About 3,308 results

ALLMedicine™ Immunodeficiencies Center

Research & Reviews  1,137 results

Cutaneous Oncology in the Immunosuppressed.
Dermatologic Clinics; Wang LL, Lin SK et. al.

Nov 22nd, 2022 - Patients with immunosuppressive conditions experience an increased frequency and severity of cutaneous malignancies. This article highlights management of keratinocyte carcinoma, melanoma, Merkel cell carcinoma, and Kaposi sarcoma in the setting o...

NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune di...
Journal of Autoimmunity; Sharfe N, Dalal I et. al.

Nov 20th, 2022 - Genetic aberrations in the NFκB pathway lead to primary immunodeficiencies with various degrees of severity. We previously demonstrated that complete ablation of the RelB transcription factor, a key component of the alternative pathway, results in...

Patterns of use of recombinant zoster vaccine among commercially-insured immunocompeten...
Vaccine Fix J, Vielot NA et. al.

Nov 18th, 2022 - The Centers for Disease Control and Prevention (CDC) recommends recombinant zoster vaccination (RZV) for adults ≥ 50 years to prevent herpes zoster (HZ) and its sequelae. Initially, no distinct recommendation was made for immunocompromised adults,...

Beyond PI3Ks: targeting phosphoinositide kinases in disease.
Nature Reviews. Drug Discovery; Burke JE, Triscott J et. al.

Nov 15th, 2022 - Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death and are generated by the tightly regulated activity of phosphoinositide kinases. Although extensive efforts have focused on drugging class I phosphoinos...

Evaluation and Work-up of Immunodeficiencies in Recurrent Acute Rhinosinusitis: A Scopi...
International Forum of Allergy & Rhinology; Mandava S, Lin J et. al.

Nov 11th, 2022 - Primary immunodeficiency disorders (PIDD) may be a risk factor for development of Recurrent Acute Rhinosinusitis (RARS). There are currently no clear guidelines for the timing and methodology of PIDD testing in patients with RARS. The aim of this ...

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Guidelines  1 results

European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
Rhinology Fokkens WJ, Lund VJ et. al.

Feb 23rd, 2020 - The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and cle...

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Drugs  13 results see all →

Clinicaltrials.gov  98 results

Studies of Skin Microbes in Healthy People and in People With Skin Conditions

Oct 14th, 2022 - Skin microbiota (bacteria, fungi, viruses, phage, archae) play a significant role in common dermatological conditions, such as atopic dermatitis/AD (eczema). Since culture-dependent methods are often biased assessments of microbial diversity, geno...

NIAID Clinical Center Genomics Opportunity Protocol

Oct 14th, 2022 - Investigators at National Institute of Allergy and Infectious Diseases (NIAID) are actively developing the infrastructure and capability for identifying the cause of heterogeneous immune-mediated disorders through whole exome and whole genome sequ...

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Oct 14th, 2022 - This protocol is designed as an adjunct to other National Institutes of Health (NIH) IRB approved protocols that allow for genetic testing, which may include those that are screening protocols for patients with rare primary immunodeficiency or imm...

Mycobacterial and Opportunistic Infections in HIV-Negative Thai and Taiwanese Patients Associated With Autoantibodies to Interferon-gamma

Oct 13th, 2022 - The acquisition of opportunistic infections has been causally linked to innate and acquired immunodeficiencies. We have recently identified a population of Asian women with autoantibodies to interferon gamma (IFN?), all of whom were diagnosed by v...

Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)

Oct 13th, 2022 - The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder ...

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News  66 results

Grifols in 15-Year Deal With Canada for Plasma-Based Medicines

Sep 8th, 2022 - (Reuters) - Spanish pharmaceutical company Grifols has struck a 15-year renewable collaboration agreement with Canada's national blood authority to increase the supply of immunoglobulins (Ig) in the country, the company said on Wednesday. Under th...

It's Dangerous to Deny the CDC's Right to Mandate Masks

Apr 28th, 2022 - This transcript has been edited for clarity. Hi. I'm Art Caplan. I'm at the Division of Medical Ethics at New York University's Grossman School of Medicine. Masks are in the news again but not necessarily for good reasons. A federal court judge in...

Primary Immunodeficiencies Linked to Early-Onset GI Cancers

Feb 7th, 2022 - The study covered in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Patients with primary immunodeficiencies, also known as inborn errors of immunity (IEIs), are at higher risk for early-o...

Vaccinate Immigrants Immediately on Arrival? Not So Fast

Sep 22nd, 2021 - The U.S. policy that calls for giving all recommended vaccines to new immigrants as soon as they step off the metaphorical boat may need a tweak, said researchers who reported a fatal outcome for one teenage girl. The 17-year-old from Central Amer...

Gene Therapy Fixes Rare Type of Deadly Immune Deficiency

May 11th, 2021 - A novel gene therapy for severe combined immunodeficiency from adenosine deaminase deficiency (ADA-SCID) restored immune cell counts without death or need for enzyme replacement therapy, researchers reported. Survival without needing to re-initiat...

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Patient Education  8 results see all →