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Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel
https://www.jacionline.org/article/S0091-6749(10)01566-6/fulltext

Dec 15th, 2010 - Food allergy is an important public health problem that affects children and adults and may be increasing in prevalence. Despite the risk of severe allergic reactions and even death, there is no current treatment for food allergy: the disease can only be managed by allergen avoidance or treatment of symptoms. The diagnosis and management of food allergy also may vary from one clinical practice ...

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137793
The New England Journal of Medicine; Stein MM, Hrusch CL et. al.

Aug 15th, 2016 - The Amish and Hutterites are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter use industrialized farming practices. The populations also show striking disparities in the prevalence of asthma, and little is known about the immune respo...

Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergenc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450939
JAMA Kor DJ, Carter RE et. al.

May 17th, 2016 - Management of acute respiratory distress syndrome (ARDS) remains largely supportive. Whether early intervention can prevent development of ARDS remains unclear. To evaluate the efficacy and safety of early aspirin administration for the prevention of ARDS. A multicenter, double-blind, placebo-controlled, randomized clinical trial conducted at 16 US academic hospitals. Between January 2, 2012, a...

Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endot...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967560
JAMA Patel BK, Wolfe KS et. al.

May 17th, 2016 - Noninvasive ventilation (NIV) with a face mask is relatively ineffective at preventing endotracheal intubation in patients with acute respiratory distress syndrome (ARDS). Delivery of NIV with a helmet may be a superior strategy for these patients. To determine whether NIV delivered by helmet improves intubation rate among patients with ARDS. Single-center randomized clinical trial of 83 patien...

Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With A...
https://doi.org/10.1001/jama.2016.3964
JAMA Virchow JC, Backer V et. al.

Apr 26th, 2016 - The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy-related asthma. To evaluate the efficacy and adverse events of the HDM SLIT tablet vs placebo for asthma exacerbations during an inhaled corticosteroid (ICS) reduction period. Double-blind, randomized, placebo-controlled trial conducted between August 2011 and April 20...

Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone.
https://doi.org/10.1056/NEJMoa1511049
The New England Journal of Medicine; Stempel DA, Raphiou IH et. al.

Mar 7th, 2016 - The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate. In...

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distr...
https://doi.org/10.1001/jama.2016.0291
JAMA Bellani G, Laffey JG et. al.

Feb 23rd, 2016 - Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts-for example prone positioning-in routine clinical practice for patients fulfilling the ARDS Be...

Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in t...
https://doi.org/10.1001/jama.2015.18318
JAMA Chawes BL, Bønnelykke K et. al.

Jan 27th, 2016 - Observational studies have suggested that increased dietary vitamin D intake during pregnancy may protect against wheezing in the offspring, but the preventive effect of vitamin D supplementation to pregnant women is unknown. To determine whether supplementation of vitamin D3 during the third trimester of pregnancy reduces the risk of persistent wheeze in the offspring. A double-blind, single-c...

Safety of live attenuated influenza vaccine in young people with egg allergy: multicent...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673102
BMJ (Clinical Research Ed.); Turner PJ, Southern J et. al.

Dec 9th, 2015 - How safe is live attenuated influenza vaccine (LAIV), which contains egg protein, in young people with egg allergy? In this open label, phase IV intervention study, 779 young people (2-18 years) with egg allergy were recruited from 30 UK allergy centres and immunised with LAIV. The cohort included 270 (34.7%) young people with previous anaphylaxis to egg, of whom 157 (20.1%) had experienced res...

Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products.
https://doi.org/10.1001/jama.2015.15572
JAMA Wang C, Graham DJ et. al.

Nov 17th, 2015 - All intravenous (IV) iron products are associated with anaphylaxis, but the comparative safety of each product has not been well established. To compare the risk of anaphylaxis among marketed IV iron products. Retrospective new user cohort study of IV iron recipients (n = 688,183) enrolled in the US fee-for-service Medicare program from January 2003 to December 2013. Analyses involving ferumoxy...

Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A ...
https://doi.org/10.1001/jamapediatrics.2015.3092
JAMA Pediatrics; Chang YS, Lin MH et. al.

Nov 16th, 2015 - Sleep disturbance is common in children with atopic dermatitis (AD), but effective clinical management for this problem is lacking. Reduced levels of nocturnal melatonin were found to be associated with sleep disturbance and increased disease severity in children with AD. Melatonin also has sleep-inducing and anti-inflammatory properties and therefore might be useful for the management of AD. T...

