ALLMedicine™ Cholinergic Urticaria Center - Clinicaltrials.gov
Immunology and Allergy Clinics of North America; Abajian M, Schoepke N et. al.
Nov 22nd, 2013 - Physical urticarias are a unique subgroup of chronic urticaria in which urticarial responses can be reproducibly induced by different specific physical stimuli acting on the skin. These conditions include urticaria factitia/symptomatic dermographism, delayed pressure urticaria, cold contact urticaria, heat contact urticaria, solar urticaria, and vibratory urticaria/angioedema. Physical urticari...
The British Journal of Dermatology; Takahagi S, Tanaka T et. al.
Sep 24th, 2008 - We previously demonstrated that the semipurified human sweat antigen causes skin reactions and histamine release from basophils via specific IgE in patients with atopic dermatitis (AD). Patients with cholinergic urticaria (ChU) also develop skin reactions and histamine release of basophils in response to autologous sweat. To study whether or not patients with ChU share sensitivity for the sweat...
Allergy and Asthma Proceedings; Otto HF, Calabria CW
Jun 24th, 2009 - With cholinergic urticaria (ChU), the ultimate diagnosis often depends on the demonstration of characteristic urticaria by appropriate provocation. Several treatment options may be helpful but traditional options (antihistamines, leukotriene inhibitors, and immunosuppressives) may be exhausted by the refractory ChU patient. Here, we describe such a case. Demonstration of immediate hypersensitiv...
Allergy Magerl M, Borzova E et. al.
Oct 1st, 2009 - The recommendations for the definition and diagnosis presented in this position paper are the result of a panel consensus meeting held in December 2008 in Berlin. This consensus meeting was a joint initiative of EAACI (European Academy of Allergology and Clinical Immunology) Dermatology Section, the EU-funded network of excellence, GA(2)LEN (Global Allergy and Asthma European Network), the EDF ...
Clinical and Experimental Dermatology; Sabroe RA
Nov 20th, 2009 - Cholinergic urticaria is one of the more common physical urticarias. Although it is often fairly mild, severe treatment-resistant disease may occur, with significant associated disability. Omalizumab, a monoclonal IgG anti-IgE antibody licensed for use in severe asthma, has recently been used successfully in several types of urticaria, including in one case of cholinergic urticaria. This paper ...
Allergy Metz M, Bergmann P et. al.
Jan 11th, 2008 - Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy.|2008|Metz M,Bergmann P,Zuberbier T,Maurer M,|therapeutic use,metabolism,therapeutic use,metabolism,drug therapy,immunology,
Current Allergy and Asthma Reports; Horikawa T, Fukunaga A et. al.
Aug 6th, 2009 - Patients with cholinergic urticaria (CU) show a number of small, short-lasting hives when their body core temperature increases, usually during sweating following exercise or bathing. The precise mechanism(s) of hive formation in CU has been unclear except for the involvement of acetylcholine. We recently reported that most CU patients show immediate-type skin responses to their own sweat, wher...
Oct 23rd, 2017 - Physical urticarias, such as delayed pressure, cholinergic, dermatographism and cold urticaria, are highly disabling conditions. Cholinergic urticaria occurs due to an active (e.g. exercise) or passive (e.g. hot bath) increase in core body temperature, causing itching and small hives with flare reaction on the trunk and limps that fade away upon cooling of the body. As it is the case of c...
Clinical and Experimental Allergy : Journal of the Britis... Asady A, Ruft J et. al.
Sep 5th, 2017 - Cholinergic urticaria (CholU) is a common skin disease characterized by the development of pinpoint-sized weals and severe itch upon physical exercise. Little is known about the epidemiology of CholU. CholU can occur at any age and has the highest prevalence among young adults. As of now, it is unclear whether patients of different age show differences in the clinical manifestation of CholU, du...
Military Medicine; Feinberg JH, Toner CB
Mar 12th, 2008 - A 22-year-old African American U.S. sailor presented with an intermittent pruritic eruption precipitated by mild activity for the last 2 years. She developed an extremely pruritic papular rash that would quickly coalesce into larger wheals following any exercise, light activity such as vacuuming, or taking hot showers. This condition had been getting progressively worse, preventing her from suc...
