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About 145 results

ALLMedicine™ Autoimmune Inner Ear Disease Center

Research & Reviews  49 results

Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
https://clinicaltrials.gov/ct2/show/NCT04806282

Feb 3rd, 2023 - Title: Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures and Discovery of Therapeutic Targets Study Description: Disorders of hearing instability remain poo...

The role of the stria vascularis in neglected otologic disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840708
Hearing Research; Johns JD, Adadey SM et. al.

Dec 31st, 2022 - The stria vascularis (SV) has been shown to play a critical role in the pathogenesis of many diseases associated with sensorineural hearing loss (SNHL), including age-related hearing loss (ARHL), noise-induced hearing loss (NIHL), hereditary heari...

Disease-Modifying Antirheumatic Drugs in the Treatment of Autoimmune Inner Ear Disease:...
https://doi.org/10.1097/MAO.0000000000003743
Otology & Neurotology : Official Publication of the Ameri... Gordis TM, Shah SR et. al.

Dec 13th, 2022 - To answer the following question: In patients with primary autoimmune inner ear disease (AIED), (population) what impact do disease-modifying antirheumatic agents (DMARDs) (intervention) when compared with no treatment or corticosteroids (comparis...

Effects of Anakinra in Subjects With Autoimmune Inner Ear Disease
https://clinicaltrials.gov/ct2/show/NCT03587701

Oct 20th, 2022 - This study will be evaluating whether or not anakinra (kineret) is superior to placebo for improving sustained hearing thresholds in patients with CR or intolerant MD and CR or intolerant AIED. Final enrollment is contingent on an acute decline in...

Cochlear implantation in systemic autoimmune disease.
https://doi.org/10.1097/MOO.0000000000000839
Current Opinion in Otolaryngology & Head and Neck Surgery; Goh X, Muzaffar J et. al.

Aug 26th, 2022 - Autoimmune inner ear disease (AIED) is a rare, but likely underrecognized cause of hearing loss. However, hearing loss is common in systemic autoimmune disease and it is important for the clinician to be familiar with the spectrum of disease. In t...

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Clinicaltrials.gov  9 results

Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
https://clinicaltrials.gov/ct2/show/NCT04806282

Feb 3rd, 2023 - Title: Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures and Discovery of Therapeutic Targets Study Description: Disorders of hearing instability remain poo...

Effects of Anakinra in Subjects With Autoimmune Inner Ear Disease
https://clinicaltrials.gov/ct2/show/NCT03587701

Oct 20th, 2022 - This study will be evaluating whether or not anakinra (kineret) is superior to placebo for improving sustained hearing thresholds in patients with CR or intolerant MD and CR or intolerant AIED. Final enrollment is contingent on an acute decline in...

Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease
https://clinicaltrials.gov/ct2/show/NCT00802529

Jun 27th, 2019 - Meniere's disease is characterised by episodic spontaneous vertigo attacks with hearing loss, ringing sounds and fullness in the ear. In one out of five patients, standard first line medical treatment is not effective in controlling vertigo attack...

A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
https://clinicaltrials.gov/ct2/show/NCT01267994

Jan 10th, 2018 - Patients with immune mediated hearing loss (also known as autoimmune hearing loss) are typically treated with corticosteroids. Of those treated, approximately 60% respond, however, that response may be lost over time. Other therapies use to date h...

Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Sudden Sensorineural Hearing Loss
https://clinicaltrials.gov/ct2/show/NCT02414152

Mar 13th, 2017 - For patients that experience an acute, sensorineural decline in hearing, timely corticosteroid administration may result in preservation of some or all of the hearing. For patients with sudden sensorineural hearing loss who have failed to respond ...

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