About 13,472 results
Asthma in Adults
Medical Clinics of North America; Nanda A, et al

Oct 27th, 2019 - Asthma affects approximately 300 million people worldwide and approximately 7.5% of adults in the United States. Among adults, asthma results in about 10.5 million physician office visits per year and affects approximately 8.7% of blacks, 7.6% of whites, and 5.8% of Hispanics. Asthma is characterized by inflammation of airways, variable airflow obstruction, and bronchial hyperresponsiveness.3 I...

Genentech Announces FDA Approval of Xofluza (Baloxavir Marboxil) for People at High Risk of Developing Influenza-Related Complications

Oct 16th, 2019 - Single-dose Xofluza is the first and only antiviral medicine indicated specifically for patients at high risk of developing serious complications from influenza (flu) The Centers for Disease Control and Prevention (CDC) defines people at high risk of serious flu complications as those who have conditions such as asthma, chronic lung disease, diabetes, heart disease, morbid obesity or adults ...

Predicting the Risk of Postoperative Pulmonary Complications
American Family Physician;

Oct 14th, 2019 - The incidence of pulmonary complications following major surgery is estimated to be 1% to 23%, with the risk varying based on patient factors and the type of surgery.1 Postoperative pulmonary complications include pneumonia, tracheobronchitis, pulmonary edema, pulmonary embolism, atelectasis, pleural effusion, pneumothorax, bronchospasm, aspiration, respiratory failure, and acute respiratory di...

Global Initiative for Asthma: Global Strategy for Asthma Management & Prevention

Sep 29th, 2019 - The 2019 update of the Global Strategy for Asthma Management and Prevention incorporates new scientific information about asthma based on a review of recent scientific literature by an international panel of experts on the GINA Science Committee. This comprehensive and practical resource about one of the most common chronic lung diseases worldwide contains extensive citations from the scientifi...

Can Mild Asthma Be Managed with Only As-Needed Inhaled Steroids Plus a Bronchodilator?

Sep 25th, 2019 - David J. Amrol, MD reviewing Hardy J et al. Lancet 2019 Sep 14 Gauthier M and Wenzel SE. Lancet 2019 Sep 14

Are Antihistamines and Steroids Helpful for Anaphylaxis?

Sep 23rd, 2019 - David J. Amrol, MD reviewing Gabrielli S et al. J Allergy Clin Immunol Pract 2019 Sep/Oct

FDA Allergenic Products Advisory Committee Votes to Support the Use of Aimmune’s PALFORZIA™ (AR101) for Peanut Allergy

Sep 12th, 2019 - Aimmune Therapeutics, Inc. (Nasdaq:AIMT), a biopharmaceutical company developing treatments for potentially life-threatening food allergies, today announced that the Allergenic Products Advisory Committee (APAC) convened by the U.S. Food and Drug Administration (FDA) voted to support the use of AR101 (proposed trade name PALFORZIA™) in children and teens with peanut allergy. PALFORZIA is a comp...

Nucala is the first biologic approved in the US for six to 11-year-old children with severe eosinophilic asthma

Sep 11th, 2019 - GlaxoSmithKline (LSE/NYSE: GSK) today announced that the US Food and Drug Administration (FDA) has approved Nucala (mepolizumab) for use in children as young as six years old who are living with severe eosinophilic asthma. Nucala is the only targeted biologic to be approved for the condition in the six to 11-year age group in the US.

Scientists discover immune cell subtype in mice that drives allergic reactions

Jul 31st, 2019 - Allergies can be life-threatening when they cause anaphylaxis, an extreme reaction with constriction of the airways and a sudden drop in blood pressure. Scientists have identified a subtype of immune cell that drives the production of antibodies (link is external) associated with anaphylaxis and other allergic reactions. The research was funded by the National Institute of Allergy and Infectio...

Clinical trial to evaluate experimental treatment in people allergic to multiple foods

Jul 31st, 2019 - Though food allergy affects more than 4.8 million children in the United States, no approved preventative treatments currently exist. While experimental desensitization strategies are available in research settings, people with food allergies must avoid known allergens and are advised to carry injectable epinephrine to prevent potentially life-threatening allergic reactions caused by accidenta...

Risk of Acute Myocardial Infarction and Ischemic Stroke in Patients with Asthma Exacerbation: A Population-Based, Self-Controlled Case Series Study
The Journal of Allergy and Clinical Immunology: In Practice; Raita, Y. et. al.

