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About 26,625 results

ALLMedicine™ Neutropenia Center

Research & Reviews  7,513 results

Stimulating the autophagic-lysosomal axis enhances host defense against fungal infectio...
https://doi.org/10.1080/15548627.2022.2090727
Autophagy Forn-Cuní G, Welvaarts L et. al.

Jul 2nd, 2022 - The increasing prevalence of antifungal-resistant human pathogenic fungi, particularly azole-resistant Aspergillus fumigatus, is a life-threatening challenge to the immunocompromised population. Autophagy-related processes such as LC3-associated p...

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma
https://clinicaltrials.gov/ct2/show/NCT01993719

Jul 1st, 2022 - Background: Adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes can mediate the regression of bulky metastatic melanoma when administered along with high-dose aldesleukin (IL-2) following a non-myeloablative lymphodepleting...

Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation
https://clinicaltrials.gov/ct2/show/NCT03663933

Jul 1st, 2022 - Background: Disorders of T-cell proliferation and/or dysregulation (TCP/D) can lead to T-cell lymphoproliferative disorders, autoimmunity, infection, and aberrant immune activation with resulting organ dysfunction, morbidity, and mortality. Alloge...

A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
https://clinicaltrials.gov/ct2/show/NCT00967785

Jul 1st, 2022 - Mozobil (TM) (plerixafor injection, Genzyme/Sanofi) is a Food and Drug Administration approved medication to mobilize CD34+ hematopoietic stem cells prior to apheresis and use in autologous transplantation in non-Hodgkin lymphoma and multiple myel...

Improving White Blood Cell Collection From Healthy Donors
https://clinicaltrials.gov/ct2/show/NCT01553214

Jul 1st, 2022 - Bacterial and fungal infections in neutropenic patients or in patients with inherited disorders of neutrophil function continue to cause substantial morbidity and mortality. In particular, fungal infections are an increasingly important cause of d...

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Guidelines  16 results

Emerging challenges in the evaluation of fever in cancer patients at risk of febrile ne...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682766
Supportive Care in Cancer : Official Journal of the Multi... Cooksley T, Font C et. al.

Nov 25th, 2020 - Patients with cancer are at higher risk of more severe COVID-19 infection and have more associated complications. The position paper describes the management of cancer patients, especially those receiving anticancer treatment, during the COVID-19 ...

Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism.
https://doi.org/10.1210/clinem/dgaa543
The Journal of Clinical Endocrinology and Metabolism; Brar PC, Heksch R et. al.

Aug 19th, 2020 - The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade. Diazoxide is the only Food and Drug Agency-approved pharmacologic treatment for neonatal hypoglycemia caused by hyperinsulinism (HI). Recent publications have hi...

ACR Appropriateness Criteria® Acute Nonlocalized Abdominal Pain.
https://doi.org/10.1016/j.jacr.2018.09.010
Journal of the American College of Radiology : JACR; , Scheirey CD et. al.

Nov 6th, 2018 - The range of pathology in adults that can produce abdominal pain is broad and necessitates an imaging approach to evaluate many different organ systems. Although localizing pain prompts directed imaging/management, clinical presentations may vary ...

Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASC...
https://doi.org/10.1200/JCO.18.00374
Journal of Clinical Oncology : Official Journal of the Am... Taplitz RA, Kennedy EB et. al.

Sep 5th, 2018 - To provide an updated joint ASCO/Infectious Diseases Society of America (IDSA) guideline on antimicrobial prophylaxis for adult patients with immunosuppression associated with cancer and its treatment. ASCO and IDSA convened an update Expert Panel...

Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: Americ...
https://doi.org/10.1200/JCO.2017.77.6211
Journal of Clinical Oncology : Official Journal of the Am... Taplitz RA, Kennedy EB et. al.

Feb 21st, 2018 - Purpose To provide an updated joint ASCO/Infectious Diseases Society of American (IDSA) guideline on outpatient management of fever and neutropenia in patients with cancer. Methods ASCO and IDSA convened an Update Expert Panel and conducted a syst...

