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About 19,428 results
CDC Emerging Infectious Diseases Coronavirus Spotlight
https://wwwnc.cdc.gov/eid/spotlight/coronavirus

Emerging Infectious Diseases journal created this spotlight to make it easier for readers to locate articles about coronavirus disease 2019 (COVID-19) as well as other coronavirus diseases in both humans and animals.

ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection
https://www.medrxiv.org/content/10.1101/2020.02.12.20022418v1

In December 2019 and January 2020, novel coronavirus (2019-nCoV) - infected pneumonia (NCIP) occurred in Wuhan, and has already posed a serious threat to public health. ACE2 (Angiotensin Converting Enzyme 2) has been shown to be one of the major receptors that mediate the entry of 2019-nCoV into human cells, which also happens in severe acute respiratory syndrome coronavirus (SARS). Several res...

Covid-19 pandemic and the skin - What should dermatologists know?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102542/
Clinics in Dermatology;

The World has changed dramatically since the COVID-19 pandemic began. Together with our social, occupational, and personal life, the new corona virus poses novel challenges for all physicians, including dermatologists. Despite the virus not being dermatotropic, several skin conditions have emerged, mainly as a result of prolonged contact to personal protective equipment and excessive personal h...

Cardiovascular disease and COVID-19
https://www.sciencedirect.com/science/article/pii/S1871402120300539
Diabetes & Metabolic Syndrome: Clinical Research & Reviews;

Many patients with coronavirus disease 2019 (COVID-19) have underlying cardiovascular (CV) disease or develop acute cardiac injury during the course of the illness. Adequate understanding of the interplay between COVID-19 and CV disease is required for optimum management of these patients.

Muscle-invasive and Metastatic Bladder Cancer
https://uroweb.org/guideline/bladder-cancer-muscle-invasive-and-metastatic/

The European Association of Urology (EAU) Guidelines Panel for Muscle-invasive and Metastatic Bladder Cancer (MIBC) have prepared these guidelines to help urologists assess the evidence-based management of MIBC and to incorporate guideline recommendations into their clinical practice.

Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals
https://www.tandfonline.com/doi/full/10.1080/09273948.2020.1738501
Ocular Immunology and Inflammation;

In December 2019, a novel coronavirus (CoV) epidemic, caused by the severe acute respiratory syndrome coronavirus – 2 (SARS-CoV-2) emerged from China. This virus causes the coronavirus disease 2019 (COVID-19). Since then, there have been anecdotal reports of ocular infection. The ocular implications of human CoV infections have not been widely studied. However, CoVs have been known to cause var...

Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients
https://www.biorxiv.org/content/10.1101/2020.03.25.009084v2.full

Recent reports suggest an association between COVID-19 and altered olfactory function. Here we analyze bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium that express molecules that mediate infection by SARS-CoV-2 (CoV-2), the causal agent in COVID-19. We find in both mouse and human datasets that olfactory sensory neurons do not express two key genes invol...

Comparison of nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection in 353 patients received tests with both specimens simultaneously
https://www.ijidonline.com/article/S1201-9712(20)30235-6/pdf
International Journal of Infectious Diseases;

Since the outbreak of coronavirus disease (COVID-19) in Wuhan in December 2019, by March 10, 2020, a total of 80,932 confirmed cases have been reported in China. Two consecutively negative RTPCR test results in respiratory tract specimens is required for the evaluation of discharge from hospital, and oropharyngeal swabs were the most common sample. However, false negative results occurred in ...

The revised clinical practice guidelines on the management of thyroid tumors by the Japan Associations of Endocrine Surgeons: Core questions and recommendations for treatments of thyroid cancer
https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ20-0025/_pdf/-char/en
Endocrine Journal;

 The Japan Associations of Endocrine Surgeons has developed the revised version of the Clinical Practice Guidelines for Thyroid Tumors. This article describes the guidelines translated into English for the 35 clinical questions relevant to the therapeutic management of thyroid cancers. The objective of the guidelines is to improve health-related outcomes in patients with thyroid tumors by en...

Cancer Pain (PDQ®)–Health Professional Version
https://www.cancer.gov/about-cancer/treatment/side-effects/pain/pain-hp-pdq?cid=eb_govdel

Pain is one of the most common symptoms in cancer patients and often has a negative impact on patients’ functional status and quality of life. The goal of the following summary is to provide evidence-based, up-to-date, and practical information on the management of cancer pain.

