JAMA Hay AD, Little P et. al.
Aug 22nd, 2017 - Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. To assess the effects of oral corticosteroids for acute lower respiratory tract infection in adults without asthma. Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014...
Medical Clinics of North America; Nanda A, et al
Oct 27th, 2019 - Asthma affects approximately 300 million people worldwide and approximately 7.5% of adults in the United States. Among adults, asthma results in about 10.5 million physician office visits per year and affects approximately 8.7% of blacks, 7.6% of whites, and 5.8% of Hispanics. Asthma is characterized by inflammation of airways, variable airflow obstruction, and bronchial hyperresponsiveness.3 I...
Oct 16th, 2019 - Single-dose Xofluza is the first and only antiviral medicine indicated specifically for patients at high risk of developing serious complications from influenza (flu) The Centers for Disease Control and Prevention (CDC) defines people at high risk of serious flu complications as those who have conditions such as asthma, chronic lung disease, diabetes, heart disease, morbid obesity or adults ...
American Family Physician;
Oct 14th, 2019 - The incidence of pulmonary complications following major surgery is estimated to be 1% to 23%, with the risk varying based on patient factors and the type of surgery.1 Postoperative pulmonary complications include pneumonia, tracheobronchitis, pulmonary edema, pulmonary embolism, atelectasis, pleural effusion, pneumothorax, bronchospasm, aspiration, respiratory failure, and acute respiratory di...
Sep 29th, 2019 - The 2019 update of the Global Strategy for Asthma Management and Prevention incorporates new scientific information about asthma based on a review of recent scientific literature by an international panel of experts on the GINA Science Committee. This comprehensive and practical resource about one of the most common chronic lung diseases worldwide contains extensive citations from the scientifi...
Sep 25th, 2019 - David J. Amrol, MD reviewing Hardy J et al. Lancet 2019 Sep 14 Gauthier M and Wenzel SE. Lancet 2019 Sep 14
Sep 23rd, 2019 - David J. Amrol, MD reviewing Gabrielli S et al. J Allergy Clin Immunol Pract 2019 Sep/Oct
Sep 12th, 2019 - Aimmune Therapeutics, Inc. (Nasdaq:AIMT), a biopharmaceutical company developing treatments for potentially life-threatening food allergies, today announced that the Allergenic Products Advisory Committee (APAC) convened by the U.S. Food and Drug Administration (FDA) voted to support the use of AR101 (proposed trade name PALFORZIA™) in children and teens with peanut allergy. PALFORZIA is a comp...
Sep 11th, 2019 - GlaxoSmithKline (LSE/NYSE: GSK) today announced that the US Food and Drug Administration (FDA) has approved Nucala (mepolizumab) for use in children as young as six years old who are living with severe eosinophilic asthma. Nucala is the only targeted biologic to be approved for the condition in the six to 11-year age group in the US.
Jul 31st, 2019 - Allergies can be life-threatening when they cause anaphylaxis, an extreme reaction with constriction of the airways and a sudden drop in blood pressure. Scientists have identified a subtype of immune cell that drives the production of antibodies (link is external) associated with anaphylaxis and other allergic reactions. The research was funded by the National Institute of Allergy and Infectio...
Jul 31st, 2019 - Though food allergy affects more than 4.8 million children in the United States, no approved preventative treatments currently exist. While experimental desensitization strategies are available in research settings, people with food allergies must avoid known allergens and are advised to carry injectable epinephrine to prevent potentially life-threatening allergic reactions caused by accidenta...
The Journal of Allergy and Clinical Immunology: In Practice; Raita, Y. et. al.
Jul 15th, 2019 - Background Patients with asthma have a high incidence of acute myocardial infarction and ischemic stroke. Objective To investigate the acute effect of asthma exacerbation on these cardiovascular events. Methods Using population-based inpatient data of 3 geographically diverse US states (Florida, Nebraska, and New York) during the period 2011 to 2014, we conducted a self-controlled case...