Jul 15th, 2019 - Background Patients with asthma have a high incidence of acute myocardial infarction and ischemic stroke. Objective To investigate the acute effect of asthma exacerbation on these cardiovascular events. Methods Using population-based inpatient data of 3 geographically diverse US states (Florida, Nebraska, and New York) during the period 2011 to 2014, we conducted a self-controlled case...

Teva Announces FDA Approval of AirDuo® Digihaler™ (fluticasone propionate 113 mcg and salmeterol 14 mcg) Inhalation Powder

Jul 14th, 2019 - Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced today that the U.S. Food and Drug Administration (FDA) has approved AirDuo® Digihaler™ (fluticasone propionate 113 mcg and salmeterol 14 mcg) Inhalation Powder, a combination therapy digital inhaler with built-in sensors that connects to a companion mobile application to provide information on inhaler use to people with asthma....

Grifols announces FDA approval of Xembify®, 20% subcutaneous immunoglobulin for primary immunodeficiencies

Jul 4th, 2019 - Grifols (MCE:GRF, MCE:GRF.P NASDAQ:GRFS), a leading global producer of plasma-derived medicines, announced today that Xembify®, its new 20% subcutaneous immunoglobulin, has been approved by the U.S. Food and Drug Administration (FDA). Xembify® is used to treat primary immunodeficiencies.

Clinical Trials | NUCALA (mepolizumab)

Jun 26th, 2019 - NUCALA (mepolizumab) has clinical data on exacerbation reduction. Learn about NUCALA for patients with severe eosinophilic asthma.

Atopic dermatitis/Eczema | DermNet NZ

Jun 24th, 2019 - Atopic dermatitis is a chronic, itchy skin condition that is very common in children but may occur at any age. It is also known as eczema and atopic eczema and was formerly known as Besnier prurigo. It is the most common form of dermatitis. Atopic dermatitis usually occurs in people who have an 'atopic tendency'. This means they may develop any or all of three closely linked conditions; atop...

Eczema - StatPearls
Nemeth, V. et. al.

Jun 3rd, 2019 - Eczema, also known as atopic dermatitis, is the most common form of dermatitis. Genetic as well as environmental factors are thought to play a part in the pathogenesis. Eczema is most commonly seen in children but can be seen in adults. People with the disease tend to have dry, itchy skin that is prone to infection. Eczema is commonly known as the "itch that rashes" due to dry skin that lea...

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease
The Cochrane Database of Systematic Reviews; Threapleton, C. et. al.

May 23rd, 2019 - Chronic obstructive pulmonary disease (COPD; including chronic bronchitis and emphysema) is a chronic respiratory condition characterised by shortness of breath, cough and recurrent exacerbations. Long‐term antibiotic use may reduce both bacterial load and inflammation in the airways. Studies have shown a reduction of exacerbations with antibiotics in comparison to placebo in people with COPD, ...

Rate of life-threatening childbirth complications increasing sharply across U.S. racial, ethnic groups

May 2nd, 2019 - Racial and ethnic disparities in severe maternal morbidity — life-threatening maternal complications associated with childbirth — have persisted and increased at high rates among U.S. women, according to an analysis of nearly 20 years of California hospital records funded by the National Institutes of Health. Known risk factors for these complications — such as blood pressure disorders, asthma ...

Interventions for hand eczema
The Cochrane Database of Systematic Reviews; Christoffers, W. et. al.

Apr 25th, 2019 - Hand eczema is an inflammation of the skin of the hands that tends to run a chronic, relapsing course. This common condition is often associated with itch, social stigma, and impairment in employment. Many different interventions of unknown effectiveness are used to treat hand eczema.

Asthma Data, Statistics, and Surveillance

Mar 24th, 2019 - The latest national and state data on the burden of asthma among children and adults.

The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing...

Mar 17th, 2019 - This clinical report updates and replaces a 2008 clinical report from the American Academy of Pediatrics, which addressed the roles of maternal and early infant diet on the prevention of atopic disease, including atopic dermatitis, asthma, and food allergy. As with the previous report, the available data still limit the ability to draw firm conclusions about various aspects of atopy prevention ...

Asthma More Common in Opioid-Dependent Patients
Boyles, S.

Feb 23rd, 2019 - The prevalence of asthma was nearly twice as high as the national average in a cohort of opioid-dependent patients receiving acute care at an inner city hospital in a New York City borough, with female sex more closely linked to higher asthma risk than male sex, researchers reported here.