Bladder Cancer Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/bladder/hp/bladder-treatment-pdq?cid=eb_govdel

Bladder cancer is the sixth most common cancer in the United States after lung cancer, prostate cancer, breast cancer, colon cancer, and lymphoma. It is the third most common cancer in men and the eleventh most common cancer in women. Of the roughly 70,000 new cases annually, about 53,000 are in men and about 18,000 are in women. Of the roughly 15,000 annual deaths, more than 10,000 are in men ...

Serology Testing for COVID-19 at CDC
https://www.cdc.gov/coronavirus/2019-ncov/lab/serology-testing.html

CDC has developed a laboratory blood test to assist with efforts to determine how much of the U.S. population has been infected with SARS-CoV-2, the virus that causes COVID-19. CDC is also using its serologic test (antibody) to evaluate the performance of commercial antibody tests.

Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea
https://www.sfndt.org/sites/www.sfndt.org/files/medias/documents/Hong et al. Ann Lab Med Avril 2020.pdf
Annals of Laboratory Medicine;

The outbreak of coronavirus disease 2019 (COVID-19), which began in December 2019, is still ongoing in Korea, with >9,000 confirmed cases as of March 25, 2020. COVID-19 is a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and real-time reverse transcription-PCR is currently the most reliable diagnostic method for COVID-19 around the world. Korean Society for Laborato...

CDC Diagnostic Test for COVID-19
https://www.cdc.gov/coronavirus/2019-ncov/lab/testing.html

CDC has developed a new laboratory test kit for use in testing patient specimens for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19. The test kit is called the “Centers for Disease Control and Prevention (CDC) 2019-Novel Coronavirus (2019-nCoV) Real-Time Reverse Transcriptase (RT)-PCR Diagnostic Panel.” It is intended for use with the Applied Biosys...

Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis
https://jamanetwork.com/journals/jama/article-abstract/2766163
JAMA

May 18th, 2020 - In this meta-analysis that included 12 trials with 92 135 participants for the primary outcome measure, blood pressure lowering with antihypertensive agents, compared with control, was associated with the development of a composite dementia or cognitive impairment outcome in 7.0% vs 7.5% of patients over a mean trial follow-up of 4.1 years, a difference that was statistically significant.

Policy Statement—Tobacco Use: A Pediatric Disease
https://pediatrics.aappublications.org/content/pediatrics/124/5/1474.full.pdf
American Academy of Pediatrics

Tobacco use and secondhand tobacco-smoke (SHS) exposure are major national and international health concerns. Pediatricians and other clinicians who care for children are uniquely positioned to assist patients and families with tobacco-use prevention and treatment. Understanding the nature and extent of tobacco use and SHS exposure is an essential first step toward the goal of eliminating toba...

The new International Society of Hypertension guidelines on hypertension
https://journals.lww.com/jhypertension/Fulltext/2020/06000/The_new_International_Society_of_Hypertension.1.aspx?context=LatestArticles
Journal of Hypertension;

The June issue of the Journal of Hypertension starts with the hypertension guidelines prepared by the International Society of Hypertension (ISH) and simultaneously published in Hypertension as well. Compared with the guidelines issued by the European Society of Cardiology (ESC)/European Society of Hypertension (ESH) and American College of Cardiology (ACC)/American Heart Association (AHA) the ...

Prevalence of Dyskinesia and OFF by 30-Minute Intervals Through the Day and Assessment of Daily Episodes of Dyskinesia and OFF: Novel Analyses of Diary Data from Gocovri Pivotal Trials
https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd181565
Journal of Parkinson's Disease;

Jul 29th, 2019 - Evaluate prevalence of troublesome dyskinesia and OFF through the day, assessed by 30-minute intervals, as well as the mean number and duration of troublesome dyskinesia and OFF episodes, transitions between PD states, and effects of Gocovri® (amantadine) extended release capsules on these episodes.

Levodopa-induced dyskinesia: clinical features, incidence, and risk factors
https://link.springer.com/article/10.1007/s00702-018-1900-6
Neurology and Preclinical Neurological Studies;

Jul 2nd, 2018 - Symptoms of Parkinson’s disease have been controlled with levodopa for many years; however, motor complications consisting of wearing off of medication effect and dyskinesias tend to occur within a few years of starting levodopa. Motor complications can begin a few months after taking levodopa, with the average time to onset estimated to be 6.5 years. Dyskinesias can be troublesome and require ...

Hypertension and the Risk of Dementia
https://www.frontiersin.org/articles/10.3389/fcvm.2020.00005/full

Hypertension, particularly midlife high blood pressure, has been related to a higher risk of cognitive decline and dementia, including Alzheimer disease. However, these associations are complex and not fully elucidated. Cerebral small vessel disease emerges as one of the most important causes. Several observational studies have shown the potential beneficial role of antihypertensive treatment i...

