MDedge Hematology and Oncology; Amy Karon

Jan 9th, 2019 - Low-dose treatment with plerixafor, a CXC chemokine receptor 4 antagonist, was well tolerated and markedly improved severe presentations of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome in three patients who could not.

Long-term side effects of CAR T cells mostly mild
https://www.mdedge.com/hematology-oncology/article/192072/cellular-therapy/long-term-side-effects-car-t-cells-mostly-mild
Neil Osterweil

Jan 4th, 2019 - SAN DIEGO – Longer-term follow-up of patients treated with CD19-targeted chimeric antigen receptor (CAR) T cells for hematologic malignancies indicates that the altered cells are generally safe, with most late events being mild in nature and possi.

To have not and then to have: A challenging immune paradox
https://www.mdedge.com/ccjm/article/152827/infectious-diseases/have-not-and-then-have-challenging-immune-paradox?channel=325
Brian F. Mandell, MD, PhD

Dec 1st, 2017 - Clinicians are well aware of the increased risk of infection in immunosuppressed patients. But the ecologic balance between infectious agents and the immune system is complex.

Immune Deficiency Foundation Seeks to Connect With Those Diagnosed With WHIM Syndrome
https://www.mdedge.com/clinicianreviews/article/137950/rare-diseases/immune-deficiency-foundation-seeks-connect-those

May 10th, 2017 - The Immune Deficiency Foundation would like to hear from individuals or families with a definite diagnosis of WHIM syndrome. WHIM is an acronym for some of the characteristic symptoms of the disorder – Warts, Hypogammaglobulinemia, Infections, and.

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