Jul 14th, 2019 - Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced today that the U.S. Food and Drug Administration (FDA) has approved AirDuo® Digihaler™ (fluticasone propionate 113 mcg and salmeterol 14 mcg) Inhalation Powder, a combination therapy digital inhaler with built-in sensors that connects to a companion mobile application to provide information on inhaler use to people with asthma....
Jul 4th, 2019 - Grifols (MCE:GRF, MCE:GRF.P NASDAQ:GRFS), a leading global producer of plasma-derived medicines, announced today that Xembify®, its new 20% subcutaneous immunoglobulin, has been approved by the U.S. Food and Drug Administration (FDA). Xembify® is used to treat primary immunodeficiencies.
Jun 26th, 2019 - NUCALA (mepolizumab) has clinical data on exacerbation reduction. Learn about NUCALA for patients with severe eosinophilic asthma.
Jun 24th, 2019 - Atopic dermatitis is a chronic, itchy skin condition that is very common in children but may occur at any age. It is also known as eczema and atopic eczema and was formerly known as Besnier prurigo. It is the most common form of dermatitis. Atopic dermatitis usually occurs in people who have an 'atopic tendency'. This means they may develop any or all of three closely linked conditions; atop...
Nemeth, V. et. al.
Jun 3rd, 2019 - Eczema, also known as atopic dermatitis, is the most common form of dermatitis. Genetic as well as environmental factors are thought to play a part in the pathogenesis. Eczema is most commonly seen in children but can be seen in adults. People with the disease tend to have dry, itchy skin that is prone to infection. Eczema is commonly known as the "itch that rashes" due to dry skin that lea...
The Cochrane Database of Systematic Reviews; Threapleton, C. et. al.
May 23rd, 2019 - Chronic obstructive pulmonary disease (COPD; including chronic bronchitis and emphysema) is a chronic respiratory condition characterised by shortness of breath, cough and recurrent exacerbations. Long‐term antibiotic use may reduce both bacterial load and inflammation in the airways. Studies have shown a reduction of exacerbations with antibiotics in comparison to placebo in people with COPD, ...
May 2nd, 2019 - Racial and ethnic disparities in severe maternal morbidity — life-threatening maternal complications associated with childbirth — have persisted and increased at high rates among U.S. women, according to an analysis of nearly 20 years of California hospital records funded by the National Institutes of Health. Known risk factors for these complications — such as blood pressure disorders, asthma ...
The Cochrane Database of Systematic Reviews; Christoffers, W. et. al.
Apr 25th, 2019 - Hand eczema is an inflammation of the skin of the hands that tends to run a chronic, relapsing course. This common condition is often associated with itch, social stigma, and impairment in employment. Many different interventions of unknown effectiveness are used to treat hand eczema.
Mar 24th, 2019 - The latest national and state data on the burden of asthma among children and adults.
Mar 20th, 2019 - Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for and treated only in pregnant women or in an individual prior to undergoing invasive urologic procedures.
Mar 17th, 2019 - This clinical report updates and replaces a 2008 clinical report from the American Academy of Pediatrics, which addressed the roles of maternal and early infant diet on the prevention of atopic disease, including atopic dermatitis, asthma, and food allergy. As with the previous report, the available data still limit the ability to draw firm conclusions about various aspects of atopy prevention ...
Feb 23rd, 2019 - The prevalence of asthma was nearly twice as high as the national average in a cohort of opioid-dependent patients receiving acute care at an inner city hospital in a New York City borough, with female sex more closely linked to higher asthma risk than male sex, researchers reported here.
Feb 21st, 2019 - American Academy of Allergy, Asthma and Immunology (AAAAI) 2019 Meeting: Read clinically focused news coverage of key developments from AAAAI 2019
Chipps, B.,et al
Dec 10th, 2018 - Asthma guidelines recommend a control-based approach to disease management in which the assessment of impairment and risk is linked to step-based therapy. Using this model, controller treatment is adjusted—upward or downward—according to a patient's level of asthma control over time.
Nov 30th, 2018 - Mastocytosis is a group of heterogeneous disorders resulting from the clonal proliferation of abnormal mast cells and their accumulation in the skin and/or in various extracutaneous organs. Systemic mastocytosis is the most common form of mastocytosis diagnosed in adults, characterized by mast cell infiltration of one or more extracutaneous organs (with or without skin involvement).