Impairments in Activities of Daily Living in Parkinson's Disease: Implications for Management
https://pubmed.ncbi.nlm.nih.gov/14530586/
NeuroRehabilitation

Sep 9th, 2003 - Parkinson's disease (PD) is a neurodegenerative disorder with progressive impairment in motor and cognitive functioning. A review of past research shows that individuals experience not only physical discomfort brought on by the illness, but also considerable psychological distress. Increased dependency on a caregiver due to impairments in activities of daily living (e.g., walking, eating, dress...

Presynaptic mechanisms of l-DOPA-induced dyskinesia: the findings, the debate, and the therapeutic implications
https://www.frontiersin.org/articles/10.3389/fneur.2014.00242/full
Frontiers in Neurology;

Dec 14th, 2014 - The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson’s disease (PD) for over 40 years. However, the response to this treatment changes with disease progression, and most patients develop dyskinesias (abnormal involuntary movements) and motor fluctuations within a few years of l-DOPA therapy.

Investigation of antihypertensive class, dementia, and cognitive decline
https://n.neurology.org/content/94/3/e267.abstract

High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original p...

Pooled Analysis of Phase 3 studies of ADS-5102 (amantadine hydrochloride) extended release capsules for Levodopa-Induced Dyskinesia: A detailed review of UDysRS Results (S56.003)
https://n.neurology.org/content/88/16_Supplement/S56.003
Neurology

Apr 16th, 2017 - Data from two Phase 3 clinical studies investigating the efficacy and safety of ADS-5102 in Parkinson’s disease (PD) patients with levodopa-induced dyskinesia (LID) were pooled to summarize results for the shared primary endpoint, Unified Dyskinesia Rating Scale (UDysRS) and its sub-components.

Metabotropic Glutamate Receptors for Parkinson's Disease Therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703788/
Parkinson's Disease;

May 28th, 2013 - Excessive glutamatergic signalling within the basal ganglia is implicated in the progression of Parkinson's disease (PD) and inthe emergence of dyskinesia associated with long-term treatment with L-DOPA. There is considerable research focus on the discovery and development of compounds that modulate glutamatergic signalling via glutamate receptors, as treatments for PD and L-DOPA-induced dyskin...

The Unified Dyskinesia Rating Scale: Presentation and clinimetric profile
https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.22341
Movement Disorders;

Nov 20th, 2008 - We developed and tested a rating scale aimed to capture the essential features of dyskinesia in Parkinson's disease (PD). Although several scales assess selected attributes of PD‐dyskinesias, no comprehensive rating tool exists. Available rating scales were evaluated by the investigators and patient focus groups.

Levodopa‐induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600052/
Postgraduate Medical Journal;

Jun 4th, 2007 - Levodopa is the most effective drug for treating Parkinson's disease. However, long‐term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa‐induced dyskinesias (LID). The underlying mechanisms f...

Advances in understanding l-DOPA-induced dyskinesia
https://www.sciencedirect.com/science/article/abs/pii/S0959438808000068?via=ihub
Current Opinion in Neurobiology;

Mar 3rd, 2008 - The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These symptoms are greatly improved by pharmacological DA replacement with l-3,4-dih...

The levodopa wearing-off phenomenon in Parkinson’s disease: pharmacokinetic considerations
https://www.tandfonline.com/doi/abs/10.1517/14656566.7.10.1399?src=recsys&journalCode=ieop20
Expert Opinion on Pharmacotherapy;

Jun 28th, 2006 - Levodopa is the most efficacious treatment in the management of Parkinson’s disease. Unfortunately, chronic use of traditional levodopa/dopa decarboxylase inhibitor formulations is associated with the development of complications, such as wearing-off and dyskinesia. In an attempt to avoid these complications, some physicians delay the introduction of levodopa or employ levodopa-sparing strategi...

Optimizing levodopa therapy for Parkinson’s disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective
https://www.dovepress.com/optimizing-levodopa-therapy-for-parkinsonrsquos-disease-with-levodopac-peer-reviewed-article-NDT
Neuropsychiatric Disease and Treatment;

Feb 7th, 2008 - After 40 years of clinical experience, levodopa remains the gold standard treatment for Parkinson’s disease (PD) despite the recent emergence of a host of new therapies. Some physicians are cautious when prescribing levodopa because of its association with motor complications. Evidence now suggests that levodopa-associated complications are a result of deep troughs in delivery of levodopa to th...

