×
About 2,473 results

ALLMedicine™ Immunodeficiencies Center

Research & Reviews  902 results

An appraisal of the frequency and severity of non-infectious manifestations in primary ...
https://doi.org/10.1016/j.jaci.2021.12.790
The Journal of Allergy and Clinical Immunology; Alligon M, Mahlaoui N et. al.

Jan 16th, 2022 - Non-infectious manifestations, i.e. allergy, autoimmunity/inflammation, lymphoproliferation and malignancies are known to be observed in many primary immunodeficiency diseases (PID) and to participate to their prognosis. In order to have a global ...

Future of Therapy for Inborn Errors of Immunity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753954
Clinical Reviews in Allergy & Immunology; Perez E

Jan 13th, 2022 - Over the past 20 years, the rapid evolution in the diagnosis and treatment of primary immunodeficiencies (PI) and the recognition of immune dysregulation as a feature in some have prompted the use of "inborn errors of immunity" (IEI) as a more enc...

Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
https://clinicaltrials.gov/ct2/show/NCT00006150

Jan 12th, 2022 - The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder ...

P064 Association Between Crohn's Disease (CD) and Transient IgM and IgG Immunodeficienc...
https://doi.org/10.14309/01.ajg.0000798856.73091.69
The American Journal of Gastroenterology; Rabello IM, Lopes ST et. al.

Jan 11th, 2022 - Background: CD is an inflammatory disease that predominantly affects the gastrointestinal tract and has a progressive course. Immunodeficiencies can occur by altering different components of innate or adaptive immune responses. Such changes put th...

NIAID Clinical Center Genomics Opportunity Protocol
https://clinicaltrials.gov/ct2/show/NCT02417766

Jan 11th, 2022 - Investigators at National Institute of Allergy and Infectious Diseases (NIAID) are actively developing the infrastructure and capability for identifying the cause of heterogeneous immune-mediated disorders through whole exome and whole genome sequ...

see more →

Guidelines  1 results

European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
https://doi.org/10.4193/Rhin20.600
Rhinology Fokkens WJ, Lund VJ et. al.

Feb 23rd, 2020 - The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and cle...

see more →

Drugs  12 results see all →

Clinicaltrials.gov  32 results

Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
https://clinicaltrials.gov/ct2/show/NCT00006150

Jan 12th, 2022 - The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder ...

NIAID Clinical Center Genomics Opportunity Protocol
https://clinicaltrials.gov/ct2/show/NCT02417766

Jan 11th, 2022 - Investigators at National Institute of Allergy and Infectious Diseases (NIAID) are actively developing the infrastructure and capability for identifying the cause of heterogeneous immune-mediated disorders through whole exome and whole genome sequ...

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
https://clinicaltrials.gov/ct2/show/NCT02579967

Jan 11th, 2022 - Background: Primary immunodeficiency diseases (PIDs) are conditions associated with major quantitative or qualitative immunologic abnormalities that are, in most cases, due to defects in cells of hematopoietic origin Participants with PID can have...

Analysis of the Immune Response to COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations
https://clinicaltrials.gov/ct2/show/NCT04852276

Dec 16th, 2021 - The novel human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease (COVID-19). This acute respiratory syndrome is associated with activation of the innate immune system and a hyper-inflammatory response which c...

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders
https://clinicaltrials.gov/ct2/show/NCT00895271

Dec 16th, 2021 - This protocol is designed as an adjunct to other National Institutes of Health (NIH) IRB approved protocols that allow for genetic testing, which may include those that are screening protocols for patients with rare primary immunodeficiency or imm...

see more →

News  40 results

Unilateral Alar Ulceration
https://www.mdedge.com/dermatology/article/234112/mixed-topics/unilateral-alar-ulceration
Patrick S. Phelan, MD, Zachary P. Nahmias, MD et. al.

Jan 5th, 2021 - The Diagnosis: Trigeminal Trophic Syndrome (Self-induced Trauma) The patient admitted to manipulation of the ala in response to persistent pain despite resolution of the herpes zoster, for which he recently had completed a course of oral acyclovir.

JAK2 Mutations and JAK Inhibitors in the Management of Myeloproliferative Neoplasms
https://www.onclive.com/view/jak2-mutations-and-jak-inhibitors-in-the-management-of-myeloproliferative-neoplasms

Dec 5th, 2020 - The Philadelphia chromosome—negative myeloproliferative neoplasms (MPNs) are clonal disorders characterized by common mutations, but with distinct clinical features, treatment considerations, and prognostic outlooks.1 Identification of the JAK2 (J...

Prolonged SARS-CoV-2 Shedding Possible With Immunocompromise
https://www.staging.medscape.com/viewarticle/940090

Nov 2nd, 2020 - NEW YORK (Reuters Health) - Shedding of infectious SARS-CoV-2 can continue for months in immunocompromised patients, according to a case report. "We weren't surprised that someone with immune problems might have a longer disease course and be cont...

Novel Study Explores Link Between Primary Immunodeficiencies, Rheumatic Diseases
https://www.staging.medscape.com/viewarticle/939605

Oct 22nd, 2020 - Fully 48% of patients with autoimmune rheumatic diseases who developed persistent hypogammaglobulinemia after initiating treatment with immunomodulatory agents harbored gene variants associated with inborn errors of immunity, according to the find...

Novel Study Explores Link Between Primary Immunodeficiencies, Rheumatic Diseases
https://www.medscape.com/viewarticle/939605

Oct 22nd, 2020 - Fully 48% of patients with autoimmune rheumatic diseases who developed persistent hypogammaglobulinemia after initiating treatment with immunomodulatory agents harbored gene variants associated with inborn errors of immunity, according to the find...

see more →

Patient Education  2 results see all →