Coverage from the American Academy of Allergy, Asthma and Immunology (AAAAI) 2019 Meeting

Feb 21st, 2019 - American Academy of Allergy, Asthma and Immunology (AAAAI) 2019 Meeting: Read clinically focused news coverage of key developments from AAAAI 2019

Efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab anti-IL-5 treatments of severe asthma – a systematic review and meta-analysis
European Clinical Respiratory Journal;

Nov 6th, 2018 - Background: New, complex, and expensive therapies targeting Interleukin-5 (IL-5) to treat severe eosinophilic asthma are emerging. Objective: To assess efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab for treating severe eosinophilic asthma. Design: A systematic review and meta-analysis on randomized, placebo-controlled, clinical trials elucidating two cri...

Clinical Guideline for the Diagnosis, Evaluation and Management of Adults and Children with Asthma

Nov 3rd, 2018 - Consider a diagnosis of asthma and perform spirometry if any of these indicators are present :The symptoms of dyspnea, cough and/or wheezing, especially nocturnal, difficulty breathing or chest tightness

Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update
Taplitz, R. et. al.

Sep 3rd, 2018 - Antibacterial and antifungal prophylaxis is recommended for patients who are at high risk of infection, including patients who are expected to have profound, protracted neutropenia, which is defined as < 100 neutrophils/µL for > 7 days or other risk factors. Herpes simplex virus–seropositive patients undergoing allogeneic hematopoietic stem-cell transplantation or leukemia induction therapy sho...

Eosinophilic Asthma | Apfed

Jun 25th, 2018 - For decades physicians have understood that a diagnosis of asthma requires further description because attacks of wheezing and shortness of breath can be associated with several underlying diseases. For example, patients allergic to animal dander, such as cat dander, who have animals as pets, may suffer from chronic severe asthma. Identification of patients with this form of asthma (referred to...

Asthma for Healthcare Professionals | CDC

Jun 18th, 2018 - Vital Signs: Asthma in Children – United States, 2001-2016 Free continuing education (CE) activity that describes trends and demographic differences in health outcomes and healthcare use for childhood asthma, based on a CDC analysis of asthma data from the 2001-2016 National Health Interview Survey for children 17 years and younger.This activity is intended for pediatricians, pulmonologists, ...

Asthma Risk Factors | American Lung Association

May 20th, 2018 - The most common risk factors for developing asthma is having a parent with asthma, having a severe respiratory infection as a child, having an allergic condition, or being exposed to certain chemical irritants or industrial dusts in the workplace.

Asthma as the Underlying Cause of Death | CDC

Apr 23rd, 2018 - Asthma deaths have decreased over time and varied by demographic characteristics. View the statistics from the Centers for Disease Control and Prevention (CDC) - National Center of Environmental Health (NCEH) - National Asthma Control Program

Current Asthma Prevalence by Weight Status Among Adults: United States, 2001–2014

Mar 15th, 2018 - Asthma is a common chronic airway disorder characterized by periods of airflow obstruction known as asthma attacks (1). Symptom frequency can range from intermittent to constant, and attack severity can vary from mild to life threatening (1). Several studies have shown that among adults, obesity is associated with an increased risk of asthma diagnosis, more frequent asthma-related health care u...

Asthma Statistics- Facts and Figures

Feb 16th, 2018 - Asthma statistics: Approximately 25.9 million Americans suffer from asthma. It is one of this country's most common and costly diseases.

Percentage of People with Asthma who Smoke

Jan 30th, 2018 - Nearly 17% of people without asthma smoke. But surprisingly, even more people with asthma smoke. About 21% of people with asthma smoke, even though cigarette smoke is known to trigger asthma attacks.

Asthma - Lab Tests

Oct 24th, 2017 - Asthma is a chronic inflammatory condition affecting the lungs. With asthma, the tubes that carry air throughout the lungs (bronchi) are inflamed and swollen, which narrows the airway and makes it more difficult to breathe. Learn about the lab tests used to help diagnose, monitor, and manage asthma.

Asthma Clinical Resources

Aug 31st, 2017 - Pathogenenesis of viral infection in exacerbations of airway disease

Sodium Intake and Health Outcomes
Strom, B. et. al.

Aug 26th, 2017 - This chapter reviews and assesses new evidence for associations between dietary sodium intake and outcomes published in the peer-reviewed literature through 2012. The health outcomes reviewed by the committee include cardiovascular disease (CVD), including stroke CVD mortality and all-cause mortality, congestive heart failure (CHF), chronic kidney disease (CKD), diabetes, cancer, and “other” ou...

