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About 1,425 results

ALLMedicine™ Torsade De Pointes Center

Research & Reviews  633 results

Revisiting the hERG safety margin after 20 years of routine hERG screening.
https://doi.org/10.1016/j.vascn.2020.106900
Journal of Pharmacological and Toxicological Methods; Leishman DJ, Abernathy MM et. al.

Aug 4th, 2020 - It has been two decades since screening new molecules and potential clinical drug candidates against the hERG potassium channel became a routine part of safety pharmacology. The earliest heuristic for what was an adequate safety margin to separate...

Adverse clinical events caused by pacemaker battery depletion: two case reports.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376836
BMC Cardiovascular Disorders; Liu J, Wen L et. al.

Jul 24th, 2020 - The clinical symptoms and adverse events caused by pacemaker battery depletion are not uncommon, but it is easy to miss or misdiagnose them clinically. To raise the level of awareness towards this clinical situation, we report two cases. We descri...

High rate pacing guided by short-term variability of repolarization prevents imminent v...
https://doi.org/10.1016/j.hrthm.2020.07.023
Heart Rhythm; Smoczyńska A, Loen V et. al.

Jul 21st, 2020 - The anesthetized, chronic complete atrioventricular block (CAVB) dog model allows reproducible inducibility of Torsade de Pointes (TdP) arrhythmias due to ventricular remodeling and after a challenge with an IKr-blocker. High rate pacing (HRP) pre...

A case of torsades de pointes induced by the third-generation EGFR-TKI, osimertinib com...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313192
BMC Pulmonary Medicine; Bian S, Tang X et. al.

Jun 25th, 2020 - Torsade de pointes (TdP) is a malignant arrhythmia that can be induced by QT internal prolongation due to a variety of factors. Here we report an elderly patient with advanced non-small cell lung cancer (NSCLC) had sudden TdP during hospitalizatio...

Risperidone alone did not induce torsade de pointes: Experimental evidence from the chr...
https://doi.org/10.1016/j.jphs.2020.05.008
Journal of Pharmacological Sciences; Nunoi Y, Chiba K et. al.

Jun 5th, 2020 - We assessed torsadogenic action of risperidone, which can potently inhibit IKr as well as α1-adrenoceptor. A toxic dose of 3 mg/kg of risperidone was intravenously administered over 10 min to chronic atrioventricular block dogs without anesthesia ...

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Guidelines  2 results

Guidelines for reporting case studies and series on drug-induced QT interval prolongati...
https://doi.org/10.1080/15563650.2019.1605077
Clinical Toxicology (Philadelphia, Pa.); Berling I, Hatten BW et. al.

Apr 25th, 2019 - Background: The assessment and management of patients with QT interval prolongation in poisoning requires an appropriate method of measuring and adjusting the QT interval for the heart rate (HR) in order to decide if the patient is at risk of life...

Prevention of torsade de pointes in hospital settings: a scientific statement from the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056123
Circulation Drew BJ, Ackerman MJ et. al.

Feb 9th, 2010 - Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.|2010|Drew BJ,Ackerman MJ,Funk M,Gibler WB,Kligfield P,|physiology,epidemiology,phy...

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Drugs  69 results see all →

Clinicaltrials.gov  717 results

Revisiting the hERG safety margin after 20 years of routine hERG screening.
https://doi.org/10.1016/j.vascn.2020.106900
Journal of Pharmacological and Toxicological Methods; Leishman DJ, Abernathy MM et. al.

Aug 4th, 2020 - It has been two decades since screening new molecules and potential clinical drug candidates against the hERG potassium channel became a routine part of safety pharmacology. The earliest heuristic for what was an adequate safety margin to separate...

Adverse clinical events caused by pacemaker battery depletion: two case reports.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376836
BMC Cardiovascular Disorders; Liu J, Wen L et. al.

Jul 24th, 2020 - The clinical symptoms and adverse events caused by pacemaker battery depletion are not uncommon, but it is easy to miss or misdiagnose them clinically. To raise the level of awareness towards this clinical situation, we report two cases. We descri...

High rate pacing guided by short-term variability of repolarization prevents imminent v...
https://doi.org/10.1016/j.hrthm.2020.07.023
Heart Rhythm; Smoczyńska A, Loen V et. al.

Jul 21st, 2020 - The anesthetized, chronic complete atrioventricular block (CAVB) dog model allows reproducible inducibility of Torsade de Pointes (TdP) arrhythmias due to ventricular remodeling and after a challenge with an IKr-blocker. High rate pacing (HRP) pre...

A case of torsades de pointes induced by the third-generation EGFR-TKI, osimertinib com...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313192
BMC Pulmonary Medicine; Bian S, Tang X et. al.

Jun 25th, 2020 - Torsade de pointes (TdP) is a malignant arrhythmia that can be induced by QT internal prolongation due to a variety of factors. Here we report an elderly patient with advanced non-small cell lung cancer (NSCLC) had sudden TdP during hospitalizatio...

Risperidone alone did not induce torsade de pointes: Experimental evidence from the chr...
https://doi.org/10.1016/j.jphs.2020.05.008
Journal of Pharmacological Sciences; Nunoi Y, Chiba K et. al.

Jun 5th, 2020 - We assessed torsadogenic action of risperidone, which can potently inhibit IKr as well as α1-adrenoceptor. A toxic dose of 3 mg/kg of risperidone was intravenously administered over 10 min to chronic atrioventricular block dogs without anesthesia ...

see more →

News  4 results

Abbott ICD Recall; Sex After Heart Attack; LVEF Sans Contrast Media
https://www.medpagetoday.com/cardiology/prevention/81440

Aug 6th, 2019 - Certain Ellipse implantable cardioverter defibrillators from Abbott are under Class I recall because of electrical failures attributed to a faulty manufacturing process, the FDA announced. Thanks to artificial intelligence, the VMS+ system may all...

Some Oral Contraceptives Tied to QT Prolongation
https://www.medpagetoday.com/cardiology/arrhythmias/74350

Aug 1st, 2018 - Action Points Healthy women on oral contraceptives may have a higher risk for drug-induced alterations of ventricular repolarization. Note that the results generate the hypothesis that drospirenone may be a risk factor for drug-induced torsade de ...

FDA Warns Anti-Nausea Drug May Trigger Arrhythmias
https://www.medpagetoday.com/hematologyoncology/chemotherapy/28538

Sep 15th, 2011 - WASHINGTON -- A drug used to treat nausea and vomiting caused by chemotherapy may trigger dangerous and possibly lethal changes in heart rhythms, the FDA warned Thursday. The drug, ondansetron (Zofran), may increase the risk of "developing prolong...

Be Ready for Drug-Induced Vfib, Groups Urge
https://www.medpagetoday.com/cardiology/arrhythmias/18358

Feb 8th, 2010 - Action Points Note that an awareness of drug-induced torsade de pointes and a protocol for treating it could save lives in the hospital when the rare condition strikes, according to a statement by three professional associations. Note that the sta...

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