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About 6,418 results

ALLMedicine™ Splenomegaly Center

Research & Reviews  3,115 results

The occurrence and treatment of hemophagocytic lymphohistiocytosis caused by multiple f...
https://doi.org/10.21037/apm-21-68
Annals of Palliative Medicine; Zhuo W, Hao D et. al.

Apr 14th, 2021 - Hemophagocytic lymphohistiocytosis (HLH) is a high-fatality disease caused by hereditary or acquired immune dysfunction, and is characterized by pathological inflammatory response. Primary HLH (pHLH) has hereditary genetic defects, and secondary H...

Myelofibrosis: challenges for preclinical models and emerging therapeutic targets.
https://doi.org/10.1080/14728222.2021.1915992
Expert Opinion on Therapeutic Targets; Morsia E, Gangat N

Apr 12th, 2021 - Introduction: Myelofibrosis (MF) is characterized by anemia, splenomegaly, constitutional symptoms and bone marrow fibrosis. MF has no curative treatment to date, except for a small subset of patients that are eligible for allogeneic hematopoietic...

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherap...
https://doi.org/10.1182/bloodadvances.2021004177
Blood Advances; Di Grande A, Peirs S et. al.

Apr 8th, 2021 - B-cell lymphoma 2 (BCL-2) has recently emerged as a therapeutic target for early T-cell progenitor acute lymphoblastic leukemia (ETP-ALL), a high-risk subtype of human T-cell ALL. The major clinical challenge with targeted therapeutics, such as th...

Neonatal systemic juvenile Xanthogranuloma with Hydrops diagnosed by Purpura skin biops...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022363
BMC Pediatrics; Uehara Y, Wada YS et. al.

Apr 7th, 2021 - Systemic juvenile xanthogranuloma is a very rare disease typically presents as skin lesions with yellow papules or nodules and is sometimes fatal. We report a case of congenital neonatal systemic juvenile xanthogranuloma with atypical skin appeara...

Contemporary risk stratification and treatment of chronic myelomonocytic leukemia.
https://doi.org/10.1002/onco.13769
The Oncologist; Tremblay D, Rippel N et. al.

Apr 1st, 2021 - Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy characterized by absolute monocytosis, one or more lineage dysplasia, and proliferative features including myeloid hyperplasia, splenomegaly, and constitutional symptoms. Due to va...

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Guidelines  1 results

Revised diagnostic criteria and classification for the autoimmune lymphoproliferative s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953894
Blood Oliveira JB, Bleesing JJ et. al.

Jun 11th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...

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Drugs  1 results see all →

Clinicaltrials.gov  3,201 results

The occurrence and treatment of hemophagocytic lymphohistiocytosis caused by multiple f...
https://doi.org/10.21037/apm-21-68
Annals of Palliative Medicine; Zhuo W, Hao D et. al.

Apr 14th, 2021 - Hemophagocytic lymphohistiocytosis (HLH) is a high-fatality disease caused by hereditary or acquired immune dysfunction, and is characterized by pathological inflammatory response. Primary HLH (pHLH) has hereditary genetic defects, and secondary H...

Myelofibrosis: challenges for preclinical models and emerging therapeutic targets.
https://doi.org/10.1080/14728222.2021.1915992
Expert Opinion on Therapeutic Targets; Morsia E, Gangat N

Apr 12th, 2021 - Introduction: Myelofibrosis (MF) is characterized by anemia, splenomegaly, constitutional symptoms and bone marrow fibrosis. MF has no curative treatment to date, except for a small subset of patients that are eligible for allogeneic hematopoietic...

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherap...
https://doi.org/10.1182/bloodadvances.2021004177
Blood Advances; Di Grande A, Peirs S et. al.

Apr 8th, 2021 - B-cell lymphoma 2 (BCL-2) has recently emerged as a therapeutic target for early T-cell progenitor acute lymphoblastic leukemia (ETP-ALL), a high-risk subtype of human T-cell ALL. The major clinical challenge with targeted therapeutics, such as th...

Neonatal systemic juvenile Xanthogranuloma with Hydrops diagnosed by Purpura skin biops...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022363
BMC Pediatrics; Uehara Y, Wada YS et. al.

Apr 7th, 2021 - Systemic juvenile xanthogranuloma is a very rare disease typically presents as skin lesions with yellow papules or nodules and is sometimes fatal. We report a case of congenital neonatal systemic juvenile xanthogranuloma with atypical skin appeara...

Cerezyme - imiglucerase injection, powder, lyophilized, for solution-Genzyme Corporation
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=df60f030-866b-4374-a31f-8ae3f6b45c38

Apr 4th, 2021 - Cerezyme® (imiglucerase for injection) is indicated for long-term enzyme replacement therapy for pediatric and adult patients with a confirmed diagnosis of Type 1 Gaucher disease that results in one or more of the following conditions: anemia thro...

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News  97 results

HDL Mimetic Restores Kidney Function, Vision in Rare Disorder
https://www.medscape.com/viewarticle/946843

Mar 3rd, 2021 - CER-001 (Abionyx Pharma), an apolipoprotein A1 (apoA-1)–containing high-density lipoprotein (HDL) mimetic, may help restore kidney function and vision for patients suffering from a rare genetic disorder linked to the progressive development of cor...

A 70-Year-Old Man With Splenomegaly: Osmosis USMLE Study Question
https://www.medscape.com/viewarticle/893938_2

Aug 6th, 2020 - Massive splenomegaly is most characteristic of chronic myelogenous leukemia (CML) and hairy cell leukemia (HCL). CML is a neoplastic proliferation of mature myeloid cells, whereas HCL is a neoplastic proliferation of mature B cells. TRAP staining ...

A 70-Year-Old Man With Splenomegaly: Osmosis USMLE Study Question
https://www.medscape.com/viewarticle/893938_1

Aug 6th, 2020 - Test yourself with this question from Osmosis.org and see how you stack up against your peers!

A 70-Year-Old Man With Splenomegaly: Osmosis USMLE Study Question
https://www.medscape.com/viewarticle/893938

Aug 6th, 2020 - Test yourself with this question from Osmosis.org and see how you stack up against your peers! You must Log In to answer this question

Fast Five Quiz: Prognosis of Primary Myelofibrosis
https://reference.medscape.com/viewarticle/933699_2

Jul 15th, 2020 - Figure 1. Enlarged spleen (splenomegaly). Light micrograph of a section through an enlarged spleen that has occurred in myelofibrosis. PMF is an uncommon disease, with an annual incidence of approximately 0.5-1.5 cases per 100,000 individuals in t...

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Patient Education  3 results see all →