Work-related Asthma Epidemiology - CDC

May 23rd, 2017 - Work-related asthma is the most prevalent occupational lung disease and is likely underrecognized in the clinical setting. Thus, a thorough occupational history is critical for identifying patients.

National Center for Health Statistics - Asthma

Jan 18th, 2017 - FastStats is an official application from the Centers for Disease Control and Prevention & (CDC) National Center for Health Statistics (NCHS) and puts access to topic-specific statistics at your fingertips.

The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA
BMC Pulmonary Medicine;

Jul 21st, 2016 - Asthma exacerbations are frequent in patients with severe disease. This report describes results from two retrospective cohort studies describing exacerbation frequency and risk, emergency department (ED)/hospital re-admissions, and asthma-related costs by asthma severity in the US and UK.

Causes and Evaluation of Chronic Dyspnea

Jul 11th, 2015 - Chronic dyspnea is shortness of breath that lasts more than one month. The perception of dyspnea varies based on behavioral and physiologic responses. Dyspnea that is greater than expected with the degree of exertion is a symptom of disease. Most cases of dyspnea result from asthma, heart failure and myocardial ischemia, chronic obstructive pulmonary disease, interstitial lung disease, pneumoni...

Diagnosis and management of eosinophilic asthma: a US perspective
Journal of Asthma and Allergy;

Apr 10th, 2014 - Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninva...

Allergic conjunctivitis: a comprehensive review of the literature
Italian Journal of Pediatrics; La Rosa, M. et. al.

Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...

Guidelines for the Diagnosis and Management of Food Allergy in the United: States Summary of the NIAID-Sponsored Expert Panel Report
National Institute of Allergy and Infectious Diseases

Dec 16th, 2010 - Food allergy (FA) is an important public health problem that affects adults and children and may be increasing in prevalence. Despite the risk of severe allergic reactions and even death, there is no current treatment for FA: the disease can only be managed by allergen avoidance or treatment of symptoms. Moreover, the diagnosis of FA may be problematic, given that nonallergic food reactions, su...

Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel

Dec 15th, 2010 - Food allergy is an important public health problem that affects children and adults and may be increasing in prevalence. Despite the risk of severe allergic reactions and even death, there is no current treatment for food allergy: the disease can only be managed by allergen avoidance or treatment of symptoms. The diagnosis and management of food allergy also may vary from one clinical practice ...


Risankizumab (ABBV-066) is an anti-IL-23 antibody being investigated for the treatment of multiple inflammatory diseases, including psoriasis, Crohn's disease, ulcerative colitis, atopic dermatitis and psoriatic arthritis.

CINRYZE® (C1 esterase inhibitor [human])

CINRYZE® (C1 esterase inhibitor [human]) is indicated for routine prophylaxis against angioedema attacks in adults, adolescents and pediatric patients (6 years of age and older) with Hereditary Angioedema (HAE).

VPRIV (velaglucerase alfa for injection)

Enzyme replacement therapy for type 1 Gaucher. See important Safety Info including hypersensitivity reactions & anaphylaxis at VPRIV.com

STRIVERDI® RESPIMAT® (olodaterol) Prescribing Information

STRIVERDI RESPIMAT Inhalation Spray is a long-acting beta2-adrenergic agonist indicated for: The long-term, once-daily maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema

HAEGARDA® (C1 Esterase Inhibitor Subcutaneous [Human]

Learn about HAEGARDA, only FDA-approved C1 esterase inhibitor subcutaneous (human) injection that can help prevent HAE attacks for your patients.

Berinert® [C1 Esterase Inhibitor (Human)]

Empower and support your HAE patients with BERINERT C1-INH replacement therapy for on-demand treatment of HAE attacks.

GRASTEK® (Timothy Grass Pollen Allergen Extract) Tablet for Sublingual Use

Find studies, dosing instructions and the safety and tolerability profile for GRASTEK®. View Safety Info & Boxed Warning.

NUCALA (mepolizumab) For Severe Eosinophilic Asthma

NUCALA is indicated for the add-on maintenance treatment of patients 12 years and older with severe asthma with an eosinophilic phenotype. NUCALA is not indicated for the relief of acute bronchospasm or status asthmaticus.

PERJETA® (pertuzumab)

Learn about PERJETA®, indicated for early and metastatic HER2 positive breast cancer. Indications: Metastatic Breast Cancer. PERJETA® (pertuzumab) is indicated for use in combination with Herceptin® (trastuzumab) and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer (MBC) who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. Earl...

