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About 145,620 results
Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in...
http://pediatrics.aappublications.org/content/132/1/e262
Wald, E.

Jun 30th, 2013 - To update the American Academy of Pediatrics clinical practice guideline regarding the diagnosis and management of acute bacterial sinusitis in children and adolescents.

An Official American Thoracic Society Clinical Practice Guideline: Exercise-induced Bronchoc...
http://www.thoracic.org/statements/resources/allergy-asthma/exercise-induced-bronchoconstriction.pdf
Jonathan P. Parsons

Apr 30th, 2013 - Exercise-induced bronchoconstriction (EIB) describes acute airway narrowing that occurs as a result of exercise. A substantial proportion of patients with asthma experience exercise-induced respiratory symptoms.

Allergic conjunctivitis: a comprehensive review of the literature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640929/
Italian Journal of Pediatrics; La Rosa, M. et. al.

Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...

A focused parameter update: Hereditary angioedema,acquired C1 inhibitor deficiency, and angi...
https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20and%20Parameters/Hereditary-angioedema-June-2013.pdf
Zuraw, B.

Feb 28th, 2013 - Hereditary angioedema (HAE) usually results from a deficiencyof the serine protease inhibitor C1 inhibitor (C1INH). (LB)There are 2 types of HAE, type I is most common.

Atopic dermatitis: A practice parameter update 2012
https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20and%20Parameters/Atopic-dermatitis-2013.pdf
Schneider, L.

Nov 30th, 2012 - Atopic dermatitis (AD) is often the first manifestation ofallergic disease. Most patients with AD will also have anotheratopic disorder, such as allergic rhinitis, asthma, or foodallergy.

Children with atopic dermatitis may have unacknowledged contact allergies contributing ...
https://doi.org/10.1111/jdv.14737
Journal of the European Academy of Dermatology and Venereology : JEADV; Simonsen AB, Johansen JD et. al.

Dec 9th, 2017 - Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in atopic dermatitis (AD) facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in ch...

Optimisation of empirical antimicrobial therapy in patients with haematological maligna...
https://doi.org/10.1016/S2352-3026(17)30211-9
The Lancet. Haematology; Aguilar-Guisado M, Espigado I et. al.

Nov 20th, 2017 - Continuation of empirical antimicrobial therapy (EAT) for febrile neutropenia in patients with haematological malignancies until neutrophil recovery could prolong the therapy unnecessarily. We aimed to establish whether EAT discontinuation driven by a clinical approach regardless of neutrophil recovery would optimise the duration of therapy. We did an investigator-driven, superiority, open-labe...

Guideline for the Management of Fever and Neutropenia in Children With Cancer and/or Undergo...
http://aphon.org/UPLOADS/Education/ebpguideline_fever_neutropeniaHPCT.pdf
Thomas Lehrnbecher

Feb 29th, 2012 - This guideline represents an evidence-based approach to FN specific to children with cancer. Although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas.

Screening for Obesity in Children and Adolescents: US Preventive Services Task Force Re...
https://doi.org/10.1001/jama.2017.6803
JAMA , Grossman DC et. al.

Jun 20th, 2017 - Based on year 2000 Centers for Disease Control and Prevention growth charts, approximately 17% of children and adolescents aged 2 to 19 years in the United States have obesity, and almost 32% of children and adolescents are overweight or have obesity. Obesity in children and adolescents is associated with morbidity such as mental health and psychological issues, asthma, obstructive sleep apnea,...

Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatmen...
https://doi.org/10.1016/j.annemergmed.2017.03.006
Annals of Emergency Medicine; Barniol C, Dehours E et. al.

May 9th, 2017 - We evaluate the efficacy of a 4-day course of prednisone added to antihistamine for the management of acute urticaria in an emergency department (ED). In this double-blind randomized clinical trial, patients were eligible for inclusion if aged 18 years or older and with acute urticaria of no more than 24 hours' duration. Patients with anaphylaxis or who had received antihistamines or glucocorti...

Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Resp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479315
JAMA Scadding GW, Calderon MA et. al.

Feb 14th, 2017 - Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placeb...

Epinephrine use in older patients with anaphylaxis: Clinical outcomes and cardiovascula...
https://doi.org/10.1016/j.resuscitation.2016.12.020
Resuscitation Kawano T, Scheuermeyer FX et. al.