Subacute thyroiditis after SARS-CoV-2 infection
https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa276/5838793

Subacute thyroiditis (SAT) is a thyroid disease of viral or post-viral origin. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China, has spread rapidly worldwide and Italy has been severely affected by this outbreak.

Top 20 Research Studies of 2019 for Primary Care Physicians
https://www.aafp.org/afp/2020/0515/p608.html

In 2019, regular surveillance of 110 English-language research journals identified 254 studies that met the criteria to become POEMs (patient-oriented evidence that matters). Physician members of the Canadian Medical Association rated these POEMs for their relevance to patients in their practices. This article summarizes the clinical questions and bottom-line answers from the top 20 POEMs of 20...

Indoor transmission of SARS-CoV-2
https://www.medrxiv.org/content/10.1101/2020.04.04.20053058v1.full.pdf

By early April 2020, the COVID-19 pandemic had infected nearly one million people and had spread to nearly all countries worldwide. It is essential to understand where and how SARS-CoV-2 is transmitted.

Re-thinking the Potential for Airborne Transmission of SARS-CoV-2
https://www.preprints.org/manuscript/202005.0126/v1

Evidence for the potential for airborne transmission of SARS-CoV-19 continues to accumulate, with important implications for healthcare workers, as well as the general public. Three lines of evidence support this conclusion. COVID-19

Youth and Tobacco Use Fact Sheet
https://www.cdc.gov/tobacco/data_statistics/fact_sheets/youth_data/tobacco_use/index.htm

Youth use of tobacco products in any form is unsafe. If cigarette smoking continues at the current rate among youth in this country, 5.6 million of today’s Americans younger than 18 will die early from a smoking-related illness. That’s about 1 of every 13 Americans aged 17 years or younger who are alive today. CDC

Blood pressure and the new ACC/AHA hypertension guidelines
https://www.sciencedirect.com/science/article/pii/S1050173819300684
Trends in Cardiovascular Medicine;

The ACC/AHA hypertension guidelines cover virtually all aspects of the diagnosis, evaluation, monitoring, secondary causes as well as drug and non-drug treatment of hypertension. Substantial and appropriate emphasis has been given to the strategies necessary for accurate measurement of blood pressure in any setting where valid blood pressure measurements are desired.

U.S. FDA Approves Evofem Biosciences' Phexxi™ (lactic acid, citric acid and potassium bitartrate), the First and Only Non-Hormonal Prescription Gel for the Prevention of Pregnancy
https://evofem.investorroom.com/2020-05-22-U-S-FDA-Approves-Evofem-Biosciences-Phexxi-TM-lactic-acid-citric-acid-and-potassium-bitartrate-the-First-and-Only-Non-Hormonal-Prescription-Gel-for-the-Prevention-of-Pregnancy

Evofem Biosciences, Inc. (NASDAQ: EVFM) today announced that the U.S. Food and Drug Administration (FDA) has approved Phexxi™ (lactic acid, citric acid and potassium bitartrate) vaginal gel for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception.

Association of dairy consumption with metabolic syndrome, hypertension and diabetes in 147 812 individuals from 21 countries
https://drc.bmj.com/content/8/1/e000826

Our aims were to assess the association of dairy intake with prevalence of metabolic syndrome (MetS) (cross-sectionally) and with incident hypertension and incident diabetes (prospectively) in a large multinational cohort study.

A NEW VASCULITIS AT THE TIME OF COVID-19
https://www.ejpd.com/images/nuova-vasculite-covid-ENG.pdf

40 days after the first autochthonous case of COVID-19 reported in Italy, we observed an “epidemic” of acute and self-healing vasculitic lesions of the hands and feet in asymptomatic children and adolescents. These lesions constituted a novelty that led us to establish a link with the other much more severe novelty, i. e. COVID-19, which also occurred almost simultaneously.

23andMe’s COVID-19 study
https://research.23andme.com/covid19/

The major goal of 23andMe’s COVID-19 study is to uncover genetic risks associated with severe outcomes of infections by SARS-CoV-2. Such associations may explain some variation in COVID-19 disease severity. In addition to providing direct-to-consumer genetic testing through the 23andMe® Service, 23andMe endeavors to advance biomedical science through genetic research.

The COVID-19 Host Genetics Initiative
https://www.covid19hg.org/

The COVID-19 host genetics initiative brings together the human genetics community to generate, share and analyze data to learn the genetic determinants of COVID-19 susceptibility, severity and outcomes. Such discoveries could help to generate hypotheses for drug repurposing, identify individuals at unusually high or low risk, and contribute to global knowledge of the biology of SARS-CoV-2 infe...