Nucala (mepolizumab) Dosing & Administration

NUCALA (mepolizumab) Injection 100 mg/mL is indicated for the add-on maintenance treatment of patients 12 years and older with severe asthma with an eosinophilic phenotype

Asthma Statistics | AAAAI

Asthma statistics gathered and reviewed by the AAAAI's leading experts.

When to Consider XOLAIR (omalizumab) for CIU

Find information on disease symptoms and patient stories for chronic idiopathic urticaria (CIU) patients who remain symptomatic despite H1 antihistamines. See full safety & Boxed Warning

CIU & You: Support for Those with CIU, a Form of Chronic Hives

CIU & You provides resources for those with chronic idiopathic urticaria, a form of chronic hives. Hear personal stories from actress Vicki Lawrence and others.

Exposure to Cleaning Products May Compromise Infants' Lungs

Feb 18th, 2020 - Keeping a clean house may protect against the spread of germs, but early exposure to household cleaning agents could have an unwanted effect on young children, according to data from a Canadian birth cohort. Infants whose caregivers reported frequent use of household cleaning products when the child was 3 to 4 months of age were at increased risk for asthma and recurrent wheeze at 3 years compa...

Migraine is Bidirectionally Associated With Asthma

Feb 18th, 2020 - Key clinical point: Migraine and asthma have a reciprocal association with each other. Major finding: Patients with asthma had a 47% higher risk for migraine ( P less than.

Dupilumab for severe AD: Expert advocates continuous treatment

Feb 18th, 2020 - Set realistic efficacy expectations Dermatologists who prescribe the newest biologics for psoriasis are accustomed to routinely seeing PASI 90 responses and even complete disease clearing. However, AD is a more challenging disease.

Neuromuscular blockade for ARDS in the ICU
Robert C. Hyzy, MD, FCCP

Feb 11th, 2020 - The ability to control the delivery of ventilation to patients having the acute respiratory distress syndrome (ARDS) without encountering patient respiratory effort via the administration of neuromuscular blocking drugs has been a potentially appealing therapeutic option for decades (Light RW, et al. Anesth Analg.

Fast Five Quiz: Atopic Dermatitis

Feb 10th, 2020 - Atopic dermatitis (AD), or atopic eczema, is a chronic inflammatory skin disorder that commonly presents as pruritic, ill-defined, dry patches with excoriations. Although AD can affect any part of the body, it usually has an age-related distribution. The condition can affect up to 20% of children and 10% of adults and is more common in urban than in rural areas, and its prevalence increases in ...

Consider allergic contact dermatitis in children with AD with disease flares, new rash
Jeff Craven

Feb 7th, 2020 - ORLANDO – Do you have pediatric patients with atopic dermatitis (AD) flares despite complying with treatment, or those who have a new rash in an unusual area? Consider patch testing to assess whether they have allergic contact dermatitis. Jeff Craven/MDedge News Dr.

Avoiding Endocrine-Disrupting Chemicals: 5 Tips

Feb 6th, 2020 - As a medical student in the late 1990s, I learned about the effects of childhood lead exposure on the developing brain, and of air pollution in children with asthma. Environmental health questions have not yet found their way into the medical board exams, yet a large body of literature tells us that the endocrine system is exquisitely vulnerable to the effects of synthetic chemicals commonly us...

Prenatal Vitamin D Therapy Fails to Prevent Childhood Asthma

Feb 5th, 2020 - NEW YORK (Reuters Health) - Updated results on a study of vitamin D and childhood asthma has concluded that giving extra doses to pregnant women fails to reduce the risk of wheezing and breathing problems in youngsters through age 6 years. The VDAART study looked at 876 women who were instructed to take a daily prenatal vitamin containing 400 IU of vitamin D beginning at 10 to 18 weeks of pregn...

Patients With Hidradenitis Suppurativa Often Turn to Alternative Medicine

Feb 4th, 2020 - NEW YORK (Reuters Health) - Complementary and alternative medicine (CAM) use is common among patients with hidradenitis suppurativa (HS), more than half of whom report dissatisfaction with conventional treatment, researchers say. "Patients with HS experience more negative impacts on quality of life when compared to other dermatologic conditions including atopic dermatitis and psoriasis," Kyla P...

Hypersensitivity Reactions to Orthopedic Implants: What’s All the Hype?

Feb 4th, 2020 - Clinical Presentation Several clinical presentations of orthopedic IHRs have been described. Perhaps the most commonly recognized is a localized cutaneous eczematous eruption, with dermatitis typically overlying the site of the implanted material.

