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About 1,178 results

ALLMedicine™ Hypogammaglobulinemia Center

Research & Reviews  435 results

New-onset Hypogammaglobulinemia and Infectious Complications Associated with Rituximab ...
https://doi.org/10.1093/rheumatology/keab626
Rheumatology (Oxford, England); Ong MS, Rothman D et. al.

Jul 31st, 2021 - To investigate the incidence and risk factors for hypogammaglobulinemia and infectious complications associated with rituximab treatment in childhood-onset rheumatic diseases. We performed a single-center retrospective study of patients (n = 85) t...

BAFF receptor polymorphisms and deficiency in humans.
https://doi.org/10.1016/j.coi.2021.06.008
Current Opinion in Immunology; Sevdali E, Block Saldana V et. al.

Jul 27th, 2021 - The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including survival, protein synthesi...

Primary hypogammaglobulinemia with IBD-like features: An ECCO CONFER Multicenter Case S...
https://doi.org/10.1093/ecco-jcc/jjab124
Journal of Crohn's & Colitis; Albshesh A, Eder P et. al.

Jul 19th, 2021 - Hypogammaglobulinemia is a disorder characterized by low serum immunoglobulin levels and had high prevalence of gastrointestinal manifestations. In some cases, clinical and endoscopic features are indistinguishable from those of inflammatory bowel...

Inborn errors of IKAROS and AIOLOS.
https://doi.org/10.1016/j.coi.2021.06.010
Current Opinion in Immunology; Yamashita M, Morio T

Jul 16th, 2021 - IKAROS is a pioneer protein of the IKZF family of transcription factors that plays an essential role in lymphocyte development. Recently, inborn errors of IKAROS have been identified in patients with B cell deficiency and hypogammaglobulinemia, an...

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Drugs  2 results see all →

Clinicaltrials.gov  13 results

Genetic Studies of Chronic Active Epstein-Barr Disease
https://clinicaltrials.gov/ct2/show/NCT00032513

May 8th, 2020 - Patients with chronic active Epstein-Barr virus (CAEBV) have (a) an illness that began as a primary infection with EBV or markedly elevated titers of antibodies to EBV, (b) histological evidence of organ disease, and (c) elevated EBV DNA levels in...

Personalized Immunotherapeutic for Antibiotic-resistant Infection
https://clinicaltrials.gov/ct2/show/NCT02508584

Jan 18th, 2020 - M. A. suffers from hypogammaglobulinemia that has been complicated by refractory Mycoplasma hominis septic arthritis. He has been receiving the antibiotic valnemulin under Emergency Investigational New Drug (eIND) 114686 following many prior treat...

Improving the Diagnosis of Common Variable Immune Deficiency
https://clinicaltrials.gov/ct2/show/NCT03335605

May 17th, 2019 - An increased susceptibility to bacterial and viral infections is the hallmark primary immunodeficiencies (PIDs). The most common PIDs requiring treatment with Ig replacement (SCIg or IVIg) is Common Variable Immune Deficiency (CVID), which is diag...

Intravenous Immunoglobulin (IVIG) in Lung Transplantation
https://clinicaltrials.gov/ct2/show/NCT00115778

Mar 5th, 2019 - An increased risk of infection despite intensive antimicrobial prophylaxis is a well-recognized complication of lung transplantation. Recent evidence suggests that immunosuppressive therapy after solid organ transplantation may lead to humoral imm...

GLILD Diagnosed in Children and Young Adults With Common Variable Immunodeficiency
https://clinicaltrials.gov/ct2/show/NCT03648567

Aug 27th, 2018 - Variable common immunodeficiency (VCID) encompasses a heterogeneous group of primitive immunodeficiencies, with variable clinical and immunological settings, but globally characterized by hypogammaglobulinemia with significant reduction of Immunog...

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News  21 results

Antibiotic, Rituximab Together Cut ANCA-Vasculitis Serious Infection Risk
https://www.medscape.com/viewarticle/950765

May 7th, 2021 - The serious infection risk associated with rituximab treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is high but can be offset by co-prescribing co-trimoxazole, data from a single-center, retrospective study re...

Risk for Hypogammaglobulinemia, Infections With Rituximab Increased in Pediatric Patients
https://www.medscape.com/viewarticle/949577

Apr 20th, 2021 - A quarter of children receiving treatment with rituximab developed hypogammaglobulinemia within 18 months of starting the drug, according to preliminary research shared at the annual scientific meeting of the Childhood Arthritis and Rheumatology R...

Novel Study Explores Link Between Primary Immunodeficiencies, Rheumatic Diseases
https://www.medscape.com/viewarticle/939605

Oct 22nd, 2020 - Fully 48% of patients with autoimmune rheumatic diseases who developed persistent hypogammaglobulinemia after initiating treatment with immunomodulatory agents harbored gene variants associated with inborn errors of immunity, according to the find...

Novel Study Explores Link Between Primary Immunodeficiencies, Rheumatic Diseases
https://www.staging.medscape.com/viewarticle/939605

Oct 22nd, 2020 - Fully 48% of patients with autoimmune rheumatic diseases who developed persistent hypogammaglobulinemia after initiating treatment with immunomodulatory agents harbored gene variants associated with inborn errors of immunity, according to the find...

IPD in children may be a signal of immunodeficiency
https://www.mdedge.com/clinicianreviews/article/209354/infectious-diseases/ipd-children-may-be-signal-immunodeficiency?channel=284
Bianca Nogrady

Oct 3rd, 2019 - Recurrent invasive pneumococcal disease in children could be a signal of underlying primary immunodeficiency, according to a systematic review published in JAMA Pediatrics. Coen Butters, BMed, DCH, of the Royal Children’s Hospital in Melbourne, an.

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