Jun 30th, 2013 - To update the American Academy of Pediatrics clinical practice guideline regarding the diagnosis and management of acute bacterial sinusitis in children and adolescents.
Jonathan P. Parsons
Apr 30th, 2013 - Exercise-induced bronchoconstriction (EIB) describes acute airway narrowing that occurs as a result of exercise. A substantial proportion of patients with asthma experience exercise-induced respiratory symptoms.
Italian Journal of Pediatrics; La Rosa, M. et. al.
Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...
Feb 28th, 2013 - Hereditary angioedema (HAE) usually results from a deficiencyof the serine protease inhibitor C1 inhibitor (C1INH). (LB)There are 2 types of HAE, type I is most common.
Nov 30th, 2012 - Atopic dermatitis (AD) is often the first manifestation ofallergic disease. Most patients with AD will also have anotheratopic disorder, such as allergic rhinitis, asthma, or foodallergy.
Journal of the European Academy of Dermatology and Venereology : JEADV; Simonsen AB, Johansen JD et. al.
Dec 9th, 2017 - Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in atopic dermatitis (AD) facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in ch...
The Lancet. Haematology; Aguilar-Guisado M, Espigado I et. al.
Nov 20th, 2017 - Continuation of empirical antimicrobial therapy (EAT) for febrile neutropenia in patients with haematological malignancies until neutrophil recovery could prolong the therapy unnecessarily. We aimed to establish whether EAT discontinuation driven by a clinical approach regardless of neutrophil recovery would optimise the duration of therapy. We did an investigator-driven, superiority, open-labe...
Feb 29th, 2012 - This guideline represents an evidence-based approach to FN specific to children with cancer. Although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas.
JAMA , Grossman DC et. al.
Jun 20th, 2017 - Based on year 2000 Centers for Disease Control and Prevention growth charts, approximately 17% of children and adolescents aged 2 to 19 years in the United States have obesity, and almost 32% of children and adolescents are overweight or have obesity. Obesity in children and adolescents is associated with morbidity such as mental health and psychological issues, asthma, obstructive sleep apnea,...
Annals of Emergency Medicine; Barniol C, Dehours E et. al.
May 9th, 2017 - We evaluate the efficacy of a 4-day course of prednisone added to antihistamine for the management of acute urticaria in an emergency department (ED). In this double-blind randomized clinical trial, patients were eligible for inclusion if aged 18 years or older and with acute urticaria of no more than 24 hours' duration. Patients with anaphylaxis or who had received antihistamines or glucocorti...
JAMA Scadding GW, Calderon MA et. al.
Feb 14th, 2017 - Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placeb...
Resuscitation Kawano T, Scheuermeyer FX et. al.
Jan 10th, 2017 - There is little data describing the differences in epinephrine (epi) administration and cardiac complications among older and younger patients with anaphylaxis. This retrospective cohort study was conducted at two urban emergency departments (ED) over a 5 year-period, and included adults who met a pre-specified criteria for anaphylaxis. Patients ≥50years of age were defined as "older". Univaria...
Annals of Emergency Medicine; Coyne CJ, Le V et. al.
Jan 3rd, 2017 - Although validated risk-stratification tools have been used to send low-risk febrile neutropenic patients home from clinic and inpatient settings, there is a dearth of research evaluating these scores in the emergency department (ED). We compare the predictive accuracy of the Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE)...
Lancet (London, England); Natsume O, Kabashima S et. al.
Dec 12th, 2016 - Evidence is accumulating that early consumption is more beneficial than is delayed introduction as a strategy for primary prevention of food allergy. However, allergic reactions caused by early introduction of such solid foods have been a problematic issue. We investigated whether or not early stepwise introduction of eggs to infants with eczema combined with optimal eczema treatment would prev...
Michael Winters, Steven Rosenbaum
Apr 10th, 2011 - The current literature on ACE-inhibitor angioedema is primarily limited to retrospective reviews, case series, and case reports. Based upon this review of the literature, ACE-inhibitor angioedema should be considered in any ED patient presenting with asymmetric swelling of the lips, tongue, floor of the mouth, face, neck or eyelids.
Lancet (London, England); Bleecker ER, FitzGerald JM et. al.
Sep 9th, 2016 - Eosinophilia is associated with worsening asthma severity and decreased lung function, with increased exacerbation frequency. We assessed the safety and efficacy of benralizumab, a monoclonal antibody against interleukin-5 receptor α that depletes eosinophils by antibody-dependent cell-mediated cytotoxicity, for patients with severe, uncontrolled asthma with eosinophilia. We did a randomised, d...
Lancet (London, England); FitzGerald JM, Bleecker ER et. al.
Sep 9th, 2016 - Benralizumab is a humanised, afucosylated, anti-interleukin-5 receptor α monoclonal antibody that induces direct, rapid, and nearly complete depletion of eosinophils. We aimed to assess the efficacy and safety of benralizumab as add-on therapy for patients with severe, uncontrolled asthma and elevated blood eosinophil counts. In this randomised, double-blind, parallel-group, placebo-controlled,...
The New England Journal of Medicine; Stempel DA, Szefler SJ et. al.
Aug 31st, 2016 - Long-acting beta-agonists (LABAs) have been shown to increase the risk of asthma-related death among adults and the risk of asthma-related hospitalization among children. It is unknown whether the concomitant use of inhaled glucocorticoids with LABAs mitigates those risks. This trial prospectively evaluated the safety of the LABA salmeterol, added to fluticasone propionate, in a fixed-dose comb...
The New England Journal of Medicine; Peters SP, Bleecker ER et. al.
Aug 31st, 2016 - Concerns remain about the safety of adding long-acting β2-agonists to inhaled glucocorticoids for the treatment of asthma. In a postmarketing safety study mandated by the Food and Drug Administration, we evaluated whether the addition of formoterol to budesonide maintenance therapy increased the risk of serious asthma-related events in patients with asthma. In this multicenter, double-blind, 26...
The New England Journal of Medicine; Stein MM, Hrusch CL et. al.
Aug 15th, 2016 - The Amish and Hutterites are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter use industrialized farming practices. The populations also show striking disparities in the prevalence of asthma, and little is known about the immune respo...