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About 1,500 results

ALLMedicine™ Torsade De Pointes Center

Research & Reviews  643 results

QTc, the Multitude of Ways It Is Calculated and Implications for Clinical Practice: A C...
https://doi.org/10.1097/PRA.0000000000000526
Journal of Psychiatric Practice; Preskorn SH, Lochmann DB et. al.

Jan 13th, 2021 - QTc stands for heart-rate corrected QT interval on the electrocardiogram and is a measure of the efficiency of repolarization of the left ventricle. Excessive prolongation, generally considered to be >500 ms, can result in a potentially fatal vent...

Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decisio...
https://doi.org/10.1002/cpt.2137
Clinical Pharmacology and Therapeutics; Strauss DG, Wu WW et. al.

Dec 17th, 2020 - After multiple drugs were removed from the market secondary to drug-induced torsade de pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in 2005 that focused on the nonclinical (S7B) and clinical (E14) asses...

Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Bl...
https://doi.org/10.1002/cpt.2133
Clinical Pharmacology and Therapeutics; Liu T, Liu J et. al.

Dec 7th, 2020 - Drugs that prolong QT may cause torsade de pointes (TdP). However, translation of nonclinical assessment of QT prolongation or hERG channel, targeted by QT-prolonging drugs, into clinical TdP risk has been insufficient to date. In this blinded stu...

Arrhythmias related to antipsychotics and antidepressants: an analysis of the summaries...
https://doi.org/10.1007/s00228-020-03049-x
European Journal of Clinical Pharmacology; Elsayed M, Abdel-Kahaar E et. al.

Nov 24th, 2020 - Most psychiatric drugs, such as antidepressants (AD) and antipsychotics (AP), may cause cardiac adverse events (CAE). We used summaries of product characteristics (SmPC) for assessing the likelihood of AD and AP to cause CAE. We identified all ori...

A pharmacovigilance study to quantify the strength of association between the combinati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738207
Expert Review of Pharmacoeconomics & Outcomes Research; Diaby V, Almutairi RD et. al.

Nov 13th, 2020 - Background: Hydroxychloroquine, an antimalarial drug, combined with azithromycin has been considered a potential treatment for COVID-19. However, these drugs may cause electrocardiogram QT prolongation (QTp) and torsade de Pointes (TdP). We examin...

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Guidelines  2 results

Guidelines for reporting case studies and series on drug-induced QT interval prolongati...
https://doi.org/10.1080/15563650.2019.1605077
Clinical Toxicology (Philadelphia, Pa.); Berling I, Hatten BW et. al.

Apr 25th, 2019 - Background: The assessment and management of patients with QT interval prolongation in poisoning requires an appropriate method of measuring and adjusting the QT interval for the heart rate (HR) in order to decide if the patient is at risk of life...

Prevention of torsade de pointes in hospital settings: a scientific statement from the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056123
Circulation Drew BJ, Ackerman MJ et. al.

Feb 9th, 2010 - Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.|2010|Drew BJ,Ackerman MJ,Funk M,Gibler WB,Kligfield P,|physiology,epidemiology,phy...

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Drugs  69 results see all →

Clinicaltrials.gov  755 results

QTc, the Multitude of Ways It Is Calculated and Implications for Clinical Practice: A C...
https://doi.org/10.1097/PRA.0000000000000526
Journal of Psychiatric Practice; Preskorn SH, Lochmann DB et. al.

Jan 13th, 2021 - QTc stands for heart-rate corrected QT interval on the electrocardiogram and is a measure of the efficiency of repolarization of the left ventricle. Excessive prolongation, generally considered to be >500 ms, can result in a potentially fatal vent...

Ziprasidone hydrochloride - ziprasidone hcl capsule-Proficient Rx LP
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=80c13492-3873-48ba-882f-58e02dc7237d

Dec 31st, 2020 - Ziprasidone hydrochloride capsules are indicated for the treatment of schizophrenia. When deciding among the alternative treatments available for the condition needing treatment, the prescriber should consider the finding of ziprasidone’ s greater...

Ziprasidone hydrochloride - ziprasidone hydrochloride capsule-Proficient Rx LP
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b650e8b6-6df7-4301-837d-3d3b650b7456

Dec 31st, 2020 - Ziprasidone hydrochloride capsules are indicated for the treatment of schizophrenia. When deciding among the alternative treatments available for the condition needing treatment, the prescriber should consider the finding of ziprasidone's greater ...

Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decisio...
https://doi.org/10.1002/cpt.2137
Clinical Pharmacology and Therapeutics; Strauss DG, Wu WW et. al.

Dec 17th, 2020 - After multiple drugs were removed from the market secondary to drug-induced torsade de pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in 2005 that focused on the nonclinical (S7B) and clinical (E14) asses...

Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Bl...
https://doi.org/10.1002/cpt.2133
Clinical Pharmacology and Therapeutics; Liu T, Liu J et. al.

Dec 7th, 2020 - Drugs that prolong QT may cause torsade de pointes (TdP). However, translation of nonclinical assessment of QT prolongation or hERG channel, targeted by QT-prolonging drugs, into clinical TdP risk has been insufficient to date. In this blinded stu...

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News  31 results

Cardiology Groups Push Back on Hydroxychloroquine, Azithromycin for COVID-19
https://www.staging.medscape.com/viewarticle/928456

Apr 8th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The nation's leading cardiology associations urged caution with hydroxychloroquine and azithromycin for COVID-19 in patients with cardiovascular d...

Cardiology Groups Push Back on Hydroxychloroquine, Azithromycin for COVID-19
https://www.medscape.com/viewarticle/928456

Apr 8th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The nation's leading cardiology associations urged caution with hydroxychloroquine and azithromycin for COVID-19 in patients with cardiovascular d...

ECG Challenge: Teen With His First Seizure
https://www.medscape.com/viewarticle/920545_2

Nov 5th, 2019 - The correct diagnosis is long QT, torsade de pointes (Figure 2). Figure 2. Courtesy of Dr Podrid. Discussion The first QRS complex is narrow and supraventricular (*). It is followed by a rapid and irregular rhythm with a rate of up to 300 beats/mi...

Abbott ICD Recall; Sex After Heart Attack; LVEF Sans Contrast Media
https://www.medpagetoday.com/cardiology/prevention/81440

Aug 6th, 2019 - Certain Ellipse implantable cardioverter defibrillators from Abbott are under Class I recall because of electrical failures attributed to a faulty manufacturing process, the FDA announced. Thanks to artificial intelligence, the VMS+ system may all...

Some Oral Contraceptives Tied to QT Prolongation
https://www.medpagetoday.com/cardiology/arrhythmias/74350

Aug 1st, 2018 - Action Points Healthy women on oral contraceptives may have a higher risk for drug-induced alterations of ventricular repolarization. Note that the results generate the hypothesis that drospirenone may be a risk factor for drug-induced torsade de ...

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