Nov 12th, 2018 - Evidence-based update using Cochrane Eyes and Vision Group-identified systematic reviews for the initial evaluation of conjunctivitis patients and discussion of associated or predisposing factors.
European Clinical Respiratory Journal;
Nov 6th, 2018 - Background: New, complex, and expensive therapies targeting Interleukin-5 (IL-5) to treat severe eosinophilic asthma are emerging. Objective: To assess efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab for treating severe eosinophilic asthma. Design: A systematic review and meta-analysis on randomized, placebo-controlled, clinical trials elucidating two cri...
Nov 3rd, 2018 - Consider a diagnosis of asthma and perform spirometry if any of these indicators are present :The symptoms of dyspnea, cough and/or wheezing, especially nocturnal, difficulty breathing or chest tightness
Taplitz, R. et. al.
Sep 3rd, 2018 - Antibacterial and antifungal prophylaxis is recommended for patients who are at high risk of infection, including patients who are expected to have profound, protracted neutropenia, which is defined as < 100 neutrophils/µL for > 7 days or other risk factors. Herpes simplex virus–seropositive patients undergoing allogeneic hematopoietic stem-cell transplantation or leukemia induction therapy sho...
Jun 25th, 2018 - For decades physicians have understood that a diagnosis of asthma requires further description because attacks of wheezing and shortness of breath can be associated with several underlying diseases. For example, patients allergic to animal dander, such as cat dander, who have animals as pets, may suffer from chronic severe asthma. Identification of patients with this form of asthma (referred to...
Jun 18th, 2018 - Vital Signs: Asthma in Children – United States, 2001-2016 Free continuing education (CE) activity that describes trends and demographic differences in health outcomes and healthcare use for childhood asthma, based on a CDC analysis of asthma data from the 2001-2016 National Health Interview Survey for children 17 years and younger.This activity is intended for pediatricians, pulmonologists, ...
May 20th, 2018 - The most common risk factors for developing asthma is having a parent with asthma, having a severe respiratory infection as a child, having an allergic condition, or being exposed to certain chemical irritants or industrial dusts in the workplace.
Randy A. Taplitz
May 9th, 2018 - To provide an updated joint ASCO/Infectious Diseases Society of American (IDSA) guideline on outpatient management of fever and neutropenia in patients with cancer.
Apr 23rd, 2018 - Asthma deaths have decreased over time and varied by demographic characteristics. View the statistics from the Centers for Disease Control and Prevention (CDC) - National Center of Environmental Health (NCEH) - National Asthma Control Program
Mar 15th, 2018 - Asthma is a common chronic airway disorder characterized by periods of airflow obstruction known as asthma attacks (1). Symptom frequency can range from intermittent to constant, and attack severity can vary from mild to life threatening (1). Several studies have shown that among adults, obesity is associated with an increased risk of asthma diagnosis, more frequent asthma-related health care u...
Feb 16th, 2018 - Asthma statistics: Approximately 25.9 million Americans suffer from asthma. It is one of this country's most common and costly diseases.
Jan 30th, 2018 - Nearly 17% of people without asthma smoke. But surprisingly, even more people with asthma smoke. About 21% of people with asthma smoke, even though cigarette smoke is known to trigger asthma attacks.
Sitton, C.,et al.
Dec 31st, 2017 - This article reviews the latest recommendations and clinical practice guidelines for peanut allergies among the pediatric population. Recommendations in this paper were compiled using information collected from a variety of publications of accredited professional organizations.
Wallace, D.,et al
Dec 18th, 2017 - The Joint Task Force on Practice Parameters, which comprises representatives of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), formed a workgroup to review evidence and provide guidance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in patients aged 12 years or older.
Crawford, J.,et al
Nov 30th, 2017 - Myeloid growth factors (MGFs) are given as supportive care to patients receiving myelosuppressive chemotherapy to reduce the incidence of neutropenia. This selection from the NCCN Guidelines for MGFs focuses on the evaluation of regimen- and patient-specific risk factors for the development of febrile neutropenia (FN), the prophylactic use of MGFs for the prevention of chemotherapy-induced FN,.