FDA okays Palforzia, first drug for peanut allergy in children
Alicia Ault

Feb 1st, 2020 - The Food and Drug Administration has approved the first drug to combat peanut allergy in children, (Palforzia, Aimmune Therapeutics), although those who take it must continue to avoid peanuts in their diets. The peanut (Arachis hypogaea) allergen powder is also the first drug ever approved to treat a food allergy.

FDA OKs Palforzia, First Drug for Peanut Allergy in Children

Jan 30th, 2020 - The US Food and Drug Administration (FDA) has approved the first drug to combat peanut allergy in children, (Palforzia, Aimmune Therapeutics), although those who take it must continue to avoid peanuts in their diets. The peanut (Arachis hypogaea) allergen powder is also the first drug ever approved to treat a food allergy. It is not a cure, but it mitigates allergic reactions, including anaphyl...

EMA Panel Backs Crisaborole (Staquis) for Atopic Dermatitis

Jan 30th, 2020 - The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended approval of crisaborole (Staquis, Pfizer) for the treatment of atopic dermatitis (eczema). Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor that suppresses secretion of certain cytokines, such as tumor necrosis factor alpha, interleukins (IL-2, IL-4, IL-5), and interferon gamma...

EMA Panel Backs Budesonide/Formoterol Hybrid for Asthma, COPD

Jan 30th, 2020 - The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has endorsed the hybrid medicine budesonide/formoterol fumarate dihydrate (Teva Pharma B.V.) for the treatment of adults with asthma and chronic obstructive pulmonary disease (COPD). The product is called Budesonide/Formoterol Teva Pharma B.V. It is a duplicate of DuoResp Spiromax (same active ingre...

Asthma News You Can Use
Lisa Hack

Jan 28th, 2020 - Useful not only as a clinical overview but also for patient information, these up-to-date statistics elucidate the prevalence of severe asthma; risk factors and triggers; and results on research into use of harmfully high doses of oral and inhaled corticosteroids. To see the data in action, start reading here.

Whole Cell Pertussis Vaccine May Help Protect Australian Infants Against Food Allergies

Jan 21st, 2020 - NEW YORK (Reuters Health) - Australian infants who received the whole pertussis (wP) vaccine were less likely to be diagnosed with food allergies than those who received the acellular pertussis (aP) vaccine in a nested case control study. "It is vital that young babies are vaccinated to protect them against whooping cough, and both the aP vaccine and the older wP whooping cough vaccines are pro...

CD1a and cosmetic-related contact dermatitis
Naissan O. Wesley, MD, Lily Talakoub, MD

Jan 21st, 2020 - As industries develop more chemical extraction techniques for synthetic or purified botanical ingredients to include in cosmetic and personal care products, the incidence of contact dermatitis is rising. Contact dermatitis (irritant or allergic) is the most common occupational skin disease, with current lifetime incidence exceeding 50%.

‘Simple’ model predicts severe neutropenia risk in lung cancer patients
Andrew D. Bowser, MDedge News

Jan 16th, 2020 - A new and simple model for predicting risk of severe neutropenia in advanced lung cancer could ease the evaluation process and help inform patient management decisions, according to investigators. The model, based on 10 pretreatment variables, appears to overcome limitations of a comprehensive risk prediction model that is not specific to lung cancer, according to Xiaowen Cao of Duke University.

Experts in Europe issue guidance on atopic dermatitis in pregnancy
MDedge Dermatology;

Jan 9th, 2020 - Systemic therapies If disease control is insufficient with topical therapy, it’s appropriate to engage in shared decision-making with the patient regarding systemic treatment. She needs to understand up front that the worldwide overall background stillbirth rate in the general population is about 3%, and that severe congenital malformations are present in up to 6% of all live births.

Dupilumab-induced head and neck erythema described in atopic dermatitis patients
Bruce Jancin

Jan 6th, 2020 - MADRID – A growing recognition that atopic dermatitis (AD) patients on dupilumab are prone to develop a paradoxical head and neck erythema that’s clinically and histologically distinct from their background skin disease emerged as a hot topic of discussion at a meeting of the European Task Force on Atopic Dermatitis held in conjunction with the annual congress of the European Academy of Dermato.

Efficacy and safety of lowering dupilumab frequency for AD
Christine Kilgore

Jan 6th, 2020 - Patients with moderate to severe atopic dermatitis who responded well to the approved dupilumab regimen of 300 mg every 2 weeks in pivotal phase 3 monotherapy trials were more likely to have a continued response over the longer term if they maintained this regimen rather than switching to longer dosing intervals or discontinuing the medication. This finding comes from a 36-week, randomized, dou.

