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About 2,393 results

ALLMedicine™ Immunodeficiencies Center

Research & Reviews  862 results

Endogenous soluble receptors sBCMA and sTACI: biomarker, immunoregulator and hurdle for...
https://doi.org/10.1016/j.coi.2021.06.015
Current Opinion in Immunology; Meinl E, Krumbholz M

Jul 31st, 2021 - BAFF and APRIL regulate B cell homeostasis by binding to their three receptors BAFFR, BCMA and TACI. The complexity of this system is further increased by shedding of these three receptors; this reduces signaling due to the display of less surface...

Pediatric Allergy: An Overview.
https://doi.org/10.1016/j.pop.2021.04.006
Primary Care; Rajaee A, Masquelin ME et. al.

Jul 28th, 2021 - Allergy is a broad topic encompassing common clinical allergic diseases, asthma, and complex immunodeficiencies. In this article, the authors discuss the most common allergic diseases and anaphylaxis and briefly review the current knowledge and ma...

SARS-CoV-2 spike glycoprotein-reactive T cells can be readily expanded from COVID-19 va...
https://doi.org/10.1002/iid3.496
Immunity, Inflammation and Disease; Taborska P, Lastovicka J et. al.

Jul 28th, 2021 - The COVID-19 vaccine was designed to provide protection against infection by the severe respiratory coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19). However, the vaccine's efficacy can be compromised in patients with immunodefic...

Role of hematopoietic cells in Mycobacterium tuberculosis infection.
https://doi.org/10.1016/j.tube.2021.102109
Tuberculosis (Edinburgh, Scotland); Tamburini B, Badami GD et. al.

Jul 28th, 2021 - Tuberculosis remains one of the most significant causes of mortality worldwide and the current situation shows a re-emergence of TB due to the emergence of new antibiotic-resistant strains and the widespread of disease caused by immunodeficiencies...

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Guidelines  1 results

European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
https://doi.org/10.4193/Rhin20.600
Rhinology Fokkens WJ, Lund VJ et. al.

Feb 23rd, 2020 - The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and cle...

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Drugs  13 results see all →

Clinicaltrials.gov  37 results

NIAID Clinical Center Genomics Opportunity Protocol
https://clinicaltrials.gov/ct2/show/NCT02417766

May 6th, 2020 - Investigators at National Institute of Allergy and Infectious Diseases (NIAID) are actively developing the infrastructure and capability for identifying the cause of heterogeneous immune-mediated disorders through whole exome and whole genome sequ...

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection
https://clinicaltrials.gov/ct2/show/NCT00006150

May 5th, 2020 - The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder ...

Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes
https://clinicaltrials.gov/ct2/show/NCT00001244

May 5th, 2020 - The purpose of this protocol is to carry out laboratory studies concerning the immunopathogenesis of Common Variable Immunodeficiency (CVI) and related primary humoral immunodeficiency diseases. Additionally, we aim to document and track the progr...

Genetic Basis of Primary Immunodeficiencies
https://clinicaltrials.gov/ct2/show/NCT00001788

Apr 24th, 2020 - The purpose of this study is to evaluate patients with primary immunodeficiency disorders to identify patients with mutations of the genes for the following proteins: Jak3, STAT1, STAT4, interleukin-7, interleukin-7 receptor, interleukin-12 recept...

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
https://clinicaltrials.gov/ct2/show/NCT02579967

Apr 20th, 2020 - Background: Primary immunodeficiency diseases (PIDs) are conditions associated with major quantitative or qualitative immunologic abnormalities that are, in most cases, due to defects in cells of hematopoietic origin Patients with PID can have lif...

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News  39 results

Inborn Errors of Immunity May Show Diverse Presenting Manifestations
https://www.medscape.com/viewarticle/951609

May 24th, 2021 - NEW YORK (Reuters Health) - Infection is the most frequent initial presenting manifestation of inborn errors of immunity (IEI), but both immune dysregulation and syndromic features may be indicative of these rare diseases, according to an analysis...

Prolonged SARS-CoV-2 Shedding Possible With Immunocompromise
https://www.staging.medscape.com/viewarticle/940090

Nov 2nd, 2020 - NEW YORK (Reuters Health) - Shedding of infectious SARS-CoV-2 can continue for months in immunocompromised patients, according to a case report. "We weren't surprised that someone with immune problems might have a longer disease course and be cont...

Novel Study Explores Link Between Primary Immunodeficiencies, Rheumatic Diseases
https://www.medscape.com/viewarticle/939605

Oct 22nd, 2020 - Fully 48% of patients with autoimmune rheumatic diseases who developed persistent hypogammaglobulinemia after initiating treatment with immunomodulatory agents harbored gene variants associated with inborn errors of immunity, according to the find...

Novel Study Explores Link Between Primary Immunodeficiencies, Rheumatic Diseases
https://www.staging.medscape.com/viewarticle/939605

Oct 22nd, 2020 - Fully 48% of patients with autoimmune rheumatic diseases who developed persistent hypogammaglobulinemia after initiating treatment with immunomodulatory agents harbored gene variants associated with inborn errors of immunity, according to the find...

COVID-19 Outcomes Vary Widely in Patients With Primary Immunodeficiencies
https://www.medscape.com/viewarticle/939374

Oct 20th, 2020 - NEW YORK (Reuters Health) - Clinical outcomes of COVID-19 in patients with primary immunodeficiency diseases range from mild illness to death, according to a small case series. "We were first surprised that we had only a few cases considering how ...

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Patient Education  5 results see all →