Jan 10th, 2017 - There is little data describing the differences in epinephrine (epi) administration and cardiac complications among older and younger patients with anaphylaxis. This retrospective cohort study was conducted at two urban emergency departments (ED) over a 5 year-period, and included adults who met a pre-specified criteria for anaphylaxis. Patients ≥50years of age were defined as "older". Univaria...

Application of the MASCC and CISNE Risk-Stratification Scores to Identify Low-Risk Febr...
https://doi.org/10.1016/j.annemergmed.2016.11.007
Annals of Emergency Medicine; Coyne CJ, Le V et. al.

Jan 3rd, 2017 - Although validated risk-stratification tools have been used to send low-risk febrile neutropenic patients home from clinic and inpatient settings, there is a dearth of research evaluating these scores in the emergency department (ED). We compare the predictive accuracy of the Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE)...

Two-step egg introduction for prevention of egg allergy in high-risk infants with eczem...
https://doi.org/10.1016/S0140-6736(16)31418-0
Lancet (London, England); Natsume O, Kabashima S et. al.

Dec 12th, 2016 - Evidence is accumulating that early consumption is more beneficial than is delayed introduction as a strategy for primary prevention of food allergy. However, allergic reactions caused by early introduction of such solid foods have been a problematic issue. We investigated whether or not early stepwise introduction of eggs to infants with eczema combined with optimal eczema treatment would prev...

What is the Emergency Department Management of Patients with Angioedema Secondary to an ACE-...
http://www.aaem.org/UserFiles/file/angioedema.pdf
Michael Winters, Steven Rosenbaum

Apr 10th, 2011 - The current literature on ACE-inhibitor angioedema is primarily limited to retrospective reviews, case series, and case reports. Based upon this review of the literature, ACE-inhibitor angioedema should be considered in any ED patient presenting with asymmetric swelling of the lips, tongue, floor of the mouth, face, neck or eyelids.

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with h...
https://doi.org/10.1016/S0140-6736(16)31324-1
Lancet (London, England); Bleecker ER, FitzGerald JM et. al.

Sep 9th, 2016 - Eosinophilia is associated with worsening asthma severity and decreased lung function, with increased exacerbation frequency. We assessed the safety and efficacy of benralizumab, a monoclonal antibody against interleukin-5 receptor α that depletes eosinophils by antibody-dependent cell-mediated cytotoxicity, for patients with severe, uncontrolled asthma with eosinophilia. We did a randomised, d...

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment...
https://doi.org/10.1016/S0140-6736(16)31322-8
Lancet (London, England); FitzGerald JM, Bleecker ER et. al.

Sep 9th, 2016 - Benralizumab is a humanised, afucosylated, anti-interleukin-5 receptor α monoclonal antibody that induces direct, rapid, and nearly complete depletion of eosinophils. We aimed to assess the efficacy and safety of benralizumab as add-on therapy for patients with severe, uncontrolled asthma and elevated blood eosinophil counts. In this randomised, double-blind, parallel-group, placebo-controlled,...

Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma.
https://doi.org/10.1056/NEJMoa1606356
The New England Journal of Medicine; Stempel DA, Szefler SJ et. al.

Aug 31st, 2016 - Long-acting beta-agonists (LABAs) have been shown to increase the risk of asthma-related death among adults and the risk of asthma-related hospitalization among children. It is unknown whether the concomitant use of inhaled glucocorticoids with LABAs mitigates those risks. This trial prospectively evaluated the safety of the LABA salmeterol, added to fluticasone propionate, in a fixed-dose comb...

Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone.
https://doi.org/10.1056/NEJMoa1511190
The New England Journal of Medicine; Peters SP, Bleecker ER et. al.

Aug 31st, 2016 - Concerns remain about the safety of adding long-acting β2-agonists to inhaled glucocorticoids for the treatment of asthma. In a postmarketing safety study mandated by the Food and Drug Administration, we evaluated whether the addition of formoterol to budesonide maintenance therapy increased the risk of serious asthma-related events in patients with asthma. In this multicenter, double-blind, 26...

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137793
The New England Journal of Medicine; Stein MM, Hrusch CL et. al.

Aug 15th, 2016 - The Amish and Hutterites are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter use industrialized farming practices. The populations also show striking disparities in the prevalence of asthma, and little is known about the immune respo...