Despite PCV, pediatric asthma patients face pneumococcal risks
Michele G. Sullivan

Jan 3rd, 2020 - Even on-time pneumococcal vaccines don’t completely protect children with asthma from developing invasive pneumococcal disease, a meta-analysis has determined. Despite receiving pneumococcal valent 7, 10, or 13, children with asthma were still almost twice as likely to develop the disease as were children without asthma, Jose A.

Adult atopic dermatitis brings increased osteoporosis risk
Bruce Jancin

Dec 30th, 2019 - MADRID – Adults with atopic dermatitis (AD) face significantly increased risks of osteoporosis and major osteoporotic fractures – even if they’ve never taken systemic corticosteroids, according to a large observational Danish national registry study. Bruce Jancin/MDedge News Dr.

New Analysis Expands on Link Between Pharma Payments, Prescribing

Dec 29th, 2019 - Doctors who receive money from drugmakers related to a specific drug prescribe that drug more heavily than doctors without such financial ties, a new ProPublica analysis found. The pattern is consistent for almost all of the most widely prescribed brand-name drugs in Medicare, including drugs that treat diabetes, asthma and more. The financial interactions include payments for delivering promot...

More Frequent Dupilumab Better for Atopic Dermatitis Control

Dec 29th, 2019 - Uncontrolled atopic dermatitis (AD) produces lesions that can be itchy, painful, and unsightly — making it difficult to sleep and threatening psychological health and quality of life.   Now a randomized follow-up trial in adults from two previous studies (SOLO 1 and SOLO 2) reports that maintenance monotherapy with dupilumab (Dupixent, Regeneron) at 300 mg weekly or biweekly over 36 weeks is th...

Which children are at greatest risk for atopic dermatitis?

Dec 24th, 2019 - The meta-analysis showed that a parental history of atopic dermatitis was associated with a 3. 3-fold greater risk of atopic dermatitis in the offspring than in families without a parental history of atopy.

Melanoma In Situ Within a Port-Wine Stain
Sabrina Martin, MD, Stephanie Martin, MD et. al.

Dec 19th, 2019 - To the Editor: Port-wine stains (PWSs) are the most common type of vascular malformations. Patients rarely develop cancers in the overlying skin.

Active Ingredient in OTC Inhaler a 'New' Drug of Abuse

Dec 18th, 2019 - SAN DIEGO ― The active ingredient in an over-the-counter nasal decongestant appears to be re-emerging as a "new" drug of abuse, addiction experts warn. Propylhexedrine (multiple brands) is indicated for relief of nasal congestion from colds, allergic rhinitis, and sinusitis. Previously considered to have low potential for abuse, new research suggests the opposite may be true. Dr Nikhil Teja "Pr...

Kids With Asthma at Greater Risk for Pneumococcal Disease

Dec 18th, 2019 - Children with asthma are at much greater risk for invasive pneumococcal disease (IPD), even if they have received the pneumococcal conjugate vaccine (PCV), a systematic review and meta-analysis have found. Jose A. Castro-Rodriguez, MD, PhD, from the Pontificia Universidad Católica de Chile, Santiago, Chile, and colleagues published their findings online December 16 in Pediatrics. "Our review an...

Beta-Blockers, ACE Inhibitors Don’t Raise Anaphylaxis Risk From Cardiac Catheterization

Dec 18th, 2019 - NEW YORK (Reuters Health) - The risk of anaphylactic reactions from contrast media used during cardiac catheterization is not increased in patients on beta-blockers or angiotensin-converting enzyme (ACE) inhibitors, according to results from a retrospective case-control study. "Now that low-osmolar contrast media (LOCM) has become the standard, it is reassuring that beta-blockers and ACE inhibi...

Fast Five Quiz: Chronic Spontaneous Urticaria

Dec 18th, 2019 - Chronic spontaneous urticaria (CSU) (also referred to as "chronic idiopathic urticaria") represents the majority of cases of chronic urticaria. CSU is defined as chronic urticaria of known or unknown etiology lasting for ≥ 6 weeks. In a subset of patients with CSU, there is an identifiable underlying autoimmune etiology (chronic autoimmune urticaria). CSU can be challenging to manage and often ...

Identifying bacterial infections in setting of atopic dermatitis
Tara Haelle

Dec 17th, 2019 - While identifying overt bacterial infections in patients with atopic dermatitis is straightforward, wide variations in clinical presentation of infections in AD and features common to both can make it difficult to make a clinical diagnosis of infections. Addressing this issue, the International Eczema Council Skin Infection Group reviewed the most current evidence on the clinical features of ba.