Oct 24th, 2017 - Asthma is a chronic inflammatory condition affecting the lungs. With asthma, the tubes that carry air throughout the lungs (bronchi) are inflamed and swollen, which narrows the airway and makes it more difficult to breathe. Learn about the lab tests used to help diagnose, monitor, and manage asthma.
Lancet (London, England); Woodcock A, Vestbo J et. al.
Sep 14th, 2017 - Evidence for management of asthma comes from closely monitored efficacy trials done in highly selected patient groups. There is a need for randomised trials that are closer to usual clinical practice. We did an open-label, randomised, controlled, two-arm effectiveness trial at 74 general practice clinics in Salford and South Manchester, UK. Patients aged 18 years or older with a general practit...
Susan M. Tarlo
Aug 31st, 2017 - The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants(includinginswimmingpools)asirritantsandsensitizers: how to evaluate types of bronchial reactions and reduce risks, (2) population-based studies of occupational obstructive diseases: use of da.
Aug 31st, 2017 - Pathogenenesis of viral infection in exacerbations of airway disease
Strom, B. et. al.
Aug 26th, 2017 - This chapter reviews and assesses new evidence for associations between dietary sodium intake and outcomes published in the peer-reviewed literature through 2012. The health outcomes reviewed by the committee include cardiovascular disease (CVD), including stroke CVD mortality and all-cause mortality, congestive heart failure (CHF), chronic kidney disease (CKD), diabetes, cancer, and “other” ou...
Jul 31st, 2017 - Allergic rhinitis (AR) is a prevalent disorder responsible for a significant and often underappreciated health burden for individuals and society (see Burden of Disease section). Guidelines to improve care for patients with AR have been evolving in an effort to respond to the introduction of new treatment approaches, to address the availability of additional studies that compare treatment optio.
May 23rd, 2017 - Work-related asthma is the most prevalent occupational lung disease and is likely underrecognized in the clinical setting. Thus, a thorough occupational history is critical for identifying patients.
Apr 30th, 2017 - The panel formulated and provided the rationale for recommendations on selected ventilatory interventions for adult patients with ARDS. Clinicians managing patients with ARDS should personalize decisions for their patients, particularly regarding the conditional recommendations in this guideline.
Mar 31st, 2017 - These are the first international evidence-based guidelines to improve the diagnosis and management of patients with FPIES.
Jan 18th, 2017 - FastStats is an official application from the Centers for Disease Control and Prevention & (CDC) National Center for Health Statistics (NCHS) and puts access to topic-specific statistics at your fingertips.
Canadian Lung Association
Jan 16th, 2017 - New research published in the Journal of American Medical Association demonstrates that people are continuing to be misdiagnosed with asthma. The findings published in the study – Reevaluation of Diagnosis in Adults with Physician-Diagnosed Asthma - show that 33 per cent of those recently diagnosed with asthma do not have it.
Y. S. Prakash
Jan 14th, 2017 - Airway remodeling (AR) is a prominent feature of asthma and other obstructive lung diseases that is minimally affected by current treatments. The goals of this Official American Thoracic Society (ATS) Research Statement are to discuss the scientific, technological, economic, and regulatory issues that deter progressof AR research and development of therapeutics targeting AR and to propose appro.
Dec 20th, 2016 - This work group report addresses the potential challenges of implementing an elimination diet for the management of EoE and provides instructions and tools for physicians, dietitians, and other allied health professionals to help guide them in planning elimination diets for both children and adult.
Megan M. Tschudy
Dec 5th, 2016 - Although traditional health care payment models have not covered the costs of home-based environmental interventions, there are emerging payment models that cover these costs, and our work group was tasked with developing this report to educate health care providers about these emerging payment models.
Gwen S. Skloot
Oct 31st, 2016 - Asthma in the elderly (>65 yr old) is common and associated with higher morbidity and mortality than asthma in younger patients. The poor outcomes in this group are due, in part, to underdiagnosis and undertreatment.