The Journal of Allergy and Clinical Immunology; Altrichter S, Chuamanochan M et. al.
Oct 12th, 2018 - Real-life treatment of cholinergic urticaria with omalizumab.|2018|Altrichter S,Chuamanochan M,Knoth H,Asady A,Ohanyan T,|
Annals of Allergy, Asthma & Immunology : Official Publica... Petalas K, Kontou-Fili K et. al.
Jun 5th, 2009 - Cholinergic urticaria is occasionally associated with bronchospasm, even in patients without a history of asthma; the underlying mechanism has not been elucidated. To evaluate bronchial hyperresponsiveness (BHR) in patients with cholinergic urticaria compared with healthy adults and patients with chronic urticaria. Patients with a history of cholinergic urticaria and a positive ergometric test ...
Journal of the European Academy of Dermatology and Venere... Altrichter S, Koch K et. al.
Jun 21st, 2016 - Cholinergic urticaria (CholU) is a frequent chronic urticaria disorder with itchy weal and flare-type skin reactions in response to physical exercise or passive warming. A higher frequency of atopy among CholU patients has been reported, but the significance of this observation is unclear. To assess the prevalence and relevance of atopy in CholU patients. Thirty CholU patients were assessed for...
Allergy Magerl M, Altrichter S et. al.
Mar 18th, 2016 - These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (Allergy, 2009). The aim of these recommendations is to improve the diagnosis and management of patients with CIndU. Our recommendations acknowledge the latest changes in our understandi...
International Journal of Dermatology; Kim JE, Jung KH et. al.
Jul 29th, 2014 - The pathogenesis of cholinergic urticaria (ChU) has been unclear except for the involvement of acetylcholine. Attempts to classify ChU according to etiology have rarely been performed. To evaluate the significance of responsiveness to autologous sweat and serum in ChU in relation to their clinical characteristics. This study involved 18 patients diagnosed with ChU between January 2010 and April...
Clinical and Experimental Dermatology; Chin YY, Chang TC et. al.
Aug 28th, 2012 - Idiopathic pure sudomotor failure (IPSF) is a subgroup of acquired idiopathic generalized anhidrosis, which is characterized by early age of onset, acute or sudden onset, concomitant sharp pain or cholinergic urticaria over the entire body, absence of autonomic dysfunction other than generalized anhidrosis, raised serum IgE level, and marked response to steroid. The aetiology of IPSF is still n...
Cutis Handfield KS, Dolan CK et. al.
May 5th, 2015 - Cholinergic urticaria (CU) is triggered by a rise in body temperature and can be complicated by bronchial hyperresponsiveness and anaphylaxis. It primarily affects young adults who actively engage in strenuous exercise, such as servicemen and servicewomen. If the patient reports a history of wheezing or difficulty breathing with urticaria, a water challenge test in a warm bath can be performed ...
The Journal of Dermatology; Munetsugu T, Fujimoto T et. al.
Mar 22nd, 2017 - Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. However, the effects of AIGA severity on the qualit...
The Journal of Dermatology; Iijima S, Kojo K et. al.
Jun 30th, 2017 - Cholinergic urticaria occasionally occurs in combination with anaphylactic symptoms. However, this has not been widely reported. Herein, we report the case of a 14-year-old Japanese male who was diagnosed with cholinergic urticaria accompanied by anaphylaxis. The patient, who was suffering from atopic dermatitis and bronchial asthma, had developed wheals after exercising or bathing, which would...
The Journal of Dermatology; Kawakami Y, Gokita M et. al.
Mar 26th, 2015 - Adrenergic urticaria (AU) is a rare type of stress-induced physical urticaria characterized by widespread pruritic urticarial papules. Diagnosis can be made by i.d. injection of adrenaline or noradrenaline, which produces the characteristic rash. Although the lesions of AU typically respond to beta-blockers such as propranolol, the therapeutic options for AU are limited. Here, we report a case ...