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About 1,421 results

ALLMedicine™ Torsade De Pointes Center

Research & Reviews  633 results

Critical repolarization gradients determine the induction of reentry-based Torsade de P...
https://doi.org/10.1016/j.hrthm.2020.09.020
Heart Rhythm; Rivaud MR, Bayer JD et. al.

Oct 8th, 2020 - Torsade de Pointes arrhythmia is a potentially lethal polymorphic ventricular tachyarrhythmia (pVT) in the setting of long QT syndrome. Arrhythmia susceptibility is influenced by risk factors modifying repolarization. To characterize repolarizatio...

Relationship between serum bepridil concentration and corrected QT interval.
https://doi.org/10.5414/CP203843
International Journal of Clinical Pharmacology and Therapeutics; Matsui K, Mukai Y et. al.

Oct 7th, 2020 - Bepridil prolongs the QT interval and can induce torsade de pointes. Although increased bepridil concentration may be a primary cause of prolonged QT, the relationship between serum bepridil concentration and prolonged QT remains unclear. We inves...

Safely Administering Potential QTc Prolonging Therapy Across a Large Healthcare System ...
https://doi.org/10.1161/CIRCEP.120.008937
Circulation. Arrhythmia and Electrophysiology; Saleh M, Gabriels J et. al.

Oct 2nd, 2020 - Background - The SARs-CoV-2 coronavirus has resulted in a global pandemic. Hydroxychloroquine ± azithromycin have been widely used to treat COVID-19 despite a paucity of evidence regarding efficacy. The incidence of torsade de pointes (TdP) remain...

Ivabradine-Induced Torsade de Pointes in Patients with Heart Failure Reduced Ejection F...
https://doi.org/10.1536/ihj.20-073
International Heart Journal; Jang JH, Kwon SW et. al.

Sep 14th, 2020 - Ivabradine is a selective inhibitor of the sinoatrial node "funny" current, prolonging the slow diastolic depolarization. As it has the ability to block the heart rate selectively, it is more effective at a faster heart rate. It is recommended for...

Revisiting the hERG safety margin after 20 years of routine hERG screening.
https://doi.org/10.1016/j.vascn.2020.106900
Journal of Pharmacological and Toxicological Methods; Leishman DJ, Abernathy MM et. al.

Aug 9th, 2020 - It has been two decades since screening new molecules and potential clinical drug candidates against the hERG potassium channel became a routine part of safety pharmacology. The earliest heuristic for what was an adequate safety margin to separate...

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Guidelines  2 results

Guidelines for reporting case studies and series on drug-induced QT interval prolongati...
https://doi.org/10.1080/15563650.2019.1605077
Clinical Toxicology (Philadelphia, Pa.); Berling I, Hatten BW et. al.

Apr 25th, 2019 - Background: The assessment and management of patients with QT interval prolongation in poisoning requires an appropriate method of measuring and adjusting the QT interval for the heart rate (HR) in order to decide if the patient is at risk of life...

Prevention of torsade de pointes in hospital settings: a scientific statement from the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056123
Circulation Drew BJ, Ackerman MJ et. al.

Feb 9th, 2010 - Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.|2010|Drew BJ,Ackerman MJ,Funk M,Gibler WB,Kligfield P,|physiology,epidemiology,phy...

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Drugs  67 results see all →

Clinicaltrials.gov  715 results

Critical repolarization gradients determine the induction of reentry-based Torsade de P...
https://doi.org/10.1016/j.hrthm.2020.09.020
Heart Rhythm; Rivaud MR, Bayer JD et. al.

Oct 8th, 2020 - Torsade de Pointes arrhythmia is a potentially lethal polymorphic ventricular tachyarrhythmia (pVT) in the setting of long QT syndrome. Arrhythmia susceptibility is influenced by risk factors modifying repolarization. To characterize repolarizatio...

Relationship between serum bepridil concentration and corrected QT interval.
https://doi.org/10.5414/CP203843
International Journal of Clinical Pharmacology and Therapeutics; Matsui K, Mukai Y et. al.

Oct 7th, 2020 - Bepridil prolongs the QT interval and can induce torsade de pointes. Although increased bepridil concentration may be a primary cause of prolonged QT, the relationship between serum bepridil concentration and prolonged QT remains unclear. We inves...

Safely Administering Potential QTc Prolonging Therapy Across a Large Healthcare System ...
https://doi.org/10.1161/CIRCEP.120.008937
Circulation. Arrhythmia and Electrophysiology; Saleh M, Gabriels J et. al.

Oct 2nd, 2020 - Background - The SARs-CoV-2 coronavirus has resulted in a global pandemic. Hydroxychloroquine ± azithromycin have been widely used to treat COVID-19 despite a paucity of evidence regarding efficacy. The incidence of torsade de pointes (TdP) remain...

Ivabradine-Induced Torsade de Pointes in Patients with Heart Failure Reduced Ejection F...
https://doi.org/10.1536/ihj.20-073
International Heart Journal; Jang JH, Kwon SW et. al.

Sep 14th, 2020 - Ivabradine is a selective inhibitor of the sinoatrial node "funny" current, prolonging the slow diastolic depolarization. As it has the ability to block the heart rate selectively, it is more effective at a faster heart rate. It is recommended for...

Ziprasidone mesylate - ziprasidone mesylate injection, powder, lyophilized, for solution-Gland Pharma Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=77a10f48-e300-465f-81b5-54be38daa4b3

Sep 6th, 2020 - Ziprasidone mesylate for injection intramuscular is indicated for acute agitation in schizophrenic patients. When deciding among the alternative treatments available for the condition needing treatment, the prescriber should consider the finding o...

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News  4 results

Abbott ICD Recall; Sex After Heart Attack; LVEF Sans Contrast Media
https://www.medpagetoday.com/cardiology/prevention/81440

Aug 6th, 2019 - Certain Ellipse implantable cardioverter defibrillators from Abbott are under Class I recall because of electrical failures attributed to a faulty manufacturing process, the FDA announced. Thanks to artificial intelligence, the VMS+ system may all...

Some Oral Contraceptives Tied to QT Prolongation
https://www.medpagetoday.com/cardiology/arrhythmias/74350

Aug 1st, 2018 - Action Points Healthy women on oral contraceptives may have a higher risk for drug-induced alterations of ventricular repolarization. Note that the results generate the hypothesis that drospirenone may be a risk factor for drug-induced torsade de ...

FDA Warns Anti-Nausea Drug May Trigger Arrhythmias
https://www.medpagetoday.com/hematologyoncology/chemotherapy/28538

Sep 15th, 2011 - WASHINGTON -- A drug used to treat nausea and vomiting caused by chemotherapy may trigger dangerous and possibly lethal changes in heart rhythms, the FDA warned Thursday. The drug, ondansetron (Zofran), may increase the risk of "developing prolong...

Be Ready for Drug-Induced Vfib, Groups Urge
https://www.medpagetoday.com/cardiology/arrhythmias/18358

Feb 8th, 2010 - Action Points Note that an awareness of drug-induced torsade de pointes and a protocol for treating it could save lives in the hospital when the rare condition strikes, according to a statement by three professional associations. Note that the sta...

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