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About 4,641 results

ALLMedicine Long QT Syndrome Center

Research & Reviews  2,207 results

A rapid solubility assay of protein domain misfolding for pathogenicity assessment of r...
https://doi.org/10.1038/s41436-020-0842-1
Genetics in Medicine : Official Journal of the American College of Medical Genetics; Anderson CL, Routes TC et. al.

Jun 1st, 2020 - DNA sequencing technology has unmasked a vast number of uncharacterized single-nucleotide variants in disease-associated genes, and efficient methods are needed to determine pathogenicity and enable clinical care. We report an E. coli-based solubi...

Genetic homozygosity in a diverse population: An experience of long QT syndrome.
https://doi.org/10.1016/j.ijcard.2020.05.056
International Journal of Cardiology; Mahdieh N, Khorgami M et. al.

May 29th, 2020 - Genomic variations have shown an ethnic-specific pattern within various cohorts. Genetic variants of KCNQ1, KCNH2, SCN5A and KCNE1 causing LQT syndrome have been described in many populations. In this article the spectrum of variants of these gene...

The QTc-Polygenic Risk Score (QTc-PRS) and its Contribution to Type 1, Type 2, and Type...
https://doi.org/10.1161/CIRCGEN.120.002922
Circulation. Genomic and Precision Medicine; Turkowski KL, Dotzler SM et. al.

May 29th, 2020 - Background - Long QT syndrome (LQTS) is characterized by a prolonged heart rate corrected QT interval (QTc). Genome-wide association studies identified common genetic variants that collectively explain ~8-10% of QTc variation in the general popula...

A Population-Based Registry of Patients With Inherited Cardiac Conditions and Resuscita...
https://doi.org/10.1016/j.jacc.2020.04.004
Journal of the American College of Cardiology; Rucinski C, Winbo A et. al.

May 28th, 2020 - The relative proportion of each cardiac inherited disease (CID) causing resuscitated sudden cardiac arrest (RSCA) on a population basis is unknown. This study describes the profile of patients with CIDs presenting with RSCA; their data were collec...

Purkinje System Hyperexcitability and Ventricular Arrhythmia Risk in Type 3 Long QT Syn...
https://doi.org/10.1016/j.hrthm.2020.05.019
Heart Rhythm; Barake W, Giudicessi JR et. al.

May 26th, 2020 - Gain-of-function variants in the SCN5A-encoded Nav1.5 sodium channel cause type 3 long QT syndrome (LQT3) and multifocal ectopic Purkinje-related premature contractions (MEPPC). Although the Purkinje system is uniquely sensitive to the action pote...

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Guidelines  1 results

Determination and Interpretation of the QT Interval
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.033943
Circulation Vink,A.,et al

Nov 18th, 2018 - Long QT syndrome (LQTS) is associated with potentially fatal arrhythmias. Treatment is very effective, but its diagnosis may be challenging. Importantly, different methods are used to assess the QT interval, which makes its recognition difficult. ...

see more →

Clinicaltrials.gov  2,311 results

A rapid solubility assay of protein domain misfolding for pathogenicity assessment of r...
https://doi.org/10.1038/s41436-020-0842-1
Genetics in Medicine : Official Journal of the American College of Medical Genetics; Anderson CL, Routes TC et. al.

Jun 1st, 2020 - DNA sequencing technology has unmasked a vast number of uncharacterized single-nucleotide variants in disease-associated genes, and efficient methods are needed to determine pathogenicity and enable clinical care. We report an E. coli-based solubi...

Genetic homozygosity in a diverse population: An experience of long QT syndrome.
https://doi.org/10.1016/j.ijcard.2020.05.056
International Journal of Cardiology; Mahdieh N, Khorgami M et. al.

May 29th, 2020 - Genomic variations have shown an ethnic-specific pattern within various cohorts. Genetic variants of KCNQ1, KCNH2, SCN5A and KCNE1 causing LQT syndrome have been described in many populations. In this article the spectrum of variants of these gene...

The QTc-Polygenic Risk Score (QTc-PRS) and its Contribution to Type 1, Type 2, and Type...
https://doi.org/10.1161/CIRCGEN.120.002922
Circulation. Genomic and Precision Medicine; Turkowski KL, Dotzler SM et. al.

May 29th, 2020 - Background - Long QT syndrome (LQTS) is characterized by a prolonged heart rate corrected QT interval (QTc). Genome-wide association studies identified common genetic variants that collectively explain ~8-10% of QTc variation in the general popula...

A Population-Based Registry of Patients With Inherited Cardiac Conditions and Resuscita...
https://doi.org/10.1016/j.jacc.2020.04.004
Journal of the American College of Cardiology; Rucinski C, Winbo A et. al.

May 28th, 2020 - The relative proportion of each cardiac inherited disease (CID) causing resuscitated sudden cardiac arrest (RSCA) on a population basis is unknown. This study describes the profile of patients with CIDs presenting with RSCA; their data were collec...

Purkinje System Hyperexcitability and Ventricular Arrhythmia Risk in Type 3 Long QT Syn...
https://doi.org/10.1016/j.hrthm.2020.05.019
Heart Rhythm; Barake W, Giudicessi JR et. al.

May 26th, 2020 - Gain-of-function variants in the SCN5A-encoded Nav1.5 sodium channel cause type 3 long QT syndrome (LQT3) and multifocal ectopic Purkinje-related premature contractions (MEPPC). Although the Purkinje system is uniquely sensitive to the action pote...

see more →

News  99 results

Genetic Variant Might Contribute to Racial Disparity in COVID-19 Cardiac Mortality
https://www.medscape.com/viewarticle/930642

May 17th, 2020 - NEW YORK (Reuters Health) — A genetic variant that increases the risk of drug-induced long QT syndrome (LQTS) and sudden cardiac death (SCD) could contribute to the higher COVID-19-related mortality seen in African Americans, researchers report. I...

Genomic Experts Throw Cold Water on Most Long QT Genes
https://www.medscape.com/viewarticle/924411

Jan 27th, 2020 - Genomics experts say evidence falls short for more than half the genes published and anointed as causing long QT syndrome (LQTS) and assessed routinely on commercial genetic test panels. Of the 17 genes previously reported in the literature to cau...

Can Video Gaming Trigger Dangerous Arrhythmias?
https://www.medscape.com/viewarticle/918728

Sep 18th, 2019 - A new case series raises the question of whether electronic gaming may cause ventricular arrhythmias and contribute to syncope in children with certain underlying conditions. The authors report on four instances of syncope resulting from ventricul...

Large Quantities of Grapefruit Juice Prolong QT Interval
https://www.medscape.com/viewarticle/913187

May 16th, 2019 - Drinking large quantities of grapefruit juice may prolong the QT interval, especially in women and those who already have long QT syndrome (LQTS), new research suggests. Investigators at Tel Aviv Sourasky Medical Center (TASMC) and Sackler Faculty...

Determination and Interpretation of the QT Interval
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.033943
Circulation Vink,A.,et al

Nov 18th, 2018 - Long QT syndrome (LQTS) is associated with potentially fatal arrhythmias. Treatment is very effective, but its diagnosis may be challenging. Importantly, different methods are used to assess the QT interval, which makes its recognition difficult. ...

see more →

Patient Education  23 results see all →