ALLMedicine Long QT Syndrome Center

Jun 1st, 2020 - DNA sequencing technology has unmasked a vast number of uncharacterized single-nucleotide variants in disease-associated genes, and efficient methods are needed to determine pathogenicity and enable clinical care. We report an E. coli-based solubi...

May 29th, 2020 - Genomic variations have shown an ethnic-specific pattern within various cohorts. Genetic variants of KCNQ1, KCNH2, SCN5A and KCNE1 causing LQT syndrome have been described in many populations. In this article the spectrum of variants of these gene...

May 29th, 2020 - Background - Long QT syndrome (LQTS) is characterized by a prolonged heart rate corrected QT interval (QTc). Genome-wide association studies identified common genetic variants that collectively explain ~8-10% of QTc variation in the general popula...

May 28th, 2020 - The relative proportion of each cardiac inherited disease (CID) causing resuscitated sudden cardiac arrest (RSCA) on a population basis is unknown. This study describes the profile of patients with CIDs presenting with RSCA; their data were collec...

May 26th, 2020 - Gain-of-function variants in the SCN5A-encoded Nav1.5 sodium channel cause type 3 long QT syndrome (LQT3) and multifocal ectopic Purkinje-related premature contractions (MEPPC). Although the Purkinje system is uniquely sensitive to the action pote...

Nov 18th, 2018 - Long QT syndrome (LQTS) is associated with potentially fatal arrhythmias. Treatment is very effective, but its diagnosis may be challenging. Importantly, different methods are used to assess the QT interval, which makes its recognition difficult. ...

Jun 1st, 2020 - DNA sequencing technology has unmasked a vast number of uncharacterized single-nucleotide variants in disease-associated genes, and efficient methods are needed to determine pathogenicity and enable clinical care. We report an E. coli-based solubi...

May 29th, 2020 - Genomic variations have shown an ethnic-specific pattern within various cohorts. Genetic variants of KCNQ1, KCNH2, SCN5A and KCNE1 causing LQT syndrome have been described in many populations. In this article the spectrum of variants of these gene...

May 29th, 2020 - Background - Long QT syndrome (LQTS) is characterized by a prolonged heart rate corrected QT interval (QTc). Genome-wide association studies identified common genetic variants that collectively explain ~8-10% of QTc variation in the general popula...

May 28th, 2020 - The relative proportion of each cardiac inherited disease (CID) causing resuscitated sudden cardiac arrest (RSCA) on a population basis is unknown. This study describes the profile of patients with CIDs presenting with RSCA; their data were collec...

May 26th, 2020 - Gain-of-function variants in the SCN5A-encoded Nav1.5 sodium channel cause type 3 long QT syndrome (LQT3) and multifocal ectopic Purkinje-related premature contractions (MEPPC). Although the Purkinje system is uniquely sensitive to the action pote...

May 17th, 2020 - NEW YORK (Reuters Health) — A genetic variant that increases the risk of drug-induced long QT syndrome (LQTS) and sudden cardiac death (SCD) could contribute to the higher COVID-19-related mortality seen in African Americans, researchers report. I...

Jan 27th, 2020 - Genomics experts say evidence falls short for more than half the genes published and anointed as causing long QT syndrome (LQTS) and assessed routinely on commercial genetic test panels. Of the 17 genes previously reported in the literature to cau...

Sep 18th, 2019 - A new case series raises the question of whether electronic gaming may cause ventricular arrhythmias and contribute to syncope in children with certain underlying conditions. The authors report on four instances of syncope resulting from ventricul...

May 16th, 2019 - Drinking large quantities of grapefruit juice may prolong the QT interval, especially in women and those who already have long QT syndrome (LQTS), new research suggests. Investigators at Tel Aviv Sourasky Medical Center (TASMC) and Sackler Faculty...

Nov 18th, 2018 - Long QT syndrome (LQTS) is associated with potentially fatal arrhythmias. Treatment is very effective, but its diagnosis may be challenging. Importantly, different methods are used to assess the QT interval, which makes its recognition difficult. ...