Oct 2nd, 2016 - Objectives: To survey active American Academy of Allergy, Asthma & Immunology members regarding their perceptions and practices concerning sleep-disordered breathing in adult and pediatric patients with rhinitis, and to review the medical literature concerning this connection to identify therapeutic implications and research gaps.
Li N, Georas S et. al.
Jul 31st, 2016 - A work group report on ultrafine particles. The objective of this article is to provide an up-to-date report on the effect of UFPs on human health and potential nanomaterial hazards.
BMC Pulmonary Medicine;
Jul 21st, 2016 - Asthma exacerbations are frequent in patients with severe disease. This report describes results from two retrospective cohort studies describing exacerbation frequency and risk, emergency department (ED)/hospital re-admissions, and asthma-related costs by asthma severity in the US and UK.
Thomas F. Patterson
Jun 25th, 2016 - Aspergillus species continue to be an important cause of life-threatening infection in immunocompromised patients. This at-risk population is comprised of patients with prolonged neutropenia, allogeneic hematopoietic stem cell transplant (HSCT), solid organ transplant (SOT), inherited or acquired immunodeficiencies, corticosteroid use, and others.
Robert F. Lemanske, Jr et. al.
Jun 2nd, 2016 - Clinicians who care for children with asthma have an obligation to coordinate asthma care with the schools. Aside from routine clinical care of asthmatic children, providers must educate the family and child about the need for an asthma treatment plan in school and support the school nurse meeting the needs of the student requiring school-based asthma care.
Apr 30th, 2016 - The first practice parameter on exercise-induced bronchoconstriction (EIB) was published in 2010. This updated practice parameter was prepared 5 years later.
Oct 31st, 2015 - The Joint Task Force on Practice Parameters (JTF) is a 13-member task force consisting of 6 representatives assigned bythe American Academy of Allergy, Asthma & Immunology, 6 bythe American College of Allergy, Asthma & Immunology, and 1 bythe Joint Council of Allergy and Immunology. This JTF oversees thedevelopment of practice parameters, selects the workgroupchair(s), and reviews drafts of the.
Oct 31st, 2015 - The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for establishing the "Practice parameter for the diagnosis and management of primary immunodeficiency. " This is a complete and comprehensive document at the current time.
Jul 11th, 2015 - Chronic dyspnea is shortness of breath that lasts more than one month. The perception of dyspnea varies based on behavioral and physiologic responses. Dyspnea that is greater than expected with the degree of exertion is a symptom of disease. Most cases of dyspnea result from asthma, heart failure and myocardial ischemia, chronic obstructive pulmonary disease, interstitial lung disease, pneumoni...
Jun 30th, 2015 - The fifth Jack Pepys Workshop on Asthma in the Workplace focused on the similarities and differences of work-related asthma (WRA) and non-work-related asthma (non-WRA). WRA includes occupational asthma (OA) and work-exacerbated asthma (WEA).
Canadian Lung Association
Apr 29th, 2015 - The Canadian Lung Association applauds the Ontario Legislature for passing a new law that allows children with asthma to carry asthma inhalers at school and would require school boards to develop a comprehensive asthma policy.
Michael D. Seidman
Feb 1st, 2015 - Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall.
Nov 30th, 2014 - This practice parameter is a joint effort between emergency physicians, who are often on the front line in the management ofanaphylaxis, and allergists-immunologists, who have a vested interest in how such patients are managed. As recognized by emergency physicians and allergists, the timely administration of epinephrine is essential to the effective treatment of anaphylaxis,and such administra.
D. Parker Jonathan
Oct 31st, 2014 - Despite the development and availability of new treatments and prescription medications, asthma remains a widespread chronic health problem in the United States. Achieving asthma control in patients is a resource-intensive enterprise that requires close assessment and personalized management.
Jul 31st, 2014 - The Yellow Zone Practice Parameter Workgroup was commissionedby the JTF to develop practice parameters that addressmanagement of acute loss of asthma control in the yellow zone. Thechair (Chitra Dinakar, MD) invited workgroup members to participatein the parameter development who are considered experts inthe field of asthma management.