What are "COVID toes?"
http://afpjournal.blogspot.com/2020/04/what-are-covid-toes.html

Anecdotal reports are emerging of patients with COVID-19 presenting with purplish patches on their toes. Sometimes, these findings are the only sign of otherwise asymptomatic COVID-19, and sometimes they are the initial presenting sign in advance of fever and upper respiratory symptoms.

Bacille Calmette-Guérin (BCG) vaccination and COVID-19
https://www.who.int/news-room/commentaries/detail/bacille-calmette-gurin-(bcg)-vaccination-and-covid-19

There is no evidence that the Bacille Calmette-Guérin vaccine (BCG) protects people against infection with COVID-19 virus. Two clinical trials addressing this question are underway, and WHO will evaluate the evidence when it is available. In the absence of evidence, WHO does not recommend BCG vaccination for the prevention of COVID-19. WHO continues to recommend neonatal BCG vaccination in coun...

Considering BCG vaccination to reduce the impact of COVID-19
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31025-4/fulltext
The Lancet;

In addition to its specific effect against tuberculosis, the BCG vaccine has beneficial nonspecific (off-target) effects on the immune system that protect against a wide range of other infections and are used routinely to treat bladder cancer. This has led to the suggestion that vaccination with BCG might have a role in protecting health-care workers and other vulnerable individuals against sev...

Hepatitis B Virus Infection in Nonpregnant Adolescents and Adults: Screening
https://uspreventiveservicestaskforce.org/uspstf/draft-recommendation/hepatitis-b-virus-infection-screening-nonpregnant

The USPSTF concludes with moderate certainty that screening for HBV infection in adolescents and adults at increased risk for infection has moderate net benefit.

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2
https://www.biorxiv.org/content/10.1101/2020.04.29.069054v2

We have developed an analysis pipeline to facilitate real-time mutation tracking in SARS-CoV-2, focusing initially on the Spike (S) protein because it mediates infection of human cells and is the target of most vaccine strategies and antibody-based therapeutics. To date we have identified thirteen mutations in Spike that are accumulating. Mutations are considered in a broader phylogenetic conte...

Profile of a killer: the complex biology powering the coronavirus pandemic
https://www.nature.com/articles/d41586-020-01315-7

Scientists are piecing together how SARS-CoV-2 operates, where it came from and what it might do next — but pressing questions remain about the source of COVID-19.

SpringerNature SARS-CoV-2 and COVID-19
https://www.springernature.com/gp/researchers/campaigns/coronavirus

Springer Nature is committed to supporting the global response to COVID-19 and has so far enabled free access to over 19,000 pieces of content, ensuring fast and direct access to the latest available research, evidence, and data. The need for continued access to research and learning has never been more important. We recognise our role in this and are committed to ensuring we are working wit...

AAAAI Resources for Clinicians During the COVID-19 Pandemic
https://education.aaaai.org/resources-for-a-i-clinicians/covid-19

As the coronavirus disease 2019 (COVID-19) spreads across the globe, we recognize the importance of our roles as healthcare providers, particularly to patients known for asthma, other allergic conditions, or immune deficiencies who may be at a higher risk of experiencing severe symptoms from the disease. The same way that you are committed to your patients, practices, and communities, we at the...

Novel Coronavirus Information Center
https://www.elsevier.com/connect/coronavirus-information-center

Elsevier’s free health and medical research on the novel coronavirus (SARS-CoV-2) and COVID-19

Smoking cessation before lung cancer diagnosis linked to longer survival
https://www.healio.com/hematology-oncology/lung-cancer/news/online/{c987a307-b1e1-44ae-aae8-0d53228ea219}/smoking-cessation-before-lung-cancer-diagnosis-linked-to-longer-survival

May 12th, 2020 - People who quit smoking prior to a lung cancer diagnosis demonstrated considerably reduced risk for death due to all causes compared with those who continued to smoke, according to study results scheduled for presentation during the ASCO20 Virtual Scientific Program.

Maintenance olaparib extends OS among women with BRCA-mutated relapsed ovarian cancer
https://www.healio.com/hematology-oncology/gynecologic-cancer/news/online/{52c91a81-35d2-44a5-bf2c-79e8db377b40}/maintenance-olaparib-extends-os-among-women-with-brca--mutated-relapsed-ovarian-cancer

May 12th, 2020 - Maintenance therapy with olaparib extended OS compared with placebo among women with platinum-sensitive, BRCA-mutated relapsed ovarian cancer, according to the final analysis of the randomized phase 3 SOLO-2 study scheduled for presentation during the ASCO20 Virtual Scientific Program.