Patch Testing for Methylisothiazolinone and Methylchloroisothiazolinone-Methylisothiazo...
https://doi.org/10.1001/jamadermatol.2015.3606
JAMA Dermatology; Yu SH, Sood A et. al.

Nov 4th, 2015 - Contact allergy to methylisothiazolinone (MI) or to the combined formulation of methylchloroisothiazolinone and MI (MCI-MI) has increased significantly, with a frequency of as much as 11.1% in patients with dermatitis; however, few cohort studies in the US population have been reported. To investigate the prevalence of contact allergies to MI and MCI-MI and the outcomes of patients with positiv...

Early Exposure to Dogs and Farm Animals and the Risk of Childhood Asthma.
https://doi.org/10.1001/jamapediatrics.2015.3219
JAMA Pediatrics; Fall T, Lundholm C et. al.

Nov 2nd, 2015 - The association between early exposure to animals and childhood asthma is not clear, and previous studies have yielded contradictory results. To determine whether exposure to dogs and farm animals confers a risk of asthma. In a nationwide cohort study, the association between early exposure to dogs and farm animals and the risk of asthma was evaluated and included all children born in Sweden fr...

Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in...
https://doi.org/10.1001/jama.2015.13277
JAMA Wechsler ME, Yawn BP et. al.

Oct 27th, 2015 - The efficacy and safety of long-acting β-agonists (LABAs) have been questioned. Black populations may be disproportionately affected by LABA risks. To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis as...

Menopause as a predictor of new-onset asthma: A longitudinal Northern European populati...
https://doi.org/10.1016/j.jaci.2015.08.019
The Journal of Allergy and Clinical Immunology; Triebner K, Johannessen A et. al.

Oct 5th, 2015 - There is limited and conflicting evidence on the effect of menopause on asthma. We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years. The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at base...

Leukotriene-receptor antagonists versus placebo in the treatment of asthma in adults an...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648683
Annals of Internal Medicine; Miligkos M, Bannuru RR et. al.

Sep 21st, 2015 - Leukotriene-receptor antagonists (LTRAs) are recommended as an alternative treatment in patients with mild asthma, but their effect compared with placebo is unclear. To determine the benefits and harms of LTRAs as monotherapy or in combination with inhaled corticosteroids compared with placebo in adults and adolescents with asthma. MEDLINE and the Cochrane Central Register of Controlled Trials ...

Severe chronic primary neutropenia in adults: report on a series of 108 patients.
https://doi.org/10.1182/blood-2015-03-634493
Blood Sicre de Fontbrune F, Moignet A et. al.

Aug 11th, 2015 - Severe chronic primary neutropenia (CPN) is a rare entity, and long-term outcome and risk factors for infections in severe CPN adults have not been described to date. We report the characteristics and outcomes of 108 severe adult CPN patients enrolled in a multi-institutional observational study. Severe CPN adults were mostly female (78%), and median age at diagnosis was 28.3 years. Diagnosis w...

Effect of a soy isoflavone supplement on lung function and clinical outcomes in patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443623
JAMA Smith LJ, Kalhan R et. al.

May 26th, 2015 - Soy isoflavone supplements are used to treat several chronic diseases, although the data supporting their use are limited. Some data suggest that supplementation with soy isoflavone may be an effective treatment for patients with poor asthma control. To determine whether a soy isoflavone supplement improves asthma control in adolescent and adult patients with poorly controlled disease. Multicen...

Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticil...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431679
BMJ (Clinical Research Ed.); Paul M, Bishara J et. al.

May 15th, 2015 - To show non-inferiority of trimethoprim-sulfamethoxazole compared with vancomycin for the treatment of severe infections due to meticillin resistant Staphylococcus aureus (MRSA). Parallel, open label, randomised controlled trial. Four acute care hospitals in Israel. Adults with severe infections caused by MRSA susceptible to trimethoprim-sulfamethoxazole and vancomycin. Patients with left sided...

Emergency Department Corticosteroid Use for Allergy or Anaphylaxis Is Not Associated Wi...
https://doi.org/10.1016/j.annemergmed.2015.03.003
Annals of Emergency Medicine; Grunau BE, Wiens MO et. al.

Mar 30th, 2015 - Corticosteroids (steroids) are often used to mitigate symptoms and prevent subsequent reactions in emergency department (ED) patients with allergic reactions, despite a lack of evidence to support their use. We sought to determine the association of steroid administration with improved clinical outcomes. Adult allergy-related encounters to 2 urban EDs during a 5-year period were identified and ...