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Drugs  291 results see all →

Clinicaltrials.gov  783 results

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma
https://clinicaltrials.gov/ct2/show/NCT01993719

Jul 1st, 2022 - Background: Adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes can mediate the regression of bulky metastatic melanoma when administered along with high-dose aldesleukin (IL-2) following a non-myeloablative lymphodepleting...

Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation
https://clinicaltrials.gov/ct2/show/NCT03663933

Jul 1st, 2022 - Background: Disorders of T-cell proliferation and/or dysregulation (TCP/D) can lead to T-cell lymphoproliferative disorders, autoimmunity, infection, and aberrant immune activation with resulting organ dysfunction, morbidity, and mortality. Alloge...

A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
https://clinicaltrials.gov/ct2/show/NCT00967785

Jul 1st, 2022 - Mozobil (TM) (plerixafor injection, Genzyme/Sanofi) is a Food and Drug Administration approved medication to mobilize CD34+ hematopoietic stem cells prior to apheresis and use in autologous transplantation in non-Hodgkin lymphoma and multiple myel...

Improving White Blood Cell Collection From Healthy Donors
https://clinicaltrials.gov/ct2/show/NCT01553214

Jul 1st, 2022 - Bacterial and fungal infections in neutropenic patients or in patients with inherited disorders of neutrophil function continue to cause substantial morbidity and mortality. In particular, fungal infections are an increasingly important cause of d...

A Study of ALRN-6924 for the Prevention of Chemotherapy-induced Side Effects (Chemoprotection)
https://clinicaltrials.gov/ct2/show/NCT04022876

Jul 1st, 2022 - During Part 1 SCLC, topotecan will be administered per standard practice on Days 1-5 of 21-day cycles. Patients will be randomized to receive 1 of 2 initial ALRN-6924 dose levels, to be administered prior to each planned topotecan dose. The incide...

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News  2,045 results

Advanced gastric cancer: Ramucirumab-irinotecan combo fails phase 2
https://www.mdedge.com/hematology-oncology/article/255632/gastrointestinal-cancer/advanced-gastric-cancer-ramucirumab

Jun 22nd, 2022 - Key clinical point: Ramucirumab in combination with irinotecan fails to improve the progression-free survival (PFS) rate at 6 months in patients with previously treated advanced gastric cancer. Major finding: The 6-month PFS rate was 26.

Azathioprine Discontinuation Linked to Genotype Regardless of Race
https://www.medscape.com/viewarticle/975928

Jun 21st, 2022 - NEW YORK (Reuters Health) - Across multiple disease settings, patients with the rs2814778-CC genotype face a higher risk of stopping azathioprine due to hematopoietic toxicity and receiving lower doses of thiopurines, regardless of race, a new stu...

Excess weight may ward off infection in breast cancer treatment
https://www.mdedge.com/hematology-oncology/article/255239/breast-cancer/excess-weight-may-ward-infection-breast-cancer
Walter Alexander

Jun 7th, 2022 - A new study shows that being overweight may offer some women undergoing treatment for breast cancer protection against neutropenia – a potentially deadly outcome that can occur as a result of chemotherapy treatment. The study was presented at the.

Commentary: Gastric Cancer Chemotherapy in Select Populations, June 2022
https://www.mdedge.com/hematology-oncology/article/255104/gastrointestinal-cancer/commentary-gastric-cancer-chemotherapy
Nataliya Uboha, MD, PhD

Jun 1st, 2022 - Dr. Nataliya Uboha, MD Chemotherapy plays a critical role in the management of patients with advanced gastroesophageal adenocarcinoma, and a fluoropyrimidine and platinum doublet (either oxaliplatin or cisplatin) is the standard regimen used.

Advanced gastric cancer: Taxane-based chemotherapy regimen improves outcomes
https://www.mdedge.com/hematology-oncology/article/254815/gastrointestinal-cancer/advanced-gastric-cancer-taxane-based

May 23rd, 2022 - Key clinical point : Taxanes plus basic chemotherapy vs basic chemotherapy alone improves oncologic outcomes in treatment-naive patients with advanced gastric cancer. Major finding: Basic chemotherapy with vs without taxanes significantly improved.

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Patient Education  2 results see all →