Maintenance Olaparib Provides Significant Long-Term OS Benefit in Relapsed Ovarian Cancer
https://www.targetedonc.com/view/maintenance-olaparib-provides-significant-long-term-os-benefit-in-relapsed-ovarian-cancer

May 12th, 2020 - Maintenance treatment with olaparib (Lynparza) demonstrated an improved median overall survival (OS) of 12.9 months over placebo in patients with platinum-sensitive relapsed ovarian cancer harboring a BRCA1/2 mutation, according to final OS results from the phase III SOLO2/ENGOT-ov21 trial.

No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial
https://www.medrxiv.org/content/10.1101/2020.04.10.20060699v1.full.pdf

Treatments are urgently needed to prevent respiratory failure and deaths from coronavirus disease 2019 (COVID-19). Hydroxychloroquine (HCQ) has received worldwide attention because of positive results from small studies.

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
http://www.onlinejacc.org/content/early/2020/04/15/j.jacc.2020.04.031?_ga=2.28510972.1929038215.1588048778-1191861644.1583881277

Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may predispose patients to thrombotic disease, both in the venous and arterial circulations, due to excessive inflammation, platelet activation, endothelial dysfunction, and stasis. In addition, many patients receiving antithrombotic therapy for thrombotic...

Smell Dysfunction: A Biomarker for COVID-19
https://onlinelibrary.wiley.com/doi/pdf/10.1002/alr.22587

SARS-CoV-2, the virus that causes COVID-19 disease, is responsible for the largest pandemic since the 1918 H1N1 influenza outbreak. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. Patient-reported smell and taste loss has been associated with COVID-19 infection, yet no empirical olfactory testing on a cohort of COVID-...

Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs
https://www.medrxiv.org/content/10.1101/2020.04.16.20067835v1

Rapid and accurate SARS-CoV-2 diagnostic testing is essential for controlling the ongoing COVID-19 pandemic. The current gold standard for COVID-19 diagnosis is real-time RT-PCR detection of SARS-CoV-2 from nasopharyngeal swabs. Low sensitivity, exposure risks to healthcare workers, and global shortages of swabs and personal protective equipment, however, necessitate the validation of new diagn...

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease
https://www.sciencedirect.com/science/article/pii/S0024320520303751
Life Sciences;

In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap in relations of COVID-19 with the previously known fatal Coronaviruses (CoVs) epidemics, SARS and MERS CoVs, was covere...

Negative Nasopharyngeal and Oropharyngeal Swabs Do Not Rule Out COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180262/
Journal of Clinical Microbiology;

Coronavirus disease 19 (COVID-19) has become the Public Health Emergency of International Concern. A diagnosis is made by the detection of a novel virus or genetically similar coronavirus by molecular assay in clinical specimens (1). Nasopharyngeal and oropharyngeal (NP/OP) samples are commonly used as a screening tool. Here, we reported a case of COVID-19 pneumonia diagnosed from bronchoalveol...

COVID-19: Guidelines for Myasthenia Gravis Management and Other Neuromuscular Disorders
https://journals.lww.com/neurotodayonline/blog/breakingnews/pages/post.aspx?PostID=950

​If your patients have myasthenia gravis, should they come in for an infusion therapy? Is it safe to start patients on a new B-cell depleting therapy? And should patients stop their immunosuppressive therapies? As the COVID-19 pandemic rages on, neurologists working with patients with neuromuscular diseases are fielding these questions with little overall specific data on the overall effect of ...

Identification of antiviral drug candidates against SARS-CoV-2 from FDA -approved drugs
https://aac.asm.org/content/aac/early/2020/04/28/AAC.00819-20.full.pdf
Antimicrobial Agents and Chemotherapy;

Drug repositioning is the only feasible option to address the COVID-19 global challenge immediately.

Maintenance Therapy with Olaparib Extends Survival in Relapsed, BRCA+ Ovarian Cancer
https://www.onclive.com/conference-coverage/asco-2020/maintenance-therapy-with-olaparib-extends-survival-in-relapsed-embrcaem-ovarian-cancer

May 12th, 2020 - Treatment with olaparib (Lynparza) in the maintenance setting extended overall survival (OS) by 12.9 months in women with platinum-sensitive relapsed ovarian cancer with BRCA1/2 mutations, compared with placebo, according to randomized phase 3 trial results presented during a 2020 ASCO Virtual Scientific Program press briefing.