Novartis Drops Asthma Drug Fevipiprant After Trial Failures

Dec 16th, 2019 - ZURICH (Reuters) - Swiss drugmaker Novartis on Monday said it is jettisoning what it had hoped would be a billion-dollar-selling asthma drug, fevipiprant, from its development program after the medicine failed another set of key trials. The drug's star fell in October when the Basel-based company announced it had failed a pair of trials in moderate asthmatic patients. Now, fevipiprant has flopp...

Errors Common in Epinephrine Use for Pediatric Anaphylaxis

Dec 16th, 2019 - NEW YORK (Reuters Health) - At least one medication error occurred in two-thirds of epinephrine administrations for simulated pediatric anaphylaxis, even in academic pediatric hospitals, a new international study has found. The errors encompassed high rates of both prescribing errors and mistakes in epinephrine administration, researchers report in The Journal of Allergy and Clinical Immunology...

Vaping increases the risk of lung disease by a third: U.S. study

Dec 16th, 2019 - CHICAGO (Reuters) - Using e-cigarettes significantly increases the risk of developing chronic lung conditions such as asthma or emphysema, U.S. researchers said on Monday. FILE PHOTO: A man uses a vape device in this illustration picture, September 19, 2019. REUTERS/Adnan Abidi/Illustration/File Photo The study, published in the American Journal of Preventive Medicine, is among the first to sho...

Fast, aggressive eczema treatment linked to fewer food allergies by age 2
Jennie Smith

Dec 16th, 2019 - Researchers in Japan report that infants with atopic dermatitis who are treated early and aggressively with corticosteroids develop fewer food allergies by age 2 years. For their research published in the Journal of Allergy and Clinical Immunology: In Practice, Yumiko Miyaji, MD, PhD, of Japan’s National Center for Child Health and Development in Tokyo and colleagues looked at 3 years’ worth of.

Atopic dermatitis in egg-, milk-allergic kids may up anaphylaxis risk
Heidi Splete

Dec 16th, 2019 - Children with atopic dermatitis and allergies to eggs and milk were at increased risk for anaphylactic reactions, compared with allergic patients without atopic dermatitis, based on retrospective data from 347 individuals. Atopic dermatitis has been associated with increased risk of food allergies, but the association and predictive factors of skin reactions to certain foods remain unclear, wro.

Novartis drops asthma drug fevipiprant after trial failures

Dec 16th, 2019 - FILE PHOTO: The company's logo is seen at the new cell and gene therapy factory of Swiss drugmaker Novartis in Stein, Switzerland, November 28, 2019. REUTERS/Arnd Wiegmann ZURICH (Reuters) - Swiss drugmaker Novartis on Monday said it is jettisoning what it had hoped would be a billion-dollar-selling asthma drug, fevipiprant, from its development program after the medicine failed another set of ...

Frequent soaks ease pediatric atopic dermatitis
Heidi Splete

Dec 14th, 2019 - A regimen of twice-daily baths followed by occlusive moisturizer improved atopic dermatitis in children with moderate to severe disease more effectively than did a twice-weekly protocol, based on data from 42 children. Guidelines for bathing frequency for children with atopic dermatitis are inconsistent and often confusing for parents, according to Ivan D.

Trending Clinical Topic: Asthma

Dec 12th, 2019 - Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook. New studies about issues related to pregnancy, concerns about repeated use of corticosteroids, and greenhouse gas emissions helped make asthma this we...

Asthma exacerbation in pregnancy impacts moms, babies
Heidi Splete

Dec 12th, 2019 - Women with asthma who suffer asthma exacerbation while pregnant are at increased risk for complications during pregnancy and delivery, and their infants are at increased risk for respiratory problems, according to data from a longitudinal study of 58,524 women with asthma. Vesnaandjic/E+/Getty Images “Asthma exacerbation during pregnancy has been found to be associated with adverse perinatal an.

Asthma exacerbation in pregnancy impacts mothers, infants
Heidi Splete

Dec 12th, 2019 - Women with asthma who suffer asthma exacerbation while pregnant are at increased risk for complications during pregnancy and delivery, and their infants are at increased risk for respiratory problems, according to data from a longitudinal study of 58,524 women with asthma. Vesnaandjic/E+/Getty Images “Asthma exacerbation during pregnancy has been found to be associated with adverse perinatal an.