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About 123 results

ALLMedicine™ Schnitzler Syndrome Center

Research & Reviews  42 results

Inflammatory diseases in hematology: a review.
https://doi.org/10.1152/ajpcell.00356.2021
American Journal of Physiology. Cell Physiology; Henrie R, Cherniawsky H et. al.

Aug 9th, 2022 - Hematopoietic cells are instrumental in generating and propagating protective inflammatory responses to infection or injury. However, excessive inflammation contributes to many diseases of the blood, bone marrow, and lymphatic system. We review th...

IgM monoclonal gammopathies of clinical significance: diagnosis and management.
https://doi.org/10.3324/haematol.2022.280953
Haematologica Khwaja J, D'Sa S et. al.

Jul 1st, 2022 - IgM monoclonal gammopathy of undetermined significance is a pre-malignant condition for Waldenstrom Macroglobulinaemia (WM) and other B-cell malignancies, defined by asymptomatic circulating IgM monoclonal protein below 30 g/l with a lymphoplasmac...

Cutaneous manifestations of monoclonal gammopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001632
Blood Cancer Journal; Claveau JS, Wetter DA et. al.

Apr 13th, 2022 - Monoclonal gammopathy associated with dermatological manifestations are a well-recognized complication. These skin disorders can be associated with infiltration and proliferation of a malignant plasma cells or by a deposition of the monoclonal imm...

Waldenstrom Macroglobulinemia Clinical Presentation
https://emedicine.medscape.com/article/207097-clinical

Feb 3rd, 2022 - History Onset is insidious and nonspecific. Many patients are asymptomatic at presentation and are diagnosed incidentally from routine blood work. Weakness, anorexia and weight loss are the most common symptoms. Merlini et al reported the frequenc...

Refractory serum immunoglobulin M elevation during anti-interleukin (IL)-1- or IL-6-tar...
https://doi.org/10.1111/1346-8138.16124
The Journal of Dermatology; Takimoto-Ito R, Kambe N et. al.

Aug 27th, 2021 - Schnitzler syndrome is characterized by chronic urticarial rash, neutrophilic dermal infiltrate, recurrent fever, bone pain, elevated C-reactive protein, and neutrophilic leukocytosis. The pathophysiology of Schnitzler syndrome is unknown, but it ...

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Clinicaltrials.gov  6 results

Study of the Efficacy and Safety of RPH-104 in Adult Subjects With Schnitzler Syndrome
https://clinicaltrials.gov/ct2/show/NCT04213274

Mar 3rd, 2020 - The study will include a screening period (up to 28 days), a double blind, placebo controlled treatment period (14 days), followed by an 8 week safety follow up period after the second dose of study drug. Subjects with an established diagnosis of ...

Ilaris (Canakinumab) in the Schnitzler Syndrome
https://clinicaltrials.gov/ct2/show/NCT01245127

Jul 5th, 2019 - Description of the study: Objectives: Primary objective: To evaluate if canakinumab 150mg every 8 weeks can induce and maintain clinical remission in patients with the Schnitzler syndrome. Secondary objectives: To test if canakinumab 150mg can ind...

Ilaris® Effects in Schnitzler Syndrome (ILESCH)
https://clinicaltrials.gov/ct2/show/NCT01390350

Jul 17th, 2018 - This is a multi-center double-blind placebo-controlled study to assess the efficacy and safety of canakinumab (trade name Ilaris®), a high-affinity monoclonal antibody that neutralizes IL-1β, in patients with Schnitzler syndrome. Efficacy is asses...

Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors
https://clinicaltrials.gov/ct2/show/NCT00933296

Sep 8th, 2017 - The Schnitzler syndrome is a rare entity characterized by an urticarial rash and recurrent fever in a patient with a monoclonal IgM component. Other frequent signs include joint, bone and muscle pain, enlarged spleen, liver and lymph nodes, increa...

Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS)
https://clinicaltrials.gov/ct2/show/NCT01045772

May 31st, 2012 - This is a single-center open label study of the IL-1 transfusion protein rilonacept in subjects with Muckle-Wells syndrome (MWS), or Schnitzler syndrome (SchS) in Germany. Prospective subjects will be recruited from a patient population previously...

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News  1 results

Successful Treatment of Schnitzler Syndrome With Canakinumab
https://www.mdedge.com/dermatology/article/86939/urticaria/successful-treatment-schnitzler-syndrome-canakinumab
Robbie Pesek, MD, Roger Fox, MD

Sep 3rd, 2014 - To the Editor: Schnitzler syndrome occurs with a triad of chronic urticaria, recurring fevers, and monoclonal gammopathy. It was recognized as a clinical entity in 1972; now nearly 200 patients are reported in the medical literature.

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