Regardless of Timing, Smoking Cessation Before Lung Cancer Diagnosis Shows Survival Benefit
https://www.onclive.com/conference-coverage/asco-2020/regardless-of-timing-smoking-cessation-before-lung-cancer-diagnosis-shows-survival-benefit

May 12th, 2020 - People who quit smoking at any time, even up to 2 years before a lung cancer diagnosis, have increased chances of survival after their diagnosis, according to data during a 2020 ASCO Virtual Scientific Program press briefing.

Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations
https://www.tandfonline.com/doi/full/10.1080/07391102.2020.1758790
Journal of Biomolecular Structure and Dynamics;

The new Corona-virus, recently called the severe acute respiratory syndrome Coronavirus (SARS-CoV-2) appears for the first time in China and more precisely in Wuhan (December 2019). This disease can be fatal. Seniors, and people with other medical conditions (diabetes, heart disease…), may be more vulnerable and become seriously ill. This is why research into drugs to treat this infection remai...

Highlighting COVID-19 Blood Clot Dangers
https://www.uspharmacist.com/article/highlighting-covid19-blood-clot-dangers

Based on recent reports that demonstrated a strong association between elevated D-dimer levels and poor prognosis, concerns have risen about thrombotic complications in patients with COVID-19. To address these concerns, the National Institute for Public Health of the Netherlands asked a group of radiology and vascular medicine experts to provide guidance for the imaging workup and treatment of ...

Do stress eating or compulsive eating influence metabolic health in a mindfulness-based weight loss intervention?
https://psycnet.apa.org/record/2019-67860-001
Health Psychology;

We aimed to understand the associations of compulsive eating (CE) and stress eating (SE) with metabolic health among adults with obesity and whether mindfulness-based weight loss training may buffer these associations.

Science points to causes of COVID-19
https://www.unenvironment.org/news-and-stories/story/science-points-causes-covid-19
UN Environment Programme;

May 21st, 2020 - The coronavirus (COVID-19) is a zoonotic disease. Zoonotic diseases are transmitted between animals and humans. Diseases passed from animals to humans are a significant threat to human health. When the symptoms are serious, our lack of prior exposure means humans have no existing antibodies to defend themselves against the disease. Recent zoonotic disease outbreaks include Severe Acute Respirat...

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS MEDICAL GUIDELINES FOR CLINICAL PRACTICE FOR THE EVALUATION AND TREATMENT OF HYPOGONADISM IN ADULT MALE PATIENTS—2002 UPDATE
https://www.aace.com/sites/default/files/2019-06/hypo-gonadism.pdf

In these clinical practice guidelines, specific recommendations are made for determining the most effective methods of diagnosing and treating hypogonadism in adult male patients. The target populations for these guidelines include the following: (1) men with primary testicular failure requiring testosterone replacement (hypergonadotropic hypogonadism); (2) male patients with gonadotropin defic...

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS MEDICAL GUIDELINES FOR CLINICAL PRACTICE FOR THE EVALUATION AND TREATMENT OF MALE SEXUAL DYSFUNCTION: A COUPLE’S PROBLEM–2003 UPDATE
https://www.aace.com/sites/default/files/2019-06/sexdysguid.pdf

The purpose of these guidelines is to present a framework for the evaluation, treatment, and follow-up of the patient—indeed, of the couple—who presents with sexual dysfunction.

Evidence-Based Clinical Guidelines for Multidisciplinary Spine Care: Diagnosis and Treatment of Low Back Pain
https://www.spine.org/Portals/0/assets/downloads/ResearchClinicalCare/Guidelines/LowBackPain.pdf

Clinical guidelines for the diagnosis and treatment of nonspecific low-back pain in patients 18 years and older, developed by the North American Spine Society with input from representatives from 11 stakeholder societies, including AAPM.

Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists - © 2011
https://journals.aace.com/doi/pdf/10.4158/EP.17.3.456

Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for...

Insight into FDA’s Revised Policy on Antibody Tests: Prioritizing Access and Accuracy
https://www.fda.gov/news-events/fda-voices/insight-fdas-revised-policy-antibody-tests-prioritizing-access-and-accuracy

High-quality antibody tests (a type of serological test) can help us understand a person’s and population’s exposure to COVID-19. A person who has been exposed to, and recovered from, COVID-19 will likely have antibodies to the SARS-CoV-2 virus in their blood. These tests may be important for guiding our next steps in the fight against this pandemic, such as by providing information on disease ...

Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study
https://www.nature.com/articles/s41413-020-0084-5

The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone conditions of SARS patients. We evaluated the recovery from lung damage and femoral head necrosis in an observational cohort study of SARS patients using pulmonary CT scans, hip joint MRI examinations, pulmonary function tests and hip jo...

Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial
https://link.springer.com/article/10.1007/s00392-018-1405-1

Symptoms and functional limitation are frequently reported by survivors of acute pulmonary embolism (PE). However, current guidelines provide no specific recommendations on which patients should be followed after acute PE, when follow-up should be performed, and which tests it should include. Definition and classification of late PE sequelae are evolving, and their predictors remain to be deter...

COVID-19 Resources: Care Recommendations for Home‑Based Ventilation Patients
https://foundation.chestnet.org/patient-education-resources/covid-19-resources-care-recommendations-home-based-ventilation-patients/

As COVID-19 continues to affect our daily lives, it’s critical that we try to limit the spread of the virus as much as possible. This is especially applicable for patients who use noninvasive positive-pressure ventilation (NIPPV), mechanical airway clearance devices, or are supported by home ventilation for other chronic respiratory failure syndromes.

New OS data with olaparib support ‘new era’ for ovarian cancer
https://www.mdedge.com/hematology-oncology/article/222254/gynecologic-cancer/new-os-data-olaparib-support-new-era-ovarian

May 13th, 2020 - Women with platinum-sensitive relapsed ovarian cancer and a BRCA mutation could see their survival extended by over a year by maintenance therapy with the PARP-inihibitor olaparib (Lynparza, AstraZeneca).

Quitting smoking just 2 years before lung cancer diagnosis may improve survival
https://www.mdedge.com/hematology-oncology/article/222276/lung-cancer/quitting-smoking-just-2-years-lung-cancer-diagnosis

May 13th, 2020 - Quitting smoking prior to a lung cancer diagnosis is associated with a survival benefit, even among patients who recently stopped smoking, according to results of a pooled analysis.

ASCO Preview: Boosting Survival in Ovarian Cancer
https://www.medpagetoday.com/meetingcoverage/asco/86486

May 13th, 2020 - Women with relapsed, platinum-sensitive ovarian cancer associated with BRCA mutations lived more than a year longer if they received olaparib (Lynparza) following chemotherapy, data from a randomized trial showed.

Quitting Smoking at Any Point Improves Lung Cancer Survival, Study Finds, 05/14/2020
https://ascopost.com/news/may-2020/quitting-smoking-at-any-point-improves-lung-cancer-survival/

People who quit smoking at any time—even 2 years before a lung cancer diagnosis—improve their chances of survival after being diagnosed with the disease, according to the results of a large international study presented by Fares et al in a press briefing in advance of the ASCO20 Virtual Scientific Program (Abstract 1512).

COVID-19: American Society for Biochemistry and Molecular Biology (ASBMB)
https://www.asbmb.org/asbmb-today/science/041020/slipping-past-the-proofreader

The virus family that causes SARS, MERS and COVID-19 has an unusual ability to evade treatment. Can new drug candidates overcome it?

AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19
https://www.gastrojournal.org/article/S0016-5085(20)30593-X/pdf?referrer=https://www.jwatch.org/na51575/2020/05/13/prevalence-gi-and-liver-manifestations-covid-19-infection
Gastroenterology

Multiple gastrointestinal (GI) symptoms including diarrhea, nausea/vomiting, and abdominal pain, as well liver enzyme abnormalities have been variably reported in patients with COVID-19. The AGA) Institute Clinical Guideline Committee and Clinical Practice Updates Committee performed a systematic review and meta-analysis of international data on GI and liver manifestations of COVID-19.

Examination of food consumption in United States adults and the prevalence of inflammatory bowel disease using National Health Interview Survey 2015
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232157
PLoS ONE;

Various diets and food components have been implicated as one of the environmental factors associated with inflammatory bowel disease (IBD). Patients are often recommended nutritional guidelines to manage disease symptoms. However, the current food consumption pattern of US adults with IBD that are nationally representative is unclear. A secondary analysis of National Health Interview Survey 20...

Gynecologic Management of Adolescents and Young Women With Seizure Disorders
https://journals.lww.com/greenjournal/FullText/2020/05000/Gynecologic_Management_of_Adolescents_and_Young.55.aspx
Obstetrics & Gynecology;

Seizure disorders frequently are diagnosed and managed during adolescence; therefore, obstetrician–gynecologists who care for adolescents should be familiar with epilepsy and other seizure disorders, as well as antiepileptic drugs. Patients diagnosed with seizure disorders during childhood may have increased seizure activity with puberty and menarche due to the neuroactive properties of endogen...