Dennis L. Stevens
Jul 14th, 2014 - A panel of national experts was convened by the Infectious Diseases Society of America (IDSA) to update the 2005 guidelines for the treatment of skin and soft tissue infections (SSTIs). The panel's recommendations were developed to be concordant with the recently published IDSA guidelines for the treatment of methicillin-resistant Staphylococcus aureus infections.
Apr 30th, 2014 - Theworkgroup was formed by the JTFPP to develop a practiceparameter to address the diagnosis and treatment of urticaria withor without angioedema. The chair, Jonathan Bernstein, MD,invited workgroup members to participate in the parameterdevelopment.
Journal of Asthma and Allergy;
Apr 10th, 2014 - Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninva...
Jan 31st, 2014 - Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex.
Kian Fan Chung
Jan 31st, 2014 - Coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy.
Kian Fan Chung
Jan 31st, 2014 - The European Respiratory Society (ERS)/American Thoracic Society (ATS) Task Force on severe asthma includes an updated definition of severe asthma, a discussion of severe asthma phenotypes in relation to genetics, natural history, pathobiology and physiology, as well as sections on evaluation and treatment of severe asthma where specific recommendations for practice are made.
Sep 30th, 2013 - This parameter was developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma & Immunology (ACAAI), and the Joint Council of Allergy, Asthma & Immunology. The AAAAI and the ACAAI have jointly accepted responsibility for establishing "Environmental assessment and remediation: a pract.
Susan M. Tarlo, Jean-Luc Malo
Jul 31st, 2013 - Work-related asthma is a common occupational lung disease. The scope of the Fourth Jack Pepys Workshop that was held in May 2010 went beyond asthma to include discussion of other occupational airway diseases, in particular occupationally related chronic obstructive pulmonary disease (COPD) and bronchiolitis.
Jun 30th, 2013 - To update the American Academy of Pediatrics clinical practice guideline regarding the diagnosis and management of acute bacterial sinusitis in children and adolescents.
Jonathan P. Parsons
Apr 30th, 2013 - Exercise-induced bronchoconstriction (EIB) describes acute airway narrowing that occurs as a result of exercise. A substantial proportion of patients with asthma experience exercise-induced respiratory symptoms.
Italian Journal of Pediatrics; La Rosa, M. et. al.
Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...
Feb 28th, 2013 - Hereditary angioedema (HAE) usually results from a deficiencyof the serine protease inhibitor C1 inhibitor (C1INH). (LB)There are 2 types of HAE, type I is most common.
Nov 30th, 2012 - Atopic dermatitis (AD) is often the first manifestation ofallergic disease. Most patients with AD will also have anotheratopic disorder, such as allergic rhinitis, asthma, or foodallergy.
Journal of the European Academy of Dermatology and Venereology : JEADV; Simonsen AB, Johansen JD et. al.
Dec 9th, 2017 - Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in atopic dermatitis (AD) facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in ch...
The Lancet. Haematology; Aguilar-Guisado M, Espigado I et. al.
Nov 20th, 2017 - Continuation of empirical antimicrobial therapy (EAT) for febrile neutropenia in patients with haematological malignancies until neutrophil recovery could prolong the therapy unnecessarily. We aimed to establish whether EAT discontinuation driven by a clinical approach regardless of neutrophil recovery would optimise the duration of therapy. We did an investigator-driven, superiority, open-labe...
Feb 29th, 2012 - This guideline represents an evidence-based approach to FN specific to children with cancer. Although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas.
JAMA , Grossman DC et. al.
Jun 20th, 2017 - Based on year 2000 Centers for Disease Control and Prevention growth charts, approximately 17% of children and adolescents aged 2 to 19 years in the United States have obesity, and almost 32% of children and adolescents are overweight or have obesity. Obesity in children and adolescents is associated with morbidity such as mental health and psychological issues, asthma, obstructive sleep apnea,...
Annals of Emergency Medicine; Barniol C, Dehours E et. al.
