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About 4,255 results

ALLMedicine™ Splenomegaly Center

Research & Reviews  1,568 results

Updated results of the placebo-controlled, phase III JAKARTA trial of fedratinib in pat...
https://doi.org/10.1111/bjh.17727
British Journal of Haematology; Pardanani A, Tefferi A et. al.

Aug 1st, 2021 - Fedratinib, an oral Janus kinase-2 (JAK2) inhibitor, reduces splenomegaly and improves symptom burden in patients with myelofibrosis. Regulatory approval of fedratinib 400-mg daily was based on results of an updated analysis of the pivotal phase I...

Variants in CASP10, a diagnostic challenge: Single center experience and review of the ...
https://doi.org/10.1016/j.clim.2021.108812
Clinical Immunology (Orlando, Fla.); Pérez EM, Shephard JLV et. al.

Jul 31st, 2021 - Autoimmune lymphoproliferative syndrome is a primary immunodeficiency caused by variants in FAS-mediated apoptosis related genes and is characterized by lymphadenopathy, splenomegaly and autoimmunity. A total of six different variants in CASP10 ha...

Epstein-Barr Virus (EBV) acute acalculous cholecystitis in an immunocompromised adult p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283645
Journal of Preventive Medicine and Hygiene; Boninsegna S, Storato S et. al.

Jul 30th, 2021 - Primary Epstein-Barr virus (EBV) infection may present with self-limiting abdominal involvement, characterized by hepatitis with mild elevation of aminotransferases, splenomegaly, and rarely with acute acalculous cholecystitis (AAC). Usually, trea...

Clinical Characteristics, Molecular Background, and Survival of Egyptian Patients With ...
https://doi.org/10.1097/MPH.0000000000002249
Journal of Pediatric Hematology/oncology; El-Beshlawy A, Abdel-Azim K et. al.

Jul 27th, 2021 - This study analyzes the general disease characteristics, impact of enzyme replacement therapy (ERT), and overall survival (OS) of 156 Egyptian patients with Gaucher disease (GD) enrolled on hormone replacement from 1998 to 2017. The mean age at di...

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Guidelines  2 results

Revised diagnostic criteria and classification for the autoimmune lymphoproliferative s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953894
Blood Oliveira JB, Bleesing JJ et. al.

Jun 12th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...

Laparoscopic splenectomy: the clinical practice guidelines of the European Association ...
https://doi.org/10.1007/s00464-007-9735-5
Surgical Endoscopy; Habermalz B, Sauerland S et. al.

Feb 23rd, 2008 - Although laparoscopic splenectomy (LS) has become the standard approach for most splenectomy cases, some areas still remain controversial. To date, the indications that preclude laparoscopic splenectomy are not clearly defined. In view of this, th...

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Drugs  9 results see all →

Clinicaltrials.gov  30 results

Natural History of Noncirrhotic Portal Hypertension
https://clinicaltrials.gov/ct2/show/NCT02417740

Apr 13th, 2020 - Noncirrhotic Portal Hypertension (NCPH) includes a spectrum of chronic liver diseases characterized by increased pressure within the portal circulation in the absence of cirrhosis. The complications from NCPH are similar to that of cirrhosis induc...

Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome
https://clinicaltrials.gov/ct2/show/NCT03383380

Feb 18th, 2020 - Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described autosomal dominant primary immunodeficiency (PID), caused by the mutations in PIK3CD gene. The manifestations of APDS mainly include recurrent respiratory tract infectio...

Ruxolitinib (INCB018424) in Participants With Primary Myelofibrosis (PMF), Post Essential Thrombocythemia-myelofibrosis and Post Polycythemia Vera-myelofibrosis (PPV-MF)
https://clinicaltrials.gov/ct2/show/NCT01348490

Jan 28th, 2020 - To evaluate the effects of treatment with ruxolitinib (INCB018424) on spleen volume, symptoms and potential side effects in participants with PMF, PPV-MF and PET-MF who have platelet counts of 50 x 10^9/L to 100 x 10^9/L. It is anticipated that in...

Combination of JAK2 Inhibitor and Erythropoiesis-stimulating Agent in Myelofibrosis
https://clinicaltrials.gov/ct2/show/NCT03208803

Jun 17th, 2019 - Myeloproliferative Neoplasms are chronic diseases; they encompass Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis with shared mutations that constitutively activate the physiologic signal-transduction pathways responsible f...

The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department
https://clinicaltrials.gov/ct2/show/NCT02463669

Mar 5th, 2019 - The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomeg...

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News  90 results

HDL Mimetic Restores Kidney Function, Vision in Rare Disorder
https://www.medscape.com/viewarticle/946843

Mar 4th, 2021 - CER-001 (Abionyx Pharma), an apolipoprotein A1 (apoA-1)–containing high-density lipoprotein (HDL) mimetic, may help restore kidney function and vision for patients suffering from a rare genetic disorder linked to the progressive development of cor...

A 40-Year-Old Man With Bumps on His Neck: Osmosis USMLE Study Question
https://www.staging.medscape.com/viewarticle/891233_2

Oct 2nd, 2020 - The patient in this question most likely has Hodgkin lymphoma, a B-cell lymphoma characterized by a proliferation of Reed-Sternberg cells (B-cells) in a reactive cellular background. Reed-Sternberg cells secrete cytokines that lead to immunologic ...

A 70-Year-Old Man With Splenomegaly: Osmosis USMLE Study Question
https://www.medscape.com/viewarticle/893938_2

Aug 7th, 2020 - Massive splenomegaly is most characteristic of chronic myelogenous leukemia (CML) and hairy cell leukemia (HCL). CML is a neoplastic proliferation of mature myeloid cells, whereas HCL is a neoplastic proliferation of mature B cells. TRAP staining ...

A 70-Year-Old Man With Splenomegaly: Osmosis USMLE Study Question
https://www.medscape.com/viewarticle/893938

Aug 7th, 2020 - Test yourself with this question from Osmosis.org and see how you stack up against your peers! You must Log In to answer this question

A 70-Year-Old Man With Splenomegaly: Osmosis USMLE Study Question
https://www.medscape.com/viewarticle/893938_1

Aug 7th, 2020 - Test yourself with this question from Osmosis.org and see how you stack up against your peers!

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Patient Education  3 results see all →