May 9th, 2017 - We evaluate the efficacy of a 4-day course of prednisone added to antihistamine for the management of acute urticaria in an emergency department (ED). In this double-blind randomized clinical trial, patients were eligible for inclusion if aged 18 years or older and with acute urticaria of no more than 24 hours' duration. Patients with anaphylaxis or who had received antihistamines or glucocorti...
JAMA Scadding GW, Calderon MA et. al.
Feb 14th, 2017 - Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placeb...
Resuscitation Kawano T, Scheuermeyer FX et. al.
Jan 10th, 2017 - There is little data describing the differences in epinephrine (epi) administration and cardiac complications among older and younger patients with anaphylaxis. This retrospective cohort study was conducted at two urban emergency departments (ED) over a 5 year-period, and included adults who met a pre-specified criteria for anaphylaxis. Patients ≥50years of age were defined as "older". Univaria...
Annals of Emergency Medicine; Coyne CJ, Le V et. al.
Jan 3rd, 2017 - Although validated risk-stratification tools have been used to send low-risk febrile neutropenic patients home from clinic and inpatient settings, there is a dearth of research evaluating these scores in the emergency department (ED). We compare the predictive accuracy of the Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE)...
Lancet (London, England); Natsume O, Kabashima S et. al.
Dec 12th, 2016 - Evidence is accumulating that early consumption is more beneficial than is delayed introduction as a strategy for primary prevention of food allergy. However, allergic reactions caused by early introduction of such solid foods have been a problematic issue. We investigated whether or not early stepwise introduction of eggs to infants with eczema combined with optimal eczema treatment would prev...
Michael Winters, Steven Rosenbaum
Apr 10th, 2011 - The current literature on ACE-inhibitor angioedema is primarily limited to retrospective reviews, case series, and case reports. Based upon this review of the literature, ACE-inhibitor angioedema should be considered in any ED patient presenting with asymmetric swelling of the lips, tongue, floor of the mouth, face, neck or eyelids.
Lancet (London, England); Bleecker ER, FitzGerald JM et. al.
Sep 9th, 2016 - Eosinophilia is associated with worsening asthma severity and decreased lung function, with increased exacerbation frequency. We assessed the safety and efficacy of benralizumab, a monoclonal antibody against interleukin-5 receptor α that depletes eosinophils by antibody-dependent cell-mediated cytotoxicity, for patients with severe, uncontrolled asthma with eosinophilia. We did a randomised, d...
Lancet (London, England); FitzGerald JM, Bleecker ER et. al.
Sep 9th, 2016 - Benralizumab is a humanised, afucosylated, anti-interleukin-5 receptor α monoclonal antibody that induces direct, rapid, and nearly complete depletion of eosinophils. We aimed to assess the efficacy and safety of benralizumab as add-on therapy for patients with severe, uncontrolled asthma and elevated blood eosinophil counts. In this randomised, double-blind, parallel-group, placebo-controlled,...
The New England Journal of Medicine; Stempel DA, Szefler SJ et. al.
Aug 31st, 2016 - Long-acting beta-agonists (LABAs) have been shown to increase the risk of asthma-related death among adults and the risk of asthma-related hospitalization among children. It is unknown whether the concomitant use of inhaled glucocorticoids with LABAs mitigates those risks. This trial prospectively evaluated the safety of the LABA salmeterol, added to fluticasone propionate, in a fixed-dose comb...
The New England Journal of Medicine; Peters SP, Bleecker ER et. al.
Aug 31st, 2016 - Concerns remain about the safety of adding long-acting β2-agonists to inhaled glucocorticoids for the treatment of asthma. In a postmarketing safety study mandated by the Food and Drug Administration, we evaluated whether the addition of formoterol to budesonide maintenance therapy increased the risk of serious asthma-related events in patients with asthma. In this multicenter, double-blind, 26...
National Institute of Allergy and Infectious Diseases
Dec 16th, 2010 - Food allergy (FA) is an important public health problem that affects adults and children and may be increasing in prevalence. Despite the risk of severe allergic reactions and even death, there is no current treatment for FA: the disease can only be managed by allergen avoidance or treatment of symptoms. Moreover, the diagnosis of FA may be problematic, given that nonallergic food reactions, su...